Strain Name:
C57BL/6J-MtgxR8156Btlr/Mmmh
Stock Number:
067582-MU
Citation ID:
RRID:MMRRC_067582-MU
Other Names:
R8156 (G1)
Major Collection:

Strain Information

Chrnb3
Name: cholinergic receptor, nicotinic, beta polypeptide 3
Synonyms: 5730417K16Rik, Acrb3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 108043
HGNC: HGNC:1963
Homologene: 36035
Arfgef2
Name: ADP ribosylation factor guanine nucleotide exchange factor 2
Synonyms: BIG2, E230011G24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99371
Homologene: 111880
Snx10
Name: sorting nexin 10
Synonyms: 2410004M09Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71982
Homologene: 32171
Chd1
Name: chromodomain helicase DNA binding protein 1
Synonyms: 4930525N21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12648
HGNC: HGNC:1915
Homologene: 68174
Dnajc2
Name: DnaJ heat shock protein family (Hsp40) member C2
Synonyms: Zrf1, Zrf2, Mida1, MIDA1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22791
Homologene: 31656
Prdm2
Name: PR domain containing 2, with ZNF domain
Synonyms: 4833427P12Rik, LOC381568, Riz1, KMT8, E330024L24Rik, Riz
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 110593
HGNC: HGNC:9347
Homologene: 40822
Asxl2
Name: ASXL transcriptional regulator 2
Synonyms: 4930556B16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75302
Homologene: 10102
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: trithorax Drosophila, ALL-1, Mll1, Cxxc7, Mll, HTRX1, All1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: D9Ertd809e, Dopey1, B130005I07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320615
Homologene: 26645
Hdac4
Name: histone deacetylase 4
Synonyms: 4932408F19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208727
Homologene: 55946
Lamb2
Name: laminin, beta 2
Synonyms: Lams, npht, Lamb-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16779
HGNC: HGNC:6487
Homologene: 1723
Ufl1
Name: UFM1 specific ligase 1
Synonyms: 1810074P20Rik, Maxer, Rcad
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67490
Homologene: 9093
Cip2a
Name: cell proliferation regulating inhibitor of protein phosphatase 2A
Synonyms: Cip2a, C330027C09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224171
Homologene: 10842
Dtna
Name: dystrobrevin alpha
Synonyms: a-DB-1, 2210407P21Rik, alpha-dystrobrevin, A0, 87K protein, adbn, Dtn
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13527
VEGA: 18
HGNC: HGNC:3057
Homologene: 20362
Myt1
Name: myelin transcription factor 1
Synonyms: NZF-2a, NZF-2b, Nztf2, Nzf2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17932
HGNC: HGNC:7622
Homologene: 3332
Trim71
Name: tripartite motif-containing 71
Synonyms: 636931, LOC382112, 2610206G21Rik, lin-41, mLin41, Lin41, mlin-41
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 636931
Homologene: 9076
Tcf20
Name: transcription factor 20
Synonyms: 2810438H08Rik, SPBP, stromelysin 1 PDGF responsive element binding protein
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21411
VEGA: 15
Homologene: 4131
Prkaa2
Name: protein kinase, AMP-activated, alpha 2 catalytic subunit
Synonyms: AMPKalpha2, 2310008I11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 108079
HGNC: HGNC:9377
Homologene: 4551
Vmn1r28
Name: vomeronasal 1 receptor 28
Synonyms: V1rc25
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171198
Homologene: 138094
Hephl1
Name: hephaestin-like 1
Synonyms: zyklopen, thd, LOC244698, cw, Zp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244698
Homologene: 9112
Rab11fip4
Name: RAB11 family interacting protein 4 (class II)
Synonyms: A730072L08Rik, RAB11-FIP4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268451
Homologene: 8803
Gpr35
Name: G protein-coupled receptor 35
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 64095
HGNC: HGNC:4492
Homologene: 3874
Lrriq1
Name: leucine-rich repeats and IQ motif containing 1
Synonyms: Gm1557, 4930503E15Rik, LOC380658
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74978
Homologene: 46007
Pcnx1
Name: pecanex 1
Synonyms: Pcnx, 3526401J03Rik, 2900024E21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 54604
VEGA: 12
Homologene: 40997
Flg2
Name: filaggrin family member 2
Synonyms: EG229574
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229574
Homologene: 134146
Taar5
Name: trace amine-associated receptor 5
Synonyms: LOC215854
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215854
Homologene: 20850
Col6a2
Name: collagen, type VI, alpha 2
Synonyms: Col6a-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12834
HGNC: HGNC:2212
Homologene: 1392
Ndor1
Name: NADPH dependent diflavin oxidoreductase 1
Synonyms: 4930447P04Rik, NR1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78797
Homologene: 7144
Alyref
Name: Aly/REF export factor
Synonyms: Refbp1, Thoc4, REF1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21681
Homologene: 38099
Kcnb2
Name: potassium voltage gated channel, Shab-related subfamily, member 2
Synonyms: 9630047L19Rik, Kv2.2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98741
HGNC: HGNC:6232
Homologene: 31263
Foxg1
Name: forkhead box G1
Synonyms: Hfh9, 2900064B05Rik, BF-1, Bf1, Hfhbf1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 15228
HGNC: HGNC:3811
Homologene: 3843
Arhgap31
Name: Rho GTPase activating protein 31
Synonyms: CdGAP
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12549
Homologene: 10644
Gpr137b
Name: G protein-coupled receptor 137B
Synonyms: C80741, 2310041G17Rik, Tm7sf1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 83924
VEGA: 13
Homologene: 2454
Gsta3
Name: glutathione S-transferase, alpha 3
Synonyms: Gst2-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14859
Homologene: 37355
Tfap2d
Name: transcription factor AP-2, delta
Synonyms: Tcfap2d
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226896
Homologene: 17700
Or10ag56
Name: olfactory receptor family 10 subfamily AG member 56
Synonyms: Olfr1118-ps, Olfr1118, GA_x6K02T2Q125-48795705-48796673, MOR264-22
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404328
Homologene: 134077
Toporsl
Name: topoisomerase I binding, arginine/serine-rich like
Synonyms: 4930547C10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68274
Homologene: 130753
Cd1d2
Name: CD1d2 antigen
Synonyms: CD1.2, Cd1b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12480
HGNC: HGNC:1637
Bend7
Name: BEN domain containing 7
Synonyms: E130319B15Rik, 1110017O21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209645
Homologene: 17660
Pskh1
Name: protein serine kinase H1
Synonyms: E130013P03Rik, b2b1230Clo
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244631
HGNC: HGNC:9529
Homologene: 48461
C4bp
Name: complement component 4 binding protein
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12269
HGNC: HGNC:1325
Zfp995
Name: zinc finger protein 995
Synonyms: 2210404O09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70081
Homologene: 133253
Lsm4
Name: LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50783
Homologene: 134555
Asb5
Name: ankyrin repeat and SOCs box-containing 5
Synonyms: 1110018D09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76294
Homologene: 12637
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 15,710,056 bp
  • A to G, chromosome 1 at 19,103,262 bp
  • A to T, chromosome 1 at 21,260,098 bp
  • G to T, chromosome 1 at 91,958,416 bp
  • A to G, chromosome 1 at 92,982,715 bp
  • T to C, chromosome 1 at 130,639,087 bp
  • C to T, chromosome 2 at 4,752,854 bp
  • T to C, chromosome 2 at 25,248,734 bp
  • A to C, chromosome 2 at 87,308,974 bp
  • GTGTGCAGAAACT to GT, chromosome 2 at 166,834,463 bp
  • T to C, chromosome 2 at 181,822,761 bp
  • T to A, chromosome 3 at 86,987,262 bp
  • T to C, chromosome 3 at 93,220,083 bp
  • T to C, chromosome 4 at 25,269,057 bp
  • A to G, chromosome 4 at 52,609,975 bp
  • T to C, chromosome 4 at 105,051,975 bp
  • A to G, chromosome 4 at 143,134,768 bp
  • A to G, chromosome 5 at 21,781,319 bp
  • T to C, chromosome 6 at 51,562,019 bp
  • T to C, chromosome 6 at 58,265,198 bp
  • A to G, chromosome 8 at 27,393,654 bp
  • T to A, chromosome 8 at 54,550,506 bp
  • G to A, chromosome 8 at 70,678,368 bp
  • G to A, chromosome 8 at 105,913,594 bp
  • A to T, chromosome 9 at 15,060,914 bp
  • T to C, chromosome 9 at 44,822,389 bp
  • A to G, chromosome 9 at 86,494,457 bp
  • C to T, chromosome 9 at 108,480,646 bp
  • A to G, chromosome 9 at 114,513,124 bp
  • T to C, chromosome 10 at 23,971,495 bp
  • T to C, chromosome 10 at 76,596,791 bp
  • A to G, chromosome 10 at 103,156,335 bp
  • A to G, chromosome 11 at 79,686,589 bp
  • T to C, chromosome 11 at 120,598,248 bp
  • A to G, chromosome 12 at 3,496,760 bp
  • A to G, chromosome 12 at 49,384,646 bp
  • C to T, chromosome 12 at 81,918,819 bp
  • T to C, chromosome 13 at 13,359,406 bp
  • A to G, chromosome 15 at 82,852,937 bp
  • G to T, chromosome 16 at 38,625,629 bp
  • A to G, chromosome 16 at 48,997,462 bp
  • T to A, chromosome 17 at 15,761,404 bp
  • T to A, chromosome 17 at 21,880,134 bp
  • T to A, chromosome 18 at 23,590,331 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8156 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067582-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.