Strain Name:
C57BL/6J-MtgxR8160Btlr/Mmmh
Stock Number:
067586-MU
Citation ID:
RRID:MMRRC_067586-MU
Other Names:
R8160 (G1)
Major Collection:

Strain Information

Kdm5b
Name: lysine demethylase 5B
Synonyms: 2210016I17Rik, D1Ertd202e, 2010009J12Rik, Jarid1b, Rb-Bp2, PLU-1, Plu1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75605
Homologene: 48448
Itsn1
Name: intersectin 1 (SH3 domain protein 1A)
Synonyms: Ese1, EHSH1, Intersectin-L, Eh domain, SH3 domain regulator of endocytosis 1, Sh3p17
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16443
HGNC: HGNC:6183
Homologene: 2277
Tasor
Name: transcription activation suppressor
Synonyms: 4933409E02Rik, D14Abb1e, Fam208a, MommeD6
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218850
VEGA: 14
Homologene: 9062
Rad51b
Name: RAD51 paralog B
Synonyms: R51H2, Rad51l1, Rad51b, mREC2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19363
VEGA: 12
HGNC: HGNC:9822
Homologene: 50190
Adam12
Name: ADAM metallopeptidase domain 12
Synonyms: ADAM12, Mltna
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11489
HGNC: HGNC:190
Homologene: 74862
Il17rc
Name: interleukin 17 receptor C
Synonyms: IL17-RL, Il17rl, 1110025H02Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171095
Homologene: 15894
Ext2
Name: exostosin glycosyltransferase 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14043
HGNC: HGNC:3513
Homologene: 345
Mettl16
Name: methyltransferase 16, N6-methyladenosine
Synonyms: A830095F14Rik, 2810013M15Rik, Mett10d, 2610100D03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67493
Homologene: 34653
Appl1
Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
Synonyms: 2900057D21Rik, 7330406P05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72993
Homologene: 32143
Nsun6
Name: NOL1/NOP2/Sun domain family member 6
Synonyms: 4933403D21Rik, NOPD1, 4933414E04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74455
Homologene: 12564
Dock8
Name: dedicator of cytokinesis 8
Synonyms: 5830472H07Rik, A130095G14Rik, 1200017A24Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76088
VEGA: 19
Homologene: 52414
Atp7b
Name: ATPase, Cu++ transporting, beta polypeptide
Synonyms: Wilson protein, WND, Atp7a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11979
HGNC: HGNC:870
Homologene: 20063
Hfm1
Name: HFM1, ATP-dependent DNA helicase homolog
Synonyms: LOC381663, A330009G12Rik, Sec63d1, Mer3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330149
Homologene: 87103
Mink1
Name: misshapen-like kinase 1 (zebrafish)
Synonyms: Misshapen/NIKs-related kinase, Map4k6, Ysk2, MINK
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 50932
Homologene: 56762
Nt5dc1
Name: 5'-nucleotidase domain containing 1
Synonyms: Nt5c2l1, 6030401B09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 319638
Homologene: 16281
Or10a49
Name: olfactory receptor family 10 subfamily A member 49
Synonyms: GA_x6K02T2PBJ9-11199311-11198367, Olfr517, MOR268-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258136
Homologene: 79413
Cdh24
Name: cadherin-like 24
Synonyms: cadherin 14-like, ENSMUSG00000022188, 1700040A22Rik, EY-cadherin
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239096
VEGA: 14
Homologene: 56951
Arhgef4
Name: Rho guanine nucleotide exchange factor 4
Synonyms: C230030N03Rik, Asef, 9330140K16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226970
HGNC: HGNC:684
Homologene: 49414
Aldh8a1
Name: aldehyde dehydrogenase 8 family, member A1
Synonyms: RALDH4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237320
Homologene: 23369
Ccl20
Name: C-C motif chemokine ligand 20
Synonyms: MIP3A, MIP-3[a], Scya20, MIP-3A, exodus-1, ST38, CKb4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20297
Homologene: 3375
St6galnac1
Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Synonyms: ST6GalNAc I, Siat7a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20445
Homologene: 7937
Ppm1h
Name: protein phosphatase 1H (PP2C domain containing)
Synonyms: C030002B11Rik, ARHCL1, A430075L18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 319468
Homologene: 18537
Fam209
Name: family with sequence similarity 209
Synonyms: 1700029J11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76426
Homologene: 19218
Oasl2
Name: 2'-5' oligoadenylate synthetase-like 2
Synonyms: Mmu-OASL, M1204
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 23962
Homologene: 128369
Nostrin
Name: nitric oxide synthase trafficker
Synonyms: mDaIP2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329416
Homologene: 43142
Or7e166
Name: olfactory receptor family 7 subfamily E member 166
Synonyms: Olfr857, MOR146-8P, GA_x6K02T2PVTD-13452606-13453535
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 257963
Homologene: 134093
Snai2
Name: snail family zinc finger 2
Synonyms: Snail2, Slug, Slugh
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20583
VEGA: 16
Homologene: 31127
Or6aa1
Name: olfactory receptor family 6 subfamily AA member 1
Synonyms: Olfr303, MOR104-2, GA_x6K02T2NHDJ-9712819-9713778
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258612
Homologene: 105157
Hipk4
Name: homeodomain interacting protein kinase 4
Synonyms: LOC233020
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233020
Homologene: 16970
Mvb12b
Name: multivesicular body subunit 12B
Synonyms: 2610200O14Rik, Fam125b, 2610528K11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72543
Homologene: 25444
Smok3c
Name: sperm motility kinase 3C
Synonyms: EG622486
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 622486
Homologene: 128738
Dchs2
Name: dachsous cadherin related 2
Synonyms: LOC229459
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100534287
4930415F15Rik
Name:
Type: Gene
Species: Mouse
Chromosome: 11
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 34,723,574 bp
  • T to A, chromosome 1 at 83,117,822 bp
  • T to A, chromosome 1 at 134,613,919 bp
  • A to G, chromosome 2 at 15,009,408 bp
  • G to T, chromosome 2 at 33,840,222 bp
  • A to T, chromosome 2 at 69,179,466 bp
  • A to T, chromosome 2 at 93,813,762 bp
  • A to T, chromosome 2 at 172,472,725 bp
  • A to T, chromosome 3 at 83,270,805 bp
  • T to C, chromosome 5 at 106,896,033 bp
  • T to C, chromosome 5 at 114,901,286 bp
  • A to G, chromosome 5 at 138,065,024 bp
  • A to G, chromosome 6 at 113,476,528 bp
  • C to T, chromosome 7 at 27,523,761 bp
  • C to T, chromosome 7 at 86,395,265 bp
  • C to T, chromosome 7 at 108,868,788 bp
  • C to T, chromosome 7 at 133,968,041 bp
  • G to A, chromosome 8 at 21,997,559 bp
  • T to A, chromosome 9 at 19,712,789 bp
  • A to G, chromosome 10 at 21,395,791 bp
  • T to A, chromosome 10 at 34,324,396 bp
  • A to T, chromosome 10 at 122,802,436 bp
  • T to C, chromosome 11 at 11,487,734 bp
  • C to T, chromosome 11 at 70,606,081 bp
  • T to C, chromosome 11 at 74,817,679 bp
  • G to A, chromosome 11 at 116,775,490 bp
  • T to A, chromosome 12 at 79,303,341 bp
  • T to C, chromosome 14 at 26,928,635 bp
  • T to A, chromosome 14 at 27,449,956 bp
  • C to A, chromosome 14 at 54,638,489 bp
  • T to C, chromosome 16 at 14,706,804 bp
  • G to A, chromosome 16 at 91,818,558 bp
  • G to A, chromosome 19 at 25,147,347 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8160 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067586-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.