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Strain Name:
C57BL/6J-MtgxR8172Btlr/Mmmh
Stock Number:
067598-MU
Citation ID:
RRID:MMRRC_067598-MU
Other Names:
R8172 (G1)
Major Collection:

Strain Information

Hlcs
Name: holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)
Synonyms: 410I21.SP6, D16Jhu34
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 110948
VEGA: 16
HGNC: HGNC:4976
Homologene: 37302
Ptprf
Name: protein tyrosine phosphatase receptor type F
Synonyms: LAR, RPTP-LAR
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19268
HGNC: HGNC:9670
Homologene: 20623
Mtmr14
Name: myotubularin related protein 14
Synonyms: 1110061O04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 97287
Homologene: 11203
Usp47
Name: ubiquitin specific peptidase 47
Synonyms: 4930502N04Rik, A630020C16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74996
Homologene: 9929
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 328329
Homologene: 42094
Proser1
Name: proline and serine rich 1
Synonyms: 2810046L04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 212127
Homologene: 13463
Tbcd
Name: tubulin-specific chaperone d
Synonyms: A030005L14Rik, 2310057L06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108903
Homologene: 4368
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 12,990,266 bp
  • T to C, chromosome 1 at 37,907,667 bp
  • C to T, chromosome 1 at 87,596,911 bp
  • A to T, chromosome 2 at 65,690,328 bp
  • T to A, chromosome 2 at 66,252,156 bp
  • A to T, chromosome 2 at 66,675,847 bp
  • A to T, chromosome 2 at 88,817,642 bp
  • G to A, chromosome 2 at 118,284,134 bp
  • T to A, chromosome 3 at 53,478,851 bp
  • T to A, chromosome 3 at 93,201,161 bp
  • T to C, chromosome 4 at 115,111,677 bp
  • A to G, chromosome 4 at 118,211,078 bp
  • T to C, chromosome 5 at 24,543,610 bp
  • C to G, chromosome 5 at 30,145,287 bp
  • C to T, chromosome 5 at 45,584,367 bp
  • A to T, chromosome 5 at 62,621,981 bp
  • T to C, chromosome 5 at 108,163,774 bp
  • C to A, chromosome 5 at 137,667,169 bp
  • T to C, chromosome 6 at 39,149,031 bp
  • T to C, chromosome 6 at 49,417,327 bp
  • T to A, chromosome 6 at 86,427,700 bp
  • T to A, chromosome 6 at 113,239,568 bp
  • T to A, chromosome 7 at 3,658,725 bp
  • T to C, chromosome 7 at 31,359,051 bp
  • T to A, chromosome 7 at 83,997,225 bp
  • T to A, chromosome 7 at 112,087,926 bp
  • G to A, chromosome 7 at 127,802,374 bp
  • G to T, chromosome 7 at 142,968,599 bp
  • G to A, chromosome 8 at 116,931,594 bp
  • T to A, chromosome 10 at 81,123,608 bp
  • C to A, chromosome 10 at 99,144,476 bp
  • T to C, chromosome 11 at 50,379,905 bp
  • T to A, chromosome 11 at 55,287,812 bp
  • A to G, chromosome 11 at 85,911,107 bp
  • C to T, chromosome 11 at 121,493,885 bp
  • T to A, chromosome 12 at 84,314,009 bp
  • T to A, chromosome 12 at 86,741,756 bp
  • T to C, chromosome 12 at 113,259,972 bp
  • C to T, chromosome 13 at 102,953,125 bp
  • T to A, chromosome 14 at 75,591,801 bp
  • C to T, chromosome 15 at 101,485,403 bp
  • A to G, chromosome 16 at 22,806,542 bp
  • T to A, chromosome 16 at 35,157,057 bp
  • G to A, chromosome 16 at 91,616,907 bp
  • A to T, chromosome 16 at 94,267,626 bp
  • A to T, chromosome 17 at 20,114,181 bp
  • C to A, chromosome 17 at 25,244,122 bp
  • T to A, chromosome 17 at 28,549,582 bp
  • C to T, chromosome 17 at 35,471,099 bp
  • A to G, chromosome 17 at 37,772,435 bp
  • A to T, chromosome 17 at 55,797,769 bp
  • C to T, chromosome 19 at 45,776,900 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8172 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067598-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.