Strain Name:
C57BL/6J-MtgxR8179Btlr/Mmmh
Stock Number:
067604-MU
Citation ID:
RRID:MMRRC_067604-MU
Other Names:
R8179 (G1)
Major Collection:

Strain Information

Slit3
Name: slit guidance ligand 3
Synonyms: Slit1, b2b2362.1Clo
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20564
Homologene: 2303
Rnf10
Name: ring finger protein 10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50849
Homologene: 40990
Cdk19
Name: cyclin dependent kinase 19
Synonyms: 2700084L06Rik, Cdc2l6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 78334
VEGA: 10
Homologene: 22862
Elovl5
Name: ELOVL fatty acid elongase 5
Synonyms: ELOVL family member 5, elongation of long chain fatty acids (yeast), 1110059L23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68801
Homologene: 41449
Arfgap2
Name: ADP-ribosylation factor GTPase activating protein 2
Synonyms: Zfp289, 2310032E02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77038
Homologene: 8735
Med30
Name: mediator complex subunit 30
Synonyms: Thrap6, 2510044J04Rik, Trap25, 1810038N03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69790
VEGA: 15
Homologene: 12329
Dnajc15
Name: DnaJ heat shock protein family (Hsp40) member C15
Synonyms: Dnajd1, MCJ, 1110003P16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66148
VEGA: 14
Homologene: 22740
Ctc1
Name: CTS telomere maintenance complex component 1
Synonyms: 1500010J02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68964
Homologene: 11830
Xrcc5
Name: X-ray repair complementing defective repair in Chinese hamster cells 5
Synonyms: Ku80, Ku86
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22596
VEGA: 1
Homologene: 40681
Ddx54
Name: DEAD box helicase 54
Synonyms: 2410015A15Rik, APR-5, DEAD (Asp-Glu-Ala-Asp) box polypeptide 54, DP97
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71990
Homologene: 5590
Traf3ip1
Name: TRAF3 interacting protein 1
Synonyms: MIP-T3, 3930402D05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74019
Homologene: 22913
Cc2d2a
Name: coiled-coil and C2 domain containing 2A
Synonyms: 5730509K17Rik, b2b1035Clo
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231214
Homologene: 18159
Frs2
Name: fibroblast growth factor receptor substrate 2
Synonyms: C330018A15Rik, SNT1, Frs2alpha
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327826
VEGA: 10
Homologene: 4846
Clmp
Name: CXADR-like membrane protein
Synonyms: 9030425E11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71566
Homologene: 11705
Slc6a11
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 11
Synonyms: D930045G19Rik, E130202I16Rik, GAT4, Gat3, Gabt4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243616
Homologene: 129935
Mmp16
Name: matrix metallopeptidase 16
Synonyms: MT3-MMP, Membrane type 3-MMP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17389
HGNC: HGNC:7162
Homologene: 55939
Map3k1
Name: mitogen-activated protein kinase kinase kinase 1
Synonyms: MEKK1, Mekk
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26401
HGNC: HGNC:6848
Homologene: 8056
Phrf1
Name: PHD and ring finger domains 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101471
Homologene: 16377
Fgfr3
Name: fibroblast growth factor receptor 3
Synonyms: sam3, HBGFR, Fgfr-3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14184
HGNC: HGNC:3690
Homologene: 55437
Lingo1
Name: leucine rich repeat and Ig domain containing 1
Synonyms: 4930471K13Rik, LINGO-1, Lrrn6a, UNQ201, LERN1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235402
Homologene: 41891
Casp8ap2
Name: caspase 8 associated protein 2
Synonyms: D4Ertd659e, FLASH
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26885
HGNC: HGNC:1510
Homologene: 8066
Pglyrp2
Name: peptidoglycan recognition protein 2
Synonyms: PGRP-L, tagl-beta, Pglyrpl, tagL-alpha, C730002N09Rik, tagL
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57757
VEGA: 17
Homologene: 49671
Mgat5b
Name: mannoside acetylglucosaminyltransferase 5, isoenzyme B
Synonyms: GnT-IX
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268510
Homologene: 27821
Rapgef3
Name: Rap guanine nucleotide exchange factor (GEF) 3
Synonyms: 2310016P22Rik, 9330170P05Rik, Epac1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223864
Homologene: 21231
Ruvbl2
Name: RuvB-like AAA ATPase 2
Synonyms: p47, mp47
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20174
Homologene: 4856
Trpc7
Name: transient receptor potential cation channel, subfamily C, member 7
Synonyms: TRP7, Trrp8
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26946
Homologene: 22689
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: b2b1289Clo, b2b1203Clo, Dnahc11, b2b1279Clo, avc4, b2b1727Clo, b2b598Clo, lrd
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Cd180
Name: CD180 antigen
Synonyms: RP105, Ly78
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17079
HGNC: HGNC:6726
Homologene: 4077
Aox1
Name: aldehyde oxidase 1
Synonyms: retinal oxidase, Aox-2, Aox2, Aox-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11761
HGNC: HGNC:553
Homologene: 68165
Ttc21b
Name: tetratricopeptide repeat domain 21B
Synonyms: 2410066K11Rik, aln, line 158, Thm1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 73668
Homologene: 57006
Mre11a
Name: MRE11A homolog A, double strand break repair nuclease
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17535
HGNC: HGNC:7230
Homologene: 4083
Mogat1
Name: monoacylglycerol O-acyltransferase 1
Synonyms: 1110064N14Rik, mDC2, 0610030A14Rik, MGAT1, Dgat2l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68393
Homologene: 105237
Abca6
Name: ATP-binding cassette, sub-family A member 6
Synonyms: 6330565N06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76184
HGNC: HGNC:36
Homologene: 71264
Slc4a10
Name: solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
Synonyms: NCBE
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94229
Homologene: 23340
Or10d5
Name: olfactory receptor family 10 subfamily D member 5
Synonyms: GA_x6K02T2PVTD-33651220-33650288, MOR224-2, Olfr975
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258825
VEGA: 9
Homologene: 27275
Mybpc2
Name: myosin binding protein C, fast-type
Synonyms: Fast-type C-protein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233199
HGNC: HGNC:7550
Homologene: 3331
Disp2
Name: dispatched RND transporter family member 2
Synonyms: DispB, B230210L08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214240
Homologene: 24916
Atf6b
Name: activating transcription factor 6 beta
Synonyms: ATF6beta, Crebl1, Creb-rp
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12915
HGNC: HGNC:2349
Homologene: 31238
Zfp110
Name: zinc finger protein 110
Synonyms: Nrif1, NRIF, 2900024E01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 65020
Homologene: 129707
Ppip5k1
Name: diphosphoinositol pentakisphosphate kinase 1
Synonyms: Hisppd2a, B430315C20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 327655
Homologene: 49395
Myot
Name: myotilin
Synonyms: Ttid, 5530402I04Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 58916
Homologene: 4942
Arhgap40
Name: Rho GTPase activating protein 40
Synonyms: Gm14203
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 545481
Homologene: 53500
Vmn2r54
Name: vomeronasal 2, receptor 54
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 666085
Homologene: 104040
Aldh18a1
Name: aldehyde dehydrogenase 18 family, member A1
Synonyms: Pycs, 2810433K04Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56454
HGNC: HGNC:9722
Homologene: 2142
Vmn2r118
Name: vomeronasal 2, receptor 118
Synonyms: EG668547, EG383258, Vmn2r119
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 383258
Homologene: 129687
Disc1
Name: disrupted in schizophrenia 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244667
HGNC: HGNC:2888
Homologene: 10257
Plppr4
Name: phospholipid phosphatase related 4
Synonyms: Lppr4, D3Bwg0562e, PRG-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229791
Homologene: 8895
Vmn2r86
Name: vomeronasal 2, receptor 86
Synonyms: EG625109
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 625109
Homologene: 129606
Gm4553
Name: predicted gene 4553
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043617
Chp1
Name: calcineurin-like EF hand protein 1
Synonyms: vac, 1500003O03Rik, Sid470p
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56398
Homologene: 5235
Zfp112
Name: zinc finger protein 112
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57745
Homologene: 49338
Rpe65
Name: retinal pigment epithelium 65
Synonyms: A930029L06Rik, Mord1, rd12
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19892
Homologene: 20108
Ahr
Name: aryl-hydrocarbon receptor
Synonyms: bHLHe76, dioxin receptor, Ahre, Ahh, Ah, In
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 11622
HGNC: HGNC:348
Homologene: 1224
Ankrd40
Name: ankyrin repeat domain 40
Synonyms: 5530600A18Rik, 1110011C06Rik, Gcap15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71452
Homologene: 12393
Sema3g
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218877
Homologene: 10602
Grin2d
Name: glutamate receptor, ionotropic, NMDA2D (epsilon 4)
Synonyms: GluN2D, NR2D, GluRepsilon4, NMDAR2D
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14814
HGNC: HGNC:4588
Homologene: 648
Ube2q2l
Name: ubiquitin conjugating enzyme E2 Q2 like
Synonyms: E330021D16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100502936
Tubg2
Name: tubulin, gamma 2
Synonyms: Tubgl
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103768
Homologene: 69216
Ace3
Name: angiotensin I converting enzyme 3
Synonyms: EG217246
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217246
Homologene: 80337
Or10z1
Name: olfactory receptor family 10 subfamily Z member 1
Synonyms: GA_x6K02T2P20D-20891507-20892448, MOR267-6, Olfr419
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258710
Homologene: 72017
Or8g53
Name: olfactory receptor family 8 subfamily G member 53
Synonyms: GA_x6K02T2PVTD-33470347-33469403, MOR171-15, Olfr968
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258605
VEGA: 9
Homologene: 121532
Cfap54
Name: cilia and flagella associated protein 54
Synonyms: LOC380653, Gm872, 4930485B16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380654
Homologene: 133438
Igkv18-36
Name: immunoglobulin kappa chain variable 18-36
Synonyms: Gm16689
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 620088
Vprbp
Name:
Type: Gene
Species: Mouse
Chromosome: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 58,097,958 bp
  • T to C, chromosome 1 at 72,356,857 bp
  • A to G, chromosome 1 at 78,527,618 bp
  • T to C, chromosome 1 at 91,500,801 bp
  • A to T, chromosome 1 at 150,722,514 bp
  • T to G, chromosome 1 at 174,250,564 bp
  • A to C, chromosome 2 at 62,243,448 bp
  • G to A, chromosome 2 at 66,201,480 bp
  • T to C, chromosome 2 at 91,275,323 bp
  • C to G, chromosome 2 at 118,792,549 bp
  • C to T, chromosome 2 at 119,547,772 bp
  • A to T, chromosome 2 at 121,341,614 bp
  • T to C, chromosome 2 at 158,539,856 bp
  • A to G, chromosome 3 at 117,331,678 bp
  • A to G, chromosome 3 at 159,624,699 bp
  • T to A, chromosome 4 at 17,853,854 bp
  • T to A, chromosome 4 at 32,643,939 bp
  • T to C, chromosome 5 at 33,727,755 bp
  • T to A, chromosome 5 at 43,699,953 bp
  • T to C, chromosome 5 at 95,519,894 bp
  • ACCTCATCTCGTC to AC, chromosome 5 at 115,260,117 bp
  • T to A, chromosome 5 at 120,627,102 bp
  • T to C, chromosome 6 at 69,992,495 bp
  • G to A, chromosome 6 at 114,245,606 bp
  • A to G, chromosome 6 at 136,401,242 bp
  • G to T, chromosome 7 at 12,632,091 bp
  • T to A, chromosome 7 at 12,844,571 bp
  • C to T, chromosome 7 at 24,125,638 bp
  • C to A, chromosome 7 at 44,509,830 bp
  • A to G, chromosome 7 at 45,422,772 bp
  • A to T, chromosome 7 at 45,858,028 bp
  • A to G, chromosome 7 at 141,256,580 bp
  • A to T, chromosome 7 at 142,164,857 bp
  • C to T, chromosome 8 at 125,087,577 bp
  • T to A, chromosome 9 at 14,797,066 bp
  • C to T, chromosome 9 at 39,771,904 bp
  • G to A, chromosome 9 at 39,950,412 bp
  • T to C, chromosome 9 at 40,781,179 bp
  • T to C, chromosome 9 at 56,619,850 bp
  • A to G, chromosome 9 at 77,976,899 bp
  • G to T, chromosome 9 at 106,857,916 bp
  • T to C, chromosome 10 at 40,394,372 bp
  • G to T, chromosome 10 at 92,997,316 bp
  • A to T, chromosome 10 at 117,076,886 bp
  • G to A, chromosome 10 at 130,453,084 bp
  • A to G, chromosome 11 at 35,664,076 bp
  • T to A, chromosome 11 at 69,024,224 bp
  • G to A, chromosome 11 at 94,334,715 bp
  • A to T, chromosome 11 at 101,160,256 bp
  • G to T, chromosome 11 at 106,004,557 bp
  • A to G, chromosome 11 at 110,245,274 bp
  • A to G, chromosome 11 at 116,931,728 bp
  • T to C, chromosome 12 at 35,510,051 bp
  • T to A, chromosome 12 at 117,878,549 bp
  • T to A, chromosome 13 at 56,887,880 bp
  • T to C, chromosome 13 at 102,705,633 bp
  • A to C, chromosome 13 at 111,749,047 bp
  • A to G, chromosome 14 at 31,220,585 bp
  • A to T, chromosome 14 at 77,852,953 bp
  • A to T, chromosome 15 at 52,712,568 bp
  • A to T, chromosome 15 at 97,760,740 bp
  • T to C, chromosome 17 at 32,416,029 bp
  • T to C, chromosome 17 at 34,653,994 bp
  • A to T, chromosome 17 at 55,608,484 bp
  • A to T, chromosome 18 at 44,354,130 bp
  • A to C, chromosome 19 at 40,557,508 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8179 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067604-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.