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Strain Name:
C57BL/6J-MtgxR8182Btlr/Mmmh
Stock Number:
067606-MU
Citation ID:
RRID:MMRRC_067606-MU
Other Names:
R8182 (G1)
Major Collection:

Strain Information

Kif3a
Name: kinesin family member 3A
Synonyms: kinesin-II subunit, Kns3, Kif3, Kifl, N-4 kinesin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16568
HGNC: HGNC:6319
Homologene: 38266
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Kif16b
Name: kinesin family member 16B
Synonyms: N-3 kinesin, 8430434E15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16558
Homologene: 135708
Rlf
Name: rearranged L-myc fusion sequence
Synonyms: 9230110M18Rik, MommeD8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 109263
Homologene: 8243
Fbrsl1
Name: fibrosin-like 1
Synonyms: LOC381668, 2410025L10Rik, Gm29766
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381668
Homologene: 45966
Ptbp2
Name: polypyrimidine tract binding protein 2
Synonyms: brPTB
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56195
Homologene: 23162
Fip1l1
Name: factor interacting with PAPOLA and CPSF1
Synonyms: Rje, 1300019H17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66899
Homologene: 136254
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 60,200,133 bp
  • T to C, chromosome 2 at 69,489,329 bp
  • A to G, chromosome 2 at 82,976,607 bp
  • C to A, chromosome 2 at 117,249,821 bp
  • G to T, chromosome 2 at 142,712,899 bp
  • T to C, chromosome 3 at 3,651,619 bp
  • A to T, chromosome 3 at 36,610,223 bp
  • A to G, chromosome 3 at 119,740,429 bp
  • T to C, chromosome 4 at 12,171,842 bp
  • G to A, chromosome 4 at 43,660,342 bp
  • T to C, chromosome 4 at 63,394,797 bp
  • G to A, chromosome 4 at 121,150,905 bp
  • C to G, chromosome 4 at 155,841,132 bp
  • G to A, chromosome 5 at 14,855,620 bp
  • T to C, chromosome 5 at 74,588,152 bp
  • T to A, chromosome 5 at 110,378,995 bp
  • T to A, chromosome 5 at 114,392,138 bp
  • T to C, chromosome 5 at 136,039,128 bp
  • T to C, chromosome 7 at 5,544,877 bp
  • A to T, chromosome 7 at 7,181,659 bp
  • A to G, chromosome 7 at 46,198,351 bp
  • T to A, chromosome 7 at 67,268,127 bp
  • T to A, chromosome 7 at 86,811,593 bp
  • T to A, chromosome 7 at 98,716,377 bp
  • G to A, chromosome 7 at 120,873,403 bp
  • C to T, chromosome 7 at 127,393,324 bp
  • A to G, chromosome 8 at 13,222,774 bp
  • C to A, chromosome 8 at 92,677,014 bp
  • A to T, chromosome 8 at 111,171,297 bp
  • G to A, chromosome 9 at 38,594,544 bp
  • A to G, chromosome 9 at 66,833,267 bp
  • A to T, chromosome 9 at 109,555,710 bp
  • T to G, chromosome 10 at 24,912,807 bp
  • T to C, chromosome 10 at 99,155,143 bp
  • T to A, chromosome 11 at 53,594,306 bp
  • T to A, chromosome 11 at 55,284,397 bp
  • T to C, chromosome 12 at 4,851,850 bp
  • A to G, chromosome 13 at 33,334,620 bp
  • G to A, chromosome 13 at 62,171,707 bp
  • A to G, chromosome 14 at 44,650,166 bp
  • T to C, chromosome 14 at 51,039,080 bp
  • C to T, chromosome 14 at 55,109,756 bp
  • A to G, chromosome 14 at 69,796,621 bp
  • A to T, chromosome 14 at 101,507,554 bp
  • T to C, chromosome 15 at 3,968,969 bp
  • T to A, chromosome 15 at 6,651,812 bp
  • C to T, chromosome 15 at 90,935,761 bp
  • A to G, chromosome 19 at 26,630,720 bp
  • A to T, chromosome 19 at 28,901,448 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8182 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067606-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.