Strain Name:
C57BL/6J-MtgxR8185Btlr/Mmmh
Stock Number:
067608-MU
Citation ID:
RRID:MMRRC_067608-MU
Other Names:
R8185 (G1)
Major Collection:

Strain Information

Kdm4c
Name: lysine (K)-specific demethylase 4C
Synonyms: Jmjd2c, 2410141F18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76804
Homologene: 41004
Ppp1r37
Name: protein phosphatase 1, regulatory subunit 37
Synonyms: Lrrc68
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232947
Homologene: 17851
Nedd4l
Name: neural precursor cell expressed, developmentally down-regulated gene 4-like
Synonyms: Nedd4-2, Nedd4b, 1300012C07Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 83814
VEGA: 18
HGNC: HGNC:7728
Homologene: 86986
Nvl
Name: nuclear VCP-like
Synonyms: 1200009I24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67459
HGNC: HGNC:8070
Homologene: 1902
Cnot1
Name: CCR4-NOT transcription complex, subunit 1
Synonyms: 6030411K04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234594
HGNC: HGNC:7877
Homologene: 9453
Fasn
Name: fatty acid synthase
Synonyms: FAS, A630082H08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14104
HGNC: HGNC:3594
Homologene: 55800
Cog7
Name: component of oligomeric golgi complex 7
Synonyms: 5630400E24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233824
Homologene: 33431
Immt
Name: inner membrane protein, mitochondrial
Synonyms: 1700082C19Rik, P87/89, mitofilin, D830041H16Rik, HMP, P87, Micos60, P89
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76614
HGNC: HGNC:6047
Homologene: 38234
Cpsf7
Name: cleavage and polyadenylation specific factor 7
Synonyms: C330017N18Rik, 5730453I16Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 269061
VEGA: 19
Homologene: 11731
Melk
Name: maternal embryonic leucine zipper kinase
Synonyms: MPK38
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17279
Homologene: 32111
Ackr3
Name: atypical chemokine receptor 3
Synonyms: Rdc1, Cmkor1, Cxcr7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12778
Homologene: 22419
Lpar1
Name: lysophosphatidic acid receptor 1
Synonyms: Kdt2, vzg-1, LPA1, Edg2, Gpcr26
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14745
HGNC: HGNC:3166
Homologene: 1072
Ebf3
Name: early B cell factor 3
Synonyms: 3110018A08Rik, Olf-1/EBF-like 2, O/E-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13593
Homologene: 56472
Klk11
Name: kallikrein related-peptidase 11
Synonyms: hippostasin, Prss20, 2310015I08Rik, TLSP
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56538
HGNC: HGNC:6359
Homologene: 27048
Mmp27
Name: matrix metallopeptidase 27
Synonyms: LOC234911
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 234911
Homologene: 23345
Cdc23
Name: CDC23 cell division cycle 23
Synonyms: D18Ertd243e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 52563
HGNC: HGNC:1724
Homologene: 3426
Ppp1r13l
Name: protein phosphatase 1, regulatory subunit 13 like
Synonyms: wa3, NFkB interacting protein 1, IASPP
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 333654
Homologene: 84635
Cubn
Name: cubilin
Synonyms: intrinsic factor-cobalamin receptor, D2Wsu88e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Ints10
Name: integrator complex subunit 10
Synonyms: 4921521J11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70885
Homologene: 10029
Cntnap4
Name: contactin associated protein-like 4
Synonyms: Caspr4, E130114F09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170571
Homologene: 24912
Vmn1r179
Name: vomeronasal 1 receptor 179
Synonyms: V1rd17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404286
Homologene: 134022
Macc1
Name: metastasis associated in colon cancer 1
Synonyms: 4732474O15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238455
Homologene: 18813
Syde2
Name: synapse defective 1, Rho GTPase, homolog 2 (C. elegans)
Synonyms: C430017H16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 214804
Homologene: 19035
Klhl5
Name: kelch-like 5
Synonyms: 1300013C10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71778
HGNC: HGNC:6356
Homologene: 56736
Frem3
Name: Fras1 related extracellular matrix protein 3
Synonyms: LOC333315
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 333315
Homologene: 35388
Chrm2
Name: cholinergic receptor, muscarinic 2, cardiac
Synonyms: muscarinic acetylcholine receptor 2, Chrm-2, AChR M2, M2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243764
HGNC: HGNC:1951
Homologene: 20190
Dsg1a
Name: desmoglein 1 alpha
Synonyms: Dsg1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13510
HGNC: HGNC:3048
Homologene: 1463
Lmln
Name: leishmanolysin-like (metallopeptidase M8 family)
Synonyms: 5330415H22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239833
Homologene: 13198
C9
Name: complement component 9
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12279
HGNC: HGNC:1358
Homologene: 74406
Or2k2
Name: olfactory receptor family 2 subfamily K member 2
Synonyms: MOR262-1, GA_x6K02T2N78B-1272842-1273783, Olfr267
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258922
HGNC: HGNC:8264
Homologene: 17436
Ggt1
Name: gamma-glutamyltransferase 1
Synonyms: GGT, CD224, dwg, Ggtp
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14598
Homologene: 68450
Or8b8
Name: olfactory receptor family 8 subfamily B member 8
Synonyms: K21, Olfr145, MOR161-6, GA_x6K02T2PVTD-31578734-31579666
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258310
HGNC: HGNC:8477
Homologene: 56568
Zfp764l1
Name: zinc finger protein 764 like 1
Synonyms: E430018J23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101604
Homologene: 138471
Nxpe4
Name: neurexophilin and PC-esterase domain family, member 4
Synonyms: D930028F11Rik, Fam55d
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244853
VEGA: 9
Homologene: 83471
Tpp1
Name: tripeptidyl peptidase I
Synonyms: Cln2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12751
HGNC: HGNC:2073
Homologene: 335
Fcgr2b
Name: Fc receptor, IgG, low affinity IIb
Synonyms: Ly-m20, F630109E10Rik, FcgammaRIIB, Fc gamma RIIB, Fcr-2, Fc[g]RII, Fcgr2, Ly-17, Fcgr2a, Fcr-3, FcgRII, CD32, LyM-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14130
Homologene: 2974
Slc7a9
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 9
Synonyms: CSNU3, bo, + amino acid transporter, bo, +AT
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 30962
Homologene: 56668
Gabrr2
Name: gamma-aminobutyric acid type A receptor subunit rho 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14409
HGNC: HGNC:4091
Homologene: 20471
Ovol1
Name: ovo like zinc finger 1
Synonyms: movo1, Ovo1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18426
VEGA: 19
HGNC: HGNC:8525
Homologene: 3354
Eif1ad5
Name: eukaryotic translation initiation factor 1A domain containing 5
Synonyms: Gm2046
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100039100
VEGA: 12
Homologene: 103865
2310003L06Rik
Name: RIKEN cDNA 2310003L06 gene
Type: Gene
Species: Mouse
Chromosome: 5
Sntn
Name: sentan, cilia apical structure protein
Synonyms: A430083B19Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218739
Homologene: 52238
Mfsd7b
Name:
Type: Gene
Species: Mouse
Chromosome: 1
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 90,213,944 bp
  • A to G, chromosome 1 at 170,966,451 bp
  • G to A, chromosome 1 at 181,144,174 bp
  • G to A, chromosome 1 at 191,015,484 bp
  • T to G, chromosome 2 at 13,294,318 bp
  • G to A, chromosome 2 at 102,824,320 bp
  • T to C, chromosome 3 at 145,988,912 bp
  • T to A, chromosome 4 at 33,082,330 bp
  • G to A, chromosome 4 at 44,360,965 bp
  • A to T, chromosome 4 at 58,486,509 bp
  • T to C, chromosome 4 at 58,785,542 bp
  • C to T, chromosome 4 at 74,373,584 bp
  • T to A, chromosome 5 at 65,156,128 bp
  • T to C, chromosome 5 at 87,972,152 bp
  • A to G, chromosome 6 at 36,523,889 bp
  • C to T, chromosome 6 at 71,872,851 bp
  • C to T, chromosome 7 at 19,372,938 bp
  • C to T, chromosome 7 at 19,532,948 bp
  • A to T, chromosome 7 at 23,928,738 bp
  • T to C, chromosome 7 at 35,452,417 bp
  • T to C, chromosome 7 at 43,776,908 bp
  • A to T, chromosome 7 at 105,749,223 bp
  • A to G, chromosome 7 at 121,977,746 bp
  • C to T, chromosome 7 at 127,393,324 bp
  • A to T, chromosome 7 at 137,225,878 bp
  • T to C, chromosome 8 at 68,796,718 bp
  • G to T, chromosome 8 at 80,612,304 bp
  • C to T, chromosome 8 at 95,761,351 bp
  • A to G, chromosome 8 at 112,665,265 bp
  • C to T, chromosome 8 at 123,127,429 bp
  • A to G, chromosome 9 at 7,573,491 bp
  • A to C, chromosome 9 at 37,898,235 bp
  • G to A, chromosome 9 at 48,393,209 bp
  • T to A, chromosome 10 at 75,585,206 bp
  • A to T, chromosome 11 at 120,812,143 bp
  • T to A, chromosome 12 at 87,973,663 bp
  • T to C, chromosome 12 at 119,447,159 bp
  • A to G, chromosome 14 at 13,679,014 bp
  • T to A, chromosome 15 at 6,491,397 bp
  • A to T, chromosome 16 at 33,089,320 bp
  • C to T, chromosome 18 at 20,340,612 bp
  • T to C, chromosome 18 at 34,641,144 bp
  • T to C, chromosome 18 at 65,209,698 bp
  • T to C, chromosome 19 at 5,551,514 bp
  • C to T, chromosome 19 at 10,536,860 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8185 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067608-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.