Strain Name:
C57BL/6J-MtgxR8186Btlr/Mmmh
Stock Number:
067609-MU
Citation ID:
RRID:MMRRC_067609-MU
Other Names:
R8186 (G1)
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, DRP, Dmdl
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Htr5b
Name: 5-hydroxytryptamine (serotonin) receptor 5B
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15564
Homologene: 74951
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, trabeculin alpha, Acf7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Lrrc2
Name: leucine rich repeat containing 2
Synonyms: 4933431K03Rik, 2400002D05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74249
Homologene: 23454
Usp48
Name: ubiquitin specific peptidase 48
Synonyms: 2810449C13Rik, D330022K21Rik, Usp31
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 170707
Homologene: 12988
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: 1810014J18Rik, 9030205D12Rik, A330063D19Rik, AD013
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109151
Homologene: 11844
Ddx19a
Name: DEAD box helicase 19a
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 19a, Eif4a-rs1, DBP5, Ddx19
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13680
Homologene: 5240
Safb2
Name: scaffold attachment factor B2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224902
Homologene: 35210
Cdc42bpg
Name: CDC42 binding protein kinase gamma
Synonyms: MRCKgamma
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240505
Homologene: 28384
Tuba1c
Name: tubulin, alpha 1C
Synonyms: M[a]6, Tuba6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22146
VEGA: 15
Homologene: 69045
Def8
Name: differentially expressed in FDCP 8
Synonyms: D8Ertd713e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23854
Homologene: 14279
Nbeal1
Name: neurobeachin like 1
Synonyms: A530050O19Rik, 2310076G13Rik, ALS2CR17, A530083I02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269198
Homologene: 16453
Styxl2
Name: serine/threonine/tyrosine interacting like 2
Synonyms: C130085G02Rik, Dusp27
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240892
Homologene: 18949
Wnt9b
Name: wingless-type MMTV integration site family, member 9B
Synonyms: Wnt14b, clf, Wnt15, clf1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22412
Homologene: 2551
Gata4
Name: GATA binding protein 4
Synonyms: Gata-4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14463
HGNC: HGNC:4173
Homologene: 1551
Hspa1b
Name: heat shock protein 1B
Synonyms: Hsp70.1, HSP70B1, hsp68, Hsp70-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15511
HGNC: HGNC:5233
Homologene: 133785
Tbccd1
Name: TBCC domain containing 1
Synonyms: 5730478M09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70573
VEGA: 16
Homologene: 32392
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: 4930545D19Rik, hyrh, hy-3, hy3, 1700034M11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Bltp2
Name: bridge-like lipid transfer protein family member 2
Synonyms: 2610507B11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72503
Homologene: 34730
Vmn2r103
Name: vomeronasal 2, receptor 103
Synonyms: EG627636
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627636
Homologene: 115024
Add2
Name: adducin 2
Synonyms: 2900072M03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11519
HGNC: HGNC:244
Homologene: 1221
Agl
Name: amylo-1,6-glucosidase, 4-alpha-glucanotransferase
Synonyms: 9630046L06Rik, 9430004C13Rik, 1110061O17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77559
HGNC: HGNC:321
Homologene: 536
Odad4
Name: outer dynein arm complex subunit 4
Synonyms: Ttc25, 4933404O19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74407
Homologene: 12860
Cped1
Name: cadherin-like and PC-esterase domain containing 1
Synonyms: A430107O13Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214642
Homologene: 57014
Vmn2r88
Name: vomeronasal 2, receptor 88
Synonyms: V2r13, V2r3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 669149
Homologene: 129606
Col4a2
Name: collagen, type IV, alpha 2
Synonyms: Col4a-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12827
HGNC: HGNC:2203
Homologene: 1390
Vmn2r105
Name: vomeronasal 2, receptor 105
Synonyms: EG627743
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627743
Homologene: 129680
Sgsm3
Name: small G protein signaling modulator 3
Synonyms: CIP85, 1810012I01Rik, Rutbc3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105835
Homologene: 9249
Phf2
Name: PHD finger protein 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18676
VEGA: 13
HGNC: HGNC:8920
Homologene: 3934
Oprk1
Name: opioid receptor, kappa 1
Synonyms: KOR-1, Oprk2, R21
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18387
HGNC: HGNC:8154
Homologene: 20253
Rdh7
Name: retinol dehydrogenase 7
Synonyms: CRAD2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54150
Homologene: 137324
Atg16l2
Name: autophagy related 16 like 2
Synonyms: 2410118P20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73683
Homologene: 18981
Kics2
Name: KICSTOR subunit 2
Synonyms: BC048403
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 270802
Homologene: 17580
Cdc25b
Name: cell division cycle 25B
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12531
HGNC: HGNC:1726
Homologene: 41451
Nfxl1
Name: nuclear transcription factor, X-box binding-like 1
Synonyms: D430033A06Rik, TCF9, 1700012H24Rik, LOC381696
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100978
Homologene: 26752
Zfp78
Name: zinc finger protein 78
Synonyms: Zfp77, KRAB12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330463
Homologene: 128524
Toporsl
Name: topoisomerase I binding, arginine/serine-rich like
Synonyms: 4930547C10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68274
Homologene: 130753
Or1e1
Name: olfactory receptor family 1 subfamily E member 1
Synonyms: Olfr21, MOR135-11, Olfr20, MTPCR55, MTPCR06, GA_x6K02T2P1NL-3514066-3515010
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258925
Homologene: 128054
C130073F10Rik
Name: RIKEN cDNA C130073F10 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242574
Sgpp2
Name: sphingosine-1-phosphate phosphatase 2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 433323
Homologene: 51848
Gm9837
Name: predicted gene 9837
Type: Gene
Species: Mouse
Chromosome: 11
Rpl11
Name: ribosomal protein L11
Synonyms: 2010203J19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67025
Homologene: 37376
Hmha1
Name:
Type: Gene
Species: Mouse
Chromosome: 10
Speer1b
Name: spermatogenesis associated glutamate (E)-rich protein 1B
Synonyms: Gm8926
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 668017
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 5,602,317 bp
  • G to C, chromosome 1 at 60,237,151 bp
  • T to C, chromosome 1 at 78,416,972 bp
  • G to A, chromosome 1 at 121,528,379 bp
  • A to G, chromosome 1 at 166,100,079 bp
  • T to G, chromosome 2 at 76,918,912 bp
  • C to T, chromosome 2 at 131,189,130 bp
  • A to G, chromosome 3 at 116,758,908 bp
  • T to A, chromosome 4 at 52,610,489 bp
  • G to A, chromosome 4 at 101,890,834 bp
  • A to T, chromosome 4 at 123,372,426 bp
  • A to C, chromosome 4 at 123,382,130 bp
  • A to G, chromosome 4 at 136,051,657 bp
  • A to G, chromosome 4 at 137,621,196 bp
  • A to G, chromosome 5 at 11,773,959 bp
  • A to G, chromosome 5 at 72,559,012 bp
  • T to C, chromosome 6 at 22,123,588 bp
  • G to A, chromosome 6 at 86,108,020 bp
  • A to G, chromosome 7 at 6,373,229 bp
  • C to T, chromosome 7 at 101,296,507 bp
  • T to C, chromosome 8 at 11,425,542 bp
  • T to A, chromosome 8 at 90,998,605 bp
  • T to C, chromosome 8 at 110,609,645 bp
  • T to A, chromosome 8 at 110,983,642 bp
  • C to A, chromosome 8 at 123,461,476 bp
  • A to G, chromosome 9 at 110,960,842 bp
  • T to C, chromosome 10 at 12,698,123 bp
  • G to A, chromosome 10 at 80,027,872 bp
  • T to A, chromosome 10 at 121,745,342 bp
  • C to A, chromosome 10 at 127,887,415 bp
  • A to T, chromosome 11 at 53,470,309 bp
  • T to C, chromosome 11 at 73,354,421 bp
  • A to G, chromosome 11 at 78,286,631 bp
  • A to G, chromosome 11 at 100,563,679 bp
  • T to C, chromosome 11 at 103,730,775 bp
  • A to G, chromosome 12 at 116,000,303 bp
  • A to G, chromosome 13 at 48,807,751 bp
  • A to T, chromosome 14 at 51,418,700 bp
  • A to G, chromosome 14 at 63,201,513 bp
  • A to C, chromosome 15 at 81,009,442 bp
  • C to A, chromosome 15 at 99,037,515 bp
  • A to G, chromosome 16 at 22,818,439 bp
  • A to T, chromosome 17 at 19,811,943 bp
  • G to T, chromosome 17 at 20,224,618 bp
  • A to T, chromosome 17 at 34,957,581 bp
  • G to A, chromosome 17 at 56,566,051 bp
  • T to A, chromosome 19 at 6,306,865 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8186 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067609-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.