Strain Name:
C57BL/6J-MtgxR8193Btlr/Mmmh
Stock Number:
067616-MU
Citation ID:
RRID:MMRRC_067616-MU
Other Names:
R8193 (G1)
Major Collection:

Strain Information

Vps54
Name: VPS54 GARP complex subunit
Synonyms: Vps54l, 5330404P15Rik, mSLP8, wr
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245944
Homologene: 5605
Tnks2
Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Synonyms: 5430432P15Rik, Parp5b
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74493
Homologene: 11890
Ints3
Name: integrator complex subunit 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229543
Homologene: 11309
Anp32e
Name: acidic nuclear phosphoprotein 32 family member E
Synonyms: CPD1, 2810018A15Rik, LANP-L
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66471
Homologene: 41519
Nomo1
Name: nodal modulator 1
Synonyms: PM5, Nomo, D7Ertd156e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 211548
Homologene: 13810
Utp18
Name: UTP18 small subunit processome component
Synonyms: 6230425C22Rik, Wdr50
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217109
Homologene: 41087
Cep350
Name: centrosomal protein 350
Synonyms: 6430546F08Rik, 4933409L06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74081
Homologene: 8879
Slc19a2
Name: solute carrier family 19 (thiamine transporter), member 2
Synonyms: DDA1, TRMA, THTR1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 116914
Homologene: 38258
Usp53
Name: ubiquitin specific peptidase 53
Synonyms: Sp6, Phxr3, mbo
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99526
Homologene: 34521
Lonp2
Name: lon peptidase 2, peroxisomal
Synonyms: 1300002A08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66887
Homologene: 12050
Rasa2
Name: RAS p21 protein activator 2
Synonyms: GAP1m, 5430433H21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 114713
HGNC: HGNC:9872
Homologene: 4745
Tcf4
Name: transcription factor 4
Synonyms: SEF-2, ITF-2, MITF-2B, MITF-2A, ME2, E2.2, TFE, E2-2, SEF2-1, ASP-I2, ITF-2b, 5730422P05Rik, bHLHb19
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 21413
Homologene: 2407
Sema4d
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Synonyms: semaphorin H, M-sema G, coll-4, CD100, Semcl2, Semaj, Semacl2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20354
Homologene: 21282
Zfp408
Name: zinc finger protein 408
Synonyms: LOC381410
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381410
Homologene: 11687
Chodl
Name: chondrolectin
Synonyms: MT75, 3110074E07Rik, PRED12
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 246048
Homologene: 11795
Cdc25c
Name: cell division cycle 25C
Synonyms: Cdc25
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12532
VEGA: 18
HGNC: HGNC:1727
Homologene: 1356
Limk2
Name: LIM domain kinase 2
Synonyms: Limk2b, Limk2a, A930024P04Rik, LIM kinase 2, whe
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16886
HGNC: HGNC:6614
Homologene: 55911
Edrf1
Name: erythroid differentiation regulatory factor 1
Synonyms: 2700050L05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 214764
Homologene: 27985
Nbeal1
Name: neurobeachin like 1
Synonyms: A530050O19Rik, ALS2CR17, A530083I02Rik, 2310076G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269198
Homologene: 16453
Nbas
Name: neuroblastoma amplified sequence
Synonyms: 4933425L03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71169
VEGA: 12
Homologene: 41073
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Pcsk5
Name: proprotein convertase subtilisin/kexin type 5
Synonyms: PC6, SPC6, PC5A, PC5/6A, b2b585Clo, b2b1549Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18552
VEGA: 19
HGNC: HGNC:8747
Homologene: 21244
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: LOC381311, A230079K17Rik, Gm980, Dnahc14
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
Vmn2r100
Name: vomeronasal 2, receptor 100
Synonyms: EG627537
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627537
Homologene: 129750
Ermap
Name: erythroblast membrane-associated protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 27028
Homologene: 22782
Nrp1
Name: neuropilin 1
Synonyms: Neuropilin-1, NP-1, NPN-1, Npn1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18186
HGNC: HGNC:8004
Homologene: 2876
Abhd18
Name: abhydrolase domain containing 18
Synonyms: 3110057O12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269423
Homologene: 105457
Xab2
Name: XPA binding protein 2
Synonyms: 0610041O14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67439
Homologene: 5738
Myo15b
Name: myosin XVB
Synonyms: LOC217328, LOC380737, E330039G21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217328
Prpf40b
Name: pre-mRNA processing factor 40B
Synonyms: 2610317D23Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54614
Homologene: 81828
Itga1
Name: integrin alpha 1
Synonyms: CD49A, Vla1, E130012M19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109700
VEGA: 13
HGNC: HGNC:6134
Homologene: 57137
Or4c105
Name: olfactory receptor family 4 subfamily C member 105
Synonyms: GA_x6K02T2Q125-50290367-50291296, MOR232-7, Olfr1202
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258454
Homologene: 133021
Rtl1
Name: retrotransposon Gaglike 1
Synonyms: Mart1, Mor1, Mar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 353326
VEGA: 12
Homologene: 120261
Zfp944
Name: zinc finger protein 944
Synonyms: 6330416L07Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 319615
VEGA: 17
Homologene: 133237
Dcbld2
Name: discoidin, CUB and LCCL domain containing 2
Synonyms: 1700055P21Rik, Esdn, CLCP1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 73379
Homologene: 12499
Adam26a
Name: ADAM metallopeptidase domain 26A
Synonyms: Dtgn4, Adam26
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13525
Homologene: 128363
Prex1
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Synonyms: P-REX1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277360
Homologene: 10821
Zfp788
Name: zinc finger protein 788
Synonyms: 2810426N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67607
Homologene: 137363
Or10d1b
Name: olfactory receptor family 10 subfamily D member 1B
Synonyms: M31, GA_x6K02T2PVTD-33400306-33399371, MOR224-8, Olfr149
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235256
VEGA: 9
Homologene: 28452
Foxg1
Name: forkhead box G1
Synonyms: BF-1, Hfh9, Hfhbf1, Bf1, 2900064B05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 15228
HGNC: HGNC:3811
Homologene: 3843
Mark1
Name: MAP/microtubule affinity regulating kinase 1
Synonyms: Emk3, B930025N23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226778
HGNC: HGNC:6896
Homologene: 49552
Fcgbp
Name: Fc fragment of IgG binding protein
Synonyms: A430096B05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 215384
Homologene: 68369
Ncf4
Name: neutrophil cytosolic factor 4
Synonyms: p40phox
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17972
HGNC: HGNC:7662
Homologene: 525
Or9g4b
Name: olfactory receptor family 9 subfamily G member 4B
Synonyms: GA_x6K02T2Q125-47264151-47265089, MOR213-3, Olfr1015
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258564
Homologene: 115499
Ugt2b35
Name: UDP glucuronosyltransferase 2 family, polypeptide B35
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243085
Homologene: 128251
Nfkbiz
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
Synonyms: Mail
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 80859
Homologene: 12734
Cyp24a1
Name: cytochrome P450, family 24, subfamily a, polypeptide 1
Synonyms: 25-hydroxyvitamin D-24-hydroxylase, 24-OHase, Cyp24, CP24
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13081
HGNC: HGNC:2602
Homologene: 68094
Crocc2
Name: ciliary rootlet coiled-coil, rootletin family member 2
Synonyms: LOC381284, E030010N08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381284
Homologene: 141152
Vmn1r172
Name: vomeronasal 1 receptor 172
Synonyms: V3R9, V1rd9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81010
Homologene: 79577
Or5t18
Name: olfactory receptor family 5 subfamily T member 18
Synonyms: K17, GA_x6K02T2Q125-48299679-48298702, MOR179-5, Olfr141
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257913
Homologene: 28042
Dnajb8
Name: DnaJ heat shock protein family (Hsp40) member B8
Synonyms: mDj6, 1700016F14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56691
Homologene: 23184
Gabra1
Name: gamma-aminobutyric acid type A receptor subunit alpha 1
Synonyms: GABAA alpha 1, Gabra-1, GABAAR alpha1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14394
HGNC: HGNC:4075
Homologene: 629
Prl7d1
Name: prolactin family 7, subfamily d, member 1
Synonyms: PRP, PLF-RP, Plfr
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18814
Homologene: 7894
Lpar5
Name: lysophosphatidic acid receptor 5
Synonyms: LOC381810, GPR93, Gpr92, LPA5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381810
Homologene: 10696
Clstn2
Name: calsyntenin 2
Synonyms: CS2, 2900042C18Rik, Cst-2, CSTN2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 64085
Homologene: 49698
Or8g2b
Name: olfactory receptor family 8 subfamily G member 2B
Synonyms: GA_x6K02T2PVTD-33539896-33540819, MOR171-13, Olfr971
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258607
VEGA: 9
Homologene: 133635
Eva1a
Name: eva-1 homolog A, regulator of programmed cell death
Synonyms: Tmem166, Fam176a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232146
Homologene: 12969
Map2k7
Name: mitogen-activated protein kinase kinase 7
Synonyms: MKK7, sek2, MAP kinase kinase 7, Jnkk2, Prkmk7, 5930412N11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 26400
HGNC: HGNC:6847
Homologene: 56548
Vmn2r113
Name: vomeronasal 2, receptor 113
Synonyms: EG434701
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 434701
Gm3086
Name: predicted gene 3086
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100040999
VEGA: 12
Igkv5-37
Name: immunoglobulin kappa variable 5-37
Synonyms: LOC384417, IgVk 23-37
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 384417
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 60,253,481 bp
  • T to A, chromosome 1 at 93,190,166 bp
  • A to T, chromosome 1 at 150,577,477 bp
  • A to G, chromosome 1 at 155,862,079 bp
  • A to G, chromosome 1 at 164,257,225 bp
  • T to C, chromosome 1 at 181,688,205 bp
  • T to G, chromosome 1 at 184,928,052 bp
  • T to C, chromosome 2 at 85,785,961 bp
  • T to G, chromosome 2 at 86,806,865 bp
  • T to A, chromosome 2 at 88,817,459 bp
  • G to T, chromosome 2 at 91,645,016 bp
  • C to A, chromosome 2 at 166,593,860 bp
  • A to G, chromosome 2 at 170,485,702 bp
  • C to A, chromosome 3 at 40,930,225 bp
  • A to G, chromosome 3 at 90,400,622 bp
  • G to A, chromosome 3 at 95,929,398 bp
  • T to C, chromosome 3 at 122,947,363 bp
  • A to T, chromosome 3 at 124,419,868 bp
  • A to G, chromosome 4 at 109,524,332 bp
  • A to G, chromosome 4 at 119,183,943 bp
  • T to A, chromosome 5 at 87,001,443 bp
  • C to A, chromosome 6 at 69,963,812 bp
  • A to T, chromosome 6 at 82,091,940 bp
  • C to T, chromosome 6 at 88,222,958 bp
  • T to C, chromosome 6 at 125,081,339 bp
  • T to A, chromosome 7 at 23,660,327 bp
  • A to T, chromosome 7 at 28,104,851 bp
  • T to A, chromosome 7 at 41,648,614 bp
  • C to T, chromosome 7 at 43,532,272 bp
  • T to C, chromosome 7 at 46,042,613 bp
  • C to T, chromosome 7 at 133,661,877 bp
  • A to C, chromosome 8 at 3,613,389 bp
  • T to C, chromosome 8 at 4,244,059 bp
  • A to T, chromosome 8 at 43,569,236 bp
  • G to T, chromosome 8 at 86,631,463 bp
  • G to T, chromosome 8 at 128,460,706 bp
  • T to C, chromosome 9 at 39,702,202 bp
  • T to C, chromosome 9 at 39,839,461 bp
  • G to A, chromosome 9 at 96,602,738 bp
  • A to G, chromosome 9 at 97,583,630 bp
  • T to C, chromosome 11 at 3,347,691 bp
  • T to C, chromosome 11 at 21,292,045 bp
  • A to G, chromosome 11 at 42,147,141 bp
  • T to C, chromosome 11 at 93,876,077 bp
  • T to C, chromosome 11 at 115,885,147 bp
  • T to C, chromosome 12 at 13,433,009 bp
  • A to G, chromosome 12 at 49,385,594 bp
  • A to G, chromosome 12 at 69,969,490 bp
  • A to G, chromosome 12 at 109,592,216 bp
  • A to G, chromosome 13 at 27,709,247 bp
  • A to T, chromosome 13 at 51,705,156 bp
  • A to G, chromosome 13 at 114,968,455 bp
  • T to C, chromosome 15 at 78,262,266 bp
  • T to A, chromosome 15 at 99,304,068 bp
  • T to C, chromosome 16 at 55,821,851 bp
  • T to A, chromosome 16 at 58,464,010 bp
  • T to C, chromosome 16 at 78,941,524 bp
  • T to A, chromosome 17 at 19,504,840 bp
  • T to A, chromosome 17 at 22,339,880 bp
  • G to T, chromosome 17 at 22,945,527 bp
  • A to T, chromosome 18 at 34,749,622 bp
  • A to T, chromosome 18 at 69,500,923 bp
  • A to G, chromosome 19 at 17,586,051 bp
  • T to C, chromosome 19 at 36,854,953 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8193 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067616-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.