Strain Name:
C57BL/6J-MtgxR8198Btlr/Mmmh
Stock Number:
067621-MU
Citation ID:
RRID:MMRRC_067621-MU
Other Names:
R8198 (G1)
Major Collection:

Strain Information

Aven
Name: apoptosis, caspase activation inhibitor
Synonyms: mAven-S, 1700013A01Rik, 1700056A21Rik, mAven-L
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74268
Homologene: 10683
Unc93b1
Name: unc-93 homolog B1, TLR signaling regulator
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54445
Homologene: 41325
Ncoa7
Name: nuclear receptor coactivator 7
Synonyms: 9030406N13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 211329
VEGA: 10
Homologene: 65245
Usp48
Name: ubiquitin specific peptidase 48
Synonyms: D330022K21Rik, Usp31, 2810449C13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 170707
Homologene: 12988
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: C130002K18Rik, 5430435M13Rik, SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans), 2610207I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233789
Homologene: 56697
Sdad1
Name: SDA1 domain containing 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231452
Homologene: 6036
Tex9
Name: testis expressed gene 9
Synonyms: tsec-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21778
Homologene: 32072
Mphosph6
Name: M phase phosphoprotein 6
Synonyms: 1110001M01Rik, C86426
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68533
HGNC: HGNC:7214
Homologene: 38100
Zgrf1
Name: zinc finger, GRF-type containing 1
Synonyms: 4930422G04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71643
Homologene: 34708
Ankrd27
Name: ankyrin repeat domain 27
Synonyms: D330003H11Rik, Varp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 245886
Homologene: 12956
Iars2
Name: isoleucine-tRNA synthetase 2, mitochondrial
Synonyms: 2010002H18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381314
Homologene: 7118
Pgr
Name: progesterone receptor
Synonyms: NR3C3, ENSMUSG00000074510, 9930019P03Rik, PR-B, PR-A, PR
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18667
HGNC: HGNC:8910
Homologene: 713
Syt13
Name: synaptotagmin XIII
Synonyms: 5730409J20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 80976
Homologene: 10823
Leng8
Name: leukocyte receptor cluster (LRC) member 8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232798
Homologene: 13612
Clca4b
Name: chloride channel accessory 4B
Synonyms: AI747448
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99709
HGNC: HGNC:2018
Homologene: 40808
Lhfpl3
Name: lipoma HMGIC fusion partner-like 3
Synonyms: A930031L14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269629
HGNC: HGNC:6589
Homologene: 26732
Lsg1
Name: large 60S subunit nuclear export GTPase 1
Synonyms: D16Bwg1547e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224092
Homologene: 5917
Mta2
Name: metastasis-associated gene family, member 2
Synonyms: mmta2, Mta1l1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 23942
HGNC: HGNC:7411
Homologene: 3480
Cd2bp2
Name: CD2 cytoplasmic tail binding protein 2
Synonyms: 1500011B02Rik, 2410024K20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70233
HGNC: HGNC:1656
Homologene: 4455
AU041133
Name: expressed sequence AU041133
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216177
Homologene: 87560
Eml5
Name: echinoderm microtubule associated protein like 5
Synonyms: C130068M19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319670
VEGA: 12
Homologene: 26807
Rad54b
Name: RAD54 homolog B (S. cerevisiae)
Synonyms: E130016E03Rik, E130016E03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 623474
Homologene: 8240
Clec4d
Name: C-type lectin domain family 4, member d
Synonyms: Clecsf8, Mpcl, mcl, mMCL
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17474
Homologene: 7844
Spink5
Name: serine peptidase inhibitor, Kazal type 5
Synonyms: 2310065D10Rik, LEKT1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 72432
Homologene: 4987
Dennd1c
Name: DENN domain containing 1C
Synonyms: 4432409M07Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70785
VEGA: 17
Homologene: 11773
Clcn2
Name: chloride channel, voltage-sensitive 2
Synonyms: ClC-2, Clc2, nmf240
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12724
HGNC: HGNC:2020
Homologene: 3213
Taf5
Name: TATA-box binding protein associated factor 5
Synonyms: 6330528C20Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226182
VEGA: 19
Homologene: 5064
Gnb3
Name: guanine nucleotide binding protein (G protein), beta 3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14695
HGNC: HGNC:4400
Homologene: 55628
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: A230061D21Rik, C030048J01Rik, LOC235639, Lba1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320429
Homologene: 45845
Shoc1
Name: shortage in chiasmata 1
Synonyms: Gm426, Mzip2, LOC242489, AI481877
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100155
Homologene: 79783
Lmntd2
Name: lamin tail domain containing 2
Synonyms: 1600016N20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72000
Homologene: 104159
Hps1
Name: HPS1, biogenesis of lysosomal organelles complex 3 subunit 1
Synonyms: 6030422N11Rik, Hermansky-Pudlak syndrome 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 192236
HGNC: HGNC:5163
Homologene: 163
Or52h7
Name: olfactory receptor family 52 subfamily H member 7
Synonyms: Olfr652, MOR31-8, GA_x6K02T2PBJ9-7191524-7192471
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259050
Homologene: 17477
Gm4922
Name: predicted gene 4922
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237300
VEGA: 10
Homologene: 50497
Adgrb1
Name: adhesion G protein-coupled receptor B1
Synonyms: B830018M07Rik, Bai1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 107831
HGNC: HGNC:943
Homologene: 1287
Unc45b
Name: unc-45 myosin chaperone B
Synonyms: UNC45, D230041A13Rik, Cmya4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217012
Homologene: 14666
Or7a36
Name: olfactory receptor family 7 subfamily A member 36
Synonyms: MOR139-1, Olfr1352, GA_x6K02T2QGN0-2828447-2827518
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 259074
Homologene: 131141
Aoah
Name: acyloxyacyl hydrolase
Synonyms: 4930433E13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 27052
VEGA: 13
HGNC: HGNC:548
Homologene: 1238
Vmn1r81
Name: vomeronasal 1 receptor 81
Synonyms: V1rg9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171244
Homologene: 74327
Tmprss11g
Name: transmembrane protease, serine 11g
Synonyms: Desc4, 9930032O22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320454
Homologene: 82239
Tdrd9
Name: tudor domain containing 9
Synonyms: 4930441E05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74691
Homologene: 14311
Itpripl2
Name: inositol 1,4,5-triphosphate receptor interacting protein-like 2
Synonyms: E030018N11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319622
Homologene: 45882
Timm10b
Name: translocase of inner mitochondrial membrane 10B
Synonyms: Tim9b, Fracture Callus 1, Tim10b, FxC1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14356
HGNC: HGNC:4022
Homologene: 8142
Semp2l2a
Name: SUMO/sentrin specific peptidase 2-like 2A
Synonyms: AF366264
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 231201
Homologene: 130042
Or7a42
Name: olfactory receptor family 7 subfamily A member 42
Synonyms: MOR139-5P, GA_x6K02T2QGN0-2857086-2856154, Olfr8
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18372
Homologene: 136441
Gm9964
Name: predicted gene 9964
Type: Gene
Species: Mouse
Chromosome: 11
Uba52rt
Name: ubiquitin A-52 residue ribosomal protein fusion product 1, retrotransposed
Synonyms: Gm11808
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 666586
H4c2
Name: H4 clustered histone 2
Synonyms: Hist1h4b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 326620
Homologene: 134466
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 185,297,506 bp
  • C to T, chromosome 2 at 28,078,318 bp
  • C to A, chromosome 2 at 92,953,554 bp
  • C to T, chromosome 2 at 112,559,775 bp
  • T to A, chromosome 3 at 127,596,024 bp
  • C to A, chromosome 3 at 144,932,406 bp
  • C to A, chromosome 4 at 3,973,346 bp
  • T to C, chromosome 4 at 11,612,440 bp
  • T to C, chromosome 4 at 59,065,174 bp
  • C to T, chromosome 4 at 137,621,159 bp
  • T to A, chromosome 5 at 23,273,335 bp
  • A to T, chromosome 5 at 86,498,493 bp
  • A to T, chromosome 5 at 92,291,952 bp
  • T to C, chromosome 6 at 123,268,006 bp
  • T to C, chromosome 6 at 124,837,037 bp
  • C to A, chromosome 7 at 4,144,171 bp
  • A to G, chromosome 7 at 12,259,955 bp
  • T to C, chromosome 7 at 35,608,455 bp
  • T to A, chromosome 7 at 104,564,933 bp
  • G to T, chromosome 7 at 105,678,330 bp
  • T to C, chromosome 7 at 118,145,606 bp
  • A to G, chromosome 7 at 118,490,596 bp
  • A to G, chromosome 7 at 127,194,404 bp
  • A to T, chromosome 7 at 141,211,221 bp
  • T to A, chromosome 8 at 13,837,056 bp
  • C to T, chromosome 8 at 117,792,710 bp
  • T to C, chromosome 9 at 8,958,410 bp
  • G to A, chromosome 9 at 72,480,658 bp
  • T to C, chromosome 9 at 111,390,812 bp
  • T to C, chromosome 10 at 18,783,592 bp
  • T to C, chromosome 10 at 30,704,668 bp
  • T to A, chromosome 10 at 78,955,724 bp
  • C to A, chromosome 10 at 78,984,609 bp
  • C to G, chromosome 10 at 82,151,415 bp
  • A to G, chromosome 11 at 79,296,579 bp
  • GC to G, chromosome 11 at 82,925,988 bp
  • G to A, chromosome 12 at 98,858,886 bp
  • T to A, chromosome 12 at 112,040,429 bp
  • C to T, chromosome 13 at 20,917,120 bp
  • C to G, chromosome 13 at 23,757,300 bp
  • T to C, chromosome 14 at 42,003,060 bp
  • C to A, chromosome 15 at 74,539,245 bp
  • A to G, chromosome 16 at 20,707,196 bp
  • A to T, chromosome 16 at 30,564,776 bp
  • T to C, chromosome 17 at 57,066,460 bp
  • A to T, chromosome 18 at 43,992,880 bp
  • T to C, chromosome 19 at 3,941,910 bp
  • A to G, chromosome 19 at 8,947,781 bp
  • C to T, chromosome 19 at 42,767,220 bp
  • T to A, chromosome 19 at 47,075,773 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8198 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067621-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.