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Strain Name:
C57BL/6J-MtgxR8198Btlr/Mmmh
Stock Number:
067621-MU
Citation ID:
RRID:MMRRC_067621-MU
Other Names:
R8198 (G1)
Major Collection:

Strain Information

Aven
Name: apoptosis, caspase activation inhibitor
Synonyms: 1700013A01Rik, mAven-S, mAven-L, 1700056A21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74268
Homologene: 10683
Unc93b1
Name: unc-93 homolog B1, TLR signaling regulator
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54445
Homologene: 41325
Ncoa7
Name: nuclear receptor coactivator 7
Synonyms: 9030406N13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 211329
VEGA: 10
Homologene: 65245
Usp48
Name: ubiquitin specific peptidase 48
Synonyms: D330022K21Rik, 2810449C13Rik, Usp31
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 170707
Homologene: 12988
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: C130002K18Rik, 5430435M13Rik, 2610207I05Rik, SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233789
Homologene: 56697
Sdad1
Name: SDA1 domain containing 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231452
Homologene: 6036
Tex9
Name: testis expressed gene 9
Synonyms: tsec-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21778
Homologene: 32072
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 185,297,506 bp
  • C to T, chromosome 2 at 28,078,318 bp
  • C to A, chromosome 2 at 92,953,554 bp
  • C to T, chromosome 2 at 112,559,775 bp
  • T to A, chromosome 3 at 127,596,024 bp
  • C to A, chromosome 3 at 144,932,406 bp
  • C to A, chromosome 4 at 3,973,346 bp
  • T to C, chromosome 4 at 11,612,440 bp
  • T to C, chromosome 4 at 59,065,174 bp
  • C to T, chromosome 4 at 137,621,159 bp
  • T to A, chromosome 5 at 23,273,335 bp
  • A to T, chromosome 5 at 86,498,493 bp
  • A to T, chromosome 5 at 92,291,952 bp
  • T to C, chromosome 6 at 123,268,006 bp
  • T to C, chromosome 6 at 124,837,037 bp
  • C to A, chromosome 7 at 4,144,171 bp
  • A to G, chromosome 7 at 12,259,955 bp
  • T to C, chromosome 7 at 35,608,455 bp
  • T to A, chromosome 7 at 104,564,933 bp
  • G to T, chromosome 7 at 105,678,330 bp
  • T to C, chromosome 7 at 118,145,606 bp
  • A to G, chromosome 7 at 118,490,596 bp
  • A to G, chromosome 7 at 127,194,404 bp
  • A to T, chromosome 7 at 141,211,221 bp
  • T to A, chromosome 8 at 13,837,056 bp
  • C to T, chromosome 8 at 117,792,710 bp
  • T to C, chromosome 9 at 8,958,410 bp
  • G to A, chromosome 9 at 72,480,658 bp
  • T to C, chromosome 9 at 111,390,812 bp
  • T to C, chromosome 10 at 18,783,592 bp
  • T to C, chromosome 10 at 30,704,668 bp
  • T to A, chromosome 10 at 78,955,724 bp
  • C to A, chromosome 10 at 78,984,609 bp
  • C to G, chromosome 10 at 82,151,415 bp
  • A to G, chromosome 11 at 79,296,579 bp
  • GC to G, chromosome 11 at 82,925,988 bp
  • G to A, chromosome 12 at 98,858,886 bp
  • T to A, chromosome 12 at 112,040,429 bp
  • C to T, chromosome 13 at 20,917,120 bp
  • C to G, chromosome 13 at 23,757,300 bp
  • T to C, chromosome 14 at 42,003,060 bp
  • C to A, chromosome 15 at 74,539,245 bp
  • A to G, chromosome 16 at 20,707,196 bp
  • A to T, chromosome 16 at 30,564,776 bp
  • T to C, chromosome 17 at 57,066,460 bp
  • A to T, chromosome 18 at 43,992,880 bp
  • T to C, chromosome 19 at 3,941,910 bp
  • A to G, chromosome 19 at 8,947,781 bp
  • C to T, chromosome 19 at 42,767,220 bp
  • T to A, chromosome 19 at 47,075,773 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8198 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067621-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.