Strain Name:
C57BL/6J-MtgxR8200Btlr/Mmmh
Stock Number:
067623-MU
Citation ID:
RRID:MMRRC_067623-MU
Other Names:
R8200 (G1)
Major Collection:

Strain Information

Nucb2
Name: nucleobindin 2
Synonyms: NEFA, Calnuc, nesfatin-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 53322
HGNC: HGNC:8044
Homologene: 3676
Trp53bp1
Name: transformation related protein 53 binding protein 1
Synonyms: p53BP1, 53BP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27223
Homologene: 4137
Ubap2l
Name: ubiquitin-associated protein 2-like
Synonyms: NICE-4, 4932431F02Rik, A430103N23Rik, 3110083O19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74383
Homologene: 136291
Brpf3
Name: bromodomain and PHD finger containing, 3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268936
Homologene: 16092
Tcof1
Name: treacle ribosome biogenesis factor 1
Synonyms: treacle
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 21453
Homologene: 68049
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: Pcp-1, Pcp1, IP3R1, InsP3R type I, P400, Ip3r, opt, wblo, Itpr-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Immt
Name: inner membrane protein, mitochondrial
Synonyms: 1700082C19Rik, HMP, D830041H16Rik, mitofilin, P87/89, P87, Micos60, P89
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76614
HGNC: HGNC:6047
Homologene: 38234
Ap3d1
Name: adaptor-related protein complex 3, delta 1 subunit
Synonyms: Bolvr, mBLVR1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11776
VEGA: 10
HGNC: HGNC:568
Homologene: 2926
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Brms1l
Name: breast cancer metastasis-suppressor 1-like
Synonyms: 0710008O11Rik, BRMS1, D12Ertd407e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 52592
VEGA: 12
Homologene: 9123
Fam120a
Name: family with sequence similarity 120, member A
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218236
VEGA: 13
Homologene: 8752
Prune2
Name: prune homolog 2
Synonyms: 6330414G02Rik, A330102H22Rik, Olfaxin, A230083H22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 353211
VEGA: 19
Homologene: 18939
Septin9
Name: septin 9
Synonyms: Sept9, PNUTL4, MSF1, Sint1, Msf, SL3-3 integration site 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53860
HGNC: HGNC:7323
Homologene: 90949
Wdr36
Name: WD repeat domain 36
Synonyms: 5730444A13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225348
VEGA: 18
Homologene: 6536
Sh3bp5l
Name: SH3 binding domain protein 5 like
Synonyms: 2310074E09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 79566
Homologene: 32584
Ndufs1
Name: NADH:ubiquinone oxidoreductase core subunit S1
Synonyms: 5830412M15Rik, 9930026A05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227197
HGNC: HGNC:7707
Homologene: 3670
Ttll5
Name: tubulin tyrosine ligase-like family, member 5
Synonyms: STAMP, 4930556H18Rik, 2310009M18Rik, 1700048H13Rik, D630041K24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320244
Homologene: 9013
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Synonyms: Care2, mCAR, MB67, ESTM32, CAR, CAR1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12355
HGNC: HGNC:7969
Homologene: 3759
Ache
Name: acetylcholinesterase
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11423
HGNC: HGNC:108
Homologene: 543
Gypa
Name: glycophorin A
Synonyms: GPA, CD235a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14934
Ccnb1ip1
Name: cyclin B1 interacting protein 1
Synonyms: LOC239083, mei4, Hei10
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239083
VEGA: 14
Homologene: 18819
Ugt2b37
Name: UDP glucuronosyltransferase 2 family, polypeptide B37
Synonyms: 0610033E06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 112417
Homologene: 137225
Thap2
Name: THAP domain containing, apoptosis associated protein 2
Synonyms: 9030625G08Rik, 2900040O07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66816
VEGA: 10
Homologene: 12039
Ppef2
Name: protein phosphatase, EF hand calcium-binding domain 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19023
HGNC: HGNC:9244
Homologene: 55959
Abtb2
Name: ankyrin repeat and BTB domain containing 2
Synonyms: BPOZ-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99382
Homologene: 15904
Rnf207
Name: ring finger protein 207
Synonyms: D330010C22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433809
Homologene: 19234
Ttll11
Name: tubulin tyrosine ligase-like family, member 11
Synonyms: D2Ertd624e, 4932702F08Rik, 4933424A20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74410
Homologene: 77534
Ces1g
Name: carboxylesterase 1G
Synonyms: Ses-1, Ces-1, Ces1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12623
HGNC: HGNC:1863
Homologene: 137354
Cmbl
Name: carboxymethylenebutenolidase homolog
Synonyms: 2310016A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69574
Homologene: 100714
Tcl1b5
Name: T cell leukemia/lymphoma 1B, 5
Synonyms: D12Ertd644e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 27382
VEGA: 12
Homologene: 83274
Catsperd
Name: cation channel sperm associated auxiliary subunit delta
Synonyms: Gm6095, 4921529N20Rik, 4933402B14Rik, Tmem146
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106757
VEGA: 17
Homologene: 51896
Plau
Name: plasminogen activator, urokinase
Synonyms: u-PA, uPA, urokinase-type plasminogen activator
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18792
VEGA: 14
HGNC: HGNC:9052
Homologene: 55670
Hyal6
Name: hyaluronoglucosaminidase 6
Synonyms: 4932701A20Rik, Hyal-ps1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74409
HGNC: HGNC:5324
Homologene: 78028
Ttc9
Name: tetratricopeptide repeat domain 9
Synonyms: 1700029M07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 69480
VEGA: 12
Homologene: 52649
Taar9
Name: trace amine-associated receptor 9
Synonyms: Ta3, Tar3, Trar3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 503558
Homologene: 65286
Vmo1
Name: vitelline membrane outer layer 1 homolog (chicken)
Synonyms: LOC327956
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327956
Homologene: 45649
Tuft1
Name: tuftelin 1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22156
Homologene: 7985
Mfsd7c
Name:
Type: Gene
Species: Mouse
Chromosome: 12
Gm43218
Name: predicted gene 43218
Type: Gene
Species: Mouse
Chromosome: 6
4930555G01Rik
Name: RIKEN cDNA 4930555G01 gene
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 108978
Homologene: 115686
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 63,170,172 bp
  • C to A, chromosome 1 at 171,217,697 bp
  • A to G, chromosome 2 at 35,944,928 bp
  • A to G, chromosome 2 at 103,700,817 bp
  • A to G, chromosome 2 at 121,236,176 bp
  • T to C, chromosome 3 at 90,023,626 bp
  • A to T, chromosome 3 at 94,616,670 bp
  • C to T, chromosome 4 at 152,314,035 bp
  • G to A, chromosome 5 at 87,240,891 bp
  • A to T, chromosome 5 at 92,245,392 bp
  • T to C, chromosome 5 at 124,828,460 bp
  • A to G, chromosome 5 at 137,294,195 bp
  • A to G, chromosome 6 at 24,734,566 bp
  • C to T, chromosome 6 at 70,240,544 bp
  • T to A, chromosome 6 at 71,871,437 bp
  • A to G, chromosome 6 at 108,394,865 bp
  • T to C, chromosome 7 at 116,533,163 bp
  • A to T, chromosome 8 at 80,494,066 bp
  • T to A, chromosome 8 at 93,328,457 bp
  • A to T, chromosome 9 at 54,480,346 bp
  • A to G, chromosome 10 at 24,109,419 bp
  • A to T, chromosome 10 at 80,722,932 bp
  • A to T, chromosome 10 at 115,376,487 bp
  • T to C, chromosome 11 at 58,331,859 bp
  • A to G, chromosome 11 at 70,514,499 bp
  • A to G, chromosome 11 at 117,232,716 bp
  • T to C, chromosome 12 at 55,844,398 bp
  • T to C, chromosome 12 at 81,660,661 bp
  • GTAGTGTATA to GTA, chromosome 12 at 85,803,148 bp
  • T to A, chromosome 12 at 85,879,410 bp
  • A to T, chromosome 12 at 105,178,953 bp
  • T to C, chromosome 13 at 48,949,119 bp
  • T to A, chromosome 14 at 5,052,797 bp
  • A to C, chromosome 14 at 20,839,113 bp
  • C to T, chromosome 14 at 50,792,293 bp
  • T to C, chromosome 15 at 31,585,393 bp
  • C to T, chromosome 17 at 28,806,274 bp
  • T to C, chromosome 17 at 56,632,368 bp
  • A to G, chromosome 18 at 32,865,926 bp
  • G to C, chromosome 18 at 60,829,051 bp
  • G to A, chromosome 19 at 17,124,973 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8200 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067623-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.