Strain Name:
C57BL/6J-MtgxR8267Btlr/Mmmh
Stock Number:
067651-MU
Citation ID:
RRID:MMRRC_067651-MU
Other Names:
R8267 (G1)
Major Collection:

Strain Information

Vps41
Name: VPS41 HOPS complex subunit
Synonyms: Vam2, mVam2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218035
VEGA: 13
Homologene: 69165
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: Dopey1, B130005I07Rik, D9Ertd809e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320615
Homologene: 26645
Nme7
Name: NME/NM23 family member 7
Synonyms: nucleoside-diphosphate kinase, Nm23-M7, non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase), D530024H21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 171567
Homologene: 8344
Acbd3
Name: acyl-Coenzyme A binding domain containing 3
Synonyms: 8430407O11Rik, Pap7, D1Ertd10e, Gocap1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 170760
Homologene: 11227
Cux1
Name: cut-like homeobox 1
Synonyms: Cux-1, Cux, CDP, Cutl1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13047
HGNC: HGNC:2557
Coro1c
Name: coronin, actin binding protein 1C
Synonyms: CRN2, coronin 3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 23790
HGNC: HGNC:2254
Homologene: 56537
Mdn1
Name: midasin AAA ATPase 1
Synonyms: D4Abb1e, 4833432B22Rik, LOC213784
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100019
Homologene: 39689
Hip1
Name: huntingtin interacting protein 1
Synonyms: E130315I21Rik, 2610109B09Rik, HIP-1, A930014B11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 215114
HGNC: HGNC:4913
Homologene: 68463
Thbs1
Name: thrombospondin 1
Synonyms: TSP1, tbsp1, Thbs-1, TSP-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21825
Homologene: 31142
Smap1
Name: small ArfGAP 1
Synonyms: 1700056O10Rik, 4921514B13Rik, 4921525H11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98366
Homologene: 134676
Abcf2
Name: ATP-binding cassette, sub-family F member 2
Synonyms: Drr3, 0710005O05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27407
Homologene: 21408
Ehbp1
Name: EH domain binding protein 1
Synonyms: KIAA0903-like, Flj21950
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216565
Homologene: 22880
Pmch
Name: pro-melanin-concentrating hormone
Synonyms: A230109K23Rik, MCH, melanin-concentrating hormone
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 110312
Homologene: 37653
Cox16
Name: cytochrome c oxidase assembly protein 16
Synonyms: 1810055I05Rik, 1810020G14Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66272
Homologene: 9520
Optn
Name: optineurin
Synonyms: TFIIIA-INTP, 4930441O07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71648
Homologene: 11085
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 665700
Homologene: 90772
Reln
Name: reelin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Vmn2r100
Name: vomeronasal 2, receptor 100
Synonyms: EG627537
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627537
Homologene: 129750
Antxr2
Name: anthrax toxin receptor 2
Synonyms: 2310046B19Rik, CMG-2, cI-35, CMG2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71914
Homologene: 43236
Dock10
Name: dedicator of cytokinesis 10
Synonyms: Jr4, Zizimin3, ZIZ3, Jr5, A630054M16Rik, 9330153B10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210293
Homologene: 45952
Vmn2r19
Name: vomeronasal 2, receptor 19
Synonyms: EG232358
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232358
Homologene: 84037
Lnx2
Name: ligand of numb-protein X 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 140887
Homologene: 17737
Or4k37
Name: olfactory receptor family 4 subfamily K member 37
Synonyms: MOR248-18, GA_x6K02T2Q125-72379864-72380781, MOR248-14P, Olfr1281
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257979
Homologene: 73992
Vmn2r59
Name: vomeronasal 2, receptor 59
Synonyms: EG628444
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628444
Homologene: 129683
Col9a1
Name: collagen, type IX, alpha 1
Synonyms: Col9a-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12839
HGNC: HGNC:2217
Homologene: 1393
Vmn2r22
Name: vomeronasal 2, receptor 22
Synonyms: EG546913
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 546913
Homologene: 84037
Rgs6
Name: regulator of G-protein signaling 6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 50779
Homologene: 68385
Or10g1b
Name: olfactory receptor family 10 subfamily G member 1B
Synonyms: MOR223-9, GA_x6K02T2RJGY-608749-609705, Olfr1511
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258268
HGNC: HGNC:8170
Homologene: 87788
Sh3tc1
Name: SH3 domain and tetratricopeptide repeats 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231147
Homologene: 10360
Akp3
Name: alkaline phosphatase 3, intestine, not Mn requiring
Synonyms: IAP, Akp-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11648
Homologene: 134333
Vmn2r71
Name: vomeronasal 2, receptor 71
Synonyms: EG233445
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233445
Homologene: 115466
Tnip3
Name: TNFAIP3 interacting protein 3
Synonyms: 9030611K07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 414084
Homologene: 47979
Kcnq5
Name: potassium voltage-gated channel, subfamily Q, member 5
Synonyms: 9230107O05Rik, D1Mgi1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226922
HGNC: HGNC:6299
Homologene: 28270
Rbms3
Name: RNA binding motif, single stranded interacting protein
Synonyms: 6720477E09Rik, 8430436O14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 207181
Homologene: 49388
Zfp382
Name: zinc finger protein 382
Synonyms: 5930415A09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233060
Homologene: 32798
Gm11127
Name: predicted gene 11127
Synonyms: Gm11127
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100529082
Homologene: 133121
Wdr97
Name: WD repeat domain 97
Synonyms: Gm35339
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 102638882
Homologene: 131539
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 21,505,385 bp
  • T to A, chromosome 1 at 23,866,284 bp
  • A to T, chromosome 1 at 24,185,186 bp
  • T to C, chromosome 1 at 80,540,328 bp
  • A to T, chromosome 1 at 87,127,739 bp
  • A to G, chromosome 1 at 150,859,254 bp
  • A to G, chromosome 1 at 164,340,775 bp
  • A to G, chromosome 1 at 180,746,848 bp
  • T to C, chromosome 2 at 5,054,651 bp
  • A to G, chromosome 2 at 31,459,179 bp
  • A to G, chromosome 2 at 111,328,815 bp
  • A to T, chromosome 2 at 118,122,513 bp
  • T to C, chromosome 4 at 32,742,485 bp
  • A to G, chromosome 5 at 22,004,112 bp
  • CAT to CATAAT, chromosome 5 at 24,576,591 bp
  • T to C, chromosome 5 at 35,706,407 bp
  • T to A, chromosome 5 at 97,965,762 bp
  • T to C, chromosome 5 at 113,847,575 bp
  • A to T, chromosome 5 at 135,428,613 bp
  • A to G, chromosome 5 at 136,282,999 bp
  • A to T, chromosome 5 at 147,029,091 bp
  • T to G, chromosome 6 at 65,605,842 bp
  • T to C, chromosome 6 at 123,336,262 bp
  • T to C, chromosome 6 at 123,638,041 bp
  • G to C, chromosome 7 at 30,134,504 bp
  • T to G, chromosome 7 at 42,012,097 bp
  • A to G, chromosome 7 at 85,615,496 bp
  • C to T, chromosome 9 at 86,514,001 bp
  • T to C, chromosome 9 at 117,056,755 bp
  • A to T, chromosome 10 at 88,091,117 bp
  • T to A, chromosome 11 at 22,146,562 bp
  • T to C, chromosome 12 at 81,480,939 bp
  • A to C, chromosome 12 at 82,651,895 bp
  • T to C, chromosome 13 at 18,810,471 bp
  • A to G, chromosome 14 at 52,390,446 bp
  • C to T, chromosome 15 at 76,356,594 bp
  • T to A, chromosome 17 at 19,522,490 bp
  • A to G, chromosome 17 at 36,056,783 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8267 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067651-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.