Strain Name:
C57BL/6J-MtgxR8213Btlr/Mmmh
Stock Number:
067655-MU
Citation ID:
RRID:MMRRC_067655-MU
Other Names:
R8213 (G1)
Major Collection:

Strain Information

Dicer1
Name: dicer 1, ribonuclease type III
Synonyms: 1110006F08Rik, D12Ertd7e, Dicer1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 192119
VEGA: 12
Homologene: 13251
Psen2
Name: presenilin 2
Synonyms: ALG-3, PS-2, PS2, Ad4h
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19165
HGNC: HGNC:9509
Homologene: 386
Thbs4
Name: thrombospondin 4
Synonyms: TSP-4, TSP4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21828
Homologene: 20691
Cdk11b
Name: cyclin dependent kinase 11B
Synonyms: CDK11-p110, PITSLRE proteins, CDK11-p46, CDK11-p58, Cdc2l2, Cdc2l1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12537
Homologene: 22416
Sgsm1
Name: small G protein signaling modulator 1
Synonyms: 2410098H20Rik, D5Bwg1524e, Rutbc2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52850
Homologene: 64485
Dock6
Name: dedicator of cytokinesis 6
Synonyms: 2410095B20Rik, 4931431C02Rik, C330023D02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319899
VEGA: 9
Homologene: 83291
Erp44
Name: endoplasmic reticulum protein 44
Synonyms: 1110001E24Rik, Txndc4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76299
Homologene: 12638
Chka
Name: choline kinase alpha
Synonyms: choline/ethanolamine kinase alpha, CK/EK-alpha, ChoK, EtnK-alpha, Chk
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12660
HGNC: HGNC:1937
Homologene: 88575
Hnrnpr
Name: heterogeneous nuclear ribonucleoprotein R
Synonyms: hnRNPR, 2610003J05Rik, Hnrpr, 2610528B01Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74326
HGNC: HGNC:5047
Homologene: 4251
Nup205
Name: nucleoporin 205
Synonyms: 3830404O05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70699
Homologene: 45971
Heatr5a
Name: HEAT repeat containing 5A
Synonyms: D930036F22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320487
VEGA: 12
Homologene: 19635
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, 2810449H11Rik, tbl
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Prdm15
Name: PR domain containing 15
Synonyms: Zfp298, E130018M06Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 114604
Homologene: 56941
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: 4930400K19Rik, 2310003F20Rik, Tulip1, Garnl1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Fgd6
Name: FYVE, RhoGEF and PH domain containing 6
Synonyms: ZFYVE24, Etohd4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13998
Homologene: 14209
Sqle
Name: squalene epoxidase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20775
Homologene: 2355
Pms2
Name: PMS1 homolog2, mismatch repair system component
Synonyms: mismatch repair, DNA mismatch repair
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18861
Homologene: 133560
Syt14
Name: synaptotagmin XIV
Synonyms: B230320I09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329324
Homologene: 17719
Mybbp1a
Name: MYB binding protein (P160) 1a
Synonyms: p67MBP, p160MBP
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18432
HGNC: HGNC:7546
Homologene: 40954
Aktip
Name: AKT interacting protein
Synonyms: Ft1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14339
Homologene: 7721
Npat
Name: nuclear protein in the AT region
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244879
HGNC: HGNC:7896
Homologene: 1888
Dnajb9
Name: DnaJ heat shock protein family (Hsp40) member B9
Synonyms: microvascular endothelial differentiation gene, mDj7, Mdg1, ERdj4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 27362
VEGA: 12
HGNC: HGNC:6968
Homologene: 32155
Inpp5f
Name: inositol polyphosphate-5-phosphatase F
Synonyms: cI-27, SAC2, 5830435P03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101490
Homologene: 8962
Nrde2
Name: nrde-2 necessary for RNA interference, domain containing
Synonyms: 6720454P05Rik, BC002230
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217827
VEGA: 12
Homologene: 41213
Serpina10
Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
Synonyms: PZI
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217847
Homologene: 9414
Trpv1
Name: transient receptor potential cation channel, subfamily V, member 1
Synonyms: capsaicin receptor, VR-1, OTRPC1, Vr1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 193034
Homologene: 12920
Avil
Name: advillin
Synonyms: DOC6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11567
Homologene: 38200
Prlr
Name: prolactin receptor
Synonyms: Pr-1, Prlr-rs1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19116
HGNC: HGNC:9446
Homologene: 733
Vwa3b
Name: von Willebrand factor A domain containing 3B
Synonyms: A230074B11Rik, 4921511C04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70853
Homologene: 27053
Dhx57
Name: DExH-box helicase 57
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106794
VEGA: 17
Homologene: 56267
Kdm5d
Name: lysine demethylase 5D
Synonyms: Smcy, Jarid1d, HY
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 20592
Homologene: 55838
A1bg
Name: alpha-1-B glycoprotein
Synonyms: C44
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 117586
VEGA: 15
HGNC: HGNC:5
Homologene: 11167
Btnl6
Name: butyrophilin-like 6
Synonyms: NG13, Gm6519
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 624681
Homologene: 106849
Polr2g
Name: polymerase (RNA) II (DNA directed) polypeptide G
Synonyms: RBP7, 2410046K11Rik, A230108L04Rik, Rpo2-7l
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67710
VEGA: 19
HGNC: HGNC:9194
Homologene: 2019
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: A530024P18Rik, 2310008C07Rik, 2310003D02Rik, mXin beta, myomaxin, Cmya3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241431
Homologene: 19388
Fhl5
Name: four and a half LIM domains 5
Synonyms: 1700027G07Rik, ACT
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 57756
Homologene: 23230
Il17ra
Name: interleukin 17 receptor A
Synonyms: VDw217, Il17r
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16172
HGNC: HGNC:5985
Homologene: 7378
Serpinb1a
Name: serine (or cysteine) peptidase inhibitor, clade B, member 1a
Synonyms: LEI, 1190005M04Rik, ovalbumin, ELANH2, M/NEI, MNEI, EIA
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66222
HGNC: HGNC:3311
Homologene: 133768
Acss1
Name: acyl-CoA synthetase short-chain family member 1
Synonyms: 1110032O15Rik, AceCS2, Acas2, Acas2l
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68738
Homologene: 56037
Tgm7
Name: transglutaminase 7
Synonyms: TGz
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 640543
Homologene: 14192
Or10a49
Name: olfactory receptor family 10 subfamily A member 49
Synonyms: GA_x6K02T2PBJ9-11199311-11198367, MOR268-4, Olfr517
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258136
Homologene: 79413
Nepn
Name: nephrocan
Synonyms: 5730521E12Rik, Npn, periolin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66650
Homologene: 23549
Filip1
Name: filamin A interacting protein 1
Synonyms: 5730485H21Rik, FILIP
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70598
Homologene: 6700
Ccdc7b
Name: coiled-coil domain containing 7B
Synonyms: 1700008F21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75453
Homologene: 49919
Vmn2r108
Name: vomeronasal 2, receptor 108
Synonyms: EG627805
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627805
Homologene: 129678
Vmn1r216
Name: vomeronasal 1 receptor 216
Synonyms: V1ri10
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171279
Homologene: 110880
Mamdc4
Name: MAM domain containing 4
Synonyms: LOC381352
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381352
Homologene: 17102
Pramel22
Name: PRAME like 22
Synonyms: Gm13088
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 277668
Homologene: 129883
Pde6a
Name: phosphodiesterase 6A, cGMP-specific, rod, alpha
Synonyms: Pdea
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225600
HGNC: HGNC:8785
Homologene: 380
Kbtbd3
Name: kelch repeat and BTB (POZ) domain containing 3
Synonyms: 2200003A07Rik, Bklhd3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69149
Homologene: 12300
Efcab5
Name: EF-hand calcium binding domain 5
Synonyms: 4930563A03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319634
Homologene: 63366
Ttll10
Name: tubulin tyrosine ligase-like family, member 10
Synonyms: 4930595O22Rik, 4833412E22Rik, Ttll5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 330010
Homologene: 51912
Zscan5b
Name: zinc finger and SCAN domain containing 5B
Synonyms: Zfg1, Zfp371
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 170734
Homologene: 129555
Igsf5
Name: immunoglobulin superfamily, member 5
Synonyms: 2010003D20Rik, Igsf5, Jam4
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72058
HGNC: HGNC:5952
Homologene: 12437
Aup1
Name: ancient ubiquitous protein 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11993
HGNC: HGNC:891
Homologene: 7239
Or4d10b
Name: olfactory receptor family 4 subfamily D member 10B
Synonyms: GA_x6K02T2RE5P-2418550-2417609, MOR239-2, Olfr1424
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258676
Homologene: 82294
Or5g9
Name: olfactory receptor family 5 subfamily G member 9
Synonyms: GA_x6K02T2Q125-47195323-47196267, MOR175-3, Olfr1009
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258565
Homologene: 17297
Arl11
Name: ADP-ribosylation factor-like 11
Synonyms: ARLTS1, C730007L20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219144
VEGA: 14
Homologene: 16319
Zfp397
Name: zinc finger protein 397
Synonyms: 2810411K16Rik, 6720480F11Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 69256
VEGA: 18
Homologene: 117445
Prl4a1
Name: prolactin family 4, subfamily a, member 1
Synonyms: PLP-A, Prlpa
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19110
Homologene: 7900
Scgb2b11
Name: secretoglobin, family 2B, member 11
Synonyms: Gm4687, Abpbg11
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043842
Homologene: 83171
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 37,128,939 bp
  • A to C, chromosome 1 at 180,245,691 bp
  • T to C, chromosome 1 at 192,986,829 bp
  • G to A, chromosome 2 at 25,566,356 bp
  • T to A, chromosome 2 at 67,476,866 bp
  • T to A, chromosome 2 at 85,721,501 bp
  • A to G, chromosome 2 at 121,101,064 bp
  • T to A, chromosome 2 at 150,619,710 bp
  • A to T, chromosome 4 at 25,207,113 bp
  • A to T, chromosome 4 at 48,208,783 bp
  • A to T, chromosome 4 at 129,221,459 bp
  • C to A, chromosome 4 at 132,498,053 bp
  • A to G, chromosome 4 at 136,317,175 bp
  • T to A, chromosome 4 at 143,654,185 bp
  • A to T, chromosome 4 at 144,330,460 bp
  • G to A, chromosome 4 at 155,639,881 bp
  • A to T, chromosome 4 at 156,036,234 bp
  • C to T, chromosome 5 at 32,937,637 bp
  • A to T, chromosome 5 at 113,251,011 bp
  • C to T, chromosome 5 at 143,914,771 bp
  • T to C, chromosome 6 at 35,225,203 bp
  • A to G, chromosome 6 at 83,054,607 bp
  • T to C, chromosome 6 at 120,473,034 bp
  • C to T, chromosome 7 at 6,233,947 bp
  • T to C, chromosome 7 at 32,209,408 bp
  • C to A, chromosome 7 at 108,868,519 bp
  • A to G, chromosome 7 at 128,679,805 bp
  • G to T, chromosome 8 at 91,124,866 bp
  • C to A, chromosome 8 at 129,178,291 bp
  • A to G, chromosome 9 at 4,331,269 bp
  • A to G, chromosome 9 at 21,831,444 bp
  • G to T, chromosome 9 at 53,570,570 bp
  • G to T, chromosome 9 at 66,450,888 bp
  • C to A, chromosome 9 at 79,818,092 bp
  • A to T, chromosome 10 at 52,391,759 bp
  • A to T, chromosome 10 at 94,044,052 bp
  • A to T, chromosome 10 at 127,008,321 bp
  • T to A, chromosome 11 at 72,444,721 bp
  • T to C, chromosome 11 at 73,254,251 bp
  • T to C, chromosome 11 at 77,116,071 bp
  • A to T, chromosome 12 at 44,207,133 bp
  • G to A, chromosome 12 at 51,891,443 bp
  • C to A, chromosome 12 at 55,722,914 bp
  • G to A, chromosome 12 at 100,131,003 bp
  • T to C, chromosome 12 at 103,628,277 bp
  • A to T, chromosome 12 at 104,702,693 bp
  • T to C, chromosome 13 at 23,099,525 bp
  • T to G, chromosome 13 at 28,023,386 bp
  • T to A, chromosome 13 at 32,842,999 bp
  • T to C, chromosome 13 at 92,760,586 bp
  • T to G, chromosome 14 at 61,311,265 bp
  • C to T, chromosome 15 at 10,329,242 bp
  • A to G, chromosome 15 at 59,321,302 bp
  • T to C, chromosome 15 at 60,919,756 bp
  • A to T, chromosome 16 at 96,372,988 bp
  • T to A, chromosome 16 at 97,807,060 bp
  • G to A, chromosome 17 at 20,470,088 bp
  • A to T, chromosome 17 at 34,508,883 bp
  • T to A, chromosome 17 at 80,275,156 bp
  • T to A, chromosome 18 at 23,960,722 bp
  • A to T, chromosome 18 at 61,220,696 bp
  • A to C, chromosome 19 at 3,885,882 bp
  • A to T, chromosome 19 at 8,798,257 bp
  • A to G, chromosome 19 at 12,059,092 bp
  • T to A, chromosome Y at 941,515 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8213 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067655-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.