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Strain Name:
C57BL/6J-MtgxR8237Btlr/Mmmh
Stock Number:
067669-MU
Citation ID:
RRID:MMRRC_067669-MU
Other Names:
R8237 (G1)
Major Collection:

Strain Information

Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Plaat1
Name: phospholipase A and acyltransferase 1
Synonyms: A-C1, 2810012B06Rik, Hrasls
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 27281
Homologene: 8452
Zmym6
Name: zinc finger, MYM-type 6
Synonyms: D4Wsu24e, 9330177P20Rik, Zfp258
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100177
Homologene: 5186
Adgrl3
Name: adhesion G protein-coupled receptor L3
Synonyms: D130075K09Rik, lectomedin 3, LEC3, 5430402I23Rik, Lphn3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319387
Homologene: 22878
Zranb2
Name: zinc finger, RAN-binding domain containing 2
Synonyms: Znf265, Zis, Zfp265
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53861
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: apollon, Bruce, A430032G04Rik, D630005A10Rik, A430040A19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Kif1b
Name: kinesin family member 1B
Synonyms: D4Mil1e, Kif1b alpha, Kif1b beta, KIF1Bp130, KIF1Bp204, N-3 kinesin, A530096N05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Nup205
Name: nucleoporin 205
Synonyms: 3830404O05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70699
Homologene: 45971
Zfp407
Name: zinc finger protein 407
Synonyms: LOC240469, LOC381139, 6430585N13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240476
Homologene: 86402
Npepps
Name: aminopeptidase puromycin sensitive
Synonyms: MP100, Psa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19155
HGNC: HGNC:7900
Homologene: 36199
Itprid2
Name: ITPR interacting domain containing 2
Synonyms: SPAG13, CS-1, CS1, KRAP, Ssfa2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70599
Homologene: 4912
Cog8
Name: component of oligomeric golgi complex 8
Synonyms: C87832
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 97484
Homologene: 13018
Chd8
Name: chromodomain helicase DNA binding protein 8
Synonyms: 5830451P18Rik, Duplin
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67772
Homologene: 72405
2810021J22Rik
Name: RIKEN cDNA 2810021J22 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69944
Homologene: 138400
Ap2a1
Name: adaptor-related protein complex 2, alpha 1 subunit
Synonyms: Adtaa
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11771
HGNC: HGNC:561
Homologene: 68997
Psrc1
Name: proline/serine-rich coiled-coil 1
Synonyms: DDA3, 5430413I02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56742
Homologene: 49603
Hes1
Name: hes family bHLH transcription factor 1
Synonyms: Hry, bHLHb39
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15205
HGNC: HGNC:5192
Homologene: 38067
Stxbp2
Name: syntaxin binding protein 2
Synonyms: Munc-18b, Munc-18-2, C79054, Sxtp2, Munc18b, muSec1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20911
Homologene: 55530
Ccn4
Name: cellular communication network factor 4
Synonyms: Elm1, CCN4, Wisp1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22402
Homologene: 2883
Ginm1
Name: glycoprotein integral membrane 1
Synonyms: BC013529
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215751
Homologene: 16347
Tex15
Name: testis expressed gene 15 meiosis and synapsis associated
Synonyms: 2210014E14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 104271
Homologene: 12837
Abca4
Name: ATP-binding cassette, sub-family A member 4
Synonyms: Rim protein, RmP, Abc10, D430003I15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11304
HGNC: HGNC:34
Homologene: 298
Zfp942
Name: zinc finger protein 942
Synonyms: 3110048L19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 73233
Homologene: 133237
Plpp2
Name: phospholipid phosphatase 2
Synonyms: Lpp2, Ppap2c
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 50784
HGNC: HGNC:9230
Homologene: 2752
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 229003
Homologene: 14118
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Lmntd1
Name: lamin tail domain containing 1
Synonyms: Lmna-rs1, 4933403M22Rik, Ifltd1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74071
Homologene: 69453
Pik3r2
Name: phosphoinositide-3-kinase regulatory subunit 2
Synonyms: p85beta
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18709
HGNC: HGNC:8980
Homologene: 3687
Nlrc5
Name: NLR family, CARD domain containing 5
Synonyms: AI451557
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 434341
Homologene: 88935
Fsip1
Name: fibrous sheath-interacting protein 1
Synonyms: 4933432K11Rik, 1700012M13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71313
Homologene: 12390
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC9, MUC5, 2300002I04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Ctse
Name: cathepsin E
Synonyms: CE, CatE, A430072O03Rik, C920004C08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13034
HGNC: HGNC:2530
Homologene: 37551
Prkce
Name: protein kinase C, epsilon
Synonyms: PKC[e], Pkce, 5830406C15Rik, PKCepsilon, PCK epsilon
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18754
HGNC: HGNC:9401
Homologene: 48343
Cspg4
Name: chondroitin sulfate proteoglycan 4
Synonyms: NG2, AN2, 4732461B14Rik, Cspg4a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 121021
VEGA: 9
HGNC: HGNC:2466
Homologene: 20445
Plbd2
Name: phospholipase B domain containing 2
Synonyms: 66.3 kDa, p76, 1300012G16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71772
Homologene: 41528
Myo15b
Name: myosin XVB
Synonyms: LOC217328, LOC380737, E330039G21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217328
Abca5
Name: ATP-binding cassette, sub-family A member 5
Synonyms: ABC13, B930033A02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217265
HGNC: HGNC:35
Homologene: 10263
Or5p69
Name: olfactory receptor family 5 subfamily P member 69
Synonyms: GA_x6K02T2PBJ9-10697517-10698461, MOR204-10, Olfr494
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258732
Homologene: 133602
Map9
Name: microtubule-associated protein 9
Synonyms: 5033421J10Rik, 5330427D05Rik, ASAP, Mtap9
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213582
Homologene: 41591
Hsd3b1
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Synonyms: D3Ertd383e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15492
Homologene: 69149
Phf2
Name: PHD finger protein 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18676
VEGA: 13
HGNC: HGNC:8920
Homologene: 3934
Usp45
Name: ubiquitin specific petidase 45
Synonyms: 3110003C05Rik, Gcap7, 4930550B20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77593
Homologene: 17674
Cbs
Name: cystathionine beta-synthase
Synonyms: HIP4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12411
HGNC: HGNC:1550
Homologene: 37258
Ptdss1
Name: phosphatidylserine synthase 1
Synonyms: PtdSer Synthase-1, PSS-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19210
VEGA: 13
HGNC: HGNC:9587
Homologene: 7494
Ceacam3
Name: CEA cell adhesion molecule 3
Synonyms: cea12, EG384557, Psg24
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384557
HGNC: HGNC:1819
Homologene: 86971
Mixl1
Name: Mix paired-like homeobox
Synonyms: Mml
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27217
Homologene: 8445
Fkbp10
Name: FK506 binding protein 10
Synonyms: FKBP65, Fkbp1-rs, Fkbp-rs1, Fkbp6, 65kDa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14230
Homologene: 7718
Pbx4
Name: pre B cell leukemia homeobox 4
Synonyms: 2410015M21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 80720
Homologene: 57027
Vmn2r69
Name: vomeronasal 2, receptor 69
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330581
Homologene: 115466
Gm10110
Name: predicted gene 10110
Type: Gene
Species: Mouse
Chromosome: 14
Lonrf2
Name: LON peptidase N-terminal domain and ring finger 2
Synonyms: 2900060P06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381338
Homologene: 18871
Serpina1b
Name: serine (or cysteine) preptidase inhibitor, clade A, member 1B
Synonyms: PI2, D12Ucla2, Spi1-2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20701
HGNC: HGNC:8941
Homologene: 20103
Spcs1
Name: signal peptidase complex subunit 1 homolog (S. cerevisiae)
Synonyms: 1810004F21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 69019
Homologene: 40915
Aim1
Name:
Type: Gene
Species: Mouse
Chromosome: 10
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 34,169,793 bp
  • T to A, chromosome 1 at 38,800,773 bp
  • T to A, chromosome 1 at 131,662,729 bp
  • G to A, chromosome 1 at 180,696,757 bp
  • T to C, chromosome 2 at 40,851,774 bp
  • T to C, chromosome 2 at 79,657,270 bp
  • A to G, chromosome 2 at 118,233,002 bp
  • T to C, chromosome 2 at 181,229,331 bp
  • C to T, chromosome 3 at 82,377,160 bp
  • C to T, chromosome 3 at 98,853,110 bp
  • C to T, chromosome 3 at 108,386,614 bp
  • T to C, chromosome 3 at 122,162,303 bp
  • A to G, chromosome 3 at 157,545,040 bp
  • T to G, chromosome 4 at 21,834,274 bp
  • A to G, chromosome 4 at 127,122,751 bp
  • T to A, chromosome 4 at 149,191,185 bp
  • CAA to CA, chromosome 5 at 81,787,561 bp
  • T to C, chromosome 5 at 120,499,049 bp
  • T to A, chromosome 6 at 35,227,503 bp
  • G to A, chromosome 6 at 145,427,420 bp
  • T to C, chromosome 7 at 17,163,157 bp
  • C to A, chromosome 7 at 44,900,796 bp
  • A to G, chromosome 7 at 85,411,132 bp
  • A to C, chromosome 7 at 108,368,027 bp
  • G to T, chromosome 7 at 119,926,413 bp
  • T to C, chromosome 7 at 141,857,960 bp
  • C to T, chromosome 8 at 3,635,695 bp
  • A to G, chromosome 8 at 33,577,399 bp
  • A to G, chromosome 8 at 69,864,443 bp
  • G to A, chromosome 8 at 70,772,150 bp
  • A to G, chromosome 8 at 94,526,125 bp
  • T to C, chromosome 8 at 107,056,291 bp
  • T to C, chromosome 9 at 56,892,680 bp
  • G to T, chromosome 10 at 7,792,655 bp
  • G to A, chromosome 10 at 43,966,380 bp
  • G to A, chromosome 10 at 79,527,460 bp
  • T to C, chromosome 11 at 58,880,547 bp
  • A to G, chromosome 11 at 97,248,200 bp
  • A to G, chromosome 11 at 100,415,959 bp
  • A to T, chromosome 11 at 110,310,155 bp
  • A to G, chromosome 11 at 115,877,001 bp
  • C to A, chromosome 12 at 103,818,804 bp
  • T to C, chromosome 12 at 115,834,256 bp
  • T to C, chromosome 13 at 13,651,732 bp
  • T to A, chromosome 13 at 48,823,038 bp
  • T to C, chromosome 13 at 66,976,777 bp
  • C to G, chromosome 14 at 31,000,701 bp
  • T to A, chromosome 14 at 41,965,495 bp
  • C to T, chromosome 14 at 52,213,352 bp
  • C to T, chromosome 14 at 89,898,241 bp
  • C to A, chromosome 15 at 66,919,234 bp
  • C to A, chromosome 16 at 29,220,354 bp
  • T to C, chromosome 16 at 30,067,229 bp
  • A to T, chromosome 17 at 21,928,245 bp
  • T to C, chromosome 17 at 31,615,480 bp
  • G to C, chromosome 17 at 74,611,131 bp
  • G to T, chromosome 17 at 86,559,218 bp
  • T to C, chromosome 18 at 84,560,144 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8237 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067669-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.