Strain Name:
C57BL/6J-MtgxR8252Btlr/Mmmh
Stock Number:
067678-MU
Citation ID:
RRID:MMRRC_067678-MU
Other Names:
R8252 (G1)
Major Collection:

Strain Information

Setd5
Name: SET domain containing 5
Synonyms: 2900045N06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72895
Homologene: 12485
Krt5
Name: keratin 5
Synonyms: Krt2-5, K5, 3300001P10Rik, Tfip8
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110308
HGNC: HGNC:6442
Homologene: 55461
Pcdh9
Name: protocadherin 9
Synonyms: 1500001L12Rik, C630029H24Rik, A730003J17Rik, LOC382930, C530050I23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211712
HGNC: HGNC:8661
Homologene: 10698
Rnf10
Name: ring finger protein 10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50849
Homologene: 40990
Prrc2b
Name: proline-rich coiled-coil 2B
Synonyms: Bat2l, 5830434P21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227723
Homologene: 106649
Wdr70
Name: WD repeat domain 70
Synonyms: 4833422F06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 545085
VEGA: 15
Homologene: 9972
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: B630009I04Rik, Helic1, ASC1p200
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Kif1b
Name: kinesin family member 1B
Synonyms: Kif1b beta, A530096N05Rik, N-3 kinesin, D4Mil1e, KIF1Bp204, KIF1Bp130, Kif1b alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Abi1
Name: abl interactor 1
Synonyms: Ssh3bp1, E3B1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11308
Homologene: 38053
Sgk1
Name: serum/glucocorticoid regulated kinase 1
Synonyms: Sgk
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20393
Homologene: 48364
Atg13
Name: autophagy related 13
Synonyms: D2Ertd391e, 1110053A20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 51897
Homologene: 32229
Uvssa
Name: UV stimulated scaffold protein A
Synonyms: D330017J19Rik, 4933407H18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71101
Homologene: 13807
Fam171b
Name: family with sequence similarity 171, member B
Synonyms: D430039N05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241520
Homologene: 18462
Spg11
Name: SPG11, spatacsin vesicle trafficking associated
Synonyms: spastic paraplegia 11, 6030465E24Rik, C530005A01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214585
Homologene: 41614
Psap
Name: prosaposin
Synonyms: SGP-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19156
HGNC: HGNC:9498
Homologene: 37680
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: LOC381562, A930005E13Rik, D930005K06Rik, Zubr1, p600, 1810009A16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69116
Homologene: 10804
Cdh19
Name: cadherin 19, type 2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227485
HGNC: HGNC:1758
Homologene: 23286
Lgr6
Name: leucine-rich repeat-containing G protein-coupled receptor 6
Synonyms: A530037C04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329252
Homologene: 49680
Msh3
Name: mutS homolog 3
Synonyms: D13Em1, Rep3, Rep-3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17686
HGNC: HGNC:7326
Homologene: 1829
Pwwp3a
Name: PWWP domain containing 3A, DNA repair factor
Synonyms: 9430059D04Rik, Mum1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68114
Homologene: 11349
Zbtb48
Name: zinc finger and BTB domain containing 48
Synonyms: Hkr3, 0610011D15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100090
HGNC: HGNC:4930
Homologene: 3905
Chst10
Name: carbohydrate sulfotransferase 10
Synonyms: ST, Hnk-1st
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98388
Homologene: 21013
Cacna1c
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms: D930026N18Rik, (alpha)1 subunit, Cchl1a1, Cav1.2, L-type Cav1.2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12288
HGNC: HGNC:1390
Homologene: 55484
Ano4
Name: anoctamin 4
Synonyms: A330096O15Rik, Tmem16d
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320091
Homologene: 66599
Lama4
Name: laminin, alpha 4
Synonyms: laminin [a]4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16775
HGNC: HGNC:6484
Homologene: 37604
Cd180
Name: CD180 antigen
Synonyms: Ly78, RP105
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17079
HGNC: HGNC:6726
Homologene: 4077
Fam135b
Name: family with sequence similarity 135, member B
Synonyms: 1700010C24Rik, A830008O07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70363
VEGA: 15
Homologene: 66605
Il36b
Name: interleukin 36B
Synonyms: 2310043N20Rik, If36b, Il1f8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69677
Homologene: 18278
Col19a1
Name: collagen, type XIX, alpha 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12823
HGNC: HGNC:2196
Homologene: 55608
Sik2
Name: salt inducible kinase 2
Synonyms: Snf1lk2, G630080D20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235344
Homologene: 22875
Clec2g
Name: C-type lectin domain family 2, member g
Synonyms: Ocilrp1, 4632413B12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70809
Homologene: 136309
Tmem229a
Name: transmembrane protein 229A
Synonyms: 6332401O19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 319832
Homologene: 85312
Rab11fip2
Name: RAB11 family interacting protein 2 (class I)
Synonyms: nRip11, Rab11-FIP2, 4930470G04Rik, A830046J09Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74998
Homologene: 8937
Sspo
Name: SCO-spondin
Synonyms: Scospondin, C79529
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243369
Homologene: 45453
Scml4
Name: Scm polycomb group protein like 4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268297
Homologene: 18262
Pla2g4a
Name: phospholipase A2, group IVA (cytosolic, calcium-dependent)
Synonyms: cytosolic PLA2, cytosolic phospholipase A2, cPLA2, Pla2g4, cPLA2alpha, Type IV PLA2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18783
HGNC: HGNC:9035
Homologene: 32059
Or4c102
Name: olfactory receptor family 4 subfamily C member 102
Synonyms: Olfr1189, GA_x6K02T2Q125-50079044-50079964, MOR237-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258768
Homologene: 81569
Nudt12
Name: nudix hydrolase 12
Synonyms: nudix (nucleoside diphosphate linked moiety X)-type motif 12, 0610016O18Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67993
Homologene: 44188
Pkd1l2
Name: polycystic kidney disease 1 like 2
Synonyms: 1700126L06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76645
Homologene: 124481
Vmn2r92
Name: vomeronasal 2, receptor 92
Synonyms: EG627111
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627111
Homologene: 115024
Sipa1l2
Name: signal-induced proliferation-associated 1 like 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244668
Homologene: 18956
Vmn2r7
Name: vomeronasal 2, receptor 7
Synonyms: 4933425M15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 319217
Homologene: 129754
Slc26a7
Name: solute carrier family 26, member 7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 208890
Homologene: 13770
Nfe2l1
Name: nuclear factor, erythroid derived 2,-like 1
Synonyms: TCF-11, NRF1, TCF11, Lcrf1, LCR-F1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18023
HGNC: HGNC:7781
Homologene: 20685
Sry
Name: sex determining region of Chr Y
Synonyms: Tdf, Tdy
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 21674
Or5p50
Name: olfactory receptor family 5 subfamily P member 50
Synonyms: MOR204-21, Olfr469, GA_x6K02T2PBJ9-10152980-10152036
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258418
Homologene: 44979
Htra3
Name: HtrA serine peptidase 3
Synonyms: 9530081K03Rik, 2210021K23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 78558
Homologene: 12697
Slamf1
Name: signaling lymphocytic activation molecule family member 1
Synonyms: Slam, IPO-3, CD150, ESTM51, CDw150
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27218
Homologene: 48162
Hecw1
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Synonyms: NEDL1, E130207I19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94253
VEGA: 13
Homologene: 9004
Cd1d2
Name: CD1d2 antigen
Synonyms: CD1.2, Cd1b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12480
HGNC: HGNC:1637
Or2t46
Name: olfactory receptor family 2 subfamily T member 46
Synonyms: MOR275-11_p, MOR275-5, Olfr325, GA_x6K02T2NKPP-844642-843680
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258261
Homologene: 133015
Iglc2
Name: immunoglobulin lambda constant 2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 110786
Trim8
Name: tripartite motif-containing 8
Synonyms: Rnf27, GERP
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 93679
VEGA: 19
Homologene: 12795
Arhgap18
Name: Rho GTPase activating protein 18
Synonyms: 4833419J07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73910
Homologene: 14135
Vgll4
Name: vestigial like family member 4
Synonyms: VGL-4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232334
Homologene: 18603
Nutm1
Name: NUT midline carcinoma, family member 1
Synonyms: Nut, BC125332
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 213765
Homologene: 18185
Thap7
Name: THAP domain containing 7
Synonyms: 1810004B07Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69009
Homologene: 12293
Tcap
Name: titin-cap
Synonyms: Telethonin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21393
Homologene: 2724
Ndufb4
Name: NADH:ubiquinone oxidoreductase subunit B4
Synonyms: 1300010H20Rik, 0610006N12Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 68194
HGNC: HGNC:7699
Homologene: 3342
Or6e1
Name: olfactory receptor family 6 subfamily E member 1
Synonyms: IC6, GA_x6K02T2QVSB-39745261-39746202, Olfr49, MOR118-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18348
Homologene: 106373
Pcdha11
Name: protocadherin alpha 11
Synonyms: Cnr7, A830022B16Rik, Crnr7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12942
HGNC: HGNC:8665
Homologene: 75095
Scgb2b11
Name: secretoglobin, family 2B, member 11
Synonyms: Abpbg11, Gm4687
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043842
Homologene: 83171
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 24,279,967 bp
  • T to C, chromosome 1 at 38,884,352 bp
  • C to T, chromosome 1 at 110,889,885 bp
  • T to A, chromosome 1 at 135,003,477 bp
  • T to C, chromosome 1 at 149,851,307 bp
  • T to A, chromosome 1 at 171,767,228 bp
  • T to C, chromosome 2 at 22,971,272 bp
  • A to T, chromosome 2 at 24,158,813 bp
  • A to T, chromosome 2 at 32,219,380 bp
  • A to G, chromosome 2 at 83,878,242 bp
  • A to G, chromosome 2 at 88,592,667 bp
  • G to C, chromosome 2 at 91,680,354 bp
  • G to T, chromosome 2 at 112,251,829 bp
  • G to T, chromosome 2 at 122,088,339 bp
  • A to G, chromosome 3 at 64,693,106 bp
  • A to C, chromosome 3 at 86,987,068 bp
  • T to C, chromosome 4 at 14,621,415 bp
  • T to A, chromosome 4 at 139,473,217 bp
  • A to T, chromosome 4 at 149,273,805 bp
  • A to T, chromosome 4 at 152,020,887 bp
  • A to G, chromosome 5 at 33,392,179 bp
  • A to G, chromosome 5 at 35,652,961 bp
  • A to T, chromosome 5 at 115,260,314 bp
  • T to C, chromosome 6 at 24,955,581 bp
  • C to T, chromosome 6 at 48,485,452 bp
  • T to A, chromosome 6 at 113,150,955 bp
  • G to T, chromosome 6 at 114,890,734 bp
  • C to T, chromosome 6 at 118,657,374 bp
  • G to A, chromosome 6 at 128,981,372 bp
  • T to C, chromosome 7 at 32,209,339 bp
  • A to G, chromosome 7 at 107,822,569 bp
  • T to C, chromosome 8 at 117,040,733 bp
  • A to T, chromosome 8 at 125,468,671 bp
  • A to G, chromosome 9 at 50,917,115 bp
  • T to A, chromosome 10 at 21,997,399 bp
  • T to A, chromosome 10 at 26,854,936 bp
  • A to T, chromosome 10 at 39,060,146 bp
  • T to C, chromosome 10 at 42,924,104 bp
  • T to A, chromosome 10 at 50,642,610 bp
  • A to G, chromosome 10 at 60,277,689 bp
  • A to G, chromosome 10 at 80,241,860 bp
  • A to G, chromosome 10 at 88,981,019 bp
  • T to A, chromosome 11 at 58,581,132 bp
  • T to C, chromosome 11 at 96,819,232 bp
  • T to C, chromosome 11 at 98,384,345 bp
  • C to A, chromosome 13 at 14,340,840 bp
  • T to A, chromosome 13 at 92,221,061 bp
  • A to G, chromosome 13 at 102,705,996 bp
  • T to A, chromosome 14 at 54,282,247 bp
  • T to C, chromosome 14 at 93,888,650 bp
  • A to T, chromosome 15 at 8,042,856 bp
  • T to A, chromosome 15 at 71,533,023 bp
  • A to T, chromosome 15 at 101,712,359 bp
  • T to C, chromosome 16 at 17,528,622 bp
  • A to T, chromosome 16 at 19,198,770 bp
  • T to C, chromosome 16 at 37,654,275 bp
  • T to A, chromosome 17 at 18,166,872 bp
  • T to C, chromosome 17 at 59,011,094 bp
  • G to C, chromosome 18 at 37,007,537 bp
  • A to G, chromosome 19 at 46,515,620 bp
  • C to T, chromosome 19 at 59,936,990 bp
  • C to A, chromosome Y at 2,663,298 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8252 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067678-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.