Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR8272Btlr/Mmmh
Stock Number:
067695-MU
Citation ID:
RRID:MMRRC_067695-MU
Other Names:
R8272 (G1)
Major Collection:

Strain Information

Slc12a1
Name: solute carrier family 12, member 1
Synonyms: Nkcc2, mBSC1, D630042G03Rik, urehr3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20495
Homologene: 286
Casp8
Name: caspase 8
Synonyms: Mch5, MACH, FLICE, Caspase-8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12370
HGNC: HGNC:1509
Homologene: 7657
Card11
Name: caspase recruitment domain family, member 11
Synonyms: CARMA1, BIMP3, 2410011D02Rik, 0610008L17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108723
Homologene: 13024
Zdbf2
Name: zinc finger, DBF-type containing 2
Synonyms: 9330107J05Rik, 4930431J08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73884
Homologene: 52868
Tmprss12
Name: transmembrane (C-terminal) protease, serine 12
Synonyms: 4930478A21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75002
VEGA: 15
Homologene: 16598
Chuk
Name: conserved helix-loop-helix ubiquitous kinase
Synonyms: Chuk1, IKK1, IKK[a], IKK-alpha, IkappaB kinase alpha, IKK 1, IKK alpha, IKKalpha, IKK-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12675
HGNC: HGNC:1974
Homologene: 979
Ddx50
Name: DExD box helicase 50
Synonyms: GU2, RH-II/Gubeta, 4933429B04Rik, 8430408E17Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 94213
VEGA: 10
Homologene: 56986
Ptpn21
Name: protein tyrosine phosphatase, non-receptor type 21
Synonyms: PTPD1, PTPRL10
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 24000
VEGA: 12
HGNC: HGNC:9651
Homologene: 5110
Dhrs7b
Name: dehydrogenase/reductase 7B
Synonyms: dehydrogenase/reductase (SDR family) member 7B
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216820
Homologene: 41044
Trim27
Name: tripartite motif-containing 27
Synonyms: Rfp
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19720
HGNC: HGNC:9975
Homologene: 111010
Nifk
Name: nucleolar protein interacting with the FHA domain of MKI67
Synonyms: C130020J04Rik, Mki67ip
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67949
Homologene: 49862
L3mbtl3
Name: L3MBTL3 histone methyl-lysine binding protein
Synonyms: MBT-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237339
Homologene: 18226
Rrp1b
Name: ribosomal RNA processing 1B
Synonyms: 2600005C20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72462
Homologene: 57086
Pcx
Name: pyruvate carboxylase
Synonyms: Pc
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18563
VEGA: 19
HGNC: HGNC:8636
Homologene: 5422
Syvn1
Name: synovial apoptosis inhibitor 1, synoviolin
Synonyms: Hrd1, 1200010C09Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74126
Homologene: 32700
Flrt3
Name: fibronectin leucine rich transmembrane protein 3
Synonyms: 5530600M07Rik, C430047I10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71436
HGNC: HGNC:3762
Homologene: 8322
Lrrc4
Name: leucine rich repeat containing 4
Synonyms: Nag14, NGL-2, NGL2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 192198
Homologene: 36403
Klf5
Name: Kruppel-like transcription factor 5
Synonyms: Bteb2, 4930520J07Rik, CKLF, IKLF
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12224
VEGA: 14
HGNC: HGNC:6349
Homologene: 37520
Brd3
Name: bromodomain containing 3
Synonyms: RINGL3, ORFX, 2410084F24Rik, Fsrg2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67382
HGNC: HGNC:1104
Homologene: 81801
Peak1
Name: pseudopodium-enriched atypical kinase 1
Synonyms: 1110049L02Rik, NKF3 kinase family member, C230081A13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244895
Homologene: 18259
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930516E05Rik, D330038K10Rik, 4930543C13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Cyp4f18
Name: cytochrome P450, family 4, subfamily f, polypeptide 18
Synonyms: 1810054N16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72054
Homologene: 128623
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh-4, C130041O22Rik, Zfh4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80892
Homologene: 23477
Cspg4b
Name: chondroitin sulfate proteoglycan 4B
Synonyms: BC067074
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408066
Col28a1
Name: collagen, type XXVIII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 213945
Homologene: 66345
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: lrd, b2b598Clo, b2b1203Clo, b2b1279Clo, b2b1289Clo, b2b1727Clo, Dnahc11, avc4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Adtrp
Name: androgen dependent TFPI regulating protein
Synonyms: 9530008L14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109254
Homologene: 13107
Myh11
Name: myosin, heavy polypeptide 11, smooth muscle
Synonyms: smMHC, SM2, SM1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17880
VEGA: 16
HGNC: HGNC:7569
Homologene: 128512
Myh7b
Name: myosin, heavy chain 7B, cardiac muscle, beta
Synonyms: Myh14
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668940
Homologene: 66117
Gm12695
Name: predicted gene 12695
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 620779
Homologene: 51847
Abca15
Name: ATP-binding cassette, sub-family A member 15
Synonyms: 4930500I12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320631
Homologene: 87255
Myoc
Name: myocilin
Synonyms: TIGR, GLC1A
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17926
HGNC: HGNC:7610
Homologene: 220
Gramd1b
Name: GRAM domain containing 1B
Synonyms: A930008A22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235283
Homologene: 18223
Vmn2r110
Name: vomeronasal 2, receptor 110
Synonyms: EG224582
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224582
Homologene: 129678
Tmod4
Name: tropomodulin 4
Synonyms: MTMOD, Sk-Tmod, skeletal tropomodulin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 50874
Homologene: 8355
Serpinb1a
Name: serine (or cysteine) peptidase inhibitor, clade B, member 1a
Synonyms: LEI, 1190005M04Rik, ovalbumin, ELANH2, M/NEI, MNEI, EIA
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66222
HGNC: HGNC:3311
Homologene: 133768
Letm2
Name: leucine zipper-EF-hand containing transmembrane protein 2
Synonyms: D030041N04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270035
Homologene: 56358
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243369
Homologene: 45453
Nlrp10
Name: NLR family, pyrin domain containing 10
Synonyms: 6430548I20Rik, Pynod, Nalp10
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244202
Homologene: 18468
Grm8
Name: glutamate receptor, metabotropic 8
Synonyms: mGluR8, Gprc1h
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14823
HGNC: HGNC:4600
Homologene: 654
Npc1l1
Name: NPC1 like intracellular cholesterol transporter 1
Synonyms: Niemann-Pick disease, type C1, 9130221N23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237636
HGNC: HGNC:7898
Homologene: 56585
Cfap45
Name: cilia and flagella associated protein 45
Synonyms: 1700028D05Rik, Nesg1, Ccdc19
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71870
Homologene: 71837
Kctd8
Name: potassium channel tetramerisation domain containing 8
Synonyms: A730087N02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243043
Homologene: 18464
Tmem38b
Name: transmembrane protein 38B
Synonyms: 1600017F22Rik, D4Ertd89e, TRIC-B
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 52076
Homologene: 10010
Rimbp3
Name: RIMS binding protein 3
Synonyms: LOC239731, LOC385766, RIM-BP3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239731
Homologene: 77940
Nanog
Name: Nanog homeobox
Synonyms: 2410002E02Rik, ENK, ecat4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71950
Homologene: 78027
Fbxw15
Name: F-box and WD-40 domain protein 15
Synonyms: Fbxo12J
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382105
Homologene: 110776
Vmn2r65
Name: vomeronasal 2, receptor 65
Synonyms: ENSMUSG00000070600
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100009609
Tead2
Name: TEA domain family member 2
Synonyms: TEF-4, TEAD-2, Etdf
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21677
Homologene: 19662
Fbxl12
Name: F-box and leucine-rich repeat protein 12
Synonyms: 3110048D16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 30843
Homologene: 32198
Ctnna3
Name: catenin alpha 3
Synonyms: Vr22, Catna3, 4930429L08Rik, alphaT-catenin, catenin (cadherin associated protein), alpha 3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216033
HGNC: HGNC:2511
Homologene: 56583
Fam98b
Name: family with sequence similarity 98, member B
Synonyms: 2610510H03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68215
Homologene: 72241
Zfp78
Name: zinc finger protein 78
Synonyms: KRAB12, Zfp77
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330463
Homologene: 128524
Btnl2
Name: butyrophilin-like 2
Synonyms: butyrophylin-like MHC class II associated, BTL-II, NG9, BTLN2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 547431
HGNC: HGNC:1142
Homologene: 10482
Rftn1
Name: raftlin lipid raft linker 1
Synonyms: 2310015N21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 76438
Homologene: 18745
Or5b102
Name: olfactory receptor family 5 subfamily B member 102
Synonyms: GA_x6K02T2RE5P-3390804-3391727, MOR202-14, Olfr1454
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258687
HGNC: HGNC:8324
Homologene: 120159
Plcxd3
Name: phosphatidylinositol-specific phospholipase C, X domain containing 3
Synonyms: B130016O10Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239318
Homologene: 45574
Ccin
Name: calicin
Synonyms: 4933417A14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 442829
HGNC: HGNC:1568
Homologene: 4306
Bid
Name: BH3 interacting domain death agonist
Synonyms: 2700049M22Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12122
HGNC: HGNC:1050
Homologene: 923
Vmn2r125
Name: vomeronasal 2, receptor 125
Synonyms: Gm20782
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 670059
VEGA: 4
Asmt
Name: acetylserotonin O-methyltransferase
Synonyms: Hiomt
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 107626
VEGA: X
HGNC: HGNC:750
Pcdhac2
Name: protocadherin alpha subfamily C, 2
Synonyms: CNRc2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 353237
HGNC: HGNC:8677
Homologene: 49562
Lrrc16a
Name:
Type: Gene
Species: Mouse
Chromosome: 13
Naaladl2
Name: N-acetylated alpha-linked acidic dipeptidase-like 2
Synonyms: LOC381500, 2810043G22Rik, EG635702
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 635702
Homologene: 45786
Or13m2-ps1
Name: olfactory receptor family 13 subfamily M member 2, pseudogene 1
Synonyms: GA_x6K02T2P3E9-4759141-4758206, MOR257-6, Olfr451-ps1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258017
Tmem263
Name: transmembrane protein 263
Synonyms: AI597468
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103266
VEGA: 10
Homologene: 17533
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 58,833,742 bp
  • A to G, chromosome 1 at 63,305,983 bp
  • G to T, chromosome 1 at 85,931,397 bp
  • A to G, chromosome 1 at 118,332,404 bp
  • T to C, chromosome 1 at 162,639,426 bp
  • G to A, chromosome 1 at 172,527,839 bp
  • A to G, chromosome 2 at 27,461,713 bp
  • G to A, chromosome 2 at 104,026,154 bp
  • T to A, chromosome 2 at 117,262,854 bp
  • T to C, chromosome 2 at 125,228,816 bp
  • G to T, chromosome 2 at 140,660,697 bp
  • A to T, chromosome 2 at 155,632,904 bp
  • T to G, chromosome 3 at 5,243,867 bp
  • T to C, chromosome 3 at 24,058,202 bp
  • C to T, chromosome 3 at 95,125,860 bp
  • G to A, chromosome 4 at 43,984,064 bp
  • T to A, chromosome 4 at 53,854,332 bp
  • A to G, chromosome 4 at 96,723,946 bp
  • A to G, chromosome 4 at 156,350,078 bp
  • T to C, chromosome 5 at 69,110,460 bp
  • A to G, chromosome 5 at 140,890,039 bp
  • G to A, chromosome 6 at 8,154,175 bp
  • A to T, chromosome 6 at 27,363,282 bp
  • T to C, chromosome 6 at 28,662,193 bp
  • A to G, chromosome 6 at 42,801,104 bp
  • A to T, chromosome 6 at 48,448,519 bp
  • T to C, chromosome 6 at 120,900,215 bp
  • T to A, chromosome 6 at 122,711,777 bp
  • A to G, chromosome 7 at 6,373,214 bp
  • A to G, chromosome 7 at 45,228,742 bp
  • A to T, chromosome 7 at 84,947,609 bp
  • A to G, chromosome 7 at 108,925,896 bp
  • A to G, chromosome 7 at 120,407,442 bp
  • A to G, chromosome 8 at 25,586,656 bp
  • G to T, chromosome 8 at 71,989,091 bp
  • C to A, chromosome 9 at 20,638,864 bp
  • T to C, chromosome 9 at 40,304,524 bp
  • A to G, chromosome 9 at 56,258,898 bp
  • A to C, chromosome 9 at 109,559,760 bp
  • C to T, chromosome 10 at 26,303,668 bp
  • A to G, chromosome 10 at 62,621,477 bp
  • T to G, chromosome 10 at 65,002,598 bp
  • T to A, chromosome 10 at 85,114,567 bp
  • T to A, chromosome 11 at 6,229,327 bp
  • C to A, chromosome 11 at 60,851,754 bp
  • G to A, chromosome 12 at 98,688,530 bp
  • T to A, chromosome 12 at 118,111,017 bp
  • G to A, chromosome 13 at 21,180,610 bp
  • T to G, chromosome 13 at 24,036,579 bp
  • A to T, chromosome 13 at 32,845,737 bp
  • G to T, chromosome 13 at 41,816,154 bp
  • A to T, chromosome 13 at 113,368,355 bp
  • G to T, chromosome 14 at 99,302,104 bp
  • G to T, chromosome 15 at 4,516,736 bp
  • A to T, chromosome 15 at 100,282,265 bp
  • T to C, chromosome 16 at 14,218,854 bp
  • T to C, chromosome 16 at 17,209,105 bp
  • A to G, chromosome 17 at 20,596,228 bp
  • A to G, chromosome 17 at 32,057,189 bp
  • G to T, chromosome 17 at 34,356,301 bp
  • G to T, chromosome 17 at 50,047,380 bp
  • T to A, chromosome 18 at 37,146,189 bp
  • A to T, chromosome 19 at 4,601,730 bp
  • G to A, chromosome 19 at 6,047,941 bp
  • G to A, chromosome 19 at 13,063,431 bp
  • A to G, chromosome 19 at 16,749,845 bp
  • A to G, chromosome 19 at 44,103,736 bp
  • A to T, chromosome X at 170,672,725 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8272 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067695-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.