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Strain Name:
C57BL/6J-MtgxR8280Btlr/Mmmh
Stock Number:
067703-MU
Citation ID:
RRID:MMRRC_067703-MU
Other Names:
R8280 (G1)
Major Collection:

Strain Information

Nmral1
Name: NmrA-like family domain containing 1
Synonyms: 1110025F24Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67824
Homologene: 41388
Prtg
Name: protogenin
Synonyms: A230098A12Rik, Igdcc5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235472
Homologene: 54453
Tmem245
Name: transmembrane protein 245
Synonyms: A630051L19Rik, D730040F13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242474
HGNC: HGNC:1363
Homologene: 41841
Trio
Name: triple functional domain (PTPRF interacting)
Synonyms: 6720464I07Rik, Solo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223435
VEGA: 15
Homologene: 20847
Mlh1
Name: mutL homolog 1
Synonyms: colon cancer, nonpolyposis type 2, 1110035C23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17350
HGNC: HGNC:7127
Homologene: 208
Apob
Name: apolipoprotein B
Synonyms: apob-100, apob-48
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Cacna2d3
Name: calcium channel, voltage-dependent, alpha2/delta subunit 3
Synonyms: alpha 2 delta-3, alpha2delta3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12294
Homologene: 74929
Fcrl2
Name: Fc receptor like 2
Synonyms: 2810439C17Rik, IFGP2, Fcrh2, moFcRH2sc, Msr2, Fcrls
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80891
Homologene: 57117
Farsa
Name: phenylalanyl-tRNA synthetase, alpha subunit
Synonyms: 0610012A19Rik, Farsla
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66590
HGNC: HGNC:3592
Homologene: 3280
Uqcrfs1
Name: ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
Synonyms: 4430402G14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66694
Homologene: 4378
Paxbp1
Name: PAX3 and PAX7 binding protein 1
Synonyms: 1810007M14Rik, Pax3/7bp, Gcfc1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67367
Homologene: 9604
Samd8
Name: sterile alpha motif domain containing 8
Synonyms: 1700010P07Rik, 1110053F04Rik, Smsr
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67630
Homologene: 41670
Robo4
Name: roundabout guidance receptor 4
Synonyms: 1200012D01Rik, Magic roundabout
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74144
Homologene: 10397
Usf3
Name: upstream transcription factor family member 3
Synonyms: LOC207806, LOC385650, 5530400K22Rik, Gm608
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207806
Homologene: 19504
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: Mdnah5, b2b1154Clo, b2b1134Clo, b2b1537Clo, b2b1565Clo, Dnahc5, b2b3491Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Fer1l4
Name: fer-1 like family member 4
Synonyms: 9130402C12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74562
Homologene: 19075
Cped1
Name: cadherin-like and PC-esterase domain containing 1
Synonyms: A430107O13Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214642
Homologene: 57014
Anxa1
Name: annexin A1
Synonyms: Lpc-1, Lpc1, Anx-1, Anx-A1, C430014K04Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16952
HGNC: HGNC:533
Homologene: 563
Alpk2
Name: alpha-kinase 2
Synonyms: Hak
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225638
Homologene: 50475
4933427D14Rik
Name: RIKEN cDNA 4933427D14 gene
Synonyms: Gm43951
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74477
Homologene: 8874
Or1o11
Name: olfactory receptor family 1 subfamily O member 11
Synonyms: MOR156-5, GA_x6K02T2PSCP-1893605-1894534, Olfr108
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258457
Homologene: 44985
Ces1c
Name: carboxylesterase 1C
Synonyms: Es-N, Es-4, Es-1, Ee-1, Es1, Ces-N
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13884
HGNC: HGNC:1863
Homologene: 117484
Cacna1e
Name: calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms: Cav2.3, Cchra1, alpha1E
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12290
HGNC: HGNC:1392
Homologene: 20185
Il10
Name: interleukin 10
Synonyms: cytokine synthesis inhibitory factor, IL-10
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16153
HGNC: HGNC:5962
Homologene: 478
Or8g21
Name: olfactory receptor family 8 subfamily G member 21
Synonyms: GA_x6K02T2PVTD-32691280-32690354, MOR171-11, Olfr935
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258741
VEGA: 9
Homologene: 133683
Lilra6
Name: leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
Synonyms: 7M1, Pira3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18726
Homologene: 134028
Naaa
Name: N-acylethanolamine acid amidase
Synonyms: 2210023K21Rik, 3830414F09Rik, Asahl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67111
HGNC: HGNC:736
Homologene: 8686
Or4k2
Name: olfactory receptor family 4 subfamily K member 2
Synonyms: GA_x6K02T2PMLR-5881670-5880717, MOR247-1, Olfr730
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258486
Homologene: 17269
Cluap1
Name: clusterin associated protein 1
Synonyms: 2310030D15Rik, 2610111M03Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 76779
Homologene: 14831
Slc22a8
Name: solute carrier family 22 (organic anion transporter), member 8
Synonyms: Roct, OAT3, mOat3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19879
VEGA: 19
Homologene: 20901
Irag1
Name: inositol 1,4,5-triphosphate receptor associated 1
Synonyms: Ris1, Mrvi1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17540
HGNC: HGNC:7237
Homologene: 4425
Dip2a
Name: disco interacting protein 2 homolog A
Synonyms: Kiaa0184-hp, 4931420H10Rik, Dip2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64451
Homologene: 41012
Or4c122
Name: olfactory receptor family 4 subfamily C member 122
Synonyms: GA_x6K02T2Q125-50696209-50695274, MOR233-1, Olfr1228
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258973
Homologene: 74217
Rragd
Name: Ras-related GTP binding D
Synonyms: 5730543C08Rik, D4Ertd174e, C030003H22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 52187
Homologene: 49667
Or8b52
Name: olfactory receptor family 8 subfamily B member 52
Synonyms: GA_x6K02T2PVTD-32368166-32367237, MOR168-2P, Olfr917
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258183
VEGA: 9
Ndufaf7
Name: NADH:ubiquinone oxidoreductase complex assembly factor 7
Synonyms: 2410091C18Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 73694
VEGA: 17
Homologene: 12508
Taar8c
Name: trace amine-associated receptor 8C
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 494546
Homologene: 77586
Cyb561d1
Name: cytochrome b-561 domain containing 1
Synonyms: 1600010M23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72023
Homologene: 45651
Or4x6
Name: olfactory receptor family 4 subfamily X member 6
Synonyms: GA_x6K02T2Q125-51551618-51550689, MOR228-3, Olfr1269
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258339
Homologene: 133727
Heatr4
Name: HEAT repeat containing 4
Synonyms: Gm17673
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 101055670
Homologene: 45728
Or6b2
Name: olfactory receptor family 6 subfamily B member 2
Synonyms: GA_x6K02T2R7CC-81277975-81278913, MOR103-3, Olfr1416
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 259040
Homologene: 17472
Fam43b
Name: family with sequence similarity 43, member B
Synonyms: OTTMUSG00000009974
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 625638
Homologene: 45810
Diras2
Name: DIRAS family, GTP-binding RAS-like 2
Synonyms: 2900052J15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68203
VEGA: 13
Homologene: 56777
Zscan4f
Name: zinc finger and SCAN domain containing 4F
Synonyms: C330039H09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 665902
Homologene: 85986
Gm4181
Name: predicted gene 4181
Type: Gene
Species: Mouse
Chromosome: 14
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 92,480,007 bp
  • C to T, chromosome 1 at 131,020,012 bp
  • T to C, chromosome 1 at 154,469,093 bp
  • A to T, chromosome 2 at 89,248,890 bp
  • C to A, chromosome 2 at 90,119,398 bp
  • T to C, chromosome 2 at 156,049,700 bp
  • G to T, chromosome 3 at 87,259,057 bp
  • A to G, chromosome 3 at 108,199,216 bp
  • A to G, chromosome 3 at 108,199,397 bp
  • A to G, chromosome 4 at 32,995,112 bp
  • A to T, chromosome 4 at 56,890,884 bp
  • T to C, chromosome 4 at 138,395,970 bp
  • T to C, chromosome 5 at 92,263,449 bp
  • G to T, chromosome 6 at 21,986,821 bp
  • A to G, chromosome 7 at 3,913,047 bp
  • A to T, chromosome 7 at 11,517,672 bp
  • G to A, chromosome 7 at 105,377,898 bp
  • T to C, chromosome 7 at 110,923,621 bp
  • A to G, chromosome 7 at 142,501,622 bp
  • T to G, chromosome 8 at 84,861,179 bp
  • T to A, chromosome 8 at 93,099,181 bp
  • T to C, chromosome 9 at 37,404,076 bp
  • T to A, chromosome 9 at 38,665,487 bp
  • C to T, chromosome 9 at 38,994,779 bp
  • A to G, chromosome 9 at 72,906,151 bp
  • A to T, chromosome 9 at 111,249,218 bp
  • T to A, chromosome 10 at 24,100,937 bp
  • C to T, chromosome 10 at 76,264,776 bp
  • A to G, chromosome 11 at 72,195,841 bp
  • T to C, chromosome 12 at 8,010,851 bp
  • C to A, chromosome 12 at 83,969,896 bp
  • A to T, chromosome 13 at 30,545,088 bp
  • A to G, chromosome 13 at 52,507,827 bp
  • G to A, chromosome 14 at 21,780,151 bp
  • C to T, chromosome 14 at 28,982,371 bp
  • A to C, chromosome 14 at 50,186,266 bp
  • A to T, chromosome 14 at 51,630,558 bp
  • A to G, chromosome 15 at 27,902,910 bp
  • G to T, chromosome 15 at 28,408,392 bp
  • A to G, chromosome 16 at 3,911,153 bp
  • A to G, chromosome 16 at 4,713,795 bp
  • A to G, chromosome 16 at 44,218,501 bp
  • G to T, chromosome 16 at 91,034,235 bp
  • T to C, chromosome 17 at 37,445,853 bp
  • G to A, chromosome 17 at 78,943,846 bp
  • A to G, chromosome 18 at 65,307,203 bp
  • T to A, chromosome 19 at 8,609,263 bp
  • A to T, chromosome 19 at 20,375,286 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8280 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067703-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.