Strain Name:
C57BL/6J-MtgxR8284Btlr/Mmmh
Stock Number:
067707-MU
Citation ID:
RRID:MMRRC_067707-MU
Other Names:
R8284 (G1)
Major Collection:

Strain Information

Xrcc1
Name: X-ray repair complementing defective repair in Chinese hamster cells 1
Synonyms: Xrcc-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22594
Homologene: 31368
Vcan
Name: versican
Synonyms: DPEAAE, 5430420N07Rik, Cspg2, hdf, heart defect, PG-M
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Kcnmb4
Name: potassium large conductance calcium-activated channel, subfamily M, beta member 4
Synonyms: 2900045G12Rik, Slowpoke beta 4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 58802
HGNC: HGNC:6289
Homologene: 8721
Shc1
Name: src homology 2 domain-containing transforming protein C1
Synonyms: p66shc, ShcA, p66
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20416
Homologene: 7934
Pml
Name: promyelocytic leukemia
Synonyms: Trim19, 1200009E24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18854
HGNC: HGNC:9113
Homologene: 13245
Fbxo31
Name: F-box protein 31
Synonyms: Fbx14, 1110003O08Rik, 2310046N15Rik, Fbxo14
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76454
Homologene: 11684
Setx
Name: senataxin
Synonyms: Als4, A930037J23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Nup214
Name: nucleoporin 214
Synonyms: D2H9S46E, CAN
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227720
HGNC: HGNC:8064
Homologene: 38008
Tlk1
Name: tousled-like kinase 1
Synonyms: 4930545J15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228012
Homologene: 130657
Sdha
Name: succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Synonyms: SDH2, 2310034D06Rik, FP, SDHF
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66945
Homologene: 3073
Ralgps2
Name: Ral GEF with PH domain and SH3 binding motif 2
Synonyms: 1810020P17Rik, 2210408F11Rik, 4921528G01Rik, 9130014M22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 78255
Homologene: 23421
Aff4
Name: AF4/FMR2 family, member 4
Synonyms: Laf4l, Alf4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 93736
Homologene: 8683
Dhx8
Name: DEAH-box helicase 8
Synonyms: RNA helicase, mDEAH6, Ddx8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217207
HGNC: HGNC:2749
Homologene: 3628
Plxna4
Name: plexin A4
Synonyms: Plxa4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243743
HGNC: HGNC:9102
Homologene: 77587
Oas1d
Name: 2'-5' oligoadenylate synthetase 1D
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100535
HGNC: HGNC:8086
Homologene: 110815
C3
Name: complement component 3
Synonyms: Plp, acylation stimulating protein, complement factor 3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12266
HGNC: HGNC:1318
Homologene: 68031
Mrpl2
Name: mitochondrial ribosomal protein L2
Synonyms: CGI-22, MRP-L14, Rpml14
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27398
Homologene: 69198
Hbp1
Name: high mobility group box transcription factor 1
Synonyms: C86454, 1700058O05Rik, C330012F01Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73389
Homologene: 8171
Ythdc1
Name: YTH domain containing 1
Synonyms: A730098D12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231386
Homologene: 15796
Adgrf5
Name: adhesion G protein-coupled receptor F5
Synonyms: Gpr116, 8430401C09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224792
VEGA: 17
Homologene: 9065
Itga4
Name: integrin alpha 4
Synonyms: VLA-4 receptor, alpha 4 subunit
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16401
HGNC: HGNC:6140
Homologene: 37364
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: Spna-1, ihj, erythroid, Spna1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20739
Homologene: 74460
Tecta
Name: tectorin alpha
Synonyms: [a]-tectorin, Tctna
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21683
Homologene: 3955
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: Gm980, Dnahc14, LOC381311, A230079K17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
Snrk
Name: SNF related kinase
Synonyms: SNRK, 2010012F07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20623
Homologene: 9797
Cnga4
Name: cyclic nucleotide gated channel alpha 4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233649
HGNC: HGNC:2152
Homologene: 13579
Tuba8
Name: tubulin, alpha 8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 53857
Homologene: 56766
Aox1
Name: aldehyde oxidase 1
Synonyms: retinal oxidase, Aox-2, Aox2, Aox-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11761
HGNC: HGNC:553
Homologene: 68165
H60b
Name: histocompatibility 60b
Synonyms: EG667281
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 667281
Homologene: 120804
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: Fmi1, flamingo, Adgrc3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Gucy2e
Name: guanylate cyclase 2e
Synonyms: ROS-GC1, GC1, GC-E
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14919
HGNC: HGNC:4689
Homologene: 55442
Prss54
Name: serine protease 54
Synonyms: 4931432M23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70993
Homologene: 19278
Or2t1
Name: olfactory receptor family 2 subfamily T member 1
Synonyms: MTPCR53, MOR274-1, GA_x6K02T2PLTE-6714644-6715597, Olfr31
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18330
HGNC: HGNC:8277
Homologene: 74028
Tmem232
Name: transmembrane protein 232
Synonyms: E130009J12Rik, LOC381107
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381107
VEGA: 17
Homologene: 54378
Piwil4
Name: piwi-like RNA-mediated gene silencing 4
Synonyms: Miwi2, MIWI2, 9230101H05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330890
Homologene: 45122
Pex13
Name: peroxisomal biogenesis factor 13
Synonyms: 2610008O20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72129
HGNC: HGNC:8855
Homologene: 1967
Or1l8
Name: olfactory receptor family 1 subfamily L member 8
Synonyms: GA_x6K02T2NLDC-33622642-33621710, Olfr355, MOR138-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258618
Homologene: 132326
Or2y1b
Name: olfactory receptor family 2 subfamily Y member 1B
Synonyms: L45, GA_x6K02T2QP88-6117098-6116163, Olfr10, MOR256-55
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18307
Homologene: 81347
Yipf7
Name: Yip1 domain family, member 7
Synonyms: 2310016N21Rik, Yip1b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75581
Homologene: 69367
Adamts14
Name: ADAM metallopeptidase with thrombospondin type 1 motif 14
Synonyms: TS14, Adamts-14
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237360
Homologene: 16383
Nars2
Name: asparaginyl-tRNA synthetase 2 (mitochondrial)(putative)
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244141
Homologene: 57002
Bpifc
Name: BPI fold containing family C
Synonyms: Bpil2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 270757
Homologene: 18383
Ppl
Name: periplakin
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19041
VEGA: 16
HGNC: HGNC:9273
Homologene: 2026
Or12d13
Name: olfactory receptor family 12 subfamily D member 13
Synonyms: GA_x6K02T2PSCP-1798423-1797482, MOR250-3, Olfr103, MOR250-8_p
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258830
Homologene: 115555
Ftcd
Name: formiminotransferase cyclodeaminase
Synonyms: glutamate formiminotransferase
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14317
HGNC: HGNC:3974
Homologene: 4848
Tcfl5
Name: transcription factor-like 5 (basic helix-loop-helix)
Synonyms: Figlb, FIG beta
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277353
Homologene: 4814
Top1mt
Name: DNA topoisomerase 1, mitochondrial
Synonyms: 2900052H09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72960
Homologene: 43082
Klra4
Name: killer cell lectin-like receptor, subfamily A, member 4
Synonyms: ly49r129, Chok, Ly49d
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16635
Homologene: 110821
Slc15a1
Name: solute carrier family 15 (oligopeptide transporter), member 1
Synonyms: PECT1, PEPT1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56643
VEGA: 14
Homologene: 38006
Trim12a
Name: tripartite motif-containing 12A
Synonyms: 2310043C01Rik, Trim12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76681
Senp8
Name: SUMO peptidase family member, NEDD8 specific
Synonyms: Prsc2, Nedp1, Den1, 9130010J17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71599
VEGA: 9
Homologene: 14084
Trbv20
Name: T cell receptor beta, variable 20
Synonyms: Tcrb-V15, Gm16911
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100124685
Sox18
Name: SRY (sex determining region Y)-box 18
Synonyms: Sry-related HMG-box gene 18, Ragl
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20672
Homologene: 7546
Zfp1002
Name: zinc finger protein 1002
Synonyms: Gm21994
Type: Gene
Species: Mouse
Chromosome: 2
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 58,076,091 bp
  • A to G, chromosome 1 at 156,828,148 bp
  • A to G, chromosome 1 at 174,179,821 bp
  • A to C, chromosome 1 at 181,773,811 bp
  • C to T, chromosome 2 at 29,145,336 bp
  • T to C, chromosome 2 at 31,996,446 bp
  • T to A, chromosome 2 at 36,928,006 bp
  • T to C, chromosome 2 at 70,714,021 bp
  • C to T, chromosome 2 at 79,321,439 bp
  • T to C, chromosome 2 at 150,255,356 bp
  • A to G, chromosome 2 at 180,638,537 bp
  • G to A, chromosome 2 at 181,670,958 bp
  • T to G, chromosome 3 at 89,421,908 bp
  • G to T, chromosome 4 at 143,950,125 bp
  • C to T, chromosome 5 at 69,517,196 bp
  • T to G, chromosome 5 at 86,816,466 bp
  • C to T, chromosome 5 at 120,919,158 bp
  • T to C, chromosome 6 at 32,152,854 bp
  • C to T, chromosome 6 at 41,188,848 bp
  • G to A, chromosome 6 at 121,222,777 bp
  • A to G, chromosome 6 at 130,065,280 bp
  • G to A, chromosome 7 at 24,572,278 bp
  • C to A, chromosome 7 at 96,951,638 bp
  • A to T, chromosome 7 at 104,306,075 bp
  • T to A, chromosome 7 at 105,408,032 bp
  • G to A, chromosome 8 at 95,559,366 bp
  • T to C, chromosome 8 at 121,560,442 bp
  • G to T, chromosome 9 at 14,727,478 bp
  • T to A, chromosome 9 at 42,378,029 bp
  • T to C, chromosome 9 at 58,229,360 bp
  • G to A, chromosome 9 at 59,737,531 bp
  • G to T, chromosome 9 at 108,846,413 bp
  • A to G, chromosome 9 at 122,160,472 bp
  • T to A, chromosome 10 at 22,287,072 bp
  • T to C, chromosome 10 at 61,198,659 bp
  • T to C, chromosome 10 at 76,578,059 bp
  • T to C, chromosome 10 at 86,000,549 bp
  • T to A, chromosome 10 at 116,418,253 bp
  • A to G, chromosome 11 at 23,655,685 bp
  • A to G, chromosome 11 at 49,318,175 bp
  • A to G, chromosome 11 at 53,404,552 bp
  • A to G, chromosome 11 at 69,232,351 bp
  • A to G, chromosome 11 at 101,757,629 bp
  • T to A, chromosome 11 at 119,428,083 bp
  • G to A, chromosome 12 at 31,937,626 bp
  • A to T, chromosome 13 at 74,331,297 bp
  • A to T, chromosome 13 at 89,704,335 bp
  • T to A, chromosome 14 at 14,329,011 bp
  • T to C, chromosome 14 at 121,489,863 bp
  • T to A, chromosome 15 at 75,667,863 bp
  • A to G, chromosome 16 at 5,132,337 bp
  • C to T, chromosome 17 at 37,336,696 bp
  • T to A, chromosome 17 at 43,455,270 bp
  • C to A, chromosome 17 at 46,647,509 bp
  • C to A, chromosome 17 at 57,223,938 bp
  • T to A, chromosome 17 at 65,402,995 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8284 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067707-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.