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Strain Name:
C57BL/6J-MtgxR8286Btlr/Mmmh
Stock Number:
067708-MU
Citation ID:
RRID:MMRRC_067708-MU
Other Names:
R8286 (G1)
Major Collection:

Strain Information

Ptprk
Name: protein tyrosine phosphatase receptor type K
Synonyms: PTPk, RPTPkappa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: Ggtb3, 2610509D04Rik, D5Ertd66e, Bwf1, Bchs, Alfy
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72145
Homologene: 22855
Sfswap
Name: splicing factor SWAP
Synonyms: 6330437E22Rik, 1190005N23Rik, Sfrs8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231769
Homologene: 134548
Pan2
Name: PAN2 poly(A) specific ribonuclease subunit
Synonyms: 1200014O24Rik, Usp52
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103135
VEGA: 10
Homologene: 5918
Eif1
Name: eukaryotic translation initiation factor 1
Synonyms: Sui1-rs1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20918
HGNC: HGNC:3249
Homologene: 135931
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: D7H15F32S1, D15F32S1h, rjs, D7H15F37S1, jdf2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Mical3
Name: microtubule associated monooxygenase, calponin and LIM domain containing 3
Synonyms: MICAL-3, C130040D16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194401
Homologene: 85288
Hif1a
Name: hypoxia inducible factor 1, alpha subunit
Synonyms: MOP1, HIF-1alpha, HIF1alpha, bHLHe78
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 15251
HGNC: HGNC:4910
Homologene: 1171
Mdn1
Name: midasin AAA ATPase 1
Synonyms: LOC213784, 4833432B22Rik, D4Abb1e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100019
Homologene: 39689
Mars1
Name: methionine-tRNA synthetase 1
Synonyms: MetRS, methionine tRNA ligase, methionyl-tRNA synthetase, Mars
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216443
HGNC: HGNC:6898
Homologene: 90878
Icam5
Name: intercellular adhesion molecule 5, telencephalin
Synonyms: CD50, Tlcn, TLN, Icam3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15898
VEGA: 9
HGNC: HGNC:5348
Homologene: 2447
Tmem234
Name: transmembrane protein 234
Synonyms: 1500002D11Rik, 4933407D05Rik, 2510006D16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76799
Homologene: 41314
Prpf39
Name: pre-mRNA processing factor 39
Synonyms: Srcs1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 328110
Homologene: 32377
Setd1a
Name: SET domain containing 1A
Synonyms: KMT2F
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233904
Homologene: 52251
Exoc1
Name: exocyst complex component 1
Synonyms: Sec3p, SEC3, A730011E05Rik, 2810407P21Rik, Sec3l1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69940
Homologene: 41241
Atp2b2
Name: ATPase, Ca++ transporting, plasma membrane 2
Synonyms: PMCA2, D6Abb2e, wms, jog, Tmy, Gena300
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11941
HGNC: HGNC:815
Homologene: 56150
Cngb1
Name: cyclic nucleotide gated channel beta 1
Synonyms: Cngb1, Cngb1b, BC016201
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 333329
HGNC: HGNC:2151
Homologene: 136420
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Cacna2d2
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 2
Synonyms: a2d2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56808
HGNC: HGNC:1400
Homologene: 4400
Dnaaf9
Name: dynein axonemal assembly factor 9
Synonyms: 4930402H24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228602
Homologene: 12623
Cped1
Name: cadherin-like and PC-esterase domain containing 1
Synonyms: A430107O13Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214642
Homologene: 57014
Abcb1b
Name: ATP-binding cassette, sub-family B member 1B
Synonyms: Mdr1, Mdr1b, mdr, Pgy1, Pgy-1, Abcb1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18669
HGNC: HGNC:40
Homologene: 69084
Trmt1l
Name: tRNA methyltransferase 1 like
Synonyms: Trm1-like, 1190005F20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98685
Homologene: 12801
Hecw2
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Synonyms: D030049F17Rik, Nedl2, A730039N16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329152
Homologene: 66192
Ctsj
Name: cathepsin J
Synonyms: rat gene/Cathepsin L-related protein, CatRLP, CATP, Cat P, Ctsp
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26898
VEGA: 13
Homologene: 137246
Abcd4
Name: ATP-binding cassette, sub-family D member 4
Synonyms: P69r, Pxmp1l
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19300
VEGA: 12
HGNC: HGNC:68
Homologene: 3703
Plxnb1
Name: plexin B1
Synonyms: 2900002G15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235611
HGNC: HGNC:9103
Homologene: 130508
Mctp1
Name: multiple C2 domains, transmembrane 1
Synonyms: 2810465F10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78771
Homologene: 75211
Adam26b
Name: a disintegrin and metallopeptidase domain 26B
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382007
Homologene: 128363
Neil2
Name: nei like 2 (E. coli)
Synonyms: LOC382913, NEH2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 382913
VEGA: 14
Homologene: 17032
Tfb2m
Name: transcription factor B2, mitochondrial
Synonyms: Hkp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15278
Homologene: 7362
Or8b35
Name: olfactory receptor family 8 subfamily B member 35
Synonyms: GA_x6K02T2PVTD-31676771-31677700, MOR162-7, Olfr881
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258413
Homologene: 74013
Flt4
Name: FMS-like tyrosine kinase 4
Synonyms: VEGFR3, VEGFR-3, Flt-4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14257
HGNC: HGNC:3767
Homologene: 7321
Dip2a
Name: disco interacting protein 2 homolog A
Synonyms: Kiaa0184-hp, 4931420H10Rik, Dip2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64451
Homologene: 41012
Vmn2r86
Name: vomeronasal 2, receptor 86
Synonyms: EG625109
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 625109
Homologene: 129606
Rassf5
Name: Ras association (RalGDS/AF-6) domain family member 5
Synonyms: 1300019G20Rik, Nore1B, Nore1A, Rapl
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 54354
Homologene: 10296
Ncald
Name: neurocalcin delta
Synonyms: D030020D09Rik, D15Ertd412e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 52589
HGNC: HGNC:7655
Homologene: 49978
Or8k23
Name: olfactory receptor family 8 subfamily K member 23
Synonyms: GA_x6K02T2Q125-47827833-47826892, MOR186-2, Olfr1056
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259020
Homologene: 27328
Vxn
Name: vexin
Synonyms: R75066, 3110035E14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76982
Homologene: 17666
Trp53rka
Name: transformation related protein 53 regulating kinase A
Synonyms: 2810408M09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381406
Homologene: 6042
Slfn9
Name: schlafen 9
Synonyms: 9830137M10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237886
Homologene: 45432
Sprr1b
Name: small proline-rich protein 1B
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20754
Homologene: 134537
Slc50a1
Name: solute carrier family 50 (sugar transporter), member 1
Synonyms: Rga, Rag1ap1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19729
Homologene: 40647
BC021891
Name:
Type: Gene
Species: Mouse
Chromosome: 8
Traj43
Name: T cell receptor alpha joining 43
Synonyms: Gm16925
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100124345
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 9,613,388 bp
  • T to C, chromosome 1 at 53,840,769 bp
  • T to C, chromosome 1 at 131,212,330 bp
  • T to A, chromosome 1 at 151,457,792 bp
  • T to C, chromosome 1 at 179,529,205 bp
  • A to G, chromosome 2 at 86,356,347 bp
  • T to C, chromosome 2 at 130,717,328 bp
  • T to C, chromosome 2 at 165,491,525 bp
  • G to A, chromosome 3 at 89,270,403 bp
  • T to C, chromosome 3 at 92,437,413 bp
  • T to C, chromosome 4 at 32,731,960 bp
  • T to C, chromosome 4 at 129,607,088 bp
  • A to T, chromosome 5 at 8,864,119 bp
  • T to C, chromosome 5 at 76,563,240 bp
  • C to T, chromosome 5 at 101,937,421 bp
  • C to T, chromosome 5 at 129,539,719 bp
  • A to T, chromosome 6 at 22,254,602 bp
  • T to C, chromosome 6 at 113,842,314 bp
  • T to C, chromosome 6 at 121,021,188 bp
  • T to G, chromosome 7 at 56,229,662 bp
  • T to C, chromosome 7 at 127,786,184 bp
  • A to G, chromosome 8 at 15,989,188 bp
  • T to A, chromosome 8 at 43,519,961 bp
  • A to T, chromosome 8 at 95,275,624 bp
  • T to A, chromosome 8 at 125,910,759 bp
  • C to A, chromosome 9 at 21,035,526 bp
  • C to A, chromosome 9 at 37,993,105 bp
  • A to G, chromosome 9 at 107,514,864 bp
  • A to G, chromosome 9 at 109,106,802 bp
  • A to T, chromosome 10 at 28,568,327 bp
  • A to C, chromosome 10 at 76,286,463 bp
  • C to A, chromosome 10 at 127,305,479 bp
  • A to G, chromosome 10 at 128,318,320 bp
  • A to G, chromosome 10 at 130,449,986 bp
  • A to G, chromosome 11 at 49,637,262 bp
  • G to C, chromosome 11 at 82,981,269 bp
  • A to G, chromosome 11 at 100,319,969 bp
  • A to G, chromosome 12 at 65,056,358 bp
  • A to G, chromosome 12 at 73,945,248 bp
  • A to G, chromosome 12 at 84,603,146 bp
  • A to T, chromosome 13 at 61,000,516 bp
  • A to T, chromosome 13 at 76,757,055 bp
  • A to G, chromosome 14 at 54,174,744 bp
  • A to T, chromosome 14 at 63,188,705 bp
  • G to T, chromosome 15 at 37,397,261 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8286 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067708-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.