Strain Name:
C57BL/6J-MtgxR8305Btlr/Mmmh
Stock Number:
067716-MU
Citation ID:
RRID:MMRRC_067716-MU
Other Names:
R8305 (G1)
Major Collection:

Strain Information

Fam117b
Name: family with sequence similarity 117, member B
Synonyms: Als2cr13, 6330416D14Rik, 2810425F24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72750
Homologene: 18307
Rptor
Name: regulatory associated protein of MTOR, complex 1
Synonyms: raptor, Rap, 4932417H02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74370
Homologene: 80210
Sbf2
Name: SET binding factor 2
Synonyms: SBF2, 4833411B01Rik, mMTMH1, B430219L04Rik, Mtmr13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319934
HGNC: HGNC:2135
Homologene: 41810
Tfap2b
Name: transcription factor AP-2 beta
Synonyms: E130018K07Rik, AP-2(beta), Tcfap2b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21419
Homologene: 20688
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: trabeculin alpha, Aclp7, Acf7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Mga
Name: MAX gene associated
Synonyms: D030062C11Rik, Mad5, C130042M01Rik, Mga
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29808
Homologene: 49351
Pum1
Name: pumilio RNA-binding family member 1
Synonyms: Pumm
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 80912
Homologene: 22830
Scn8a
Name: sodium channel, voltage-gated, type VIII, alpha
Synonyms: nmf58, med, motor end-plate disease, Nav1.6, nmf2, NMF335, ataxia 3, NaCh6, seal, mnd2, nmf335, nur14, mnd-2, C630029C19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20273
Homologene: 7927
Usp32
Name: ubiquitin specific peptidase 32
Synonyms: 2900074J03Rik, 6430526O11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237898
Homologene: 13066
Cep290
Name: centrosomal protein 290
Synonyms: Kiaa, Nphp6, b2b1454Clo, b2b1752Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Arih1
Name: ariadne RBR E3 ubiquitin protein ligase 1
Synonyms: UIP77
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23806
HGNC: HGNC:689
Homologene: 111871
Senp7
Name: SUMO1/sentrin specific peptidase 7
Synonyms: 2410152H17Rik, 6030449K19Rik, 2810413I22Rik, 2900036C23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66315
Homologene: 10778
Cux1
Name: cut-like homeobox 1
Synonyms: Cutl1, CDP, Cux, Cux-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13047
HGNC: HGNC:2557
Mdn1
Name: midasin AAA ATPase 1
Synonyms: 4833432B22Rik, D4Abb1e, LOC213784
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100019
Homologene: 39689
Stt3b
Name: STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
Synonyms: Simp, 1300006C19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68292
VEGA: 9
Homologene: 7387
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: eyes2, heb, eyem02Jus, crf11, QBRICK
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329872
Homologene: 27049
Plxna4
Name: plexin A4
Synonyms: Plxa4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243743
HGNC: HGNC:9102
Homologene: 77587
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230895
Homologene: 15583
Ttc23
Name: tetratricopeptide repeat domain 23
Synonyms: 1600012K10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67009
Homologene: 11289
Enpp3
Name: ectonucleotide pyrophosphatase/phosphodiesterase 3
Synonyms: CD203c
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 209558
VEGA: 10
HGNC: HGNC:3358
Homologene: 3683
Mvk
Name: mevalonate kinase
Synonyms: 2310010A05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17855
HGNC: HGNC:7530
Homologene: 372
Angptl3
Name: angiopoietin-like 3
Synonyms: hypl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 30924
HGNC: HGNC:491
Homologene: 8499
Prss58
Name: serine protease 58
Synonyms: BC048599
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232717
Homologene: 65285
Rbm43
Name: RNA binding motif protein 43
Synonyms: 0610033I05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71684
Homologene: 12715
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: CI-MPR, IGF-II/CI-MPR, Mpr300, M6P/IGF2R, CD222, mannose-6-phosphate receptor, cation independent
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Sptbn2
Name: spectrin beta, non-erythrocytic 2
Synonyms: Spnb3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20743
VEGA: 19
Homologene: 48482
Kif24
Name: kinesin family member 24
Synonyms: 4933425J19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 109242
Homologene: 52346
Itpkc
Name: inositol 1,4,5-trisphosphate 3-kinase C
Synonyms: 9130023N17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233011
Homologene: 11868
Dennd1a
Name: DENN domain containing 1A
Synonyms: 6030446I19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227801
Homologene: 17141
Flt3
Name: FMS-like tyrosine kinase 3
Synonyms: CD135, Flk-2, Flt-3, Flk2, wmfl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14255
HGNC: HGNC:3765
Homologene: 3040
Kat2a
Name: K(lysine) acetyltransferase 2A
Synonyms: Gcn5l2, 1110051E14Rik, Gcn5, PCAF-B/GCN5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14534
HGNC: HGNC:4201
Homologene: 41343
Dnajc6
Name: DnaJ heat shock protein family (Hsp40) member C6
Synonyms: 2810027M23Rik, auxilin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72685
Homologene: 8865
Cilp
Name: cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
Synonyms: C130036G17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214425
HGNC: HGNC:1980
Homologene: 2679
Col24a1
Name: collagen, type XXIV, alpha 1
Synonyms: 5430404K19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71355
Homologene: 65061
Kcnd2
Name: potassium voltage-gated channel, Shal-related family, member 2
Synonyms: Kv4.2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16508
HGNC: HGNC:6238
Homologene: 40828
Kcnu1
Name: potassium channel, subfamily U, member 1
Synonyms: Slo3, Kcnma3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16532
Homologene: 7392
Apoa4
Name: apolipoprotein A-IV
Synonyms: Apoa-4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11808
HGNC: HGNC:602
Homologene: 47927
Sema6b
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
Synonyms: semaZ, VIb, Seman, Sema
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20359
VEGA: 17
Homologene: 8428
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22635
Homologene: 124417
Actl7a
Name: actin-like 7a
Synonyms: t-actin 2, Tact2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11470
HGNC: HGNC:161
Homologene: 7613
Ankhd1
Name: ankyrin repeat and KH domain containing 1
Synonyms: 1110004O12Rik, 9130019P20Rik, 4933432B13Rik, A530027J04Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 108857
Homologene: 87006
Adam5
Name: a disintegrin and metallopeptidase domain 5
Synonyms: tMDCII
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11499
HGNC: HGNC:212
Homologene: 49138
Or10al3
Name: olfactory receptor family 10 subfamily AL member 3
Synonyms: MOR263-7, Olfr119, GA_x6K02T2PSCP-2159633-2160598
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258095
Homologene: 17195
Filip1
Name: filamin A interacting protein 1
Synonyms: 5730485H21Rik, FILIP
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70598
Homologene: 6700
Map3k19
Name: mitogen-activated protein kinase kinase kinase 19
Synonyms: Ysk4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22625
Homologene: 19318
Igsf11
Name: immunoglobulin superfamily, member 11
Synonyms: 1700025L02Rik, BT-IgSF
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207683
Homologene: 17613
Pcdhb14
Name: protocadherin beta 14
Synonyms: PcdhbN, Pcdhb17, 2210006M07Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93885
Homologene: 70876
Or2n1
Name: olfactory receptor family 2 subfamily N member 1
Synonyms: Olfr134, MOR256-5, GA_x6K02T2PSCP-2623613-2624551
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258829
Homologene: 110603
Clca3b
Name: chloride channel accessory 3B
Synonyms: Clca4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229927
HGNC: HGNC:2017
Homologene: 135610
Pcsk7
Name: proprotein convertase subtilisin/kexin type 7
Synonyms: SPC7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18554
VEGA: 9
HGNC: HGNC:8748
Homologene: 37955
Clca3a1
Name: chloride channel accessory 3A1
Synonyms: Clca1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12722
HGNC: HGNC:2017
Homologene: 77224
Plin5
Name: perilipin 5
Synonyms: Lsdp5, 2310076L09Rik, MLDP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66968
Homologene: 41654
Accsl
Name: 1-aminocyclopropane-1-carboxylate synthase (inactive)-like
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381411
Homologene: 86007
Kbtbd12
Name: kelch repeat and BTB (POZ) domain containing 12
Synonyms: 4933428M03Rik, 4833415F11Rik, Klhdc6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74589
Homologene: 52613
4930578I06Rik
Name: RIKEN cDNA 4930578I06 gene
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67750
VEGA: 14
Homologene: 49859
Slc6a17
Name: solute carrier family 6 (neurotransmitter transporter), member 17
Synonyms: NTT4, D130012J15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229706
Homologene: 27775
Timm10b
Name: translocase of inner mitochondrial membrane 10B
Synonyms: Fracture Callus 1, Tim9b, FxC1, Tim10b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14356
HGNC: HGNC:4022
Homologene: 8142
Emc9
Name: ER membrane protein complex subunit 9
Synonyms: Fam158a, Cgi112, 1500005A01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 85308
Homologene: 41095
Bbs2
Name: Bardet-Biedl syndrome 2
Synonyms: 2410125H22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67378
HGNC: HGNC:967
Homologene: 12122
Defa30
Name: defensin, alpha, 30
Synonyms: Gm15284
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100038927
Homologene: 113382
Or14c44
Name: olfactory receptor family 14 subfamily C member 44
Synonyms: MOR221-1P, MOR221-4, MOR211-8P, GA_x6K02T2NHDJ-9695951-9695766, MOR221-1P, Olfr301, Olfr302, Olfr1531-ps1, GA_x6K02T2NHDJ-9693313-9692378
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257958
Homologene: 128067
Vgll4
Name: vestigial like family member 4
Synonyms: VGL-4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232334
Homologene: 18603
Asb14
Name: ankyrin repeat and SOCS box-containing 14
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 142687
Homologene: 15445
Gja10
Name: gap junction protein, alpha 10
Synonyms: Cx59, Cx57, connexin-57, Cx-57
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14610
Homologene: 7733
Igkv9-129
Name: immunoglobulin kappa variable 9-129
Synonyms: immunoglobulin kappa light chain
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 692182
Gm7356
Name: predicted gene 7356
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 664821
Homologene: 133217
RP23-56A14.9
Name:
Type: Gene
Species: Mouse
Chromosome: 7
BC089597
Name:
Type: Gene
Species: Mouse
Chromosome: 10
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 19,226,436 bp
  • A to G, chromosome 1 at 59,913,623 bp
  • T to A, chromosome 1 at 127,817,270 bp
  • G to A, chromosome 2 at 37,858,081 bp
  • A to G, chromosome 2 at 51,926,700 bp
  • A to T, chromosome 2 at 93,866,078 bp
  • T to A, chromosome 2 at 119,946,319 bp
  • T to A, chromosome 3 at 107,473,585 bp
  • C to T, chromosome 3 at 144,759,166 bp
  • T to A, chromosome 3 at 144,825,937 bp
  • T to C, chromosome 3 at 145,474,182 bp
  • G to A, chromosome 4 at 32,602,441 bp
  • G to T, chromosome 4 at 32,725,107 bp
  • A to G, chromosome 4 at 41,428,825 bp
  • T to A, chromosome 4 at 56,743,744 bp
  • T to A, chromosome 4 at 82,999,989 bp
  • A to G, chromosome 4 at 99,031,311 bp
  • C to T, chromosome 4 at 101,623,787 bp
  • A to T, chromosome 4 at 123,395,621 bp
  • A to G, chromosome 4 at 130,771,920 bp
  • A to G, chromosome 4 at 145,092,288 bp
  • T to C, chromosome 5 at 114,450,779 bp
  • T to C, chromosome 5 at 136,360,009 bp
  • T to C, chromosome 5 at 137,450,551 bp
  • T to C, chromosome 5 at 147,348,054 bp
  • T to A, chromosome 6 at 21,726,198 bp
  • C to T, chromosome 6 at 32,211,065 bp
  • C to T, chromosome 6 at 40,895,660 bp
  • A to T, chromosome 6 at 67,840,222 bp
  • T to C, chromosome 6 at 88,618,150 bp
  • G to T, chromosome 6 at 114,890,652 bp
  • A to T, chromosome 7 at 27,214,519 bp
  • A to C, chromosome 7 at 67,662,387 bp
  • G to T, chromosome 7 at 86,412,779 bp
  • T to C, chromosome 7 at 105,640,669 bp
  • T to G, chromosome 7 at 110,371,618 bp
  • A to G, chromosome 7 at 142,135,623 bp
  • A to T, chromosome 8 at 21,135,459 bp
  • G to A, chromosome 8 at 24,810,703 bp
  • T to C, chromosome 8 at 25,891,990 bp
  • A to C, chromosome 8 at 94,074,325 bp
  • T to G, chromosome 9 at 45,910,409 bp
  • T to A, chromosome 9 at 46,241,155 bp
  • T to A, chromosome 9 at 59,396,487 bp
  • G to A, chromosome 9 at 65,279,004 bp
  • G to T, chromosome 9 at 79,820,475 bp
  • T to C, chromosome 9 at 115,254,931 bp
  • C to G, chromosome 10 at 24,824,929 bp
  • C to A, chromosome 10 at 100,544,934 bp
  • T to A, chromosome 10 at 127,876,995 bp
  • A to T, chromosome 11 at 85,032,185 bp
  • A to C, chromosome 11 at 100,709,478 bp
  • T to A, chromosome 11 at 119,811,986 bp
  • A to T, chromosome 14 at 26,912,097 bp
  • A to G, chromosome 14 at 55,585,099 bp
  • C to T, chromosome 14 at 63,971,395 bp
  • A to C, chromosome 15 at 101,040,506 bp
  • C to A, chromosome 16 at 39,007,224 bp
  • T to A, chromosome 16 at 56,155,240 bp
  • T to C, chromosome 17 at 12,733,860 bp
  • T to A, chromosome 17 at 14,001,437 bp
  • T to A, chromosome 17 at 37,701,498 bp
  • C to A, chromosome 17 at 38,175,573 bp
  • T to C, chromosome 17 at 56,115,221 bp
  • C to T, chromosome 17 at 56,127,084 bp
  • T to C, chromosome 18 at 36,647,166 bp
  • T to A, chromosome 18 at 37,450,022 bp
  • T to A, chromosome 19 at 4,729,130 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8305 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067716-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.