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Strain Name:
C57BL/6J-MtgxR8315Btlr/Mmmh
Stock Number:
067720-MU
Citation ID:
RRID:MMRRC_067720-MU
Other Names:
R8315 (G1)
Major Collection:

Strain Information

Ppp2r2a
Name: protein phosphatase 2, regulatory subunit B, alpha
Synonyms: 2410004D02Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71978
VEGA: 14
HGNC: HGNC:9304
Homologene: 2035
Met
Name: met proto-oncogene
Synonyms: HGF receptor, c-Met, Par4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Emx1
Name: empty spiracles homeobox 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13796
HGNC: HGNC:3340
Homologene: 55799
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Zfp523
Name: zinc finger protein 523
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224656
Homologene: 2569
Ptpn3
Name: protein tyrosine phosphatase, non-receptor type 3
Synonyms: PTPCL, 9530011I20Rik, PTP-H1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 545622
HGNC: HGNC:9655
Homologene: 74451
Aff1
Name: AF4/FMR2 family, member 1
Synonyms: Af4, Rob, 9630032B01Rik, Mllt2h
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17355
HGNC: HGNC:7135
Homologene: 4340
Kazn
Name: kazrin, periplakin interacting protein
Synonyms: 2310007B04Rik, 9030409G11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71529
Homologene: 16235
Cstf3
Name: cleavage stimulation factor, 3' pre-RNA, subunit 3
Synonyms: 4732468G05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228410
HGNC: HGNC:2485
Homologene: 1014
Tle1
Name: transducin-like enhancer of split 1
Synonyms: Grg1, Estm14, C230057C06Rik, Tle4l
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21885
Homologene: 21058
Rsf1
Name: remodeling and spacing factor 1
Synonyms: p325, XAP8, Hbxap, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Tmem87a
Name: transmembrane protein 87A
Synonyms: A930025J12Rik, Elkin1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 211499
Homologene: 9165
Cct3
Name: chaperonin containing TCP1 subunit 3
Synonyms: TriC-P5, Cctg, Tcp1-rs3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12462
HGNC: HGNC:1616
Homologene: 4373
Slc45a4
Name: solute carrier family 45, member 4
Synonyms: 9330175B01Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 106068
Homologene: 69908
Shb
Name: src homology 2 domain-containing transforming protein B
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230126
Homologene: 74458
Dcp2
Name: decapping mRNA 2
Synonyms: 2410015D23Rik, 5730537H01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70640
Homologene: 13968
Dpp8
Name: dipeptidylpeptidase 8
Synonyms: 4932434F09Rik, 2310004I03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74388
VEGA: 9
Homologene: 57098
Lamc1
Name: laminin, gamma 1
Synonyms: Lamb2, laminin B2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226519
HGNC: HGNC:6492
Homologene: 1724
Egfr
Name: epidermal growth factor receptor
Synonyms: avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, Erbb, Wa5, 9030024J15Rik, Errb1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13649
HGNC: HGNC:3236
Homologene: 74545
Gda
Name: guanine deaminase
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14544
HGNC: HGNC:4212
Homologene: 3171
Gpr152
Name: G protein-coupled receptor 152
Synonyms: LOC269053, A930009H15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 269053
VEGA: 19
Homologene: 35474
Tbccd1
Name: TBCC domain containing 1
Synonyms: 5730478M09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70573
VEGA: 16
Homologene: 32392
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Lama2
Name: laminin, alpha 2
Synonyms: merosin, mer
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Elf3
Name: E74-like factor 3
Synonyms: jen, ESX, ESE-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13710
HGNC: HGNC:3318
Homologene: 3265
Myh15
Name: myosin, heavy chain 15
Synonyms: EG667772
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 667772
VEGA: 16
Homologene: 18929
Txndc11
Name: thioredoxin domain containing 11
Synonyms: EF-hand binding protein 1, EFP1, Txdc11, 2810408E11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106200
Homologene: 9301
Tecta
Name: tectorin alpha
Synonyms: [a]-tectorin, Tctna
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21683
Homologene: 3955
Dpyd
Name: dihydropyrimidine dehydrogenase
Synonyms: DPD, E330028L06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99586
HGNC: HGNC:3012
Homologene: 85
Ahnak2
Name: AHNAK nucleoprotein 2
Synonyms: LOC382643
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100041194
Homologene: 131081
Or8c13
Name: olfactory receptor family 8 subfamily C member 13
Synonyms: GA_x6K02T2PVTD-31862167-31861217, MOR170-9, Olfr891
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258471
Homologene: 74210
Dnaaf9
Name: dynein axonemal assembly factor 9
Synonyms: 4930402H24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228602
Homologene: 12623
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: bl, E130113P14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Rtp4
Name: receptor transporter protein 4
Synonyms: 5830458K16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67775
Homologene: 56944
Phf8l
Name: PHD finger protein 8 like
Synonyms: 4921501E09Rik, Phf8-ps
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74042
VEGA: 17
Homologene: 66275
Or6c209
Name: olfactory receptor family 6 subfamily C member 209
Synonyms: GA_x6K02T2PULF-11325750-11326685, MOR114-2, Olfr799
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258929
Homologene: 37000
Vmn2r66
Name: vomeronasal 2, receptor 66
Synonyms: F830104D24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233437
Homologene: 115466
Pla2g4a
Name: phospholipase A2, group IVA (cytosolic, calcium-dependent)
Synonyms: cPLA2, Type IV PLA2, cytosolic PLA2, cPLA2alpha, cytosolic phospholipase A2, Pla2g4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18783
HGNC: HGNC:9035
Homologene: 32059
Wdr90
Name: WD repeat domain 90
Synonyms: 3230401M21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106618
Homologene: 27066
Csf2rb
Name: colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
Synonyms: AIC2B, common beta chain, CDw131, beta c, Bc, Il5rb, Il3r, Il3rb1, Csf2rb1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12983
VEGA: 15
HGNC: HGNC:2436
Homologene: 339
Cyp4f39
Name: cytochrome P450, family 4, subfamily f, polypeptide 39
Synonyms: 4732474A20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320997
VEGA: 17
Homologene: 69814
Cimip4
Name: ciliary microtubule inner protein 4
Synonyms: 1700061J05Rik, Tex33
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73376
VEGA: 15
Homologene: 18682
Rad21l
Name: RAD21-like (S. pombe)
Synonyms: Gm14160
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668929
Homologene: 82650
H2-T10
Name: histocompatibility 2, T region locus 10
Synonyms: H-2T10
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15024
Ppp3r2
Name: protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II)
Synonyms: PP2B beta 2, CaNB2, CnB2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19059
HGNC: HGNC:9318
Homologene: 133815
Gba2
Name: glucosidase beta 2
Synonyms: bile acid
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230101
Homologene: 10859
Rftn1
Name: raftlin lipid raft linker 1
Synonyms: 2310015N21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 76438
Homologene: 18745
Or10ag2
Name: olfactory receptor family 10 subfamily AG member 2
Synonyms: GA_x6K02T2Q125-48917235-48918206, MOR264-17, Olfr1123
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258347
Homologene: 105187
Mrgpra3
Name: MAS-related GPR, member A3
Synonyms: G protein-coupled receptor, MrgA3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233222
Homologene: 131159
Ajap1
Name: adherens junction associated protein 1
Synonyms: LOC230959
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230959
Homologene: 10312
Hoxd11
Name: homeobox D11
Synonyms: Hox-5.4, Hox-4.6, E230017H14Rik, Hox-5.5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15431
HGNC: HGNC:5134
Homologene: 7368
Vmn1r223
Name: vomeronasal 1 receptor 223
Synonyms: Gm11330
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100036518
Homologene: 110880
Dynlt2a2
Name: dynein light chain Tctex-type 2A2
Synonyms: Dynlt2, Gm3448, Dynlt2b
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100041639
VEGA: 17
Homologene: 7971
Pbx2
Name: pre B cell leukemia homeobox 2
Synonyms: G17
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18515
HGNC: HGNC:8633
Homologene: 48115
Inka1
Name: inka box actin regulator 1
Synonyms: Inka1, 6230427J02Rik, Fam212a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68176
Homologene: 19818
Prox2
Name: prospero homeobox 2
Synonyms: 1700058C01Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73422
Homologene: 18421
Saa4
Name: serum amyloid A 4
Synonyms: Saa-5, Saa-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20211
Homologene: 4750
Fam150b
Name:
Type: Gene
Species: Mouse
Chromosome: 12
Trav13d-1
Name: T cell receptor alpha variable 13D-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 640931
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,284,420 bp
  • A to G, chromosome 1 at 135,256,576 bp
  • T to C, chromosome 1 at 149,886,214 bp
  • A to T, chromosome 1 at 153,243,421 bp
  • G to A, chromosome 2 at 74,683,122 bp
  • C to A, chromosome 2 at 87,418,651 bp
  • G to T, chromosome 2 at 104,590,581 bp
  • C to T, chromosome 2 at 120,403,960 bp
  • ATCCTCCTCCTCCTCCTCC to ATCCTCCTCCTCCTCC, chromosome 2 at 130,770,735 bp
  • A to T, chromosome 2 at 151,655,240 bp
  • C to T, chromosome 2 at 175,171,847 bp
  • A to G, chromosome 3 at 88,313,257 bp
  • A to T, chromosome 3 at 119,314,885 bp
  • AAAGAACCGTGTATACCGCCTGGGATGGAAAGAA to AAA, chromosome 4 at 43,569,937 bp
  • A to G, chromosome 4 at 45,489,079 bp
  • A to C, chromosome 4 at 49,681,705 bp
  • A to T, chromosome 4 at 57,270,063 bp
  • A to T, chromosome 4 at 72,126,191 bp
  • C to T, chromosome 4 at 142,141,691 bp
  • G to T, chromosome 4 at 153,432,356 bp
  • A to G, chromosome 5 at 34,109,373 bp
  • G to A, chromosome 5 at 96,743,182 bp
  • G to T, chromosome 5 at 103,811,090 bp
  • C to T, chromosome 5 at 146,268,251 bp
  • T to C, chromosome 6 at 17,533,957 bp
  • A to G, chromosome 6 at 85,194,106 bp
  • T to A, chromosome 7 at 46,729,628 bp
  • A to T, chromosome 7 at 47,601,303 bp
  • T to A, chromosome 7 at 84,994,724 bp
  • CGGCGGCGG to CGGCGGCGGGGGCGGCGG, chromosome 7 at 97,579,923 bp
  • T to C, chromosome 9 at 38,180,209 bp
  • C to T, chromosome 9 at 42,387,825 bp
  • T to C, chromosome 9 at 65,080,851 bp
  • C to A, chromosome 9 at 107,984,307 bp
  • T to C, chromosome 10 at 27,422,659 bp
  • G to A, chromosome 10 at 129,647,653 bp
  • A to T, chromosome 11 at 9,378,460 bp
  • A to G, chromosome 11 at 9,585,502 bp
  • A to G, chromosome 11 at 16,875,027 bp
  • G to T, chromosome 12 at 30,884,851 bp
  • A to G, chromosome 12 at 85,095,408 bp
  • T to A, chromosome 12 at 112,781,133 bp
  • A to G, chromosome 13 at 23,250,169 bp
  • C to A, chromosome 14 at 52,851,602 bp
  • T to C, chromosome 14 at 67,023,728 bp
  • T to G, chromosome 15 at 73,589,556 bp
  • G to A, chromosome 15 at 78,347,381 bp
  • T to C, chromosome 15 at 78,378,486 bp
  • G to T, chromosome 16 at 11,075,601 bp
  • A to G, chromosome 16 at 22,822,814 bp
  • C to T, chromosome 16 at 23,613,248 bp
  • C to A, chromosome 16 at 49,120,018 bp
  • A to G, chromosome 17 at 14,970,455 bp
  • A to T, chromosome 17 at 25,845,425 bp
  • G to A, chromosome 17 at 28,202,588 bp
  • A to G, chromosome 17 at 32,482,202 bp
  • C to A, chromosome 17 at 33,067,064 bp
  • A to G, chromosome 17 at 34,592,733 bp
  • A to G, chromosome 17 at 36,119,013 bp
  • A to G, chromosome 17 at 50,002,637 bp
  • T to C, chromosome 18 at 44,396,004 bp
  • C to T, chromosome 19 at 4,143,470 bp
  • T to A, chromosome 19 at 21,417,071 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8315 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067720-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.