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Strain Name:
C57BL/6J-MtgxR8361Btlr/Mmmh
Stock Number:
067735-MU
Citation ID:
RRID:MMRRC_067735-MU
Other Names:
R8361 (G1)
Major Collection:

Strain Information

Uso1
Name: USO1 vesicle docking factor
Synonyms: transcytosis associated protein p115, TAP, Vdp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56041
Homologene: 2754
Gtf2h3
Name: general transcription factor IIH, polypeptide 3
Synonyms: 5033417D07Rik, BTF2, D5Ertd679e, 34kDa
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 209357
HGNC: HGNC:4657
Homologene: 1160
Dnajc11
Name: DnaJ heat shock protein family (Hsp40) member C11
Synonyms: E030019A03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230935
Homologene: 14558
Usp5
Name: ubiquitin specific peptidase 5 (isopeptidase T)
Synonyms: Ucht
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22225
Homologene: 55758
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005
Carmil1
Name: capping protein regulator and myosin 1 linker 1
Synonyms: 1110037D04Rik, Lrrc16, Carmil, Lrrc16a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68732
Homologene: 9757
Smurf1
Name: SMAD specific E3 ubiquitin protein ligase 1
Synonyms: 4930431E10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75788
Homologene: 10712
Safb2
Name: scaffold attachment factor B2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224902
Homologene: 35210
Pias1
Name: protein inhibitor of activated STAT 1
Synonyms: GBP, 2900068C24Rik, Ddxbp1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56469
VEGA: 9
HGNC: HGNC:2752
Homologene: 22953
Stt3b
Name: STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
Synonyms: Simp, 1300006C19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68292
VEGA: 9
Homologene: 7387
Rxfp3
Name: relaxin family peptide receptor 3
Synonyms: Salpr, Rln3r1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239336
Homologene: 9568
Alg2
Name: ALG2 alpha-1,3/1,6-mannosyltransferase
Synonyms: ALPG2, CDGIi, 1300013N08Rik, 1110018A23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56737
Homologene: 5930
Spink5
Name: serine peptidase inhibitor, Kazal type 5
Synonyms: LEKT1, 2310065D10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 72432
Homologene: 4987
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: Mdnah5, b2b1154Clo, b2b1134Clo, b2b1537Clo, b2b1565Clo, Dnahc5, b2b3491Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Dhx36
Name: DEAH-box helicase 36
Synonyms: Ddx36, 2810407E23Rik, RHAU
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72162
Homologene: 6356
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20192
Homologene: 68151
Zfp654
Name: zinc finger protein 654
Synonyms: 1600021C16Rik, 1810008K20Rik, Gm5488
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72020
Homologene: 10114
Slc3a1
Name: solute carrier family 3, member 1
Synonyms: NTAA, D2H
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20532
VEGA: 17
Homologene: 37289
Eml3
Name: echinoderm microtubule associated protein like 3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225898
VEGA: 19
Homologene: 27044
Aox4
Name: aldehyde oxidase 4
Synonyms: AOH2, 2310003G12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71872
Homologene: 70273
Zfp616
Name: zinc finger protein 616
Synonyms: Gm12330
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327963
Homologene: 88945
Fam163b
Name: family with sequence similarity 163, member B
Synonyms: C630035N08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 109349
Homologene: 106097
Or10k2
Name: olfactory receptor family 10 subfamily K member 2
Synonyms: GA_x6K02T2NUPS-11609807-11610751, MOR267-16, Olfr370
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 258267
Homologene: 74037
Hmbox1
Name: homeobox containing 1
Synonyms: F830020C16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219150
Homologene: 11589
Sestd1
Name: SEC14 and spectrin domains 1
Synonyms: 1500031J16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228071
Homologene: 45505
Lrriq3
Name: leucine-rich repeats and IQ motif containing 3
Synonyms: 4930438B07Rik, 4930511J15Rik, 4933403H06Rik, Lrrc44
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74435
Homologene: 23668
Fbxw2
Name: F-box and WD-40 domain protein 2
Synonyms: MD6, Fwd2, FBW2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 30050
Homologene: 8131
1700109H08Rik
Name: RIKEN cDNA 1700109H08 gene
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77036
Homologene: 130776
Ighv1-36
Name: immunoglobulin heavy variable 1-36
Synonyms: Gm16715
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 629897
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 58,240,839 bp
  • T to A, chromosome 1 at 166,642,270 bp
  • G to A, chromosome 2 at 27,112,638 bp
  • A to G, chromosome 2 at 34,807,414 bp
  • A to T, chromosome 2 at 77,187,228 bp
  • A to G, chromosome 2 at 112,653,130 bp
  • A to T, chromosome 3 at 62,480,800 bp
  • G to A, chromosome 3 at 155,101,218 bp
  • T to C, chromosome 4 at 47,471,848 bp
  • C to A, chromosome 4 at 151,970,911 bp
  • A to G, chromosome 5 at 3,582,153 bp
  • A to G, chromosome 5 at 92,189,262 bp
  • T to C, chromosome 5 at 124,595,668 bp
  • T to A, chromosome 5 at 144,883,696 bp
  • C to T, chromosome 6 at 124,824,985 bp
  • A to G, chromosome 8 at 83,542,086 bp
  • T to C, chromosome 9 at 62,919,386 bp
  • A to G, chromosome 9 at 115,254,920 bp
  • A to G, chromosome 11 at 74,084,650 bp
  • T to A, chromosome 12 at 114,880,007 bp
  • A to C, chromosome 13 at 24,067,130 bp
  • T to C, chromosome 14 at 64,896,840 bp
  • A to G, chromosome 14 at 103,138,814 bp
  • C to A, chromosome 15 at 11,036,698 bp
  • G to T, chromosome 15 at 28,331,810 bp
  • T to C, chromosome 16 at 20,738,737 bp
  • T to C, chromosome 16 at 64,791,857 bp
  • T to C, chromosome 17 at 56,583,061 bp
  • C to T, chromosome 17 at 85,037,212 bp
  • G to T, chromosome 18 at 43,989,462 bp
  • A to G, chromosome 19 at 8,937,437 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8361 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067735-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.