Strain Name:
C57BL/6J-MtgxR8380Btlr/Mmmh
Stock Number:
067747-MU
Citation ID:
RRID:MMRRC_067747-MU
Other Names:
R8380 (G1)
Major Collection:

Strain Information

Pomt1
Name: protein-O-mannosyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99011
HGNC: HGNC:9202
Homologene: 68548
Top1
Name: topoisomerase (DNA) I
Synonyms: D130064I21Rik, Top-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21969
Homologene: 2467
Cep131
Name: centrosomal protein 131
Synonyms: AZ1, Azi1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12009
Homologene: 7638
Cenpc1
Name: centromere protein C1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12617
HGNC: HGNC:1854
Homologene: 1371
Wdr1
Name: WD repeat domain 1
Synonyms: D5Wsu185e, Aip1, rede
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22388
Homologene: 6628
Als2
Name: alsin Rho guanine nucleotide exchange factor
Synonyms: Als2cr6, 3222402C23Rik, 9430073A21Rik, Alsin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74018
HGNC: HGNC:443
Homologene: 23264
Dhx40
Name: DEAH-box helicase 40
Synonyms: ARG147, DDX40, 2410016C14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67487
Homologene: 57000
Chek1
Name: checkpoint kinase 1
Synonyms: Chk1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12649
HGNC: HGNC:1925
Homologene: 975
Rnf17
Name: ring finger protein 17
Synonyms: MMIP-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 30054
VEGA: 14
Homologene: 23727
Atp6v1b2
Name: ATPase, H+ transporting, lysosomal V1 subunit B2
Synonyms: Atp6b2, HO57
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11966
HGNC: HGNC:854
Homologene: 1279
Rasal1
Name: RAS protein activator like 1 (GAP1 like)
Synonyms: MRASAL
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19415
HGNC: HGNC:9873
Homologene: 3423
Scaf4
Name: SR-related CTD-associated factor 4
Synonyms: Sfrs15, Srsf15, Sra4
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224432
VEGA: 16
Homologene: 16227
Bhlhe40
Name: basic helix-loop-helix family, member e40
Synonyms: eip1 (E47 interaction protein 1), DEC1, cytokine response gene 8, Stra13, CR8, Bhlhb2, Clast5, C130042M06Rik, Sharp2, Stra14
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20893
HGNC: HGNC:1046
Homologene: 2722
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77505
Homologene: 131117
Cyp2c70
Name: cytochrome P450, family 2, subfamily c, polypeptide 70
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226105
Homologene: 120027
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Or11g26
Name: olfactory receptor family 11 subfamily G member 26
Synonyms: MOR106-6, Olfr742, GA_x6K02T2PMLR-6224293-6225228
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258422
Homologene: 74163
Pls1
Name: plastin 1 (I-isoform)
Synonyms: I-fimbrin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102502
HGNC: HGNC:9090
Homologene: 68270
Ahnak
Name: AHNAK nucleoprotein
Synonyms: DY6, 1110004P15Rik, 2310047C17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Or10q1b
Name: olfactory receptor family 10 subfamily Q member 1B
Synonyms: MOR266-8, GA_x6K02T2RE5P-4037809-4038768, Olfr1491
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258342
Adam2
Name: a disintegrin and metallopeptidase domain 2
Synonyms: Ftnb, Ph30-beta, fertilin beta
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11495
VEGA: 14
HGNC: HGNC:198
Homologene: 1127
Pdlim3
Name: PDZ and LIM domain 3
Synonyms: ALP
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 53318
Homologene: 75063
Vill
Name: villin-like
Synonyms: Villp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22351
Homologene: 22650
Clip2
Name: CAP-GLY domain containing linker protein 2
Synonyms: CLIP-115, WSCR4, Cyln2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269713
HGNC: HGNC:2586
Homologene: 20718
Ccdc121rt3
Name: coiled-coil domain containing 121, retrogene 3
Synonyms: Gm6583
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 625424
Homologene: 116059
Papss1
Name: 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Synonyms: Asapk, SK1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23971
HGNC: HGNC:8603
Homologene: 81740
Nt5c2
Name: 5'-nucleotidase, cytosolic II
Synonyms: cN-II, NT5B, PNT5
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76952
HGNC: HGNC:8022
Homologene: 8158
Or10c1
Name: olfactory receptor family 10 subfamily C member 1
Synonyms: Olfr95, GA_x6K02T2PSCP-1651760-1650822, MOR263-6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258506
HGNC: HGNC:8165
Homologene: 71990
Snrpa
Name: small nuclear ribonucleoprotein polypeptide A
Synonyms: C430021M15Rik, U1A, U1 snRNP, Rnu1a1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 53607
Homologene: 133537
Armc7
Name: armadillo repeat containing 7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 276905
Homologene: 11603
Lrrc36
Name: leucine rich repeat containing 36
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270091
Homologene: 23090
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 59,211,308 bp
  • A to G, chromosome 2 at 32,245,607 bp
  • A to G, chromosome 2 at 52,197,811 bp
  • A to G, chromosome 2 at 160,717,395 bp
  • C to T, chromosome 3 at 131,631,695 bp
  • C to G, chromosome 5 at 38,540,521 bp
  • C to A, chromosome 5 at 86,046,416 bp
  • T to C, chromosome 5 at 112,355,325 bp
  • C to T, chromosome 5 at 120,666,355 bp
  • T to C, chromosome 5 at 134,502,797 bp
  • TG to TGG, chromosome 6 at 108,664,857 bp
  • G to T, chromosome 7 at 27,187,288 bp
  • G to T, chromosome 7 at 105,677,866 bp
  • A to T, chromosome 8 at 45,917,535 bp
  • A to G, chromosome 8 at 69,103,390 bp
  • T to A, chromosome 8 at 105,426,828 bp
  • T to A, chromosome 9 at 36,712,112 bp
  • G to A, chromosome 9 at 95,775,385 bp
  • A to G, chromosome 9 at 119,057,849 bp
  • G to A, chromosome 11 at 86,806,585 bp
  • G to T, chromosome 11 at 115,475,900 bp
  • T to A, chromosome 11 at 120,077,028 bp
  • T to C, chromosome 14 at 50,515,840 bp
  • TG to T, chromosome 14 at 56,424,542 bp
  • C to T, chromosome 14 at 66,037,557 bp
  • A to G, chromosome 16 at 90,260,245 bp
  • T to A, chromosome 17 at 37,211,341 bp
  • T to C, chromosome 19 at 9,017,855 bp
  • T to C, chromosome 19 at 13,705,244 bp
  • C to T, chromosome 19 at 40,187,225 bp
  • A to T, chromosome 19 at 46,889,050 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8380 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067747-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.