Strain Name:
C57BL/6J-MtgxR8398Btlr/Mmmh
Stock Number:
067761-MU
Citation ID:
RRID:MMRRC_067761-MU
Other Names:
R8398 (G1)
Major Collection:

Strain Information

Ptch1
Name: patched 1
Synonyms: Ptc, wig, Patched 1, A230106A15Rik, Ptc1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Dbh
Name: dopamine beta hydroxylase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13166
HGNC: HGNC:2689
Homologene: 615
Mta1
Name: metastasis associated 1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 116870
HGNC: HGNC:7410
Homologene: 3442
Mast2
Name: microtubule associated serine/threonine kinase 2
Synonyms: Mtssk, MAST205
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17776
Homologene: 7428
Ndnf
Name: neuron-derived neurotrophic factor
Synonyms: epidermacan, A930038C07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68169
Homologene: 11593
Mtmr12
Name: myotubularin related protein 12
Synonyms: Pip3ap, C730015A02Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 268783
Homologene: 10403
Cnot6
Name: CCR4-NOT transcription complex, subunit 6
Synonyms: A230103N10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104625
Homologene: 69187
Dvl2
Name: dishevelled segment polarity protein 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13543
HGNC: HGNC:3086
Homologene: 20927
Arap2
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Synonyms: Centd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212285
Homologene: 9064
Smc4
Name: structural maintenance of chromosomes 4
Synonyms: Smc4l1, 2500002A22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70099
Homologene: 4015
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: SYNE-1, A330049M09Rik, enaptin165, nesprin-1, C130039F11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Sars1
Name: seryl-tRNA synthetase 1
Synonyms: Strs, Sars
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20226
Homologene: 4751
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Glud1
Name: glutamate dehydrogenase 1
Synonyms: Gdh-X, Glud
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14661
Homologene: 55885
D5Ertd579e
Name: DNA segment, Chr 5, ERATO Doi 579, expressed
Synonyms: A930018H20Rik, 9030221A05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320661
Homologene: 19716
Fchsd1
Name: FCH and double SH3 domains 1
Synonyms: A030002D08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319262
Homologene: 14127
Sugp1
Name: SURP and G patch domain containing 1
Synonyms: Sf4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70616
Homologene: 12360
Heatr6
Name: HEAT repeat containing 6
Synonyms: 2700008B19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217026
Homologene: 11116
Noc3l
Name: NOC3 like DNA replication regulator
Synonyms: Fad24
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 57753
VEGA: 19
Homologene: 39642
Asap3
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
Synonyms: UPLC1, Ddefl1, 9430088F20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230837
Homologene: 41190
Slc9a1
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 1
Synonyms: Nhe-1, antiporter, Apnh, Nhe1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20544
Homologene: 20660
Pcgf3
Name: polycomb group ring finger 3
Synonyms: 2310035N15Rik, Rnf3, RNF3A, DONG1, D630042K08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69587
Homologene: 4605
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244646
Homologene: 14627
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Gpr98, Mass1, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
V1rd19
Name: vomeronasal 1 receptor, D19
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404287
Homologene: 104166
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Gm10985
Name: predicted gene 10985
Type: Gene
Species: Mouse
Chromosome: 3
Hsd3b5
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5
Synonyms: 3(beta)HSDV
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15496
Homologene: 104115
Gjd4
Name: gap junction protein, delta 4
Synonyms: 9430022F06Rik, connexin 39, Cx39
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225152
VEGA: 18
Homologene: 17692
Zfp947
Name: zinc finger protein 947
Synonyms: Gm4769
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210853
Homologene: 133253
Slc1a4
Name: solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
Synonyms: ASCT1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 55963
Homologene: 20655
Bbof1
Name: basal body orientation factor 1
Synonyms: Ccdc176, 2900006K08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 72873
Homologene: 75215
Thbd
Name: thrombomodulin
Synonyms: TM, CD141
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21824
Homologene: 308
Sun1
Name: Sad1 and UNC84 domain containing 1
Synonyms: Unc84a, 4632417G13Rik, 5730434D03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77053
Homologene: 11544
Myot
Name: myotilin
Synonyms: Ttid, 5530402I04Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 58916
Homologene: 4942
Mex3b
Name: mex3 RNA binding family member B
Synonyms: Rkhd3, 4931439A04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108797
Homologene: 13570
Spon2
Name: spondin 2, extracellular matrix protein
Synonyms: Mindin, M-spondin, 2310045I24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100689
Homologene: 40843
Hoxa9
Name: homeobox A9
Synonyms: D6a9, Hox-1.7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15405
HGNC: HGNC:5109
Homologene: 7766
Or5w14
Name: olfactory receptor family 5 subfamily W member 14
Synonyms: Olfr1137, MOR177-20, MOR40-9P, GA_x6K02T2Q125-49215724-49214792
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258101
Homologene: 79380
Psg27
Name: pregnancy-specific beta-1-glycoprotein 27
Synonyms: cea15, EG545925
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545925
Homologene: 110989
Scrn2
Name: secernin 2
Synonyms: SES2, D11Moh48
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217140
Homologene: 26698
Amh
Name: anti-Mullerian hormone
Synonyms: MIS, Mullerian inhibiting substance
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11705
VEGA: 10
HGNC: HGNC:464
Homologene: 68060
Gm10428
Name: predicted gene 10428
Type: Gene
Species: Mouse
Chromosome: 11
Sppl2b
Name: signal peptide peptidase like 2B
Synonyms: 3110056O03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73218
VEGA: 10
Homologene: 10605
Pcdha11
Name: protocadherin alpha 11
Synonyms: A830022B16Rik, Cnr7, Crnr7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12942
HGNC: HGNC:8665
Homologene: 75095
Gm3045
Name: predicted gene 3045
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100040926
Homologene: 129855
Ccl21a
Name: C-C motif chemokine ligand 21 (serine)
Synonyms: CKb9, Gm1987, Scya21b, 6Ckine, Exodus-2, Scya21, 6CKBAC2, ALP, Tca4, SLC
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18829
Homologene: 2247
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 2 at 27,174,898 bp
  • C to T, chromosome 2 at 40,701,807 bp
  • A to G, chromosome 2 at 87,711,831 bp
  • C to T, chromosome 2 at 148,406,680 bp
  • A to G, chromosome 2 at 180,197,034 bp
  • A to C, chromosome 3 at 53,845,253 bp
  • T to C, chromosome 3 at 69,025,851 bp
  • T to A, chromosome 3 at 98,619,404 bp
  • C to T, chromosome 3 at 108,428,173 bp
  • T to C, chromosome 4 at 42,773,412 bp
  • A to T, chromosome 4 at 116,308,749 bp
  • A to T, chromosome 4 at 133,419,503 bp
  • G to A, chromosome 4 at 136,234,393 bp
  • G to T, chromosome 5 at 33,216,810 bp
  • G to A, chromosome 5 at 36,614,277 bp
  • A to T, chromosome 5 at 62,748,909 bp
  • A to G, chromosome 5 at 108,499,643 bp
  • A to G, chromosome 5 at 139,236,653 bp
  • T to C, chromosome 6 at 52,224,423 bp
  • T to C, chromosome 6 at 65,704,378 bp
  • T to C, chromosome 7 at 18,561,912 bp
  • C to A, chromosome 7 at 24,003,949 bp
  • T to A, chromosome 7 at 82,869,634 bp
  • A to G, chromosome 8 at 70,071,133 bp
  • C to T, chromosome 8 at 109,623,888 bp
  • T to C, chromosome 10 at 5,124,923 bp
  • T to C, chromosome 10 at 80,805,560 bp
  • CTGTCACA to C, chromosome 10 at 80,866,068 bp
  • TGTCACAGGT to TGT, chromosome 10 at 80,866,069 bp
  • T to C, chromosome 11 at 20,307,982 bp
  • C to T, chromosome 11 at 49,702,618 bp
  • T to C, chromosome 11 at 62,753,347 bp
  • T to A, chromosome 11 at 70,008,302 bp
  • A to C, chromosome 11 at 83,781,338 bp
  • G to T, chromosome 11 at 97,030,904 bp
  • T to C, chromosome 12 at 84,428,414 bp
  • T to A, chromosome 12 at 113,131,622 bp
  • A to G, chromosome 13 at 56,429,467 bp
  • T to C, chromosome 13 at 63,525,125 bp
  • T to C, chromosome 13 at 81,182,678 bp
  • A to G, chromosome 14 at 34,311,271 bp
  • T to A, chromosome 15 at 12,265,609 bp
  • A to T, chromosome 17 at 22,146,121 bp
  • C to T, chromosome 18 at 9,280,326 bp
  • G to A, chromosome 18 at 37,013,063 bp
  • G to A, chromosome 18 at 37,966,524 bp
  • A to G, chromosome 18 at 44,354,816 bp
  • A to T, chromosome 19 at 38,795,110 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8398 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067761-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.