Strain Name:
C57BL/6J-MtgxR8417Btlr/Mmmh
Stock Number:
067771-MU
Citation ID:
RRID:MMRRC_067771-MU
Other Names:
R8417 (G1)
Major Collection:

Strain Information

Vcan
Name: versican
Synonyms: hdf, DPEAAE, heart defect, 5430420N07Rik, PG-M, Cspg2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Prkcd
Name: protein kinase C, delta
Synonyms: PKCdelta, PKC[d], Pkcd, D14Ertd420e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18753
HGNC: HGNC:9399
Homologene: 55963
Slit3
Name: slit guidance ligand 3
Synonyms: b2b2362.1Clo, Slit1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20564
Homologene: 2303
Lgi3
Name: leucine-rich repeat LGI family, member 3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 213469
VEGA: 14
Homologene: 16406
Gdf3
Name: growth differentiation factor 3
Synonyms: Vgr2, Gdf-3, Vgr-2, ecat9
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14562
HGNC: HGNC:4218
Homologene: 7336
Casp12
Name: caspase 12
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12364
Homologene: 7654
Lamc1
Name: laminin, gamma 1
Synonyms: laminin B2, Lamb2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226519
HGNC: HGNC:6492
Homologene: 1724
Gsdma3
Name: gasdermin A3
Synonyms: Fgn, Bsk, Rco2, Rim3, Gsdm1l, Gsdm3, Dfl
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 450219
Adamtsl1
Name: ADAMTS-like 1
Synonyms: 5930437A14Rik, punctin-1, 6720426B09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77739
Homologene: 64642
Ighmbp2
Name: immunoglobulin mu DNA binding protein 2
Synonyms: Smbp2, Catf1, Smubp2, p110 subunit, RIPE3b1, Smbp-2, sma, AEP
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20589
HGNC: HGNC:5542
Homologene: 1642
Morc1
Name: microrchidia 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17450
VEGA: 16
HGNC: HGNC:7198
Homologene: 7843
Plekhm2
Name: pleckstrin homology domain containing, family M (with RUN domain) member 2
Synonyms: 2310034J19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69582
Homologene: 19575
Pbrm1
Name: polybromo 1
Synonyms: 2310032M22Rik, 2610016F04Rik, Pb1, BAF180
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66923
Homologene: 10044
Stag3
Name: STAG3 cohesin complex component
Synonyms: SA-2, stromalin 3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50878
Homologene: 40844
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: 4930545D19Rik, hyrh, hy-3, hy3, 1700034M11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Lmod2
Name: leiomodin 2 (cardiac)
Synonyms: C-Lmod
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 93677
HGNC: HGNC:6648
Homologene: 28302
Adgrb3
Name: adhesion G protein-coupled receptor B3
Synonyms: Bai3, A830096D10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210933
HGNC: HGNC:945
Homologene: 1289
Nlrp4b
Name: NLR family, pyrin domain containing 4B
Synonyms: Nalp-gamma, Nalp4b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210045
Homologene: 65242
Prdm8
Name: PR domain containing 8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77630
Homologene: 129760
Bsn
Name: bassoon
Synonyms: presynaptic cytomatrix protein
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12217
HGNC: HGNC:1117
Homologene: 31161
Fam227b
Name: family with sequence similarity 227, member B
Synonyms: 4930525F21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75823
Homologene: 27384
Or12k5
Name: olfactory receptor family 12 subfamily K member 5
Synonyms: MOR159-4, Olfr358, GA_x6K02T2NLDC-33697309-33696317
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227789
Homologene: 74157
Cyp3a59
Name: cytochrome P450, family 3, subfamily a, polypeptide 59
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041449
Homologene: 135775
Fcna
Name: ficolin A
Synonyms: Fcn1, ficolin A
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14133
Homologene: 117949
Or5t7
Name: olfactory receptor family 5 subfamily T member 17
Synonyms: Olfr1086, MOR179-2, GA_x6K02T2Q125-48168771-48167839
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258585
Homologene: 73975
Zeb2
Name: zinc finger E-box binding homeobox 2
Synonyms: 9130203F04Rik, SIP1, Zfhx1b, Zfx1b, D130016B08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 24136
Homologene: 8868
Tgfbr2
Name: transforming growth factor, beta receptor II
Synonyms: TBR-II, TbetaRII, TbetaR-II, 1110020H15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21813
VEGA: 9
Homologene: 2435
Ccn6
Name: cellular communication network factor 6
Synonyms: LOC327743, Wisp3, CCN6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327743
VEGA: 10
Homologene: 77038
Gm5592
Name: predicted gene 5592
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434172
Homologene: 45597
Hsd3b9
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 9
Synonyms: Gm4450
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100043461
Homologene: 104115
Clpp
Name: caseinolytic mitochondrial matrix peptidase proteolytic subunit
Synonyms: D17Wsu160e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 53895
VEGA: 17
HGNC: HGNC:2084
Homologene: 4385
Tnfrsf26
Name: tumor necrosis factor receptor superfamily, member 26
Synonyms: Tnfrh3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244237
Homologene: 52188
Tmtc2
Name: transmembrane and tetratricopeptide repeat containing 2
Synonyms: D330034A10Rik, 8430438D04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 278279
Homologene: 25521
Preb
Name: prolactin regulatory element binding
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50907
HGNC: HGNC:9356
Homologene: 40877
Ankrd33
Name: ankyrin repeat domain 33
Synonyms: A930021G21Rik, Panky
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 208258
VEGA: 15
Homologene: 16992
Mbl2
Name: mannose-binding lectin (protein C) 2
Synonyms: MBL-C, MBL, MBP-C
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17195
VEGA: 19
HGNC: HGNC:6922
Homologene: 110436
AB124611
Name: cDNA sequence AB124611
Synonyms: LOC382062, HIDE1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382062
Homologene: 87291
Spata19
Name: spermatogenesis associated 19
Synonyms: 1700001L23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75469
VEGA: 9
Homologene: 12602
Gm6882
Name: predicted gene 6882
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628475
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 25,488,053 bp
  • A to G, chromosome 1 at 153,230,769 bp
  • C to A, chromosome 2 at 25,624,851 bp
  • T to A, chromosome 2 at 37,004,646 bp
  • C to T, chromosome 2 at 45,022,996 bp
  • A to G, chromosome 2 at 86,676,805 bp
  • C to A, chromosome 2 at 126,121,062 bp
  • G to A, chromosome 3 at 98,456,415 bp
  • G to A, chromosome 4 at 86,156,689 bp
  • T to C, chromosome 4 at 141,627,825 bp
  • G to A, chromosome 5 at 30,960,117 bp
  • A to T, chromosome 5 at 98,184,531 bp
  • A to G, chromosome 5 at 138,308,588 bp
  • A to T, chromosome 5 at 146,090,685 bp
  • G to A, chromosome 6 at 24,603,385 bp
  • T to G, chromosome 6 at 122,606,607 bp
  • T to A, chromosome 7 at 10,725,953 bp
  • A to G, chromosome 7 at 21,427,295 bp
  • A to G, chromosome 7 at 41,288,551 bp
  • C to T, chromosome 7 at 143,614,902 bp
  • T to C, chromosome 8 at 110,569,392 bp
  • G to T, chromosome 9 at 5,352,263 bp
  • T to C, chromosome 9 at 21,529,085 bp
  • A to G, chromosome 9 at 27,397,970 bp
  • C to A, chromosome 9 at 88,843,138 bp
  • G to A, chromosome 9 at 108,111,452 bp
  • A to T, chromosome 9 at 116,110,129 bp
  • T to A, chromosome 10 at 39,151,211 bp
  • A to T, chromosome 10 at 105,413,236 bp
  • A to T, chromosome 11 at 35,610,611 bp
  • A to G, chromosome 11 at 98,629,777 bp
  • T to C, chromosome 13 at 89,688,743 bp
  • T to C, chromosome 14 at 30,609,251 bp
  • T to A, chromosome 14 at 31,027,462 bp
  • T to C, chromosome 14 at 70,534,806 bp
  • C to A, chromosome 15 at 101,119,449 bp
  • T to C, chromosome 16 at 48,460,740 bp
  • T to C, chromosome 17 at 56,990,661 bp
  • T to C, chromosome 19 at 3,261,590 bp
  • G to T, chromosome 19 at 30,239,484 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8417 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067771-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.