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Strain Name:
C57BL/6J-MtgxR7684Btlr/Mmmh
Stock Number:
067780-MU
Citation ID:
RRID:MMRRC_067780-MU
Other Names:
R7684 (G1)
Major Collection:

Strain Information

Thy1
Name: thymus cell antigen 1, theta
Synonyms: CD90, Thy-1, Thy 1.2, Thy1.1, Thy-1.2, Thy1.2, T25
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21838
Homologene: 4580
Tyrp1
Name: tyrosinase-related protein 1
Synonyms: Tyrp, isa, TRP-1, TRP1, Oca3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22178
Homologene: 464
Dnmt3a
Name: DNA methyltransferase 3A
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13435
HGNC: HGNC:2978
Homologene: 7294
Arhgef7
Name: Rho guanine nucleotide exchange factor
Synonyms: Cool, PIX, Pak interacting exchange factor, p85SPR, betaPix-c, betaPix-b, cool-1, betaPix
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54126
Homologene: 2895
Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: alpha13.2, Cav3.2, T-type Cav3.2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Tfap2b
Name: transcription factor AP-2 beta
Synonyms: AP-2(beta), E130018K07Rik, Tcfap2b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21419
Homologene: 20688
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to C, chromosome 1 at 19,214,287 bp
  • T to C, chromosome 1 at 126,026,857 bp
  • T to C, chromosome 1 at 153,127,025 bp
  • T to C, chromosome 1 at 156,690,645 bp
  • T to C, chromosome 2 at 14,449,859 bp
  • A to T, chromosome 2 at 25,239,082 bp
  • T to C, chromosome 2 at 87,388,028 bp
  • A to G, chromosome 2 at 119,520,203 bp
  • C to T, chromosome 2 at 129,367,357 bp
  • T to C, chromosome 2 at 170,841,424 bp
  • T to C, chromosome 2 at 174,468,417 bp
  • A to T, chromosome 3 at 5,751,088 bp
  • A to T, chromosome 3 at 29,690,185 bp
  • T to A, chromosome 3 at 79,670,907 bp
  • A to T, chromosome 3 at 89,210,432 bp
  • T to C, chromosome 3 at 93,219,649 bp
  • A to T, chromosome 3 at 105,979,956 bp
  • A to G, chromosome 3 at 129,321,445 bp
  • T to A, chromosome 4 at 55,008,908 bp
  • C to A, chromosome 4 at 80,840,625 bp
  • T to A, chromosome 4 at 115,518,352 bp
  • T to C, chromosome 4 at 118,782,274 bp
  • A to G, chromosome 4 at 141,774,568 bp
  • A to T, chromosome 4 at 147,613,342 bp
  • G to T, chromosome 4 at 149,996,062 bp
  • A to G, chromosome 4 at 154,281,828 bp
  • A to G, chromosome 5 at 3,830,723 bp
  • A to T, chromosome 5 at 31,307,797 bp
  • T to A, chromosome 5 at 64,316,486 bp
  • A to G, chromosome 5 at 110,697,352 bp
  • A to G, chromosome 5 at 128,601,416 bp
  • T to C, chromosome 6 at 84,100,135 bp
  • T to A, chromosome 6 at 85,950,560 bp
  • T to C, chromosome 7 at 103,561,218 bp
  • G to A, chromosome 7 at 104,049,460 bp
  • A to T, chromosome 7 at 116,388,077 bp
  • C to A, chromosome 7 at 125,471,176 bp
  • G to T, chromosome 7 at 143,490,840 bp
  • T to C, chromosome 8 at 3,169,753 bp
  • T to A, chromosome 8 at 11,819,663 bp
  • T to C, chromosome 8 at 88,627,235 bp
  • T to A, chromosome 8 at 92,909,195 bp
  • T to G, chromosome 8 at 122,407,426 bp
  • A to G, chromosome 9 at 15,988,268 bp
  • G to A, chromosome 9 at 44,046,558 bp
  • A to T, chromosome 9 at 65,559,534 bp
  • T to C, chromosome 9 at 65,731,080 bp
  • A to T, chromosome 9 at 74,147,010 bp
  • T to A, chromosome 9 at 107,911,563 bp
  • T to C, chromosome 9 at 121,850,256 bp
  • A to G, chromosome 11 at 5,570,113 bp
  • A to T, chromosome 11 at 69,357,866 bp
  • T to C, chromosome 11 at 97,147,733 bp
  • T to C, chromosome 12 at 3,897,340 bp
  • A to T, chromosome 12 at 54,068,826 bp
  • A to G, chromosome 12 at 76,612,195 bp
  • G to A, chromosome 12 at 113,491,576 bp
  • A to T, chromosome 13 at 77,612,540 bp
  • T to C, chromosome 14 at 8,039,807 bp
  • A to G, chromosome 14 at 30,810,354 bp
  • A to T, chromosome 14 at 39,472,565 bp
  • A to G, chromosome 14 at 45,147,868 bp
  • A to G, chromosome 15 at 85,058,781 bp
  • A to T, chromosome 15 at 90,649,247 bp
  • A to G, chromosome 16 at 88,562,447 bp
  • A to T, chromosome 16 at 90,786,118 bp
  • A to G, chromosome 17 at 25,389,372 bp
  • A to G, chromosome 17 at 45,547,003 bp
  • T to G, chromosome 17 at 46,509,889 bp
  • T to C, chromosome 17 at 48,416,698 bp
  • G to T, chromosome 17 at 50,047,380 bp
  • A to G, chromosome 17 at 56,269,984 bp
  • T to C, chromosome 18 at 20,863,502 bp
  • A to G, chromosome 19 at 8,609,930 bp
  • A to G, chromosome 19 at 8,811,764 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7684 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067780-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.