Strain Name:
C57BL/6J-MtgxR8292Btlr/Mmmh
Stock Number:
067782-MU
Citation ID:
RRID:MMRRC_067782-MU
Other Names:
R8292 (G1)
Major Collection:

Strain Information

Chrna6
Name: cholinergic receptor, nicotinic, alpha polypeptide 6
Synonyms: alpha6 nAChR, Acra6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11440
Homologene: 20888
Clcnka
Name: chloride channel, voltage-sensitive Ka
Synonyms: Clcnk1, CLC-K1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12733
Homologene: 65
Get4
Name: golgi to ER traffic protein 4
Synonyms: 1110007L15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67604
Homologene: 41080
Tlr6
Name: toll-like receptor 6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21899
Homologene: 21223
Usp32
Name: ubiquitin specific peptidase 32
Synonyms: 2900074J03Rik, 6430526O11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237898
Homologene: 13066
Luzp1
Name: leucine zipper protein 1
Synonyms: 2700072H04Rik, Luzp
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269593
Homologene: 11545
Glcci1
Name: glucocorticoid induced transcript 1
Synonyms: Tssn1, Fam117c, 2310047L21Rik, GIG18, A130036A18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 170772
Homologene: 15773
Racgap1
Name: Rac GTPase-activating protein 1
Synonyms: Band25, gtl11, GTPase, MgcRacGAP
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 26934
HGNC: HGNC:9804
Homologene: 8077
Prr12
Name: proline rich 12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233210
Homologene: 18957
Arfgef1
Name: ADP ribosylation factor guanine nucleotide exchange factor 1
Synonyms: BIG1, P200, ARFGEP1, D730028O18Rik, D130059B05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211673
Homologene: 4687
Rps6ka5
Name: ribosomal protein S6 kinase, polypeptide 5
Synonyms: MSK1, 6330404E13Rik, 3110005L17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73086
VEGA: 12
Homologene: 48302
Bcas3
Name: BCAS3 microtubule associated cell migration factor
Synonyms: 2610028P08Rik, 1500019F07Rik, K20D4, Phaf2, breast carcinoma amplified sequence 3, rudhira
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192197
Homologene: 9778
Mc4r
Name: melanocortin 4 receptor
Synonyms: Pkcp, Fatboy
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17202
VEGA: 18
HGNC: HGNC:6932
Homologene: 4320
Clptm1l
Name: CLPTM1-like
Synonyms: C130052I12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218335
VEGA: 13
Homologene: 12767
Zbtb40
Name: zinc finger and BTB domain containing 40
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230848
Homologene: 8912
Son
Name: Son DNA binding protein
Synonyms: 2900011L12Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20658
Homologene: 10551
Robo1
Name: roundabout guidance receptor 1
Synonyms: DUTT1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19876
Homologene: 2206
Etv6
Name: ets variant 6
Synonyms: Tel, translocation-ets-leukemia
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14011
HGNC: HGNC:3495
Homologene: 37560
Cdc42
Name: cell division cycle 42
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12540
HGNC: HGNC:1736
Homologene: 137230
Krr1
Name: KRR1, small subunit (SSU) processome component, homolog (yeast)
Synonyms: Hrb2, 2610511F02Rik, D10Ertd773e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52705
HGNC: HGNC:5176
Homologene: 5114
Nid2
Name: nidogen 2
Synonyms: entactin-2, entactin 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18074
VEGA: 14
Homologene: 40575
Akirin2
Name: akirin 2
Synonyms: 2700059D21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433693
Homologene: 9988
Mfng
Name: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Synonyms: manic fringe
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17305
HGNC: HGNC:7038
Homologene: 1803
Smpd3
Name: sphingomyelin phosphodiesterase 3, neutral
Synonyms: fro, neutral sphingomyelinase II, nSMase2, Nsm2, 4631433G07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 58994
Homologene: 10260
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Nell1
Name: NEL-like 1
Synonyms: l7R6, B230343H07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 338352
HGNC: HGNC:7750
Homologene: 4486
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: crash, Adgrc1, Crsh, Scy
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Acacb
Name: acetyl-Coenzyme A carboxylase beta
Synonyms: Accb, Acc2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100705
HGNC: HGNC:85
Homologene: 74382
Kif5c
Name: kinesin family member 5C
Synonyms: Khc
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16574
HGNC: HGNC:6325
Homologene: 56234
Farp2
Name: FERM, RhoGEF and pleckstrin domain protein 2
Synonyms: D030026M03Rik, Fir
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227377
Homologene: 8877
Mprip
Name: myosin phosphatase Rho interacting protein
Synonyms: Rhoip3, Gm34094, RIP3, p116Rip, p116 Rho interacting protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26936
Homologene: 9034
Impg2
Name: interphotoreceptor matrix proteoglycan 2
Synonyms: PG10.2, IPM200, Spacrcan
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224224
Homologene: 9439
Rbbp8
Name: retinoblastoma binding protein 8, endonuclease
Synonyms: 9930104E21Rik, CtIP
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225182
VEGA: 18
HGNC: HGNC:9891
Homologene: 28546
Npr2
Name: natriuretic peptide receptor 2
Synonyms: cn, guanylyl cyclase-B, pwe
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230103
HGNC: HGNC:7944
Homologene: 2970
Myom2
Name: myomesin 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17930
HGNC: HGNC:7614
Homologene: 2953
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: Dvwa, EG235580, Vwa6, 1110001D15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68553
Homologene: 130754
Tmem143
Name: transmembrane protein 143
Synonyms: 2310076O21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70209
Homologene: 10105
Tex14
Name: testis expressed gene 14 intercellular bridge forming factor
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 83560
Homologene: 12838
Ttc28
Name: tetratricopeptide repeat domain 28
Synonyms: 2310015L07Rik, TPRBK
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 209683
Homologene: 41023
Rbbp9
Name: retinoblastoma binding protein 9, serine hydrolase
Synonyms: Bog
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26450
HGNC: HGNC:9892
Homologene: 4816
Dixdc1
Name: DIX domain containing 1
Synonyms: Ccd1, 4930563F16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330938
Homologene: 82369
Tiam2
Name: T cell lymphoma invasion and metastasis 2
Synonyms: STEF, 3000002F19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 24001
VEGA: 17
Homologene: 40796
Gbp2
Name: guanylate binding protein 2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14469
Homologene: 10289
Mrgprg
Name: MAS-related GPR, member G
Synonyms: MrgG, LOC381974
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381974
Homologene: 28580
Rbm20
Name: RNA binding motif protein 20
Synonyms: 2010003H22Rik, 1110018J23Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73713
Homologene: 28386
Psg16
Name: pregnancy specific beta-1-glycoprotein 16
Synonyms: Cea11, bCEA
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26436
Mrgprb3
Name: MAS-related GPR, member B3
Synonyms: MrgB3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404238
Homologene: 138632
Akr1c14
Name: aldo-keto reductase family 1, member C14
Synonyms: 9030611N15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105387
Homologene: 138093
Cibar1
Name: CBY1 interacting BAR domain containing 1
Synonyms: 6720467C03Rik, Fam92a
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68099
Homologene: 12234
Hace1
Name: HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
Synonyms: A730034A22Rik, 1700042J16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 209462
Homologene: 10807
Mrgprb4
Name: MAS-related GPR, member B4
Synonyms: MrgB4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233230
Homologene: 115575
Slc35f6
Name: solute carrier family 35, member F6
Synonyms: p40, 5730478O19Rik, 4930471M23Rik, Tango9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74919
Homologene: 9896
Gm14295
Name: predicted gene 14295
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 100039123
Homologene: 133105
Gm5407
Name: predicted gene 5407
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 386061
VEGA: 16
Srgn
Name: serglycin
Synonyms: Prg1, Sgc
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19073
HGNC: HGNC:9361
Homologene: 137238
Bcl2l10
Name: Bcl2-like 10
Synonyms: Boo, Diva
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12049
VEGA: 9
HGNC: HGNC:993
Homologene: 8396
Gm15800
Name:
Type: Gene
Species: Mouse
Chromosome: 5
Aim1l
Name:
Type: Gene
Species: Mouse
Chromosome: 4
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 10,156,969 bp
  • T to C, chromosome 1 at 93,528,628 bp
  • A to T, chromosome 2 at 49,735,485 bp
  • T to C, chromosome 2 at 144,548,097 bp
  • T to A, chromosome 2 at 176,809,558 bp
  • G to A, chromosome 3 at 142,623,823 bp
  • T to G, chromosome 4 at 12,153,963 bp
  • T to C, chromosome 4 at 34,566,007 bp
  • T to A, chromosome 4 at 43,643,086 bp
  • T to C, chromosome 4 at 134,075,531 bp
  • T to G, chromosome 4 at 136,542,453 bp
  • T to C, chromosome 4 at 136,999,567 bp
  • T to C, chromosome 4 at 137,336,073 bp
  • G to A, chromosome 4 at 141,397,961 bp
  • G to T, chromosome 5 at 30,656,031 bp
  • A to C, chromosome 5 at 64,953,791 bp
  • A to G, chromosome 5 at 111,223,257 bp
  • A to T, chromosome 5 at 114,200,494 bp
  • G to A, chromosome 5 at 121,317,225 bp
  • A to G, chromosome 5 at 139,262,931 bp
  • G to A, chromosome 6 at 8,558,549 bp
  • T to C, chromosome 6 at 134,248,546 bp
  • G to A, chromosome 7 at 17,093,776 bp
  • A to G, chromosome 7 at 45,034,688 bp
  • A to G, chromosome 7 at 45,909,540 bp
  • A to T, chromosome 7 at 48,198,806 bp
  • G to T, chromosome 7 at 48,643,507 bp
  • T to C, chromosome 7 at 50,258,247 bp
  • A to C, chromosome 7 at 141,809,263 bp
  • A to T, chromosome 7 at 143,764,919 bp
  • A to G, chromosome 8 at 15,132,888 bp
  • A to T, chromosome 8 at 27,406,726 bp
  • T to C, chromosome 8 at 106,264,790 bp
  • A to G, chromosome 9 at 50,710,689 bp
  • T to C, chromosome 9 at 75,347,878 bp
  • A to T, chromosome 9 at 106,076,877 bp
  • C to G, chromosome 10 at 45,711,461 bp
  • A to T, chromosome 10 at 62,507,668 bp
  • T to A, chromosome 10 at 111,977,116 bp
  • T to A, chromosome 11 at 59,759,514 bp
  • T to A, chromosome 11 at 85,077,401 bp
  • C to A, chromosome 11 at 85,457,903 bp
  • G to A, chromosome 11 at 87,497,838 bp
  • A to T, chromosome 12 at 100,678,532 bp
  • A to G, chromosome 13 at 4,080,995 bp
  • A to T, chromosome 13 at 73,617,735 bp
  • T to G, chromosome 14 at 19,768,278 bp
  • T to C, chromosome 15 at 78,773,170 bp
  • C to A, chromosome 15 at 85,907,618 bp
  • A to T, chromosome 15 at 99,622,246 bp
  • T to A, chromosome 16 at 49,297,187 bp
  • A to T, chromosome 16 at 56,260,626 bp
  • A to T, chromosome 16 at 72,972,532 bp
  • G to A, chromosome 16 at 91,656,657 bp
  • T to C, chromosome 17 at 3,506,867 bp
  • T to C, chromosome 18 at 11,705,712 bp
  • A to T, chromosome 18 at 66,860,011 bp
  • C to A, chromosome 19 at 53,851,499 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8292 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067782-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.