Strain Name:
C57BL/6J-MtgxR8370Btlr/Mmmh
Stock Number:
067809-MU
Citation ID:
RRID:MMRRC_067809-MU
Other Names:
R8370 (G1)
Major Collection:

Strain Information

Mrps18b
Name: mitochondrial ribosomal protein S18B
Synonyms: 2400002C15Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66973
Homologene: 32205
Zranb3
Name: zinc finger, RAN-binding domain containing 3
Synonyms: 4933425L19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226409
Homologene: 32770
Eprs1
Name: glutamyl-prolyl-tRNA synthetase 1
Synonyms: 2410081F06Rik, Qprs, 3010002K18Rik, Eprs
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 107508
HGNC: HGNC:3418
Homologene: 5870
Fry
Name: FRY microtubule binding protein
Synonyms: cg003, 9330186A19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320365
Homologene: 113770
Smchd1
Name: SMC hinge domain containing 1
Synonyms: 4931400A14Rik, MommeD1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74355
Homologene: 23665
Rsf1
Name: remodeling and spacing factor 1
Synonyms: p325, XAP8, Hbxap, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Commd1
Name: COMM domain containing 1
Synonyms: Murr1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17846
Homologene: 17604
Nfrkb
Name: nuclear factor related to kappa B binding protein
Synonyms: A530090G11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235134
HGNC: HGNC:7802
Homologene: 4492
Mmp17
Name: matrix metallopeptidase 17
Synonyms: MT4-MMP, membrane type-4 matrix metalloproteinase
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 23948
HGNC: HGNC:7163
Homologene: 22669
Numb
Name: NUMB endocytic adaptor protein
Synonyms: m-numb
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18222
HGNC: HGNC:8060
Homologene: 2775
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Ncam1
Name: neural cell adhesion molecule 1
Synonyms: CD56, NCAM-1, NCAM-120, NCAM-140, NCAM-180, E-NCAM, NCAM
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17967
HGNC: HGNC:7656
Homologene: 40754
Clca4b
Name: chloride channel accessory 4B
Synonyms: AI747448
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99709
HGNC: HGNC:2018
Homologene: 40808
Prss58
Name: serine protease 58
Synonyms: BC048599
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232717
Homologene: 65285
Srebf1
Name: sterol regulatory element binding transcription factor 1
Synonyms: SREBP-1, ADD-1, SREBP-1c, SREBP-1a, SREBP1, SREBP1c, bHLHd1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20787
Homologene: 3079
Zbtb48
Name: zinc finger and BTB domain containing 48
Synonyms: 0610011D15Rik, Hkr3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100090
HGNC: HGNC:4930
Homologene: 3905
Nav1
Name: neuron navigator 1
Synonyms: POMFIL3, 9930003A20Rik, C230080M11Rik, unc53H1, steerin-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215690
Homologene: 10719
Dhx57
Name: DExH-box helicase 57
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106794
VEGA: 17
Homologene: 56267
Ephb2
Name: Eph receptor B2
Synonyms: eteck, Erk, Tyro5, Prkm5, Nuk, Drt, Hek5, Sek3, Qek5, Cek5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13844
HGNC: HGNC:3393
Homologene: 37925
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Trim14
Name: tripartite motif-containing 14
Synonyms: 5830400N10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74735
Homologene: 13241
Golgb1
Name: golgin B1
Synonyms: Giantin, C130074L01Rik, F730017E11Rik, 6330407A06Rik, Gm6840
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224139
HGNC: HGNC:4429
Homologene: 68401
Cav1
Name: caveolin 1, caveolae protein
Synonyms: Cav-1, caveolin-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12389
HGNC: HGNC:1527
Homologene: 1330
Armc2
Name: armadillo repeat containing 2
Synonyms: 2610018I05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 213402
Homologene: 41848
Pfpl
Name: pore forming protein-like
Synonyms: Epcs5, Epcs50
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56093
VEGA: 19
Homologene: 130704
Or5b123
Name: olfactory receptor family 5 subfamily B member 123
Synonyms: GA_x6K02T2RE5P-3951719-3952666, MOR202-18, Olfr1487
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258629
Homologene: 110492
Klhl33
Name: kelch-like 33
Synonyms: EG546611
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 546611
VEGA: 14
Homologene: 52385
Ccdc202
Name: coiled-coil domain containing 202
Synonyms: 4921530L21Rik, Spertl
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66732
VEGA: 14
Homologene: 41645
Adamts5
Name: ADAM metallopeptidase with thrombospondin type 1 motif 5
Synonyms: ADAM-TS5, 9530092O11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 23794
VEGA: 16
HGNC: HGNC:221
Homologene: 5109
Or6ae1
Name: olfactory receptor family 6 subfamily AE member 1
Synonyms: GA_x6K02T2PBJ9-42315125-42314187, MOR103-5, Olfr522
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258954
Homologene: 62435
Ptx4
Name: pentraxin 4
Synonyms: 1110018H23Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68509
VEGA: 17
Homologene: 19179
Ribc2
Name: RIB43A domain with coiled-coils 2
Synonyms: 4930579A10Rik, Trib
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67747
VEGA: 15
Homologene: 9230
Miga2
Name: mitoguardin 2
Synonyms: R74766, 5730472N09Rik, Fam73b
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 108958
Homologene: 13125
Kcnq5
Name: potassium voltage-gated channel, subfamily Q, member 5
Synonyms: 9230107O05Rik, D1Mgi1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226922
HGNC: HGNC:6299
Homologene: 28270
Clec4a4
Name: C-type lectin domain family 4, member a4
Synonyms: Dcir2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 474145
Homologene: 133910
Spata31d1e
Name: spermatogenesis associated 31 subfamily D, member 1E
Synonyms: 1700014D04Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 102638268
Homologene: 140986
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 21,479,424 bp
  • T to C, chromosome 1 at 127,967,933 bp
  • T to A, chromosome 1 at 135,471,144 bp
  • T to A, chromosome 1 at 185,399,257 bp
  • AAGAG to AAG, chromosome 2 at 30,375,743 bp
  • T to C, chromosome 2 at 40,998,105 bp
  • T to C, chromosome 2 at 177,832,592 bp
  • T to C, chromosome 2 at 180,201,487 bp
  • A to G, chromosome 3 at 144,926,063 bp
  • A to T, chromosome 4 at 46,523,711 bp
  • A to G, chromosome 4 at 136,655,991 bp
  • A to G, chromosome 4 at 152,021,287 bp
  • A to G, chromosome 5 at 129,605,578 bp
  • C to A, chromosome 5 at 150,395,819 bp
  • A to G, chromosome 6 at 17,339,294 bp
  • C to A, chromosome 6 at 40,895,424 bp
  • G to A, chromosome 6 at 122,991,799 bp
  • A to G, chromosome 7 at 45,421,642 bp
  • CGGCGGC to CGGCGGCGGGGGCGGC, chromosome 7 at 97,579,929 bp
  • A to T, chromosome 7 at 140,162,768 bp
  • T to A, chromosome 9 at 31,405,579 bp
  • T to A, chromosome 9 at 49,557,131 bp
  • C to T, chromosome 9 at 110,488,613 bp
  • T to A, chromosome 10 at 41,923,837 bp
  • A to T, chromosome 11 at 22,982,104 bp
  • T to C, chromosome 11 at 60,202,196 bp
  • A to T, chromosome 12 at 83,808,200 bp
  • T to C, chromosome 13 at 59,743,952 bp
  • A to T, chromosome 14 at 33,093,251 bp
  • C to T, chromosome 14 at 50,892,232 bp
  • T to C, chromosome 14 at 95,882,494 bp
  • T to G, chromosome 15 at 85,143,288 bp
  • A to G, chromosome 16 at 36,912,317 bp
  • A to G, chromosome 16 at 85,899,993 bp
  • C to A, chromosome 17 at 25,123,340 bp
  • T to C, chromosome 17 at 35,912,362 bp
  • G to A, chromosome 17 at 71,394,913 bp
  • A to T, chromosome 17 at 80,245,763 bp
  • A to T, chromosome 19 at 12,429,911 bp
  • T to A, chromosome 19 at 13,619,297 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8370 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067809-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.