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Strain Name:
C57BL/6J-MtgxR8379Btlr/Mmmh
Stock Number:
067810-MU
Citation ID:
RRID:MMRRC_067810-MU
Other Names:
R8379 (G1)
Major Collection:

Strain Information

Grm1
Name: glutamate receptor, metabotropic 1
Synonyms: mGluR1, Grm1, Gprc1a, nmf373, rcw, 4930455H15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14816
HGNC: HGNC:4593
Homologene: 649
Ptpn14
Name: protein tyrosine phosphatase, non-receptor type 14
Synonyms: PTP36, C130080N23Rik, OTTMUSG00000022087
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19250
HGNC: HGNC:9647
Homologene: 3941
Prrc2b
Name: proline-rich coiled-coil 2B
Synonyms: 5830434P21Rik, Bat2l
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227723
Homologene: 106649
Col18a1
Name: collagen, type XVIII, alpha 1
Synonyms: endostatin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12822
HGNC: HGNC:2195
Homologene: 7673
Csnk1e
Name: casein kinase 1, epsilon
Synonyms: CKI epsilon, tau, KC1epsilon, CKIepsilon, CK1epsilon
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 27373
Homologene: 121695
Ulk1
Name: unc-51 like kinase 1
Synonyms: Unc51.1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22241
Homologene: 2640
Csnk1a1
Name: casein kinase 1, alpha 1
Synonyms: 4632404G05Rik, 2610208K14Rik, 5430427P18Rik, CK1a
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93687
HGNC: HGNC:2451
Homologene: 111694
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 37,801,878 bp
  • G to T, chromosome 1 at 75,503,857 bp
  • G to T, chromosome 1 at 161,251,090 bp
  • C to A, chromosome 1 at 173,974,732 bp
  • T to A, chromosome 1 at 189,833,401 bp
  • C to A, chromosome 2 at 32,214,654 bp
  • T to C, chromosome 2 at 126,742,571 bp
  • T to A, chromosome 2 at 180,137,102 bp
  • A to T, chromosome 2 at 182,000,482 bp
  • A to T, chromosome 4 at 24,629,194 bp
  • A to G, chromosome 4 at 32,756,453 bp
  • A to T, chromosome 4 at 63,346,118 bp
  • C to A, chromosome 5 at 104,211,705 bp
  • T to G, chromosome 5 at 110,650,962 bp
  • C to A, chromosome 5 at 110,787,665 bp
  • C to T, chromosome 5 at 120,666,355 bp
  • C to A, chromosome 5 at 123,927,061 bp
  • T to C, chromosome 5 at 134,901,703 bp
  • T to C, chromosome 5 at 142,788,402 bp
  • A to T, chromosome 6 at 3,963,849 bp
  • T to A, chromosome 6 at 31,458,965 bp
  • A to G, chromosome 6 at 135,922,969 bp
  • A to G, chromosome 6 at 147,030,345 bp
  • G to T, chromosome 7 at 35,524,057 bp
  • C to T, chromosome 7 at 43,047,846 bp
  • C to T, chromosome 7 at 43,970,343 bp
  • G to A, chromosome 7 at 45,218,081 bp
  • G to T, chromosome 7 at 100,293,779 bp
  • A to G, chromosome 7 at 103,538,976 bp
  • T to C, chromosome 7 at 105,385,135 bp
  • A to T, chromosome 7 at 119,834,285 bp
  • C to A, chromosome 7 at 141,644,312 bp
  • T to C, chromosome 8 at 27,453,326 bp
  • T to A, chromosome 8 at 128,964,936 bp
  • T to C, chromosome 9 at 114,492,167 bp
  • A to C, chromosome 9 at 123,089,078 bp
  • G to A, chromosome 10 at 10,689,135 bp
  • C to T, chromosome 10 at 77,053,238 bp
  • A to G, chromosome 10 at 84,613,605 bp
  • A to T, chromosome 10 at 103,389,187 bp
  • G to A, chromosome 11 at 3,371,162 bp
  • A to G, chromosome 11 at 34,207,530 bp
  • A to G, chromosome 11 at 46,677,200 bp
  • C to A, chromosome 11 at 70,969,781 bp
  • T to C, chromosome 11 at 72,029,300 bp
  • A to G, chromosome 11 at 100,118,880 bp
  • C to A, chromosome 11 at 116,775,499 bp
  • A to C, chromosome 11 at 119,491,897 bp
  • A to G, chromosome 13 at 52,909,313 bp
  • A to G, chromosome 13 at 55,524,020 bp
  • T to G, chromosome 13 at 59,702,854 bp
  • A to T, chromosome 14 at 26,925,415 bp
  • TG to T, chromosome 14 at 56,424,542 bp
  • A to G, chromosome 15 at 58,009,800 bp
  • T to C, chromosome 15 at 79,420,682 bp
  • G to A, chromosome 15 at 85,232,572 bp
  • T to A, chromosome 16 at 44,286,392 bp
  • A to G, chromosome 16 at 49,081,188 bp
  • A to T, chromosome 16 at 73,933,700 bp
  • T to G, chromosome 17 at 65,983,944 bp
  • A to G, chromosome 17 at 66,130,025 bp
  • T to C, chromosome 18 at 61,555,854 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8379 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067810-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.