Strain Name:
C57BL/6J-MtgxR8412Btlr/Mmmh
Stock Number:
067816-MU
Citation ID:
RRID:MMRRC_067816-MU
Other Names:
R8412 (G1)
Major Collection:

Strain Information

Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: 9930031C03Rik, brain spectrin, elf1, spectrin G, beta fodrin, Spnb2, non-erythrocytic, Spnb-2, elf3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Irx3
Name: Iroquois related homeobox 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16373
Homologene: 7385
Ntrk3
Name: neurotrophic tyrosine kinase, receptor, type 3
Synonyms: TrkC
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18213
HGNC: HGNC:8033
Homologene: 49183
Pds5b
Name: PDS5 cohesin associated factor B
Synonyms: Aprin, AS3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100710
Homologene: 41001
Taok3
Name: TAO kinase 3
Synonyms: 2900006A08Rik, A430105I05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330177
Homologene: 83279
Virma
Name: vir like m6A methyltransferase associated
Synonyms: 1110037F02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66185
Homologene: 41043
Mcm3
Name: minichromosome maintenance complex component 3
Synonyms: p1.m, Mcmd, P1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17215
HGNC: HGNC:6945
Homologene: 1791
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: Pcp-1, Pcp1, IP3R1, InsP3R type I, P400, Ip3r, opt, wblo, Itpr-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Cnot10
Name: CCR4-NOT transcription complex, subunit 10
Synonyms: 2600001P13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78893
VEGA: 9
Homologene: 41040
Slc12a3
Name: solute carrier family 12, member 3
Synonyms: TSC, NCC
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20497
Homologene: 287
Apob
Name: apolipoprotein B
Synonyms: apob-48, apob-100
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Arhgap23
Name: Rho GTPase activating protein 23
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 58996
Homologene: 104145
Snrnp40
Name: small nuclear ribonucleoprotein 40 (U5)
Synonyms: 0610009C03Rik, Wdr57
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66585
Homologene: 3538
Scamp3
Name: secretory carrier membrane protein 3
Synonyms: Sc3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 24045
Homologene: 4164
Zfp54
Name: zinc finger protein 54
Synonyms: Zfp76, clone 18, Zfp-54, KRAB10
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22712
Homologene: 129791
Nob1
Name: NIN1/RPN12 binding protein 1 homolog
Synonyms: Nob1p, Psmd8bp1, 1700021I09Rik, ART-4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67619
Homologene: 31924
Med23
Name: mediator complex subunit 23
Synonyms: X83317, ESTM7, sno, Crsp3, Sur2, 3000002A17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70208
HGNC: HGNC:2372
Homologene: 3552
Tube1
Name: tubulin, epsilon 1
Synonyms: 2310061K05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71924
VEGA: 10
Homologene: 17762
Ppme1
Name: protein phosphatase methylesterase 1
Synonyms: PME-1, 2700017M01Rik, 1110069N17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72590
Homologene: 6099
Usp8
Name: ubiquitin specific peptidase 8
Synonyms: Ubpy
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 84092
Homologene: 3782
Tnfrsf25
Name: tumor necrosis factor receptor superfamily, member 25
Synonyms: WSL-1, APO-3, TR3, DDR3, Tnfrsf12, WSL-LR, LARD, TRAMP, DR3, Wsl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 85030
Homologene: 13202
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244646
Homologene: 14627
Ndst4
Name: N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
Synonyms: 4930439H17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 64580
Homologene: 11208
Lamc3
Name: laminin gamma 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 23928
HGNC: HGNC:6494
Homologene: 21222
Gucy2d
Name: guanylate cyclase 2d
Synonyms: guanylyl cyclase D
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14918
Homologene: 71540
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239420
Homologene: 65982
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: E130113P14Rik, bl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Atg2a
Name: autophagy related 2A
Synonyms: 1810013C15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 329015
Homologene: 86985
Ifi47
Name: interferon gamma inducible protein 47
Synonyms: Igrd, Iigp4, IRG-47, 47kDa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15953
Homologene: 49169
Vmn2r58
Name: vomeronasal 2, receptor 58
Synonyms: EG628422
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628422
Bmi1
Name: Bmi1 polycomb ring finger oncogene
Synonyms: Bmi-1, Pcgf4, Bmi1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12151
Homologene: 3797
Cdh26
Name: cadherin-like 26
Synonyms: LOC381409
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381409
Homologene: 18643
Slc9a9
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 9
Synonyms: 5730527A11Rik, Nhe9
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 331004
Homologene: 69753
Slc22a14
Name: solute carrier family 22 (organic cation transporter), member 14
Synonyms: LOC382113
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382113
HGNC: HGNC:8495
Homologene: 3530
Apba2
Name: amyloid beta precursor protein binding family A member 2
Synonyms: X11-like, Mint 2, X11L
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11784
HGNC: HGNC:579
Homologene: 4021
Zfp780b
Name: zinc finger protein 780B
Synonyms: B230208L21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 338354
Homologene: 85969
Ace
Name: angiotensin I converting enzyme
Synonyms: CD143
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11421
HGNC: HGNC:2707
Homologene: 37351
Ak8
Name: adenylate kinase 8
Synonyms: 1190002A17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68870
Homologene: 17622
Slc19a3
Name: solute carrier family 19, member 3
Synonyms: ThTr2, A230084E24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 80721
Homologene: 23530
Zeb2
Name: zinc finger E-box binding homeobox 2
Synonyms: 9130203F04Rik, SIP1, Zfhx1b, Zfx1b, D130016B08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 24136
Homologene: 8868
Tspan32
Name: tetraspanin 32
Synonyms: Art-1, Tspan32, Phemx, D7Wsu37e, Tssc6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27027
Homologene: 10650
1700056E22Rik
Name: RIKEN cDNA 1700056E22 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73363
Homologene: 137387
Pus7l
Name: pseudouridylate synthase 7-like
Synonyms: 3000003F02Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78895
Homologene: 12842
Bhmt2
Name: betaine-homocysteine methyltransferase 2
Synonyms: D13Ucla2, C81077
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 64918
HGNC: HGNC:1048
Homologene: 49496
Rpp21
Name: ribonuclease P 21 subunit
Synonyms: Rpp21, 0610037N01Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67676
Homologene: 41592
Tas1r1
Name: taste receptor, type 1, member 1
Synonyms: T1R1, TR1, Gpr70, T1r1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 110326
Homologene: 12888
Gm14295
Name: predicted gene 14295
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 100039123
Homologene: 133105
Trim12a
Name: tripartite motif-containing 12A
Synonyms: Trim12, 2310043C01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76681
Defa29
Name: defensin, alpha, 29
Synonyms: CRS1C-2, Defcr-rs1, 2010300L12Rik, 2010319H24Rik, Defa-rs1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13218
Homologene: 85974
Cnpy1
Name: canopy FGF signaling regulator 1
Synonyms: 1500012D20Rik, 9630008K15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269637
Homologene: 89678
Cenpx
Name: centromere protein X
Synonyms: Stra13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20892
Homologene: 88844
Scgb1b7
Name: secretoglobin, family 1B, member 7
Synonyms: Abpa7, Gm6662
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 626305
Homologene: 114479
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 20,816,756 bp
  • C to T, chromosome 1 at 83,014,812 bp
  • T to A, chromosome 1 at 184,033,159 bp
  • C to T, chromosome 2 at 18,684,303 bp
  • A to G, chromosome 2 at 28,739,631 bp
  • A to G, chromosome 2 at 31,912,116 bp
  • T to C, chromosome 2 at 44,998,952 bp
  • T to C, chromosome 2 at 126,742,658 bp
  • G to A, chromosome 2 at 176,809,629 bp
  • A to G, chromosome 2 at 178,462,724 bp
  • T to C, chromosome 3 at 89,181,218 bp
  • A to T, chromosome 3 at 125,570,790 bp
  • T to A, chromosome 4 at 11,521,261 bp
  • T to A, chromosome 4 at 130,384,523 bp
  • T to C, chromosome 4 at 152,032,576 bp
  • T to C, chromosome 4 at 152,119,682 bp
  • A to T, chromosome 5 at 28,209,208 bp
  • T to C, chromosome 5 at 96,596,852 bp
  • A to G, chromosome 5 at 117,266,037 bp
  • G to T, chromosome 5 at 150,719,959 bp
  • A to G, chromosome 6 at 108,363,620 bp
  • A to T, chromosome 7 at 27,963,126 bp
  • A to T, chromosome 7 at 31,712,954 bp
  • T to C, chromosome 7 at 41,864,298 bp
  • T to A, chromosome 7 at 64,745,798 bp
  • A to G, chromosome 7 at 78,356,149 bp
  • T to C, chromosome 7 at 98,443,839 bp
  • A to T, chromosome 7 at 100,335,091 bp
  • A to T, chromosome 7 at 104,304,337 bp
  • T to C, chromosome 7 at 143,005,958 bp
  • T to A, chromosome 8 at 21,326,046 bp
  • G to T, chromosome 8 at 91,800,400 bp
  • T to C, chromosome 8 at 94,334,067 bp
  • T to A, chromosome 8 at 107,421,598 bp
  • T to A, chromosome 8 at 109,633,390 bp
  • A to C, chromosome 9 at 95,229,039 bp
  • T to C, chromosome 9 at 114,610,670 bp
  • T to C, chromosome 9 at 119,180,856 bp
  • C to A, chromosome 10 at 24,908,734 bp
  • T to A, chromosome 10 at 39,145,661 bp
  • A to G, chromosome 11 at 30,138,457 bp
  • A to C, chromosome 11 at 49,095,598 bp
  • C to T, chromosome 11 at 97,466,028 bp
  • T to A, chromosome 11 at 105,979,266 bp
  • A to T, chromosome 11 at 120,711,732 bp
  • A to G, chromosome 12 at 8,008,069 bp
  • T to A, chromosome 13 at 93,662,312 bp
  • C to T, chromosome 15 at 47,636,398 bp
  • C to T, chromosome 15 at 94,527,975 bp
  • C to T, chromosome 17 at 21,434,648 bp
  • T to A, chromosome 17 at 36,257,699 bp
  • T to C, chromosome 19 at 6,244,524 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8412 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067816-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.