Strain Name:
C57BL/6J-MtgxR8427Btlr/Mmmh
Stock Number:
067821-MU
Citation ID:
RRID:MMRRC_067821-MU
Other Names:
R8427 (G1)
Major Collection:

Strain Information

Sema6d
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Synonyms: 1110067B02Rik, Sema6D-6, Sema6D-5, Sema6D-4, Sema6D-2, Sema6D-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214968
Homologene: 16195
Bcl2l2
Name: BCL2-like 2
Synonyms: bclw, Gtrgal2, Gtrosa41, Bcl-w
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12050
Homologene: 2989
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Wfs1
Name: wolframin ER transmembrane glycoprotein
Synonyms: wolframin, Wolfram syndrome 1 homolog (human)
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22393
Homologene: 4380
Copb1
Name: coatomer protein complex, subunit beta 1
Synonyms: Copb1, 2610019B04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70349
HGNC: HGNC:2231
Homologene: 5664
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: trithorax Drosophila, HTRX1, ALL-1, All1, Cxxc7, Mll, Mll1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Slc38a2
Name: solute carrier family 38, member 2
Synonyms: 5033402L14Rik, SNAT2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67760
VEGA: 15
Homologene: 23132
Cnot1
Name: CCR4-NOT transcription complex, subunit 1
Synonyms: 6030411K04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234594
HGNC: HGNC:7877
Homologene: 9453
Xdh
Name: xanthine dehydrogenase
Synonyms: Xox-1, Xox1, Xor, xanthine oxidase, XO
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22436
VEGA: 17
Homologene: 324
Nfrkb
Name: nuclear factor related to kappa B binding protein
Synonyms: A530090G11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235134
HGNC: HGNC:7802
Homologene: 4492
Nf2
Name: neurofibromin 2
Synonyms: schwannomin, moesin-ezrin-radixin-like protein, merlin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18016
HGNC: HGNC:7773
Homologene: 2180
Mdh1
Name: malate dehydrogenase 1, NAD (soluble)
Synonyms: Mor-2, MDH-s, Mor2, B230377B03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17449
HGNC: HGNC:6970
Homologene: 4324
Npas4
Name: neuronal PAS domain protein 4
Synonyms: LE-PAS, Nxf, Npas4
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225872
VEGA: 19
Homologene: 15333
Scube2
Name: signal peptide, CUB domain, EGF-like 2
Synonyms: ICRFP703N2430Q5.1, ICRFP703B1614Q5.1, 4932442O19Rik, Cegf1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56788
Homologene: 36383
Atp13a5
Name: ATPase type 13A5
Synonyms: C630015F21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268878
Homologene: 77451
Lifr
Name: LIF receptor alpha
Synonyms: soluble differentiation-stimulating factor receptor, A230075M04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16880
VEGA: 15
HGNC: HGNC:6597
Homologene: 1735
Ppa1
Name: pyrophosphatase (inorganic) 1
Synonyms: 2010317E03Rik, Pyp
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67895
HGNC: HGNC:9226
Homologene: 5356
Crmp1
Name: collapsin response mediator protein 1
Synonyms: Ulip3, DRP-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12933
HGNC: HGNC:2365
Homologene: 20347
Rpp30
Name: ribonuclease P/MRP 30 subunit
Synonyms: TSG15, Rnasep2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54364
VEGA: 19
Homologene: 38180
Bccip
Name: BRCA2 and CDKN1A interacting protein
Synonyms: TOK-1, 1110013J05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66165
HGNC: HGNC:978
Homologene: 41629
Tmprss3
Name: transmembrane protease, serine 3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 140765
Homologene: 56985
Trpm2
Name: transient receptor potential cation channel, subfamily M, member 2
Synonyms: Trrp7, LTRPC2, TRPC7, 9830168K16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 28240
Homologene: 20709
Man1a2
Name: mannosidase, alpha, class 1A, member 2
Synonyms: Man1b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17156
HGNC: HGNC:6822
Homologene: 55982
Cib1
Name: calcium and integrin binding 1
Synonyms: Kip
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23991
Homologene: 4654
Cubn
Name: cubilin
Synonyms: D2Wsu88e, intrinsic factor-cobalamin receptor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Pld1
Name: phospholipase D1
Synonyms: Pld1b, Pld1a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18805
HGNC: HGNC:9067
Homologene: 116234
Tnr
Name: tenascin R
Synonyms: janusin, restrictin, TN-R, J1-tenascin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21960
Homologene: 124416
Celsr2
Name: cadherin, EGF LAG seven-pass G-type receptor 2
Synonyms: mfmi1, flamingo, EGFL2, Adgrc2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53883
HGNC: HGNC:3231
Homologene: 1078
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Strc
Name: stereocilin
Synonyms: DFNB16
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 140476
Homologene: 15401
Tnn
Name: tenascin N
Synonyms: Tnw, tenascin-W
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329278
Homologene: 18634
Eml1
Name: echinoderm microtubule associated protein like 1
Synonyms: ELP79, 1110008N23Rik, A930030P13Rik, heco
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68519
HGNC: HGNC:3330
Homologene: 20931
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217843
Homologene: 41397
Ccdc146
Name: coiled-coil domain containing 146
Synonyms: 4930528G09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75172
Homologene: 67159
Or12k5
Name: olfactory receptor family 12 subfamily K member 5
Synonyms: GA_x6K02T2NLDC-33697309-33696317, MOR159-4, Olfr358
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227789
Homologene: 74157
Hoxb3
Name: homeobox B3
Synonyms: Hox-2.7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15410
HGNC: HGNC:5114
Homologene: 1617
Adrb2
Name: adrenergic receptor, beta 2
Synonyms: beta 2-AR, Badm, Adrb-2, beta 2-adrenoceptor, Gpcr7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 11555
VEGA: 18
HGNC: HGNC:286
Homologene: 30948
Trim42
Name: tripartite motif-containing 42
Synonyms: 4930486B16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78911
Homologene: 12712
Cdr2l
Name: cerebellar degeneration-related protein 2-like
Synonyms: D030068L24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237988
Homologene: 35390
Vmn1r173
Name: vomeronasal 1 receptor 173
Synonyms: Gm5892
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545934
Homologene: 79577
Dab2
Name: disabled 2, mitogen-responsive phosphoprotein
Synonyms: D15Wsu122e, 5730435J12Rik, p96, D630005B22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13132
HGNC: HGNC:2662
Homologene: 1026
Ddx28
Name: DEAD box helicase 28
Synonyms: Mddx28, 2410004K13Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71986
Homologene: 10164
Ube2q2
Name: ubiquitin-conjugating enzyme E2Q family member 2
Synonyms: 3010021M21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 109161
Homologene: 45455
Zfp229
Name: zinc finger protein 229
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381067
Homologene: 136287
Vmn2r16
Name: vomeronasal 2, receptor 16
Synonyms: EG384220
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384220
Homologene: 104825
Skida1
Name: SKI/DACH domain containing 1
Synonyms: 5730507N06Rik, 2810030E01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72668
Homologene: 66327
Plscr4
Name: phospholipid scramblase 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235527
Homologene: 23217
Or11h4b
Name: olfactory receptor family 11 subfamily H member 4B
Synonyms: GA_x6K02T2PMLR-6420220-6419279, MOR106-7, MOR106-16, Olfr747
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258264
Homologene: 10652
V1ra8
Name: vomeronasal 1 receptor, A8
Synonyms: Vmn1r-ps33
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113850
Slc40a1
Name: solute carrier family 40 (iron-regulated transporter), member 1
Synonyms: Ol5, ferroportin1, IREG1, FPN1, metal transporting protein 1, MTP1, Slc11a3, Dusg, Pcm
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 53945
Homologene: 40959
Ovch2
Name: ovochymase 2
Synonyms: 9230106D23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244199
Homologene: 18255
Ifit1bl1
Name: interferon induced protein with tetratricpeptide repeats 1B like 1
Synonyms: Gm14446
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 667373
Homologene: 78213
Kcnh3
Name: potassium voltage-gated channel, subfamily H (eag-related), member 3
Synonyms: ether a go-go like, Elk2, Melk2, C030044P22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16512
VEGA: 15
HGNC: HGNC:6252
Homologene: 32150
Mical1
Name: microtubule associated monooxygenase, calponin and LIM domain containing 1
Synonyms: Nical
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 171580
Homologene: 11246
4930447C04Rik
Name: RIKEN cDNA 4930447C04 gene
Synonyms: Six6as, Six6os1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75801
Homologene: 49922
Rnf133
Name: ring finger protein 133
Synonyms: Greul2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 386611
Homologene: 44549
Plat
Name: plasminogen activator, tissue
Synonyms: t-PA, tPA, D8Ertd2e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18791
HGNC: HGNC:9051
Homologene: 717
Slc29a2
Name: solute carrier family 29 (nucleoside transporters), member 2
Synonyms: ENT2, Der12, HNP36
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13340
VEGA: 19
Homologene: 37493
Iapp
Name: islet amyloid polypeptide
Synonyms: amylin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15874
HGNC: HGNC:5329
Homologene: 36024
B4galt7
Name: beta-1,4-galactosyltransferase 7
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218271
HGNC: HGNC:930
Homologene: 5248
Zscan4-ps1
Name: zinc finger and SCAN domain containing 4, pseudogene 1
Synonyms: EG545912
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545912
Or4f4-ps1
Name: olfactory receptor family 4 subfamily F member 4, pseudogene 1
Synonyms: GA_x6K02T2Q125-72550790-72551728, MOR245-32_p, OTTMUSG00000015084, Olfr1291, Olfr1291-ps1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257819
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 45,912,338 bp
  • A to T, chromosome 1 at 159,886,231 bp
  • G to A, chromosome 1 at 160,130,686 bp
  • G to C, chromosome 2 at 13,428,756 bp
  • A to T, chromosome 2 at 18,046,591 bp
  • G to T, chromosome 2 at 37,004,782 bp
  • T to C, chromosome 2 at 69,451,297 bp
  • T to C, chromosome 2 at 76,746,557 bp
  • A to G, chromosome 2 at 111,499,965 bp
  • T to G, chromosome 2 at 121,377,531 bp
  • T to A, chromosome 2 at 124,665,277 bp
  • A to T, chromosome 3 at 28,088,646 bp
  • A to T, chromosome 3 at 100,684,685 bp
  • A to C, chromosome 3 at 108,392,633 bp
  • T to C, chromosome 5 at 21,399,792 bp
  • C to A, chromosome 5 at 36,968,087 bp
  • C to T, chromosome 5 at 37,291,195 bp
  • T to A, chromosome 5 at 109,340,272 bp
  • T to C, chromosome 6 at 23,649,406 bp
  • A to G, chromosome 6 at 90,203,577 bp
  • T to A, chromosome 6 at 142,298,886 bp
  • A to T, chromosome 7 at 11,068,520 bp
  • A to T, chromosome 7 at 23,702,534 bp
  • A to G, chromosome 7 at 80,228,001 bp
  • G to A, chromosome 7 at 107,794,000 bp
  • T to A, chromosome 7 at 109,800,590 bp
  • A to G, chromosome 7 at 114,226,754 bp
  • A to G, chromosome 7 at 133,709,491 bp
  • G to T, chromosome 8 at 22,772,232 bp
  • A to G, chromosome 8 at 95,734,324 bp
  • A to G, chromosome 8 at 106,010,280 bp
  • A to G, chromosome 9 at 31,419,027 bp
  • A to G, chromosome 9 at 44,845,423 bp
  • T to C, chromosome 9 at 55,184,966 bp
  • C to T, chromosome 9 at 92,490,790 bp
  • A to T, chromosome 9 at 97,363,121 bp
  • G to T, chromosome 10 at 41,478,595 bp
  • A to G, chromosome 10 at 61,660,925 bp
  • A to T, chromosome 10 at 77,911,402 bp
  • T to A, chromosome 11 at 4,791,118 bp
  • C to T, chromosome 11 at 21,564,138 bp
  • CGGCGGTGGCGG to CGGCGGTGGCGGTGGCGG, chromosome 11 at 96,345,589 bp
  • TGGCGG to TGGCGGAGGCGG, chromosome 11 at 96,345,595 bp
  • C to A, chromosome 11 at 115,394,039 bp
  • T to A, chromosome 11 at 115,991,718 bp
  • G to T, chromosome 12 at 72,903,286 bp
  • A to T, chromosome 12 at 103,079,038 bp
  • C to A, chromosome 12 at 108,530,321 bp
  • T to A, chromosome 13 at 55,609,325 bp
  • T to A, chromosome 14 at 50,681,149 bp
  • A to G, chromosome 14 at 54,885,403 bp
  • A to T, chromosome 15 at 6,429,359 bp
  • A to G, chromosome 15 at 7,190,981 bp
  • G to T, chromosome 15 at 96,692,413 bp
  • T to C, chromosome 15 at 99,227,053 bp
  • T to C, chromosome 16 at 29,349,002 bp
  • T to C, chromosome 17 at 21,746,834 bp
  • T to A, chromosome 17 at 31,188,384 bp
  • T to C, chromosome 17 at 73,935,931 bp
  • A to G, chromosome 18 at 62,179,274 bp
  • A to C, chromosome 19 at 4,986,080 bp
  • A to T, chromosome 19 at 5,030,420 bp
  • A to T, chromosome 19 at 34,599,266 bp
  • A to G, chromosome 19 at 36,094,412 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8427 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067821-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.