Strain Name:
C57BL/6J-MtgxR8433Btlr/Mmmh
Stock Number:
067823-MU
Citation ID:
RRID:MMRRC_067823-MU
Other Names:
R8433 (G1)
Major Collection:

Strain Information

Tpx2
Name: TPX2, microtubule-associated
Synonyms: REPP86, 2610005B21Rik, DIL2, p100
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72119
HGNC: HGNC:1249
Homologene: 8107
Parn
Name: poly(A)-specific ribonuclease (deadenylation nuclease)
Synonyms: DAN, 1200003I18Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74108
VEGA: 16
HGNC: HGNC:8609
Homologene: 31098
Prpf3
Name: pre-mRNA processing factor 3
Synonyms: 3632413F13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70767
Homologene: 3447
Mtch2
Name: mitochondrial carrier 2
Synonyms: 2310034D24Rik, HSPC032, 4930539J07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56428
Homologene: 8645
Phldb1
Name: pleckstrin homology like domain, family B, member 1
Synonyms: D330037A14Rik, LL5A
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102693
Homologene: 15903
Trim39
Name: tripartite motif-containing 39
Synonyms: tfp, E130103K13Rik, RING-B box-coiled-coil-B30.2, 1100001D15Rik, Rnf23, RBCC-B30.2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 79263
Homologene: 10940
Foxk1
Name: forkhead box K1
Synonyms: Mnf, A630048H08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17425
Homologene: 82414
Rnf6
Name: ring finger protein (C3H2C3 type) 6
Synonyms: 1200013I08Rik, 5730419H05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74132
Homologene: 14036
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930543C13Rik, D330038K10Rik, 4930516E05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Eral1
Name: Era like 12S mitochondrial rRNA chaperone 1
Synonyms: 9130407C09Rik, 2610524P08Rik, MERA-W, MERA-S
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57837
HGNC: HGNC:3424
Homologene: 4167
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329178
Homologene: 122243
Tnn
Name: tenascin N
Synonyms: tenascin-W, Tnw
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329278
Homologene: 18634
Chtf18
Name: CTF18, chromosome transmission fidelity factor 18
Synonyms: CTF18, 6030457M03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 214901
Homologene: 32532
Scarf1
Name: scavenger receptor class F, member 1
Synonyms: SREC, SREC-I
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380713
Homologene: 2741
Zfp541
Name: zinc finger protein 541
Synonyms: EG666528
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 666528
Homologene: 12991
Or8k53
Name: olfactory receptor family 8 subfamily K member 53
Synonyms: GA_x6K02T2Q125-47819205-47818258, Olfr1055, MOR186-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259023
Homologene: 131140
Svop
Name: SV2 related protein
Synonyms: msvop, 1110030H18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68666
Homologene: 41283
Gsta3
Name: glutathione S-transferase, alpha 3
Synonyms: Gst2-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14859
Homologene: 37355
Zswim5
Name: zinc finger SWIM-type containing 5
Synonyms: 4933426E21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74464
Homologene: 18958
Armh1
Name: armadillo-like helical domain containing 1
Synonyms: Ncrna00082, LOC381544, LOC381543, Gm1661
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381544
Homologene: 28727
Wdr35
Name: WD repeat domain 35
Synonyms: 4930459M12Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74682
Homologene: 10814
Sorcs3
Name: sortilin-related VPS10 domain containing receptor 3
Synonyms: 6330404A12Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66673
VEGA: 19
Homologene: 8986
Mapk8ip2
Name: mitogen-activated protein kinase 8 interacting protein 2
Synonyms: JNK-interacting protein, 3230402N03Rik, IB2, Jip2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 60597
HGNC: HGNC:6883
Homologene: 8201
Or56a3b
Name: olfactory receptor family 56 subfamily A member 3B
Synonyms: GA_x6K02T2PBJ9-7750163-7751110, MOR40-14, Olfr681
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404318
Homologene: 81538
Zfp764l1
Name: zinc finger protein 764 like 1
Synonyms: E430018J23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101604
Homologene: 138471
Cfhr1
Name: complement factor H-related 1
Synonyms: Cfhl1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 50702
Homologene: 55632
Or55b4
Name: olfactory receptor family 55 subfamily B member 4
Synonyms: MOR42-3, Olfr544, GA_x6K02T2PBJ9-5206624-5205620
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257926
Homologene: 133590
Slc5a6
Name: solute carrier family 5 (sodium-dependent vitamin transporter), member 6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330064
Homologene: 23277
Ptger3
Name: prostaglandin E receptor 3 (subtype EP3)
Synonyms: Pgerep3, Ptgerep3, EP3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19218
HGNC: HGNC:9595
Homologene: 105703
Ndufc1
Name: NADH:ubiquinone oxidoreductase subunit C1
Synonyms: 2310016K22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66377
HGNC: HGNC:7705
Homologene: 1865
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 21,264,948 bp
  • A to T, chromosome 1 at 66,638,028 bp
  • A to T, chromosome 1 at 139,557,538 bp
  • G to A, chromosome 1 at 160,097,220 bp
  • G to A, chromosome 2 at 86,346,800 bp
  • T to A, chromosome 2 at 90,847,161 bp
  • A to G, chromosome 2 at 152,880,136 bp
  • A to G, chromosome 3 at 51,408,890 bp
  • A to G, chromosome 3 at 95,851,651 bp
  • A to C, chromosome 3 at 157,643,955 bp
  • A to G, chromosome 4 at 116,986,810 bp
  • A to G, chromosome 4 at 117,228,338 bp
  • G to A, chromosome 5 at 31,037,462 bp
  • A to G, chromosome 5 at 114,032,761 bp
  • T to C, chromosome 5 at 142,448,784 bp
  • A to G, chromosome 5 at 146,211,278 bp
  • C to T, chromosome 7 at 16,072,074 bp
  • A to T, chromosome 7 at 102,484,784 bp
  • T to C, chromosome 7 at 105,121,724 bp
  • C to T, chromosome 7 at 127,393,324 bp
  • C to T, chromosome 9 at 44,716,462 bp
  • G to A, chromosome 11 at 75,521,032 bp
  • A to G, chromosome 11 at 78,075,483 bp
  • G to A, chromosome 12 at 9,008,495 bp
  • G to A, chromosome 15 at 89,457,866 bp
  • C to A, chromosome 16 at 13,667,549 bp
  • A to G, chromosome 17 at 25,726,944 bp
  • A to G, chromosome 17 at 36,260,705 bp
  • A to T, chromosome 19 at 16,741,236 bp
  • C to T, chromosome 19 at 48,206,474 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8433 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067823-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.