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Strain Name:
C57BL/6J-MtgxR8506Btlr/Mmmh
Stock Number:
067842-MU
Citation ID:
RRID:MMRRC_067842-MU
Other Names:
R8506 (G1)
Major Collection:

Strain Information

Fga
Name: fibrinogen alpha chain
Synonyms: Fib, ENSMUSG00000059807
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14161
HGNC: HGNC:3661
Homologene: 428
Cdc25a
Name: cell division cycle 25A
Synonyms: D9Ertd393e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12530
HGNC: HGNC:1725
Homologene: 1355
Lamb1
Name: laminin B1
Synonyms: Lamb-1, C81607, C80098, D130003D08Rik, Lamb1-1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16777
HGNC: HGNC:6486
Homologene: 1722
Pmp22
Name: peripheral myelin protein 22
Synonyms: Gas-3, TRE002
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18858
HGNC: HGNC:9118
Homologene: 7482
App
Name: amyloid beta precursor protein
Synonyms: betaAPP, Abeta, protease nexin II, Adap, Cvap, appican, E030013M08Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11820
VEGA: 16
HGNC: HGNC:620
Homologene: 56379
Kcnj5
Name: potassium inwardly-rectifying channel, subfamily J, member 5
Synonyms: Kir3.4, GIRK4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16521
VEGA: 9
HGNC: HGNC:6266
Homologene: 20248
Osbpl1a
Name: oxysterol binding protein-like 1A
Synonyms: LOC328902, G430090F17Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 64291
Homologene: 84746
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 45,442,784 bp
  • A to G, chromosome 1 at 64,714,662 bp
  • G to A, chromosome 1 at 75,505,656 bp
  • G to C, chromosome 1 at 191,076,635 bp
  • T to G, chromosome 1 at 191,983,267 bp
  • T to C, chromosome 2 at 73,343,462 bp
  • A to G, chromosome 2 at 86,228,578 bp
  • T to C, chromosome 2 at 86,658,401 bp
  • A to T, chromosome 2 at 87,857,837 bp
  • T to C, chromosome 2 at 103,732,237 bp
  • G to A, chromosome 3 at 46,446,397 bp
  • A to G, chromosome 3 at 83,033,316 bp
  • A to T, chromosome 3 at 83,301,174 bp
  • G to A, chromosome 3 at 130,629,473 bp
  • A to G, chromosome 4 at 137,610,718 bp
  • C to T, chromosome 4 at 148,241,570 bp
  • T to A, chromosome 5 at 14,540,745 bp
  • T to C, chromosome 5 at 24,588,297 bp
  • T to C, chromosome 5 at 37,383,142 bp
  • C to A, chromosome 5 at 41,819,055 bp
  • A to T, chromosome 5 at 76,964,590 bp
  • A to T, chromosome 5 at 104,310,081 bp
  • A to G, chromosome 5 at 109,059,404 bp
  • T to A, chromosome 5 at 136,308,504 bp
  • A to G, chromosome 5 at 136,988,976 bp
  • G to A, chromosome 6 at 30,126,257 bp
  • T to A, chromosome 6 at 87,188,173 bp
  • A to G, chromosome 6 at 146,418,416 bp
  • G to T, chromosome 7 at 6,100,776 bp
  • C to A, chromosome 7 at 19,852,270 bp
  • T to C, chromosome 7 at 99,453,950 bp
  • T to A, chromosome 7 at 103,051,502 bp
  • G to A, chromosome 7 at 140,493,423 bp
  • G to A, chromosome 8 at 23,096,835 bp
  • T to C, chromosome 8 at 47,192,073 bp
  • A to T, chromosome 8 at 84,887,166 bp
  • C to T, chromosome 9 at 3,335,616 bp
  • A to G, chromosome 9 at 32,322,332 bp
  • A to G, chromosome 9 at 44,341,624 bp
  • A to G, chromosome 9 at 66,473,581 bp
  • A to G, chromosome 9 at 81,979,238 bp
  • A to T, chromosome 9 at 101,942,972 bp
  • T to G, chromosome 9 at 109,005,599 bp
  • T to C, chromosome 9 at 109,891,752 bp
  • A to G, chromosome 10 at 23,985,631 bp
  • G to A, chromosome 10 at 43,928,356 bp
  • T to A, chromosome 10 at 112,455,632 bp
  • T to A, chromosome 11 at 63,158,264 bp
  • A to C, chromosome 11 at 119,148,958 bp
  • A to T, chromosome 12 at 31,329,361 bp
  • A to C, chromosome 12 at 69,208,960 bp
  • A to T, chromosome 12 at 81,594,960 bp
  • A to G, chromosome 12 at 115,024,108 bp
  • T to C, chromosome 13 at 13,476,174 bp
  • A to G, chromosome 13 at 21,983,619 bp
  • A to G, chromosome 14 at 14,114,181 bp
  • T to A, chromosome 15 at 35,446,745 bp
  • G to T, chromosome 15 at 86,033,085 bp
  • T to G, chromosome 16 at 20,152,934 bp
  • T to C, chromosome 16 at 31,968,901 bp
  • A to C, chromosome 16 at 85,082,816 bp
  • T to C, chromosome 16 at 97,875,421 bp
  • T to A, chromosome 17 at 20,584,365 bp
  • T to C, chromosome 17 at 30,721,134 bp
  • A to T, chromosome 17 at 36,907,258 bp
  • A to T, chromosome 17 at 45,545,401 bp
  • G to A, chromosome 18 at 12,768,586 bp
  • A to G, chromosome 18 at 37,738,684 bp
  • G to T, chromosome 19 at 6,847,322 bp
  • A to G, chromosome 19 at 13,411,240 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8506 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067842-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.