Strain Name:
C57BL/6J-MtgxR8515Btlr/Mmmh
Stock Number:
067847-MU
Citation ID:
RRID:MMRRC_067847-MU
Other Names:
R8515 (G1)
Major Collection:

Strain Information

Pcf11
Name: PCF11 cleavage and polyadenylation factor subunit
Synonyms: 5730417B17Rik, 2500001H09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74737
Homologene: 32282
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNAPDcs, DNA-PK, slip, XRCC7, DNA-PKcs, dxnph, DOXNPH
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Fam110b
Name: family with sequence similarity 110, member B
Synonyms: 1700012H17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242297
Homologene: 17518
Herc4
Name: hect domain and RLD 4
Synonyms: 4921531D01Rik, 1700056O17Rik, 9530080M15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67345
VEGA: 10
Homologene: 56715
Ski
Name: ski sarcoma viral oncogene homolog (avian)
Synonyms: 2310012I02Rik, 2610001A11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20481
Homologene: 31124
Rab3gap2
Name: RAB3 GTPase activating protein subunit 2
Synonyms: 1110059F07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98732
Homologene: 40842
Wac
Name: WW domain containing adaptor with coiled-coil
Synonyms: 1110067P07Rik, Wwp4, A230035H12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225131
Homologene: 41148
Ccnb2
Name: cyclin B2
Synonyms: CycB2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12442
VEGA: 9
HGNC: HGNC:1580
Homologene: 74359
Bptf
Name: bromodomain PHD finger transcription factor
Synonyms: 9430093H17Rik, Falz
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207165
HGNC: HGNC:3581
Homologene: 114397
Ndufs4
Name: NADH:ubiquinone oxidoreductase core subunit S4
Synonyms: 6720411N02Rik, C1-18k
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17993
VEGA: 13
HGNC: HGNC:7711
Homologene: 1866
Kdm3b
Name: KDM3B lysine (K)-specific demethylase 3B
Synonyms: JHDM2B, 5830462I21Rik, Jmjd1b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 277250
VEGA: 18
HGNC: HGNC:1337
Homologene: 41145
Rcn1
Name: reticulocalbin 1
Synonyms: Rcn
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19672
HGNC: HGNC:9934
Homologene: 20637
Naca
Name: nascent polypeptide-associated complex alpha polypeptide
Synonyms: LOC380777, skNAC
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17938
VEGA: 10
HGNC: HGNC:7629
Homologene: 136025
Sptb
Name: spectrin beta, erythrocytic
Synonyms: LOC383567, brain erythroid spectrin (235E), spectrin R, D330027P03Rik, Spnb-1, Spnb1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20741
Homologene: 295
Ppp3cb
Name: protein phosphatase 3, catalytic subunit, beta isoform
Synonyms: 1110063J16Rik, Calnb, PP2BA beta, Cnab, CnAbeta
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19056
HGNC: HGNC:9315
Homologene: 56429
Kif3b
Name: kinesin family member 3B
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16569
HGNC: HGNC:6320
Homologene: 55849
Aak1
Name: AP2 associated kinase 1
Synonyms: 5530400K14Rik, D6Ertd245e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 269774
Homologene: 128746
Osbpl10
Name: oxysterol binding protein-like 10
Synonyms: 4933433D06Rik, C820004B04Rik, OPR-10
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74486
Homologene: 69240
Rab35
Name: RAB35, member RAS oncogene family
Synonyms: H-ray, 9530019H02Rik, RAB1C
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77407
HGNC: HGNC:9774
Homologene: 21361
Zfand2a
Name: zinc finger, AN1-type domain 2A
Synonyms: Airap
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100494
Homologene: 64373
Zfp345
Name: zinc finger protein 345
Synonyms: OTTMUSG00000015743
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 545471
Homologene: 134546
Pak6
Name: p21 (RAC1) activated kinase 6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214230
Homologene: 23200
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: C130041O22Rik, Zfh-4, Zfh4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80892
Homologene: 23477
Spata31d1c
Name: spermatogenesis associated 31 subfamily D, member 1C
Synonyms: 4932441B19Rik, Fam75d1c
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238683
VEGA: 13
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: b2b1289Clo, b2b1203Clo, Dnahc11, b2b1279Clo, avc4, b2b1727Clo, b2b598Clo, lrd
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Uckl1
Name: uridine-cytidine kinase 1-like 1
Synonyms: Urkl1, 1110007H10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68556
Homologene: 101414
Clk4
Name: CDC like kinase 4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12750
Homologene: 56895
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Sis
Name: sucrase isomaltase
Synonyms: sucrase-isomaltase, Si-s, 2010204N08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69983
Homologene: 37424
Adcy3
Name: adenylate cyclase 3
Synonyms: AC3, ACIII
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104111
HGNC: HGNC:234
Homologene: 2978
Slc22a21
Name: solute carrier family 22 (organic cation transporter), member 21
Synonyms: Slc22a9, Octn3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56517
Homologene: 137336
Acss3
Name: acyl-CoA synthetase short-chain family member 3
Synonyms: 8430416H19Rik, LOC380660
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380660
Homologene: 11587
Pik3r6
Name: phosphoinositide-3-kinase regulatory subunit 5
Synonyms: p87PIKAP, p84 Pikap
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104709
Homologene: 46215
Gm4787
Name: predicted gene 4787
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 214321
Homologene: 86950
Pcnx1
Name: pecanex 1
Synonyms: Pcnx, 3526401J03Rik, 2900024E21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 54604
VEGA: 12
Homologene: 40997
Myo15b
Name: myosin XVB
Synonyms: LOC217328, E330039G21Rik, LOC380737
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217328
Grik1
Name: glutamate receptor, ionotropic, kainate 1
Synonyms: Glur-5, GluK5, D16Ium24, D16Ium24e, A830007B11Rik, Glur5, Glurbeta1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14805
HGNC: HGNC:4579
Homologene: 68992
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Man2a2
Name: mannosidase 2, alpha 2
Synonyms: alpha mannosidase IIx, 4931438M07Rik, 1700052O22Rik, MX
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 140481
HGNC: HGNC:6825
Homologene: 55954
Ctbs
Name: chitobiase
Synonyms: 2210401K11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74245
HGNC: HGNC:2496
Homologene: 3231
Nkx6-3
Name: NK6 homeobox 3
Synonyms: Nkx6.3, 9130417I07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74561
Homologene: 46375
Cyp2d22
Name: cytochrome P450, family 2, subfamily d, polypeptide 22
Synonyms: 2D22
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 56448
VEGA: 15
Homologene: 75003
Mmp19
Name: matrix metallopeptidase 19
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 58223
VEGA: 10
HGNC: HGNC:7165
Homologene: 1820
Vmn1r215
Name: vomeronasal 1 receptor 215
Synonyms: V1ri2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171253
Homologene: 110880
Shank3
Name: SH3 and multiple ankyrin repeat domains 3
Synonyms: ProSAP2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 58234
Homologene: 75163
Spdl1
Name: spindle apparatus coiled-coil protein 1
Synonyms: 2810049B11Rik, 2600001J17Rik, 1700018I02Rik, Ccdc99
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70385
Homologene: 9837
Slc40a1
Name: solute carrier family 40 (iron-regulated transporter), member 1
Synonyms: Dusg, MTP1, FPN1, Ol5, Pcm, Slc11a3, ferroportin1, metal transporting protein 1, IREG1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 53945
Homologene: 40959
Skint1
Name: selection and upkeep of intraepithelial T cells 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 639781
Homologene: 87538
Fbxo40
Name: F-box protein 40
Synonyms: 9830003A13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207215
Homologene: 9459
Aldh1b1
Name: aldehyde dehydrogenase 1 family, member B1
Synonyms: 2700007F14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72535
HGNC: HGNC:407
Homologene: 115470
Hao2
Name: hydroxyacid oxidase 2
Synonyms: Hao3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56185
HGNC: HGNC:4810
Homologene: 97412
Kmo
Name: kynurenine 3-monooxygenase
Synonyms: kynurenine 3-hydroxylase
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98256
HGNC: HGNC:6381
Homologene: 2729
Wbp1
Name: WW domain binding protein 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22377
Homologene: 8267
Clec4a4
Name: C-type lectin domain family 4, member a4
Synonyms: Dcir2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 474145
Homologene: 133910
Rom1
Name: rod outer segment membrane protein 1
Synonyms: Rgsc1156, M101156, Rom-1, Tspan23
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19881
VEGA: 19
Homologene: 276
Snrpa1
Name: small nuclear ribonucleoprotein polypeptide A'
Synonyms: U2 snRNP-A', 1500015N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68981
Homologene: 2325
Heatr4
Name: HEAT repeat containing 4
Synonyms: Gm17673
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 101055670
Homologene: 45728
Preb
Name: prolactin regulatory element binding
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50907
HGNC: HGNC:9356
Homologene: 40877
Coro2a
Name: coronin, actin binding protein 2A
Synonyms: 9030208C03Rik, IR10, coronin 4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 107684
HGNC: HGNC:2255
Homologene: 2546
Tef
Name: thyrotroph embryonic factor
Synonyms: 2310028D20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21685
Homologene: 31140
Nim1k
Name: NIM1 serine/threonine protein kinase
Synonyms: E130304F04Rik, Nim1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 245269
VEGA: 13
Homologene: 25286
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 45,912,307 bp
  • A to T, chromosome 1 at 175,647,152 bp
  • G to C, chromosome 1 at 185,262,820 bp
  • C to T, chromosome 2 at 105,389,119 bp
  • G to T, chromosome 2 at 118,689,997 bp
  • G to C, chromosome 2 at 150,472,428 bp
  • C to T, chromosome 2 at 153,316,507 bp
  • T to C, chromosome 2 at 181,574,487 bp
  • A to T, chromosome 3 at 5,399,474 bp
  • T to A, chromosome 3 at 72,929,409 bp
  • A to T, chromosome 3 at 98,883,647 bp
  • T to A, chromosome 3 at 146,458,813 bp
  • T to C, chromosome 4 at 5,799,380 bp
  • C to T, chromosome 4 at 45,803,818 bp
  • ACCAGAAGAGCCATCCAG to ACCAG, chromosome 4 at 46,544,117 bp
  • T to C, chromosome 4 at 112,010,724 bp
  • T to C, chromosome 4 at 155,160,626 bp
  • A to G, chromosome 5 at 30,959,378 bp
  • G to A, chromosome 5 at 115,643,408 bp
  • A to C, chromosome 5 at 139,473,791 bp
  • C to T, chromosome 6 at 83,119,885 bp
  • A to G, chromosome 6 at 86,925,130 bp
  • T to A, chromosome 6 at 123,004,023 bp
  • G to A, chromosome 7 at 66,070,633 bp
  • A to T, chromosome 7 at 80,368,290 bp
  • T to A, chromosome 7 at 92,658,790 bp
  • A to T, chromosome 8 at 23,153,691 bp
  • A to G, chromosome 9 at 70,413,100 bp
  • C to A, chromosome 9 at 115,176,068 bp
  • T to A, chromosome 10 at 63,315,786 bp
  • T to A, chromosome 10 at 82,288,602 bp
  • A to G, chromosome 10 at 106,948,663 bp
  • T to C, chromosome 10 at 128,044,243 bp
  • T to C, chromosome 10 at 128,795,602 bp
  • G to A, chromosome 11 at 34,813,425 bp
  • G to A, chromosome 11 at 51,275,261 bp
  • T to G, chromosome 11 at 53,956,078 bp
  • A to G, chromosome 11 at 68,539,957 bp
  • A to T, chromosome 11 at 107,055,238 bp
  • G to A, chromosome 11 at 115,858,784 bp
  • T to C, chromosome 12 at 4,212,187 bp
  • A to T, chromosome 12 at 76,612,041 bp
  • T to A, chromosome 12 at 81,377,269 bp
  • A to G, chromosome 12 at 81,962,716 bp
  • A to G, chromosome 12 at 83,954,704 bp
  • C to T, chromosome 12 at 117,975,798 bp
  • A to G, chromosome 13 at 23,075,867 bp
  • G to T, chromosome 13 at 65,033,177 bp
  • T to C, chromosome 13 at 114,288,803 bp
  • G to A, chromosome 13 at 119,712,450 bp
  • T to A, chromosome 14 at 20,531,776 bp
  • T to A, chromosome 15 at 81,802,836 bp
  • T to C, chromosome 15 at 82,373,912 bp
  • C to A, chromosome 15 at 89,503,572 bp
  • A to G, chromosome 16 at 15,664,368 bp
  • G to A, chromosome 16 at 32,755,255 bp
  • A to G, chromosome 16 at 36,970,653 bp
  • A to T, chromosome 16 at 87,923,282 bp
  • A to G, chromosome 18 at 7,871,606 bp
  • C to A, chromosome 18 at 12,411,631 bp
  • G to T, chromosome 18 at 34,793,076 bp
  • A to G, chromosome 19 at 8,929,101 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8515 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067847-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.