Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR8516Btlr/Mmmh
Stock Number:
067848-MU
Citation ID:
RRID:MMRRC_067848-MU
Other Names:
R8516 (G1)
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, Dmdl, DRP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Gria2
Name: glutamate receptor, ionotropic, AMPA2 (alpha 2)
Synonyms: GluR-B, GluR2, Glur-2, Glur2, GluA2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14800
HGNC: HGNC:4572
Homologene: 20225
Xrn1
Name: 5'-3' exoribonuclease 1
Synonyms: mXrn1, Dhm2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 24127
Homologene: 5894
Hap1
Name: huntingtin-associated protein 1
Synonyms: HAP-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15114
HGNC: HGNC:4812
Homologene: 2935
Sf3b1
Name: splicing factor 3b, subunit 1
Synonyms: SAP155, Prp10, SF3b155, 2810001M05Rik, Targ4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 81898
Homologene: 6696
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: D7H15F32S1, D15F32S1h, rjs, D7H15F37S1, jdf2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, Ankyrin-3, AnkG, 2900054D09Rik, Ankyrin-G
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Cisd2
Name: CDGSH iron sulfur domain 2
Synonyms: 1500031D15Rik, 1500026J14Rik, B630006A20Rik, 1500009M05Rik, Miner1, Zcd2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67006
Homologene: 36436
Exd1
Name: exonuclease 3'-5' domain containing 1
Synonyms: 4932702D22Rik, Exdl1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241624
Homologene: 17627
Psip1
Name: PC4 and SFRS1 interacting protein 1
Synonyms: Psip2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 101739
HGNC: HGNC:9527
Homologene: 13242
Actr8
Name: ARP8 actin-related protein 8
Synonyms: ARP8, 5730542K05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56249
VEGA: 14
Homologene: 11286
Dpp8
Name: dipeptidylpeptidase 8
Synonyms: 4932434F09Rik, 2310004I03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74388
VEGA: 9
Homologene: 57098
Uba6
Name: ubiquitin-like modifier activating enzyme 6
Synonyms: 5730469D23Rik, Ube1l2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231380
Homologene: 10080
Casc3
Name: exon junction complex subunit
Synonyms: Btz, Mln51
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192160
Homologene: 7208
Upf2
Name: UPF2 regulator of nonsense transcripts homolog (yeast)
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 326622
Homologene: 6101
Trim2
Name: tripartite motif-containing 2
Synonyms: neural activity-related ring finger protein, narf
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80890
Homologene: 22882
Zfp953
Name: zinc finger protein 953
Synonyms: E130120F12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 629016
Adamtsl1
Name: ADAMTS-like 1
Synonyms: punctin-1, 6720426B09Rik, 5930437A14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77739
Homologene: 64642
Lgr6
Name: leucine-rich repeat-containing G protein-coupled receptor 6
Synonyms: A530037C04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329252
Homologene: 49680
Eif2s1
Name: eukaryotic translation initiation factor 2, subunit 1 alpha
Synonyms: 2410026C18Rik, eIF2alpha, Eif2a, 0910001O23Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13665
HGNC: HGNC:3265
Homologene: 3020
Ppp3ca
Name: protein phosphatase 3, catalytic subunit, alpha isoform
Synonyms: PP2B alpha 1, PP2BA alpha, CnA, Caln, Calna, 2900074D19Rik, CN
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19055
HGNC: HGNC:9314
Homologene: 55497
Pop4
Name: processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae)
Synonyms: Rpp29, 1110023P21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66161
Homologene: 31392
Aasdhppt
Name: aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Synonyms: 2810407B07Rik, AASD-PPT, CGI-80, LYS5, LYS2, 2010309J24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67618
Homologene: 9130
Arhgap28
Name: Rho GTPase activating protein 28
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268970
Homologene: 18264
Peak1
Name: pseudopodium-enriched atypical kinase 1
Synonyms: 1110049L02Rik, NKF3 kinase family member, C230081A13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244895
Homologene: 18259
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269700
Homologene: 28297
Tmem167
Name: transmembrane protein 167
Synonyms: 5730424F14Rik, 0610041E09Rik, Gm10085
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66074
Homologene: 41626
Scn1a
Name: sodium channel, voltage-gated, type I, alpha
Synonyms: Nav1.1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20265
Homologene: 21375
Zc3h12a
Name: zinc finger CCCH type containing 12A
Synonyms: Mcpip1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230738
Homologene: 11824
Pgm5
Name: phosphoglucomutase 5
Synonyms: 9530034F03Rik, aciculin
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226041
HGNC: HGNC:8908
Homologene: 74881
Gpn2
Name: GPN-loop GTPase 2
Synonyms: Atpbd1b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100210
Homologene: 7006
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239420
Homologene: 65982
Vmn2r110
Name: vomeronasal 2, receptor 110
Synonyms: EG224582
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224582
Homologene: 129678
Trim30b
Name: tripartite motif-containing 30B
Synonyms: Trim30-1, A530023O14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244183
Defb7
Name: defensin beta 7
Synonyms: mBD7, Defb15
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 246080
Plch2
Name: phospholipase C, eta 2
Synonyms: PLCeta2, A930027K05Rik, Plcl4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269615
Homologene: 85172
Acte1
Name: actin, epsilon 1
Synonyms: LOC244239, Gm498
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 102636989
Homologene: 131918
Emilin1
Name: elastin microfibril interfacer 1
Synonyms: 5830419M17Rik, gp115, EMILIN-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100952
Homologene: 5117
Pde3b
Name: phosphodiesterase 3B, cGMP-inhibited
Synonyms: 9830102A01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18576
HGNC: HGNC:8779
Homologene: 709
Rgs22
Name: regulator of G-protein signalling 22
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 626596
Homologene: 75047
Piwil2
Name: piwi-like RNA-mediated gene silencing 2
Synonyms: Miwi like, mili
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 57746
VEGA: 14
Homologene: 23071
Atp8a2
Name: ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
Synonyms: Ib, wl, agil
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50769
Homologene: 4443
Vmn1r30
Name: vomeronasal 1 receptor 30
Synonyms: V1rc9, V1rc22
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171195
Homologene: 137652
Cldn15
Name: claudin 15
Synonyms: 2210009B08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 60363
HGNC: HGNC:2036
Homologene: 8646
Wnt10b
Name: wingless-type MMTV integration site family, member 10B
Synonyms: Wnt12
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22410
VEGA: 15
Homologene: 20721
Zfp112
Name: zinc finger protein 112
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57745
Homologene: 49338
P4ha3
Name: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III
Synonyms: D930031A02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320452
Homologene: 27943
Snrpa1
Name: small nuclear ribonucleoprotein polypeptide A'
Synonyms: U2 snRNP-A', 1500015N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68981
Homologene: 2325
Bahd1
Name: bromo adjacent homology domain containing 1
Synonyms: LOC228536
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228536
Homologene: 8976
Zfp786
Name: zinc finger protein 786
Synonyms: A730012O14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330301
Homologene: 51849
Or52w1
Name: olfactory receptor family 52 subfamily W member 1
Synonyms: GA_x6K02T2PBJ9-7994144-7995106, MOR36-1, Olfr692
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258352
Homologene: 64859
Hadha
Name: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
Synonyms: Mtpa
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 97212
HGNC: HGNC:4801
Homologene: 152
Spem2
Name: SPEM family member 2
Synonyms: 4933402P03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108803
Homologene: 52178
Coprs
Name: coordinator of PRMT5, differentiation stimulator
Synonyms: MGC11316, 1700029I03Rik, COPR5, 2410022L05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66423
Homologene: 10180
Wfdc18
Name: WAP four-disulfide core domain 18
Synonyms: WDNM1, Kal1, Expi
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14038
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 55,012,103 bp
  • G to T, chromosome 1 at 135,075,283 bp
  • T to C, chromosome 2 at 6,018,971 bp
  • C to T, chromosome 2 at 66,326,134 bp
  • A to G, chromosome 2 at 118,916,971 bp
  • A to T, chromosome 2 at 119,520,073 bp
  • T to C, chromosome 3 at 80,706,987 bp
  • C to T, chromosome 3 at 84,208,320 bp
  • T to C, chromosome 3 at 135,411,013 bp
  • T to A, chromosome 3 at 136,877,768 bp
  • C to T, chromosome 4 at 83,466,715 bp
  • A to G, chromosome 4 at 86,342,543 bp
  • T to C, chromosome 4 at 110,251,379 bp
  • T to A, chromosome 4 at 125,119,839 bp
  • C to T, chromosome 4 at 133,584,831 bp
  • T to C, chromosome 4 at 154,986,307 bp
  • A to T, chromosome 5 at 30,126,584 bp
  • G to A, chromosome 5 at 30,917,171 bp
  • T to C, chromosome 5 at 44,007,099 bp
  • A to C, chromosome 5 at 86,127,748 bp
  • A to T, chromosome 5 at 121,349,010 bp
  • G to T, chromosome 5 at 136,974,696 bp
  • A to T, chromosome 6 at 47,820,543 bp
  • T to G, chromosome 6 at 58,435,124 bp
  • G to A, chromosome 7 at 24,123,964 bp
  • A to T, chromosome 7 at 38,267,402 bp
  • G to A, chromosome 7 at 56,206,570 bp
  • G to A, chromosome 7 at 66,070,633 bp
  • A to G, chromosome 7 at 100,314,662 bp
  • A to G, chromosome 7 at 104,357,404 bp
  • A to G, chromosome 7 at 105,368,769 bp
  • A to T, chromosome 7 at 114,526,849 bp
  • T to A, chromosome 7 at 143,897,274 bp
  • G to T, chromosome 8 at 13,885,065 bp
  • A to T, chromosome 8 at 19,497,607 bp
  • A to T, chromosome 9 at 4,309,373 bp
  • T to C, chromosome 9 at 56,260,000 bp
  • C to A, chromosome 9 at 65,078,009 bp
  • T to A, chromosome 9 at 96,048,391 bp
  • T to A, chromosome 10 at 12,486,510 bp
  • T to A, chromosome 10 at 69,927,729 bp
  • G to A, chromosome 11 at 51,275,261 bp
  • T to C, chromosome 11 at 69,816,895 bp
  • T to A, chromosome 11 at 83,709,158 bp
  • C to T, chromosome 11 at 98,822,781 bp
  • T to C, chromosome 11 at 100,356,067 bp
  • G to A, chromosome 12 at 78,881,162 bp
  • T to A, chromosome 13 at 67,345,355 bp
  • T to A, chromosome 13 at 90,098,396 bp
  • G to T, chromosome 14 at 29,990,899 bp
  • A to T, chromosome 14 at 31,666,867 bp
  • A to C, chromosome 14 at 59,691,472 bp
  • A to G, chromosome 14 at 70,420,739 bp
  • A to G, chromosome 15 at 36,010,335 bp
  • G to A, chromosome 15 at 47,629,365 bp
  • A to T, chromosome 15 at 98,772,880 bp
  • A to G, chromosome 17 at 20,574,613 bp
  • T to C, chromosome 17 at 67,873,073 bp
  • T to A, chromosome 19 at 24,815,710 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8516 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067848-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.