Strain Name:
C57BL/6J-MtgxR8517Btlr/Mmmh
Stock Number:
067849-MU
Citation ID:
RRID:MMRRC_067849-MU
Other Names:
R8517 (G1)
Major Collection:

Strain Information

Dnajc3
Name: DnaJ heat shock protein family (Hsp40) member C3
Synonyms: Prkri, Dnajc3, p58IPK, Dnajc3a, mp58, Dnajc3b
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100037258
VEGA: 14
HGNC: HGNC:9439
Homologene: 2486
Nmu
Name: neuromedin U
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56183
HGNC: HGNC:7859
Homologene: 4863
Map7
Name: microtubule-associated protein 7
Synonyms: ste, Mtap7, mste, mshi, E-MAP-115
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17761
VEGA: 10
HGNC: HGNC:6869
Homologene: 20851
Fgd4
Name: FYVE, RhoGEF and PH domain containing 4
Synonyms: Frabin-alpha, Frabin-beta, Frabin, Frabin-gamma, 9330209B17Rik, ZFYVE6
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224014
Homologene: 26727
Pml
Name: promyelocytic leukemia
Synonyms: Trim19, 1200009E24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18854
HGNC: HGNC:9113
Homologene: 13245
Anapc5
Name: anaphase-promoting complex subunit 5
Synonyms: 2510006G12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 59008
Homologene: 41118
Gtf3c1
Name: general transcription factor III C 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233863
HGNC: HGNC:4664
Homologene: 31040
Tcof1
Name: treacle ribosome biogenesis factor 1
Synonyms: treacle
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 21453
Homologene: 68049
Pon1
Name: paraoxonase 1
Synonyms: Pon
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18979
HGNC: HGNC:9204
Homologene: 68058
Rasal2
Name: RAS protein activator like 2
Synonyms: A330066M24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226525
HGNC: HGNC:9874
Homologene: 35217
Nup85
Name: nucleoporin 85
Synonyms: Pcnt1, frount
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 445007
HGNC: HGNC:8734
Homologene: 11755
Abca17
Name: ATP-binding cassette, sub-family A member 17
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381072
Homologene: 86807
Hdc
Name: histidine decarboxylase
Synonyms: Hdc-c, L-histidine decarboxylase, Hdc-s, Hdc-e, Hdc-a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15186
HGNC: HGNC:4855
Homologene: 20490
Farsb
Name: phenylalanyl-tRNA synthetase, beta subunit
Synonyms: Farslb, Farsl, PheRS alpha, Frsb
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23874
Homologene: 4160
Ccdc171
Name: coiled-coil domain containing 171
Synonyms: 4930473A06Rik, 4930418J05Rik, A330015D16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320226
Homologene: 27942
Pbrm1
Name: polybromo 1
Synonyms: 2310032M22Rik, 2610016F04Rik, Pb1, BAF180
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66923
Homologene: 10044
Dennd5b
Name: DENN domain containing 5B
Synonyms: 9330160C06Rik, D030011O10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320560
Homologene: 44911
Tarbp1
Name: TAR RNA binding protein 1
Synonyms: Gm17296
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212728
Homologene: 38082
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Ttc8
Name: tetratricopeptide repeat domain 8
Synonyms: 0610012F22Rik, BBS8
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76260
Homologene: 14988
F5
Name: coagulation factor V
Synonyms: Cf-5, Cf5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14067
HGNC: HGNC:3542
Homologene: 104
Clspn
Name: claspin
Synonyms: E130314M08Rik, C85083
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269582
Homologene: 11138
Rims1
Name: regulating synaptic membrane exocytosis 1
Synonyms: C030033M19Rik, RIM1alpha, RIM1, RIM1a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 116837
Homologene: 128399
Myo7b
Name: myosin VIIB
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17922
HGNC: HGNC:7607
Homologene: 81947
Gprc6a
Name: G protein-coupled receptor, family C, group 6, member A
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 210198
VEGA: 10
Homologene: 17529
Kcnh2
Name: potassium voltage-gated channel, subfamily H (eag-related), member 2
Synonyms: ether a go-go related, LQT, ERG1, Lqt2, merg1b, M-erg, merg1a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16511
HGNC: HGNC:6251
Homologene: 201
Aoc1
Name: amine oxidase, copper-containing 1
Synonyms: 1600012D06Rik, Abp1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76507
HGNC: HGNC:80
Homologene: 68159
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329942
Homologene: 89034
Nwd2
Name: NACHT and WD repeat domain containing 2
Synonyms: 3110047P20Rik, B830017A01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319807
Homologene: 14974
Krtap16-1
Name: keratin associated protein 16-1
Synonyms: AI450886
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100504183
Homologene: 99988
Sart1
Name: squamous cell carcinoma antigen recognized by T cells 1
Synonyms: U5-110K
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20227
VEGA: 19
Homologene: 133770
Slfn8
Name: schlafen 8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 276950
Homologene: 45432
Kcnj12
Name: potassium inwardly-rectifying channel, subfamily J, member 12
Synonyms: IRK2, MB-IRK2, Kir2.2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16515
Homologene: 7793
Cr2
Name: complement receptor 2
Synonyms: CD35, Cr-2, Cr1, C3DR, CD21, Cr-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12902
HGNC: HGNC:2336
Homologene: 55611
Fbh1
Name: F-box DNA helicase 1
Synonyms: Fbx18, Fbxo18
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 50755
Homologene: 9272
Zbtb49
Name: zinc finger and BTB domain containing 49
Synonyms: 4930518A03Rik, Zfp509
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75079
Homologene: 34825
Dyrk2
Name: dual-specificity tyrosine phosphorylation regulated kinase 2
Synonyms: 1810038L18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69181
VEGA: 10
HGNC: HGNC:3093
Homologene: 48437
Or52n2b
Name: olfactory receptor family 52 subfamily N member 2B
Synonyms: MOR34-11, GA_x6K02T2PBJ9-7546146-7545166, Olfr667, MOR34-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259062
Homologene: 121559
Scnm1
Name: sodium channel modifier 1
Synonyms: 3110001I17Rik, Scnm1-ps
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69269
Homologene: 11431
Snph
Name: syntaphilin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241727
Homologene: 8817
Dcst1
Name: DC-STAMP domain containing 1
Synonyms: A330106H01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77772
Homologene: 14981
Fam217b
Name: family with sequence similarity 217, member B
Synonyms: 9030418K01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71532
Homologene: 49697
Cpsf4l
Name: cleavage and polyadenylation specific factor 4-like
Synonyms: 1500000C01Rik, D11Ertd636e, 0610010C04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52670
Homologene: 32669
2310002L09Rik
Name: RIKEN cDNA 2310002L09 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71886
Homologene: 36448
Zfp263
Name: zinc finger protein 263
Synonyms: 1200014J04Rik, mFPM315, NT2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74120
Homologene: 4197
Rpia
Name: ribose 5-phosphate isomerase A
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19895
Homologene: 6943
Zfp46
Name: zinc finger protein 46
Synonyms: Zfp-46
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22704
Homologene: 40684
Copz2
Name: coatomer protein complex, subunit zeta 2
Synonyms: zeta2-COP, nonclathrin coat protein zeta2-COP, 1110012D12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56358
Homologene: 69215
Pcdhgb1
Name: protocadherin gamma subfamily B, 1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93699
HGNC: HGNC:8708
Homologene: 81867
Dchs2
Name: dachsous cadherin related 2
Synonyms: LOC229459
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100534287
Igkv5-39
Name: immunoglobulin kappa variable 5-39
Synonyms: LOC384415
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 620017
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 22,483,165 bp
  • A to T, chromosome 1 at 78,463,296 bp
  • T to C, chromosome 1 at 157,146,279 bp
  • T to A, chromosome 1 at 164,176,253 bp
  • T to C, chromosome 1 at 195,155,899 bp
  • A to G, chromosome 2 at 11,777,430 bp
  • C to G, chromosome 2 at 126,597,970 bp
  • A to T, chromosome 2 at 150,268,123 bp
  • A to G, chromosome 2 at 151,593,721 bp
  • T to A, chromosome 2 at 178,420,772 bp
  • A to G, chromosome 3 at 83,271,112 bp
  • A to G, chromosome 3 at 89,365,148 bp
  • A to C, chromosome 3 at 95,132,823 bp
  • A to T, chromosome 4 at 73,942,969 bp
  • G to A, chromosome 4 at 83,743,061 bp
  • A to G, chromosome 4 at 126,566,219 bp
  • G to A, chromosome 4 at 128,552,686 bp
  • A to G, chromosome 4 at 136,291,147 bp
  • A to T, chromosome 5 at 24,326,638 bp
  • T to A, chromosome 5 at 38,200,653 bp
  • A to G, chromosome 5 at 63,791,582 bp
  • T to C, chromosome 5 at 76,345,479 bp
  • T to C, chromosome 5 at 122,821,030 bp
  • T to C, chromosome 6 at 5,171,769 bp
  • C to T, chromosome 6 at 48,906,710 bp
  • T to G, chromosome 6 at 69,900,569 bp
  • C to A, chromosome 6 at 70,766,646 bp
  • T to C, chromosome 6 at 73,178,457 bp
  • A to C, chromosome 6 at 149,029,121 bp
  • T to A, chromosome 7 at 104,916,474 bp
  • A to T, chromosome 7 at 125,654,551 bp
  • T to A, chromosome 8 at 126,444,195 bp
  • T to A, chromosome 9 at 58,220,368 bp
  • T to C, chromosome 10 at 20,261,835 bp
  • G to T, chromosome 10 at 51,631,241 bp
  • T to C, chromosome 10 at 118,861,021 bp
  • T to C, chromosome 11 at 61,069,373 bp
  • T to A, chromosome 11 at 83,004,142 bp
  • A to G, chromosome 11 at 96,853,483 bp
  • A to T, chromosome 11 at 99,985,698 bp
  • C to A, chromosome 11 at 113,708,825 bp
  • T to C, chromosome 11 at 115,564,564 bp
  • A to G, chromosome 12 at 98,943,335 bp
  • C to A, chromosome 14 at 31,067,782 bp
  • G to T, chromosome 14 at 118,953,177 bp
  • T to C, chromosome 16 at 3,746,896 bp
  • G to A, chromosome 16 at 16,422,645 bp
  • C to A, chromosome 17 at 24,317,233 bp
  • G to T, chromosome 18 at 31,967,191 bp
  • T to A, chromosome 18 at 37,682,064 bp
  • G to C, chromosome 18 at 60,829,051 bp
  • A to G, chromosome 19 at 5,383,197 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8517 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067849-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.