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Strain Name:
C57BL/6J-MtgxR8316Btlr/Mmmh
Stock Number:
067854-MU
Citation ID:
RRID:MMRRC_067854-MU
Other Names:
R8316 (G1)
Major Collection:

Strain Information

Dnmt3a
Name: DNA methyltransferase 3A
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13435
HGNC: HGNC:2978
Homologene: 7294
Pdzk1ip1
Name: PDZK1 interacting protein 1
Synonyms: 0610007F13Rik, 2700030M23Rik, Map17
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67182
Homologene: 4213
Rfc1
Name: replication factor C (activator 1) 1
Synonyms: RFC140, Alp145, 140kDa, Recc1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19687
HGNC: HGNC:9969
Homologene: 2187
Usp15
Name: ubiquitin specific peptidase 15
Synonyms: Gcap18, 4921514G19Rik, E430033I05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14479
VEGA: 10
Homologene: 101542
Mical3
Name: microtubule associated monooxygenase, calponin and LIM domain containing 3
Synonyms: MICAL-3, C130040D16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194401
Homologene: 85288
Prpf8
Name: pre-mRNA processing factor 8
Synonyms: DBF3/PRP8, Prp8, D11Bwg0410e, Sfprp8l
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192159
Homologene: 4706
Zmat3
Name: zinc finger matrin type 3
Synonyms: Wig1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22401
Homologene: 32545
Mms22l
Name: MMS22-like, DNA repair protein
Synonyms: F730047E07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 212377
Homologene: 18874
Pum2
Name: pumilio RNA-binding family member 2
Synonyms: Pumm2, 5730503J23Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 80913
Homologene: 69183
Zbtb2
Name: zinc finger and BTB domain containing 2
Synonyms: LOC381990
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 381990
VEGA: 10
Homologene: 10837
Alb
Name: albumin
Synonyms: Alb-1, Alb1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11657
HGNC: HGNC:399
Homologene: 405
Recql5
Name: RecQ protein-like 5
Synonyms: Recql5b, Recq5b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 170472
HGNC: HGNC:9950
Homologene: 31232
Fibcd1
Name: fibrinogen C domain containing 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98970
Homologene: 122246
Celf2
Name: CUGBP, Elav-like family member 2
Synonyms: Napor-2, ETR-3, B230345P09Rik, Cugbp2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14007
HGNC: HGNC:2550
Homologene: 4783
Lzic
Name: leucine zipper and CTNNBIP1 domain containing
Synonyms: 1810030J04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69151
Homologene: 12301
2610008E11Rik
Name: RIKEN cDNA 2610008E11 gene
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72128
Homologene: 86705
AW209491
Name: expressed sequence AW209491
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105351
VEGA: 13
Homologene: 11439
Marchf6
Name: membrane associated ring-CH-type finger 6
Synonyms: F830029L24Rik, March6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223455
VEGA: 15
Homologene: 4301
Zcchc2
Name: zinc finger, CCHC domain containing 2
Synonyms: 9930114B20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227449
Homologene: 9808
Itpr3
Name: inositol 1,4,5-triphosphate receptor 3
Synonyms: Itpr-3, Ip3r3, tf
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16440
HGNC: HGNC:6182
Homologene: 1675
Mecom
Name: MDS1 and EVI1 complex locus
Synonyms: ZNFPR1B1, Prdm3, MDS1-EVI1, Evi-1, D630039M04Rik, Jbo, Evi1, Mds1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14013
HGNC: HGNC:3498
Homologene: 21086
Dcn
Name: decorin
Synonyms: DC, SLRR1B
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13179
VEGA: 10
HGNC: HGNC:2705
Homologene: 22430
Aqp9
Name: aquaporin 9
Synonyms: 1700020I22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 64008
HGNC: HGNC:643
Homologene: 41405
Pld1
Name: phospholipase D1
Synonyms: Pld1b, Pld1a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18805
HGNC: HGNC:9067
Homologene: 116234
Myh15
Name: myosin, heavy chain 15
Synonyms: EG667772
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 667772
VEGA: 16
Homologene: 18929
Ush2a
Name: usherin
Synonyms: MUSH2A, A930011D15Rik, LOC381317, LOC269160, A930037M10Rik, Ushrn, Ush2a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Trim80
Name: tripartite motif-containing 80
Synonyms: 4933422H20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 432613
Homologene: 46325
Uspl1
Name: ubiquitin specific peptidase like 1
Synonyms: E430026A01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231915
Homologene: 4235
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: A230061D21Rik, LOC235639, C030048J01Rik, Lba1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320429
Homologene: 45845
Mroh8
Name: maestro heat-like repeat family member 8
Synonyms: 4922505G16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 629499
Homologene: 51864
Plcxd1
Name: phosphatidylinositol-specific phospholipase C, X domain containing 1
Synonyms: LOC231597, A330045H12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 403178
Homologene: 138628
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243369
Homologene: 45453
Cmpk2
Name: cytidine/uridine monophosphate kinase 2
Synonyms: TDKI, 1200004E04Rik, Tyki
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22169
VEGA: 12
Homologene: 10748
Slco1c1
Name: solute carrier organic anion transporter family, member 1c1
Synonyms: OATP-F, Slc21a14
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58807
Homologene: 23008
Or5p5
Name: olfactory receptor family 5 subfamily P member 5
Synonyms: GA_x6K02T2PBJ9-10144091-10145011, MOR204-33P, Olfr467
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257919
Homologene: 81542
4933427D14Rik
Name: RIKEN cDNA 4933427D14 gene
Synonyms: Gm43951
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74477
Homologene: 8874
Aox4
Name: aldehyde oxidase 4
Synonyms: AOH2, 2310003G12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71872
Homologene: 70273
Ehhadh
Name: enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
Synonyms: HD, MFP, L-bifunctional enzyme, L-PBE, 1300002P22Rik, MFP1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74147
HGNC: HGNC:3247
Homologene: 1486
Ccdc57
Name: coiled-coil domain containing 57
Synonyms: 4933434G05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71276
Homologene: 52351
Or6c70
Name: olfactory receptor family 6 subfamily C member 70
Synonyms: GA_x6K02T2PULF-11553313-11552381, MOR113-5, MOR113-8, Olfr814
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 259165
Homologene: 133585
Ppm1n
Name: protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232941
Homologene: 58958
Abcc10
Name: ATP-binding cassette, sub-family C member 10
Synonyms: Mrp7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224814
HGNC: HGNC:52
Homologene: 58616
Or5p58
Name: olfactory receptor family 5 subfamily P member 58
Synonyms: GA_x6K02T2PBJ9-10424354-10423383, MOR204-14, Olfr482
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258728
Homologene: 133604
Or51a10
Name: olfactory receptor family 51 subfamily A member 10
Synonyms: GA_x6K02T2PBJ9-6784380-6783436, MOR13-6, Olfr642
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258326
Homologene: 17196
Spata9
Name: spermatogenesis associated 9
Synonyms: 4930599C08Rik, 1700030K01Rik, A930023H06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75571
VEGA: 13
Homologene: 12609
Cfap210
Name: cilia and flagella associated protein 210
Synonyms: 4930525K21Rik, 4930578N16Rik, Ccdc173
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75051
Homologene: 18989
Ugt2b34
Name: UDP glucuronosyltransferase 2 family, polypeptide B34
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100727
Homologene: 117389
Txndc16
Name: thioredoxin domain containing 16
Synonyms: 5730420B22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70561
Homologene: 18197
Septin14
Name: septin 14
Synonyms: 1700016K13Rik, Sept14
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74222
Homologene: 87501
Gpr156
Name: G protein-coupled receptor 156
Synonyms: Gababl
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239845
VEGA: 16
Homologene: 17683
Sri
Name: sorcin
Synonyms: Sor, 2210417O06Rik, 2900070H08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 109552
Homologene: 37736
Msl1
Name: male specific lethal 1
Synonyms: 4930463F05Rik, 2810017F12Rik, 4121402D02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74026
Homologene: 129785
Fam150b
Name:
Type: Gene
Species: Mouse
Chromosome: 12
Smok2a
Name: sperm motility kinase 2A
Synonyms: Smok2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27263
Homologene: 128738
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 58,254,311 bp
  • A to G, chromosome 1 at 106,032,114 bp
  • G to T, chromosome 1 at 188,446,702 bp
  • C to T, chromosome 2 at 6,547,103 bp
  • T to C, chromosome 2 at 31,833,779 bp
  • A to G, chromosome 2 at 69,781,943 bp
  • G to T, chromosome 2 at 157,229,959 bp
  • A to G, chromosome 3 at 28,024,212 bp
  • C to T, chromosome 3 at 29,957,380 bp
  • T to C, chromosome 3 at 32,341,521 bp
  • T to C, chromosome 4 at 24,578,855 bp
  • G to T, chromosome 4 at 48,426,199 bp
  • T to A, chromosome 4 at 115,089,126 bp
  • C to T, chromosome 4 at 149,488,070 bp
  • A to G, chromosome 5 at 8,063,317 bp
  • T to C, chromosome 5 at 65,278,734 bp
  • T to A, chromosome 5 at 86,891,390 bp
  • A to G, chromosome 5 at 90,468,590 bp
  • A to T, chromosome 5 at 110,102,314 bp
  • A to G, chromosome 5 at 129,696,130 bp
  • C to T, chromosome 5 at 149,198,681 bp
  • G to A, chromosome 6 at 48,482,688 bp
  • T to C, chromosome 6 at 120,934,983 bp
  • T to A, chromosome 6 at 141,546,914 bp
  • T to C, chromosome 7 at 19,278,377 bp
  • A to T, chromosome 7 at 104,049,622 bp
  • G to T, chromosome 7 at 107,814,823 bp
  • A to G, chromosome 7 at 108,095,243 bp
  • G to A, chromosome 8 at 21,134,693 bp
  • A to G, chromosome 9 at 71,138,213 bp
  • A to G, chromosome 9 at 111,349,302 bp
  • A to C, chromosome 10 at 4,369,084 bp
  • A to C, chromosome 10 at 79,067,739 bp
  • T to C, chromosome 10 at 97,495,077 bp
  • G to T, chromosome 10 at 123,123,943 bp
  • A to G, chromosome 10 at 129,874,022 bp
  • A to T, chromosome 11 at 72,168,786 bp
  • A to G, chromosome 11 at 75,499,815 bp
  • A to T, chromosome 11 at 98,800,248 bp
  • A to T, chromosome 11 at 115,441,180 bp
  • G to A, chromosome 11 at 115,894,035 bp
  • C to T, chromosome 11 at 120,885,916 bp
  • T to A, chromosome 12 at 3,896,965 bp
  • T to A, chromosome 12 at 8,713,456 bp
  • A to G, chromosome 12 at 26,474,137 bp
  • G to T, chromosome 12 at 30,884,851 bp
  • A to G, chromosome 13 at 14,637,764 bp
  • C to A, chromosome 13 at 75,977,771 bp
  • A to G, chromosome 14 at 45,211,184 bp
  • T to C, chromosome 14 at 61,189,619 bp
  • G to A, chromosome 15 at 4,951,264 bp
  • A to G, chromosome 15 at 31,482,504 bp
  • G to A, chromosome 16 at 21,766,303 bp
  • A to G, chromosome 16 at 37,997,974 bp
  • C to A, chromosome 16 at 49,120,018 bp
  • T to C, chromosome 17 at 13,226,273 bp
  • T to C, chromosome 17 at 27,106,225 bp
  • A to G, chromosome 17 at 36,168,262 bp
  • G to T, chromosome 17 at 46,327,809 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8316 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067854-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.