Strain Name:
C57BL/6J-MtgxR8333Btlr/Mmmh
Stock Number:
067861-MU
Citation ID:
RRID:MMRRC_067861-MU
Other Names:
R8333 (G1)
Major Collection:

Strain Information

Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, Acf7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Mrpl13
Name: mitochondrial ribosomal protein L13
Synonyms: 1110002D09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68537
Homologene: 90894
Rabgap1
Name: RAB GTPase activating protein 1
Synonyms: Gapcena
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227800
Homologene: 49301
Dcp1a
Name: decapping mRNA 1A
Synonyms: 4930568L04Rik, SMIF, Mitc1, 1110066A22Rik, D14Ertd817e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 75901
VEGA: 14
Homologene: 10178
Kctd17
Name: potassium channel tetramerisation domain containing 17
Synonyms: 2900008M13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72844
Homologene: 23468
Ncapg
Name: non-SMC condensin I complex, subunit G
Synonyms: Hcapg, MFT.M05.13, 5730507H05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54392
Homologene: 44071
Usp33
Name: ubiquitin specific peptidase 33
Synonyms: 9830169D19Rik, Vdu1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170822
Homologene: 8996
Amigo2
Name: adhesion molecule with Ig like domain 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105827
VEGA: 15
Homologene: 18649
Pax7
Name: paired box 7
Synonyms: Pax-7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18509
HGNC: HGNC:8621
Homologene: 55665
Cdh23
Name: cadherin related 23 (otocadherin)
Synonyms: mdfw, ahl, nmf112, nmf252, 4930542A03Rik, nmf181, sals, USH1D, bob
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22295
Homologene: 11142
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: Scy, Crsh, Adgrc1, crash
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Scn2a
Name: sodium channel, voltage-gated, type II, alpha
Synonyms: Nav1.2, Scn2a1, A230052E19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110876
Homologene: 75001
Dlgap2
Name: DLG associated protein 2
Synonyms: DAP2, Sapap2, 6430596N04Rik, SAP90/PSD-95-associated protein 2, PSD-95/SAP90-binding protein 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244310
HGNC: HGNC:2906
Homologene: 3484
Stard9
Name: StAR related lipid transfer domain containing 9
Synonyms: E230025N21Rik, Kif16a, 4831403C07Rik, N-3 kinesin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668880
Homologene: 130712
Ecm2
Name: extracellular matrix protein 2, female organ and adipocyte specific
Synonyms: tenonectin, 9030618O22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 407800
VEGA: 13
HGNC: HGNC:3154
Homologene: 1064
Baiap2l1
Name: BAI1-associated protein 2-like 1
Synonyms: 1300006M19Rik, IRTKS
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66898
Homologene: 23123
Pbk
Name: PDZ binding kinase
Synonyms: 2810434B10Rik, D14Ertd732e, TOPK
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 52033
Homologene: 32415
Cerkl
Name: ceramide kinase-like
Synonyms: Rp26
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228094
Homologene: 52396
Lrrc19
Name: leucine rich repeat containing 19
Synonyms: 9130022A01Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100061
Homologene: 36410
Padi6
Name: peptidyl arginine deiminase, type VI
Synonyms: Padi5, Pad6, ePAD
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242726
Homologene: 17695
Slc45a3
Name: solute carrier family 45, member 3
Synonyms: IPCA-6, 2210413P12Rik, Pcanap6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 212980
HGNC: HGNC:8642
Homologene: 23813
Lrrc9
Name: leucine rich repeat containing 9
Synonyms: 4921529O18Rik, 4930432K16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 78257
Homologene: 12692
Cfap43
Name: cilia and flagella associated protein 43
Synonyms: Wdr96, 4930428C11Rik, 4930463G05Rik, D19Ertd652e, 4632415N18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 100048534
Homologene: 36425
Or8c11
Name: olfactory receptor family 8 subfamily C member 11
Synonyms: Olfr900, GA_x6K02T2PVTD-32071567-32072508, MOR170-15, MOR170-13, MOR170-2, GA_x6K02T2MYUG-9124-8183, Olfr251
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 404313
VEGA: 9
Homologene: 133654
Cldn13
Name: claudin 13
Synonyms: 2500004B14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57255
HGNC: HGNC:2046
Slc40a1
Name: solute carrier family 40 (iron-regulated transporter), member 1
Synonyms: Dusg, MTP1, FPN1, Ol5, Pcm, Slc11a3, ferroportin1, metal transporting protein 1, IREG1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 53945
Homologene: 40959
Tle2
Name: transducin-like enhancer of split 2
Synonyms: Grg2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21886
Homologene: 20693
BC005624
Name: cDNA sequence BC005624
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227707
Homologene: 9551
Gpr182
Name: G protein-coupled receptor 182
Synonyms: Admr, Gpcr17, G10-D, AM-R, NOW, Gpcr22
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11536
Homologene: 5255
Wdr38
Name: WD repeat domain 38
Synonyms: 1700123D08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76646
Homologene: 79011
Grid1
Name: glutamate receptor, ionotropic, delta 1
Synonyms: GluRdelta1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14803
HGNC: HGNC:4575
Homologene: 69017
Rhno1
Name: RAD9-HUS1-RAD1 interacting nuclear orphan 1
Synonyms: 2510047L19Rik, 5930416I19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72440
Gpr156
Name: G protein-coupled receptor 156
Synonyms: Gababl
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239845
VEGA: 16
Homologene: 17683
Chfr
Name: checkpoint with forkhead and ring finger domains
Synonyms: RNF116, 5730484M20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231600
Homologene: 10078
Cyb5rl
Name: cytochrome b5 reductase-like
Synonyms: 2810410C14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230582
Homologene: 45506
Nim1k
Name: NIM1 serine/threonine protein kinase
Synonyms: E130304F04Rik, Nim1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 245269
VEGA: 13
Homologene: 25286
Igkv8-34
Name: immunoglobulin kappa variable 8-34
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 620126
HGNC: HGNC:5834
Or8k31-ps1
Name: olfactory receptor family 8 subfamily K member 31, pseudogene 1
Synonyms: GA_x6K02T2Q125-48011447-48010506, Olfr1077-ps1, MOR189-4P
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 625853
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 45,911,279 bp
  • A to G, chromosome 1 at 131,978,190 bp
  • G to T, chromosome 2 at 30,973,736 bp
  • C to T, chromosome 2 at 37,495,698 bp
  • T to C, chromosome 2 at 38,999,349 bp
  • A to C, chromosome 2 at 65,683,847 bp
  • C to T, chromosome 2 at 76,723,594 bp
  • A to G, chromosome 2 at 79,338,578 bp
  • A to T, chromosome 2 at 86,526,071 bp
  • T to A, chromosome 2 at 120,701,789 bp
  • C to T, chromosome 3 at 152,374,660 bp
  • T to A, chromosome 4 at 94,639,350 bp
  • T to A, chromosome 4 at 107,068,678 bp
  • T to C, chromosome 4 at 123,385,452 bp
  • T to A, chromosome 4 at 139,830,203 bp
  • T to C, chromosome 4 at 140,737,376 bp
  • C to T, chromosome 5 at 45,674,463 bp
  • G to A, chromosome 5 at 110,154,937 bp
  • T to A, chromosome 5 at 134,914,996 bp
  • A to C, chromosome 5 at 144,280,881 bp
  • T to C, chromosome 6 at 70,044,353 bp
  • G to T, chromosome 6 at 128,357,765 bp
  • T to A, chromosome 8 at 14,778,295 bp
  • G to A, chromosome 9 at 38,378,616 bp
  • T to A, chromosome 10 at 60,314,611 bp
  • C to T, chromosome 10 at 81,577,684 bp
  • T to C, chromosome 10 at 127,749,921 bp
  • C to T, chromosome 12 at 72,481,543 bp
  • T to C, chromosome 13 at 49,518,383 bp
  • G to A, chromosome 13 at 119,712,486 bp
  • A to G, chromosome 14 at 30,522,926 bp
  • T to C, chromosome 14 at 35,569,638 bp
  • T to A, chromosome 14 at 65,817,231 bp
  • A to G, chromosome 15 at 55,557,283 bp
  • CAGCTGGAGGAGC to CAGC, chromosome 15 at 78,436,913 bp
  • T to C, chromosome 15 at 86,031,414 bp
  • T to C, chromosome 15 at 97,245,285 bp
  • T to C, chromosome 16 at 37,992,054 bp
  • G to T, chromosome 19 at 47,897,326 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8333 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067861-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.