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Strain Name:
C57BL/6J-MtgxR8335Btlr/Mmmh
Stock Number:
067863-MU
Citation ID:
RRID:MMRRC_067863-MU
Other Names:
R8335 (G1)
Major Collection:

Strain Information

Ptpn3
Name: protein tyrosine phosphatase, non-receptor type 3
Synonyms: PTPCL, 9530011I20Rik, PTP-H1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 545622
HGNC: HGNC:9655
Homologene: 74451
Xpo1
Name: exportin 1
Synonyms: Crm1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103573
Homologene: 2554
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: DHC1b, DHC2, 4432416O06Rik, D330044F14Rik, D030010H02Rik, Dnchc2, b2b414Clo, m407Asp, m152Asp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Paxip1
Name: PAX interacting (with transcription-activation domain) protein 1
Synonyms: PTIP, D5Ertd149e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 55982
HGNC: HGNC:8624
Ccdc47
Name: coiled-coil domain containing 47
Synonyms: asp4, 2610204L23Rik, calumin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67163
Homologene: 41351
Trhde
Name: TRH-degrading enzyme
Synonyms: 9330155P21Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237553
Homologene: 75007
Sox6
Name: SRY (sex determining region Y)-box 6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20679
Homologene: 22631
Sall3
Name: spalt like transcription factor 3
Synonyms: Msal, Msal-1, Spalt, Salt, B130022O04Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20689
VEGA: 18
Homologene: 18142
Depdc1a
Name: DEP domain containing 1a
Synonyms: 5830484J08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76131
Homologene: 9834
Mttp
Name: microsomal triglyceride transfer protein
Synonyms: MTP, 1810043K16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17777
HGNC: HGNC:7467
Homologene: 212
Tnfsf8
Name: tumor necrosis factor (ligand) superfamily, member 8
Synonyms: Cd30L, CD153, CD30LG
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21949
Homologene: 950
Plekhg4
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 4
Synonyms: 4931414L13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102075
Homologene: 18516
Tnn
Name: tenascin N
Synonyms: Tnw, tenascin-W
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329278
Homologene: 18634
Mink1
Name: misshapen-like kinase 1 (zebrafish)
Synonyms: Misshapen/NIKs-related kinase, MINK, Ysk2, Map4k6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 50932
Homologene: 56762
Pxdn
Name: peroxidasin
Synonyms: 2310075M15Rik, VPO1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 69675
Homologene: 33907
Synpo2
Name: synaptopodin 2
Synonyms: myopodin, Myo, 9530006G20Rik, 1110069I04Rik, 2310068J10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 118449
Homologene: 15400
Stat2
Name: signal transducer and activator of transcription 2
Synonyms: 1600010G07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20847
VEGA: 10
Homologene: 3952
Vsig10
Name: V-set and immunoglobulin domain containing 10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231668
Homologene: 10414
Mug2
Name: murinoglobulin 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17837
HGNC: HGNC:9750
Homologene: 136663
Il27ra
Name: interleukin 27 receptor, alpha
Synonyms: WSX-1, IL-27R, Tccr
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50931
Homologene: 3562
Spata20
Name: spermatogenesis associated 20
Synonyms: Tisp78
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217116
Homologene: 11264
Pkp3
Name: plakophilin 3
Synonyms: 2310056L12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56460
HGNC: HGNC:9025
Homologene: 5200
Zfp616
Name: zinc finger protein 616
Synonyms: Gm12330
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327963
Homologene: 88945
Or4a67
Name: olfactory receptor family 4 subfamily A member 67
Synonyms: GA_x6K02T2Q125-50243231-50242221, MOR225-12, Olfr1200
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257887
Homologene: 123770
Vmn1r209
Name: vomeronasal 1 receptor 209
Synonyms: Gm11315
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 432736
Homologene: 110880
Tmem214
Name: transmembrane protein 214
Synonyms: 4921530J21Rik, 1110039B18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68796
Homologene: 9801
Prss33
Name: serine protease 33
Synonyms: tryptase-6, mT6, Eos
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 353130
Homologene: 77185
Or10ag57
Name: olfactory receptor family 10 subfamily AG member 57
Synonyms: GA_x6K02T2Q125-48880078-48881058, MOR264-1, Olfr1122
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259033
Homologene: 73977
Pm20d2
Name: peptidase M20 domain containing 2
Synonyms: LOC242377, Acy1l2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242377
Homologene: 19025
Mfsd8
Name: major facilitator superfamily domain containing 8
Synonyms: 2810423E13Rik, Cln7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72175
Homologene: 115814
Or8k3b
Name: olfactory receptor family 8 subfamily K member 3B
Synonyms: GA_x6K02T2Q125-48182406-48181465, MOR188-5, Olfr1087
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258843
Tacr2
Name: tachykinin receptor 2
Synonyms: Tac2r
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21337
VEGA: 10
Homologene: 55548
Or13l2
Name: olfactory receptor family 13 subfamily L member 2
Synonyms: GA_x6K02T2R76Y-3201307-3200360, MOR217-1, Olfr1402
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 258272
VEGA: 3
Homologene: 17165
Vmn2r29
Name: vomeronasal 2, receptor 29
Synonyms: 6430701C03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76229
Homologene: 113703
Gm6356
Name: predicted gene 6356
Type: Gene
Species: Mouse
Chromosome: 14
Ttc6
Name: tetratricopeptide repeat domain 6
Synonyms: LOC217602, EG639426, Gm9813, 4921506M07Rik, AU024163
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70846
Homologene: 78002
Gatb
Name: glutamyl-tRNA amidotransferase subunit B
Synonyms: 9430026F02Rik, Pet112l, Pet112
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229487
HGNC: HGNC:8849
Homologene: 3357
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 160,118,483 bp
  • T to A, chromosome 2 at 86,690,168 bp
  • A to G, chromosome 2 at 87,387,860 bp
  • G to T, chromosome 2 at 88,767,773 bp
  • G to A, chromosome 2 at 91,170,239 bp
  • G to A, chromosome 3 at 40,835,193 bp
  • T to C, chromosome 3 at 85,574,321 bp
  • T to C, chromosome 3 at 97,410,708 bp
  • T to A, chromosome 3 at 123,114,534 bp
  • C to T, chromosome 3 at 138,103,212 bp
  • C to A, chromosome 3 at 159,523,222 bp
  • T to C, chromosome 4 at 33,189,245 bp
  • A to T, chromosome 4 at 57,235,286 bp
  • A to G, chromosome 4 at 63,834,115 bp
  • T to C, chromosome 5 at 27,766,124 bp
  • A to G, chromosome 5 at 30,872,122 bp
  • T to C, chromosome 5 at 117,348,370 bp
  • A to T, chromosome 6 at 122,040,584 bp
  • A to G, chromosome 7 at 7,231,446 bp
  • G to A, chromosome 7 at 115,701,714 bp
  • T to C, chromosome 7 at 141,087,756 bp
  • A to T, chromosome 8 at 84,039,501 bp
  • G to T, chromosome 8 at 105,376,216 bp
  • A to T, chromosome 9 at 7,084,941 bp
  • A to T, chromosome 10 at 62,265,167 bp
  • A to G, chromosome 10 at 114,486,704 bp
  • G to A, chromosome 10 at 128,276,583 bp
  • T to G, chromosome 11 at 23,280,603 bp
  • C to T, chromosome 11 at 70,609,575 bp
  • A to T, chromosome 11 at 74,083,900 bp
  • T to C, chromosome 11 at 94,482,543 bp
  • C to G, chromosome 11 at 106,208,258 bp
  • T to C, chromosome 11 at 106,208,259 bp
  • A to G, chromosome 12 at 30,002,097 bp
  • A to G, chromosome 12 at 57,660,291 bp
  • A to C, chromosome 12 at 115,604,124 bp
  • T to A, chromosome 13 at 22,805,807 bp
  • A to G, chromosome 14 at 6,971,838 bp
  • A to G, chromosome 17 at 23,834,595 bp
  • G to A, chromosome 18 at 80,969,586 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8335 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067863-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.