Strain Name:
C57BL/6J-MtgxR8341Btlr/Mmmh
Stock Number:
067865-MU
Citation ID:
RRID:MMRRC_067865-MU
Other Names:
R8341 (G1)
Major Collection:

Strain Information

Map2k5
Name: mitogen-activated protein kinase kinase 5
Synonyms: MEK5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23938
VEGA: 9
HGNC: HGNC:6845
Homologene: 115933
Rbx1
Name: ring-box 1
Synonyms: ROC1, 1500002P15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 56438
VEGA: 15
HGNC: HGNC:9928
Homologene: 134530
Kmt2e
Name: lysine (K)-specific methyltransferase 2E
Synonyms: D230038D11Rik, 1810033J14Rik, Mll5, 9530077A04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69188
Homologene: 18822
Slc44a2
Name: solute carrier family 44, member 2
Synonyms: CTL2, 1110028E10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68682
VEGA: 9
Homologene: 10711
Thbs3
Name: thrombospondin 3
Synonyms: Thbs-3, TSP3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 21827
Homologene: 5159
Tnks
Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Synonyms: D130072O21Rik, 4930554K12Rik, mTNKS1, TANK1, tankyrase 1, Parp5a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21951
Homologene: 18405
Ints9
Name: integrator complex subunit 9
Synonyms: D14Ertd231e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 210925
VEGA: 14
Homologene: 10096
Slc12a2
Name: solute carrier family 12, member 2
Synonyms: sodium/potassium/chloride cotransporters, sy-ns, Nkcc1, mBSC2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20496
VEGA: 18
Homologene: 20283
Arfgef1
Name: ADP ribosylation factor guanine nucleotide exchange factor 1
Synonyms: D730028O18Rik, D130059B05Rik, BIG1, ARFGEP1, P200
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211673
Homologene: 4687
Zgrf1
Name: zinc finger, GRF-type containing 1
Synonyms: 4930422G04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71643
Homologene: 34708
Itprid2
Name: ITPR interacting domain containing 2
Synonyms: Ssfa2, CS1, CS-1, SPAG13, KRAP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70599
Homologene: 4912
Ptbp1
Name: polypyrimidine tract binding protein 1
Synonyms: Ptb, hnRNP I
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19205
HGNC: HGNC:9583
Homologene: 49188
Camkmt
Name: calmodulin-lysine N-methyltransferase
Synonyms: 1700106N22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 73582
VEGA: 17
Homologene: 11704
Ppp1r7
Name: protein phosphatase 1, regulatory subunit 7
Synonyms: SDS22, 2310014J01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66385
HGNC: HGNC:9295
Homologene: 2032
Adam11
Name: a disintegrin and metallopeptidase domain 11
Synonyms: Mdc
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11488
HGNC: HGNC:189
Homologene: 7614
Eif2ak1
Name: eukaryotic translation initiation factor 2 alpha kinase 1
Synonyms: Hri
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15467
Homologene: 8290
Lyn
Name: LYN proto-oncogene, Src family tyrosine kinase
Synonyms: Hck-2, Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17096
HGNC: HGNC:6735
Homologene: 55649
Klrk1
Name: killer cell lectin-like receptor subfamily K, member 1
Synonyms: NKG2-D, Nkg2d, D6H12S2489E
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 27007
Homologene: 7209
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: perlecan, Plc, Pcn, per
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Osbpl7
Name: oxysterol binding protein-like 7
Synonyms: 4933437E18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71240
Homologene: 79672
Clp1
Name: CLP1, cleavage and polyadenylation factor I subunit
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98985
Homologene: 4975
Qser1
Name: glutamine and serine rich 1
Synonyms: 4732486I23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99003
Homologene: 11710
Szt2
Name: SZT2 subunit of KICSTOR complex
Synonyms: seaizure threshold 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230676
Homologene: 49413
Amfr
Name: autocrine motility factor receptor
Synonyms: gp78
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23802
HGNC: HGNC:463
Homologene: 888
Cubn
Name: cubilin
Synonyms: intrinsic factor-cobalamin receptor, D2Wsu88e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Uckl1
Name: uridine-cytidine kinase 1-like 1
Synonyms: Urkl1, 1110007H10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68556
Homologene: 101414
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329178
Homologene: 122243
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Olfm2
Name: olfactomedin 2
Synonyms: A030009A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244723
VEGA: 9
Homologene: 14380
Myo7b
Name: myosin VIIB
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17922
HGNC: HGNC:7607
Homologene: 81947
Map6
Name: microtubule-associated protein 6
Synonyms: Mtap6, F-STOP, 2810411E12Rik, STOP
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17760
HGNC: HGNC:6868
Homologene: 7850
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239420
Homologene: 65982
Henmt1
Name: HEN1 methyltransferase homolog 1 (Arabidopsis)
Synonyms: 4921515J06Rik, Hen1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66715
Homologene: 32638
Abca8b
Name: ATP-binding cassette, sub-family A member 8b
Synonyms: Abca8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 27404
HGNC: HGNC:38
Homologene: 56029
Or2b4
Name: olfactory receptor family 2 subfamily B member 4
Synonyms: A3, GA_x6K02T2PSCP-2264806-2265753, Olfr124, MOR256-3, SR1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 259064
Homologene: 74266
Myo1c
Name: myosin IC
Synonyms: myosin-Ibeta, mm1beta, myr2, C80397
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17913
HGNC: HGNC:7597
Homologene: 32046
Vmn2r73
Name: vomeronasal 2, receptor 73
Synonyms: EG620928
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 620928
Homologene: 115466
Map3k13
Name: mitogen-activated protein kinase kinase kinase 13
Synonyms: C130026N12Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 71751
VEGA: 16
HGNC: HGNC:6852
Homologene: 37958
C1s1
Name: complement component 1, s subcomponent 1
Synonyms: C1s
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50908
HGNC: HGNC:1247
Homologene: 1314
Vsig10l
Name: V-set and immunoglobulin domain containing 10 like
Synonyms: 2210412E05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75690
Homologene: 35386
Serpinb9f
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9f
Synonyms: Spi13, NK21, ovalbumin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20709
HGNC: HGNC:8955
Homologene: 69093
Ano9
Name: anoctamin 9
Synonyms: 5430425C04Rik, Tp53i5, Trp53i5, Tmem16j
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71345
Homologene: 67083
St6galnac1
Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Synonyms: Siat7a, ST6GalNAc I
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20445
Homologene: 7937
Ceacam15
Name: CEA cell adhesion molecule 15
Synonyms: C430002N04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101434
Homologene: 131210
Shisa9
Name: shisa family member 9
Synonyms: CKAMP44, 2700045P11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72555
Homologene: 109462
Bace2
Name: beta-site APP-cleaving enzyme 2
Synonyms: 1110059C24Rik, ALP56, BAE2, CEAP1, ARP1, ASP21, CDA13
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 56175
VEGA: 16
HGNC: HGNC:934
Homologene: 22696
Rft1
Name: RFT1 homolog
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 328370
Homologene: 5343
Frk
Name: fyn-related kinase
Synonyms: GTK, BSK/IYK
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14302
VEGA: 10
HGNC: HGNC:3955
Homologene: 48065
Srarp
Name: steroid receptor associated and regulated protein
Synonyms: LOC277744, Gm694
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 277744
Homologene: 18717
Zswim5
Name: zinc finger SWIM-type containing 5
Synonyms: 4933426E21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74464
Homologene: 18958
Krtap5-21
Name: keratin associated protein 5-21
Synonyms: Gm7579
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 105243090
Slc23a1
Name: solute carrier family 23 (nucleobase transporters), member 1
Synonyms: Slc23a2, YSPL3, SVCT1, D18Ucla2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20522
Homologene: 40769
Ttc4
Name: tetratricopeptide repeat domain 4
Synonyms: L62, 2810002P21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72354
Homologene: 31249
Fez1
Name: fasciculation and elongation protein zeta 1
Synonyms: UNC-76, zygin I, UNC76
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235180
HGNC: HGNC:3659
Homologene: 21063
Ppp4r3c2
Name: protein phosphatase 4 regulatory subunit 3C2
Synonyms: 4932429P05Rik
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 245509
Homologene: 87617
Dpp4
Name: dipeptidylpeptidase 4
Synonyms: Cd26, THAM, Dpp-4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13482
HGNC: HGNC:3009
Homologene: 3279
B3gnt9
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
Synonyms: B3gnt9-ps
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 97440
Homologene: 13250
Snx21
Name: sorting nexin family member 21
Synonyms: 5730407K14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 101113
Homologene: 43132
Stambpl1
Name: STAM binding protein like 1
Synonyms: 8230401J17Rik, 1700095N21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76630
Homologene: 23253
Mpv17
Name: MpV17 mitochondrial inner membrane protein
Synonyms: Tg.Mpv17
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17527
HGNC: HGNC:7224
Homologene: 39746
Klhl41
Name: kelch-like 41
Synonyms: LOC228003, Kbtbd10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228003
Homologene: 4421
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 10,154,328 bp
  • T to C, chromosome 1 at 66,649,033 bp
  • G to A, chromosome 1 at 93,346,278 bp
  • C to A, chromosome 2 at 13,428,724 bp
  • C to T, chromosome 2 at 62,347,890 bp
  • T to C, chromosome 2 at 69,670,524 bp
  • A to T, chromosome 2 at 79,657,718 bp
  • T to C, chromosome 2 at 84,723,773 bp
  • A to G, chromosome 2 at 104,789,475 bp
  • A to G, chromosome 2 at 164,791,885 bp
  • T to A, chromosome 2 at 181,569,719 bp
  • G to A, chromosome 3 at 89,225,391 bp
  • T to C, chromosome 3 at 108,958,592 bp
  • T to A, chromosome 3 at 127,560,915 bp
  • T to C, chromosome 4 at 3,743,304 bp
  • A to G, chromosome 4 at 106,665,696 bp
  • A to G, chromosome 4 at 116,986,792 bp
  • G to T, chromosome 4 at 118,392,836 bp
  • C to G, chromosome 4 at 137,518,979 bp
  • T to C, chromosome 4 at 141,433,396 bp
  • A to T, chromosome 5 at 23,499,453 bp
  • A to C, chromosome 5 at 31,154,103 bp
  • A to T, chromosome 5 at 143,884,937 bp
  • C to T, chromosome 6 at 124,531,156 bp
  • T to C, chromosome 6 at 129,622,700 bp
  • C to A, chromosome 7 at 16,672,003 bp
  • T to C, chromosome 7 at 43,463,954 bp
  • T to A, chromosome 7 at 85,857,920 bp
  • A to G, chromosome 7 at 99,268,440 bp
  • T to A, chromosome 7 at 141,102,334 bp
  • T to A, chromosome 7 at 142,212,119 bp
  • A to T, chromosome 8 at 34,873,045 bp
  • A to G, chromosome 8 at 93,999,178 bp
  • C to T, chromosome 8 at 105,253,865 bp
  • C to T, chromosome 9 at 20,672,622 bp
  • T to C, chromosome 9 at 21,342,199 bp
  • T to C, chromosome 9 at 36,876,309 bp
  • T to A, chromosome 9 at 63,339,098 bp
  • G to A, chromosome 10 at 34,586,283 bp
  • A to C, chromosome 10 at 79,863,211 bp
  • C to T, chromosome 11 at 75,671,427 bp
  • T to G, chromosome 11 at 97,060,163 bp
  • C to A, chromosome 11 at 102,776,536 bp
  • T to A, chromosome 11 at 109,955,050 bp
  • T to A, chromosome 11 at 116,768,888 bp
  • T to A, chromosome 13 at 33,327,307 bp
  • T to C, chromosome 14 at 30,689,881 bp
  • T to A, chromosome 14 at 65,036,414 bp
  • T to C, chromosome 15 at 47,698,151 bp
  • T to C, chromosome 15 at 81,473,877 bp
  • T to C, chromosome 16 at 11,997,151 bp
  • G to T, chromosome 16 at 21,921,584 bp
  • A to T, chromosome 16 at 37,071,771 bp
  • C to T, chromosome 16 at 97,356,908 bp
  • G to A, chromosome 17 at 37,805,652 bp
  • T to C, chromosome 17 at 85,439,580 bp
  • T to C, chromosome 18 at 31,983,926 bp
  • C to T, chromosome 18 at 35,622,535 bp
  • T to G, chromosome 18 at 57,879,209 bp
  • A to T, chromosome 19 at 34,234,001 bp
  • A to T, chromosome X at 89,754,716 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8341 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067865-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.