Strain Name:
C57BL/6J-MtgxR8410Btlr/Mmmh
Stock Number:
067880-MU
Citation ID:
RRID:MMRRC_067880-MU
Other Names:
R8410 (G1)
Major Collection:

Strain Information

Wrn
Name: Werner syndrome RecQ like helicase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22427
Homologene: 6659
St3gal5
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 5
Synonyms: 3S-T, ST3Gal V, [a]2, GM3 synthase, GM3-specific sialytransferase, Siat9, mST3Gal V
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20454
Homologene: 2893
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: my, b2b1562Clo, 6030440P17Rik, ne, 8430406N05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454
Gapdhs
Name: glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
Synonyms: Gapds, Gapd-s
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14447
Homologene: 101265
Nbea
Name: neurobeachin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: 6230420N16Rik, Depdc2, C030045D06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109294
Homologene: 23523
Ticrr
Name: TOPBP1-interacting checkpoint and replication regulator
Synonyms: 5730590G19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77011
Homologene: 67120
Zfp516
Name: zinc finger protein 516
Synonyms: Zfp26l, C330029B10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 329003
VEGA: 18
Homologene: 37122
Arfgef1
Name: ADP ribosylation factor guanine nucleotide exchange factor 1
Synonyms: D730028O18Rik, D130059B05Rik, BIG1, ARFGEP1, P200
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211673
Homologene: 4687
Heatr5a
Name: HEAT repeat containing 5A
Synonyms: D930036F22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320487
VEGA: 12
Homologene: 19635
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, p325, C030033M12Rik, Hbxap, XAP8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Atoh1
Name: atonal bHLH transcription factor 1
Synonyms: Hath1, bHLHa14, Math1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11921
HGNC: HGNC:797
Homologene: 31297
Myh14
Name: myosin, heavy polypeptide 14
Synonyms: 2400004E04Rik, NMHC II-C
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71960
Homologene: 23480
Dsp
Name: desmoplakin
Synonyms: 5730453H04Rik, DP, rul, 2300002E22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Syt2
Name: synaptotagmin II
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20980
Homologene: 22516
Chsy1
Name: chondroitin sulfate synthase 1
Synonyms: skt
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269941
Homologene: 8950
Armc5
Name: armadillo repeat containing 5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233912
Homologene: 32601
Ruvbl2
Name: RuvB-like AAA ATPase 2
Synonyms: p47, mp47
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20174
Homologene: 4856
Zyx
Name: zyxin
Synonyms: R75157
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22793
Homologene: 31164
Sall3
Name: spalt like transcription factor 3
Synonyms: Msal, Msal-1, B130022O04Rik, Spalt, Salt
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20689
VEGA: 18
Homologene: 18142
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Alox15
Name: arachidonate 15-lipoxygenase
Synonyms: L-12LO, Alox12l, 12-LO
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11687
HGNC: HGNC:433
Homologene: 44935
D930020B18Rik
Name: RIKEN cDNA D930020B18 gene
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216393
Homologene: 87610
Or13n4
Name: olfactory receptor family 13 subfamily N member 4
Synonyms: MOR260-4, Olfr702, GA_x6K02T2PBJ9-9202245-9201289
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258590
Homologene: 121512
Jakmip1
Name: janus kinase and microtubule interacting protein 1
Synonyms: 5830437M04Rik, C330021K24Rik, Gababrbp, Marlin-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76071
Homologene: 90789
Vmn2r102
Name: vomeronasal 2, receptor 102
Synonyms: EG224572
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224572
Homologene: 115024
Stac3
Name: SH3 and cysteine rich domain 3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237611
Homologene: 17039
Caskin1
Name: CASK interacting protein 1
Synonyms: C630036E02Rik, 3300002N10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268932
VEGA: 17
Homologene: 25873
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Usp43
Name: ubiquitin specific peptidase 43
Synonyms: C630032K07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216835
Homologene: 129879
1700001K19Rik
Name: RIKEN cDNA 1700001K19 gene
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66323
VEGA: 12
Homologene: 19832
Slc15a5
Name: solute carrier family 15, member 5
Synonyms: 9830102E05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 277898
Homologene: 65333
Or2v2
Name: olfactory receptor family 2 subfamily V member 2
Synonyms: Olfr1396, MOR276-2, GA_x6K02T2QP88-6321048-6321995
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258334
Homologene: 28537
Tent5b
Name: terminal nucleotidyltransferase 5B
Synonyms: Fam46b, 4732473B16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100342
Homologene: 24928
Or6x1
Name: olfactory receptor family 6 subfamily X member 1
Synonyms: Olfr986, GA_x6K02T2PVTD-33886895-33887833, MOR104-3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258608
VEGA: 9
Homologene: 105185
Zfp456
Name: zinc finger protein 456
Synonyms: Rslcan-13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408065
Homologene: 110878
Eci2
Name: enoyl-Coenzyme A delta isomerase 2
Synonyms: Peci, DRS1, ACBD2, HCA88
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 23986
Homologene: 38145
D1Pas1
Name: DNA segment, Chr 1, Pasteur Institute 1
Synonyms: Pl10
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 110957
HGNC: HGNC:2745
Homologene: 135966
Rrm2
Name: ribonucleotide reductase M2
Synonyms: R2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20135
Homologene: 20277
Asl
Name: argininosuccinate lyase
Synonyms: 2510006M18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 109900
HGNC: HGNC:746
Homologene: 32
Uqcrb
Name: ubiquinol-cytochrome c reductase binding protein
Synonyms: QP-C, 2210415M14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67530
Homologene: 38164
Frmpd2
Name: FERM and PDZ domain containing 2
Synonyms: Gm626, LOC380890, ENSMUSG00000071536, LOC268729, Frmpd2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268729
Homologene: 51854
Or4f4-ps1
Name: olfactory receptor family 4 subfamily F member 4, pseudogene 1
Synonyms: Olfr1291, Olfr1291-ps1, MOR245-32_p, GA_x6K02T2Q125-72550790-72551728, OTTMUSG00000015084
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257819
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 10,159,642 bp
  • G to T, chromosome 1 at 11,153,657 bp
  • T to A, chromosome 1 at 46,356,659 bp
  • G to A, chromosome 1 at 134,746,864 bp
  • A to T, chromosome 1 at 186,968,315 bp
  • A to G, chromosome 2 at 76,709,641 bp
  • T to A, chromosome 2 at 111,499,702 bp
  • A to G, chromosome 3 at 53,539,177 bp
  • A to G, chromosome 3 at 56,037,263 bp
  • A to G, chromosome 4 at 133,487,051 bp
  • G to A, chromosome 5 at 37,117,484 bp
  • A to G, chromosome 5 at 130,013,510 bp
  • A to T, chromosome 6 at 42,356,450 bp
  • G to A, chromosome 6 at 64,729,650 bp
  • A to G, chromosome 6 at 72,142,297 bp
  • A to T, chromosome 6 at 138,012,155 bp
  • G to A, chromosome 7 at 30,737,910 bp
  • G to T, chromosome 7 at 44,633,483 bp
  • T to C, chromosome 7 at 45,431,332 bp
  • T to A, chromosome 7 at 66,125,463 bp
  • A to G, chromosome 7 at 79,667,675 bp
  • CGGCGGCGG to CGGCGGCGGGGGCGGCGG, chromosome 7 at 97,579,917 bp
  • T to A, chromosome 7 at 106,824,538 bp
  • C to T, chromosome 7 at 128,240,151 bp
  • C to T, chromosome 8 at 33,269,020 bp
  • C to T, chromosome 9 at 40,187,436 bp
  • A to G, chromosome 10 at 121,685,530 bp
  • G to A, chromosome 10 at 127,503,330 bp
  • A to T, chromosome 11 at 49,113,684 bp
  • T to G, chromosome 11 at 67,856,320 bp
  • T to C, chromosome 11 at 70,344,927 bp
  • T to C, chromosome 12 at 24,708,623 bp
  • T to A, chromosome 12 at 51,938,120 bp
  • A to T, chromosome 12 at 110,668,711 bp
  • T to C, chromosome 13 at 34,978,035 bp
  • A to G, chromosome 13 at 38,196,815 bp
  • C to A, chromosome 13 at 66,900,786 bp
  • A to G, chromosome 13 at 67,372,796 bp
  • G to A, chromosome 14 at 33,495,667 bp
  • T to C, chromosome 17 at 19,677,934 bp
  • T to C, chromosome 17 at 24,502,149 bp
  • G to A, chromosome 18 at 80,973,754 bp
  • G to T, chromosome 18 at 82,956,333 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8410 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067880-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.