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Strain Name:
C57BL/6J-MtgxR8511Btlr/Mmmh
Stock Number:
067888-MU
Citation ID:
RRID:MMRRC_067888-MU
Other Names:
R8511 (G1)
Major Collection:

Strain Information

Fga
Name: fibrinogen alpha chain
Synonyms: Fib, ENSMUSG00000059807
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14161
HGNC: HGNC:3661
Homologene: 428
Foxj2
Name: forkhead box J2
Synonyms: Fhx
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 60611
Homologene: 10187
Ggnbp2
Name: gametogenetin binding protein 2
Synonyms: DIF-3, Zfp403, D330017P12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217039
Homologene: 11750
Prtg
Name: protogenin
Synonyms: A230098A12Rik, Igdcc5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235472
Homologene: 54453
Ckap5
Name: cytoskeleton associated protein 5
Synonyms: 3110043H24Rik, 4930432B04Rik, D730027C18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75786
Homologene: 8844
Dock9
Name: dedicator of cytokinesis 9
Synonyms: B230309H04Rik, D14Wsu89e, Zizimin1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105445
Homologene: 41026
Hic2
Name: hypermethylated in cancer 2
Synonyms: HRG22
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 58180
Homologene: 9020
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 127,847,418 bp
  • T to C, chromosome 1 at 139,457,308 bp
  • A to G, chromosome 1 at 162,286,042 bp
  • T to A, chromosome 2 at 59,901,814 bp
  • T to C, chromosome 2 at 76,749,522 bp
  • T to A, chromosome 2 at 91,615,147 bp
  • G to A, chromosome 2 at 105,930,755 bp
  • T to A, chromosome 2 at 121,093,660 bp
  • A to G, chromosome 2 at 132,381,502 bp
  • A to G, chromosome 3 at 8,509,555 bp
  • A to G, chromosome 3 at 37,436,748 bp
  • A to T, chromosome 3 at 62,428,929 bp
  • A to T, chromosome 3 at 83,031,757 bp
  • A to G, chromosome 3 at 108,682,083 bp
  • G to T, chromosome 4 at 45,885,347 bp
  • A to G, chromosome 4 at 128,368,899 bp
  • A to G, chromosome 4 at 136,541,339 bp
  • G to A, chromosome 5 at 8,134,558 bp
  • T to A, chromosome 5 at 24,545,908 bp
  • A to G, chromosome 5 at 31,075,821 bp
  • A to G, chromosome 5 at 74,212,288 bp
  • T to C, chromosome 5 at 123,653,906 bp
  • A to T, chromosome 5 at 137,446,846 bp
  • A to G, chromosome 6 at 8,754,726 bp
  • A to G, chromosome 6 at 29,755,532 bp
  • C to A, chromosome 6 at 71,920,520 bp
  • A to G, chromosome 6 at 121,038,552 bp
  • C to T, chromosome 6 at 122,831,445 bp
  • A to G, chromosome 7 at 3,739,348 bp
  • C to T, chromosome 7 at 43,970,343 bp
  • A to G, chromosome 7 at 74,303,242 bp
  • A to G, chromosome 7 at 79,097,935 bp
  • A to T, chromosome 7 at 85,006,818 bp
  • A to T, chromosome 7 at 131,102,012 bp
  • T to A, chromosome 8 at 71,685,550 bp
  • A to G, chromosome 8 at 120,152,562 bp
  • T to C, chromosome 8 at 122,899,729 bp
  • A to G, chromosome 9 at 39,950,159 bp
  • A to T, chromosome 9 at 53,912,811 bp
  • T to C, chromosome 9 at 72,890,874 bp
  • T to C, chromosome 9 at 119,789,915 bp
  • T to C, chromosome 10 at 81,587,996 bp
  • C to T, chromosome 11 at 6,403,190 bp
  • C to T, chromosome 11 at 6,676,709 bp
  • T to C, chromosome 11 at 11,590,056 bp
  • T to G, chromosome 11 at 16,896,949 bp
  • T to A, chromosome 11 at 55,309,237 bp
  • T to C, chromosome 11 at 62,883,737 bp
  • C to T, chromosome 11 at 84,837,989 bp
  • T to A, chromosome 12 at 37,244,397 bp
  • T to A, chromosome 12 at 49,385,085 bp
  • A to G, chromosome 12 at 51,787,871 bp
  • A to G, chromosome 12 at 76,008,873 bp
  • G to A, chromosome 12 at 84,433,971 bp
  • A to T, chromosome 14 at 121,627,389 bp
  • T to C, chromosome 14 at 121,681,435 bp
  • C to G, chromosome 15 at 77,585,010 bp
  • T to C, chromosome 15 at 77,585,011 bp
  • C to T, chromosome 15 at 77,750,073 bp
  • T to C, chromosome 15 at 80,474,227 bp
  • T to C, chromosome 15 at 101,290,622 bp
  • T to A, chromosome 16 at 17,258,010 bp
  • G to A, chromosome 16 at 46,464,000 bp
  • A to T, chromosome 16 at 96,058,738 bp
  • G to T, chromosome 16 at 97,568,462 bp
  • A to T, chromosome 17 at 19,394,181 bp
  • A to T, chromosome 17 at 24,505,936 bp
  • G to A, chromosome 17 at 56,447,440 bp
  • A to G, chromosome 18 at 25,132,937 bp
  • A to G, chromosome 19 at 9,012,355 bp
  • C to A, chromosome 19 at 46,330,919 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8511 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067888-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.