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Strain Name:
C57BL/6J-MtgxR8513Btlr/Mmmh
Stock Number:
067889-MU
Citation ID:
RRID:MMRRC_067889-MU
Other Names:
R8513 (G1)
Major Collection:

Strain Information

Myo1e
Name: myosin IE
Synonyms: 2310020N23Rik, 9130023P14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71602
VEGA: 9
HGNC: HGNC:7599
Homologene: 55864
Ptpn3
Name: protein tyrosine phosphatase, non-receptor type 3
Synonyms: PTPCL, 9530011I20Rik, PTP-H1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 545622
HGNC: HGNC:9655
Homologene: 74451
Armc9
Name: armadillo repeat containing 9
Synonyms: 5730415N24Rik, 3830422A13Rik, 4831423D23Rik, 4930438O05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 78795
Homologene: 11847
Dot1l
Name: DOT1 like histone lysine methyltransferase
Synonyms: mDot1, KMT4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 208266
Homologene: 32779
Naa15
Name: N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Synonyms: tubedown, Tbdn-1, 5730450D16Rik, mNAT1, Narg1, ASTBDN
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74838
Homologene: 14211
Ilf3
Name: interleukin enhancer binding factor 3
Synonyms: NF90
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16201
VEGA: 9
HGNC: HGNC:6038
Homologene: 7785
Ctdp1
Name: CTD phosphatase subunit 1
Synonyms: 4930563P03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67655
HGNC: HGNC:2498
Homologene: 31254
Cdc73
Name: cell division cycle 73, Paf1/RNA polymerase II complex component
Synonyms: C130030P16Rik, 8430414L16Rik, Hrpt2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214498
Homologene: 11571
Zfp512
Name: zinc finger protein 512
Synonyms: 2500002M11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269639
Homologene: 13026
Kdm3b
Name: KDM3B lysine (K)-specific demethylase 3B
Synonyms: 5830462I21Rik, JHDM2B, Jmjd1b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 277250
VEGA: 18
HGNC: HGNC:1337
Homologene: 41145
Apoe
Name: apolipoprotein E
Synonyms: Apoe
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11816
HGNC: HGNC:613
Homologene: 30951
Slit2
Name: slit guidance ligand 2
Synonyms: Slil3, Drad-1, E130320P19Rik, E030015M03Rik, b2b1200.1Clo
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20563
Homologene: 3516
Rab7
Name: RAB7, member RAS oncogene family
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19349
HGNC: HGNC:9788
Homologene: 3408
Cpxm2
Name: carboxypeptidase X, M14 family member 2
Synonyms: 4632435C11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 55987
Homologene: 69259
Tmem201
Name: transmembrane protein 201
Synonyms: D4Ertd429e, Samp1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230917
Homologene: 35319
Tmem184b
Name: transmembrane protein 184b
Synonyms: 4732495E13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223693
VEGA: 15
HGNC: HGNC:1310
Homologene: 6396
Galnt3
Name: polypeptide N-acetylgalactosaminyltransferase 3
Synonyms: ppGaNTase-T3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14425
HGNC: HGNC:4125
Homologene: 55827
Fgd3
Name: FYVE, RhoGEF and PH domain containing 3
Synonyms: ZFYVE5, 5830461L01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 30938
Homologene: 22925
Spata31d1c
Name: spermatogenesis associated 31 subfamily D, member 1C
Synonyms: Fam75d1c, 4932441B19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238683
VEGA: 13
Ralgps1
Name: Ral GEF with PH domain and SH3 binding motif 1
Synonyms: RALGPS1A, RALGEF2, 5830418G11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241308
Homologene: 65163
Vmn1r37
Name: vomeronasal 1 receptor 37
Synonyms: V1rc10
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171183
Homologene: 110800
Zfp942
Name: zinc finger protein 942
Synonyms: 3110048L19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 73233
Homologene: 133237
Gml2
Name: glycosylphosphatidylinositol anchored molecule like 2
Synonyms: HemT, hematopoietic cell-specific transcript, 1700057K19Rik, Hemt1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 15202
HGNC: HGNC:4375
Homologene: 48071
Cpt2
Name: carnitine palmitoyltransferase 2
Synonyms: CPTII, CPT II
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12896
HGNC: HGNC:2330
Homologene: 77
Stab1
Name: stabilin 1
Synonyms: MS-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 192187
Homologene: 9035
Bsn
Name: bassoon
Synonyms: presynaptic cytomatrix protein
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12217
HGNC: HGNC:1117
Homologene: 31161
Evpl
Name: envoplakin
Synonyms: 210kDa protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14027
HGNC: HGNC:3503
Homologene: 1506
Kiz
Name: kizuna centrosomal protein
Synonyms: LOC228730, Ncrna00153, Gm114, Plk1s1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228730
Homologene: 10219
Spata2l
Name: spermatogenesis associated 2-like
Synonyms: 2610039E05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78779
Homologene: 32729
Setdb2
Name: SET domain, bifurcated 2
Synonyms: LOC239122, KMT1F
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239122
Homologene: 12903
Nlrp6
Name: NLR family, pyrin domain containing 6
Synonyms: Nalp6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101613
Homologene: 15881
Tpp1
Name: tripeptidyl peptidase I
Synonyms: Cln2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12751
HGNC: HGNC:2073
Homologene: 335
Snrpa1
Name: small nuclear ribonucleoprotein polypeptide A'
Synonyms: U2 snRNP-A', 1500015N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68981
Homologene: 2325
Hepacam
Name: hepatocyte cell adhesion molecule
Synonyms: 2900042E01Rik, Glialcam
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72927
Homologene: 17652
Pde2a
Name: phosphodiesterase 2A, cGMP-stimulated
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207728
HGNC: HGNC:8777
Homologene: 1952
Pacsin3
Name: protein kinase C and casein kinase substrate in neurons 3
Synonyms: 4921507A02Rik, 6330413E15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 80708
HGNC: HGNC:8572
Homologene: 41117
Coro2a
Name: coronin, actin binding protein 2A
Synonyms: coronin 4, IR10, 9030208C03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 107684
HGNC: HGNC:2255
Homologene: 2546
Ntf5
Name: neurotrophin 5
Synonyms: NT-4, NT4/5, NT4, neurotrophin-4, Ntf-5, Ntf4, 2900040K06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78405
HGNC: HGNC:8024
Homologene: 4503
Pcdhgb1
Name: protocadherin gamma subfamily B, 1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93699
HGNC: HGNC:8708
Homologene: 81867
Pcdha6
Name: protocadherin alpha 6
Synonyms: Cnr2, Crnr2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12937
Homologene: 75098
Or1e28-ps1
Name: olfactory receptor family 1 subfamily E member 28, pseudogene 1
Synonyms: GA_x6K02T2P1NL-3884648-3883708, MOR135-22, Olfr388-ps1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258182
Trav7-2
Name: T cell receptor alpha variable 7-2
Synonyms: Gm13952
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 634132
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 86,162,683 bp
  • C to A, chromosome 1 at 143,617,391 bp
  • T to C, chromosome 2 at 33,336,614 bp
  • A to T, chromosome 2 at 66,093,720 bp
  • A to C, chromosome 2 at 91,262,805 bp
  • A to G, chromosome 2 at 146,870,764 bp
  • T to A, chromosome 3 at 51,460,023 bp
  • ACCAGAAGAGCCATCCAG to ACCAG, chromosome 4 at 46,544,117 bp
  • G to A, chromosome 4 at 57,270,085 bp
  • G to A, chromosome 4 at 107,906,926 bp
  • A to T, chromosome 4 at 149,727,923 bp
  • T to C, chromosome 5 at 31,480,081 bp
  • T to A, chromosome 5 at 48,224,708 bp
  • A to G, chromosome 6 at 66,731,836 bp
  • T to C, chromosome 6 at 88,004,268 bp
  • C to A, chromosome 7 at 19,696,640 bp
  • A to G, chromosome 7 at 45,415,755 bp
  • G to A, chromosome 7 at 66,070,633 bp
  • A to T, chromosome 7 at 101,509,765 bp
  • A to T, chromosome 7 at 105,749,579 bp
  • A to T, chromosome 7 at 132,143,702 bp
  • A to C, chromosome 7 at 140,922,830 bp
  • T to C, chromosome 8 at 123,233,699 bp
  • A to G, chromosome 9 at 21,388,636 bp
  • A to G, chromosome 9 at 37,380,634 bp
  • T to A, chromosome 9 at 70,320,088 bp
  • T to C, chromosome 9 at 108,114,510 bp
  • T to C, chromosome 10 at 80,791,426 bp
  • A to G, chromosome 11 at 73,724,322 bp
  • C to T, chromosome 11 at 116,229,744 bp
  • T to C, chromosome 13 at 49,263,924 bp
  • G to T, chromosome 13 at 65,033,177 bp
  • C to A, chromosome 14 at 31,149,790 bp
  • C to T, chromosome 14 at 53,391,021 bp
  • G to A, chromosome 14 at 59,402,390 bp
  • C to G, chromosome 15 at 74,824,155 bp
  • A to T, chromosome 15 at 79,369,923 bp
  • T to C, chromosome 17 at 21,928,301 bp
  • G to T, chromosome 18 at 34,793,076 bp
  • T to C, chromosome 18 at 36,969,176 bp
  • A to G, chromosome 18 at 37,680,528 bp
  • G to A, chromosome 18 at 80,449,463 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8513 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067889-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.