Strain Name:
C57BL/6J-MtgxR8536Btlr/Mmmh
Stock Number:
067890-MU
Citation ID:
RRID:MMRRC_067890-MU
Other Names:
R8536 (G1)
Major Collection:

Strain Information

Dst
Name: dystonin
Synonyms: Macf2, A830042E19Rik, Bpag1, Bpag, bullous pemphigoid antigen 1, nmf203, athetoid, nmf339, BPAG1, BPAG1-n, 2310001O04Rik, bullous pemphigoid antigen 1, ah
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Rnf145
Name: ring finger protein 145
Synonyms: 3732413I11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74315
Homologene: 14427
Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 9030227G01Rik, 2510002A14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72313
Homologene: 103956
Nek6
Name: NIMA (never in mitosis gene a)-related expressed kinase 6
Synonyms: 1300007C09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 59126
HGNC: HGNC:7749
Homologene: 49379
Plxdc1
Name: plexin domain containing 1
Synonyms: 2410003I07Rik, Tem7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72324
Homologene: 10700
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: D5Ertd66e, Bwf1, 2610509D04Rik, Bchs, Ggtb3, Alfy
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72145
Homologene: 22855
Numa1
Name: nuclear mitotic apparatus protein 1
Synonyms: NuMA, 6720401E04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101706
HGNC: HGNC:8059
Homologene: 38150
Dnm1l
Name: dynamin 1-like
Synonyms: Drp1, Dnmlp1, 6330417M19Rik, python
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74006
VEGA: 16
HGNC: HGNC:2973
Homologene: 6384
Wls
Name: wntless WNT ligand secretion mediator
Synonyms: Gpr177, 5031439A09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68151
Homologene: 11779
Rbm26
Name: RNA binding motif protein 26
Synonyms: C230097K14Rik, 1700009P03Rik, Pro1777
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74213
Homologene: 41468
Mmp2
Name: matrix metallopeptidase 2
Synonyms: Clg4a, MMP-2, GelA, 72kDa type IV collagenase, gelatinase A, 72kDa gelatinase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17390
HGNC: HGNC:7166
Homologene: 3329
Fchsd1
Name: FCH and double SH3 domains 1
Synonyms: A030002D08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319262
Homologene: 14127
Fibcd1
Name: fibrinogen C domain containing 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98970
Homologene: 122246
Ttc7b
Name: tetratricopeptide repeat domain 7B
Synonyms: Ttc7l1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104718
VEGA: 12
Homologene: 14675
Mttp
Name: microsomal triglyceride transfer protein
Synonyms: MTP, 1810043K16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17777
HGNC: HGNC:7467
Homologene: 212
Abca4
Name: ATP-binding cassette, sub-family A member 4
Synonyms: Rim protein, RmP, D430003I15Rik, Abc10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11304
HGNC: HGNC:34
Homologene: 298
Trpm1
Name: transient receptor potential cation channel, subfamily M, member 1
Synonyms: 4732499L03Rik, Mlsn1, melastatin, LTRPC1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17364
HGNC: HGNC:7146
Homologene: 19940
Scn5a
Name: sodium channel, voltage-gated, type V, alpha
Synonyms: Nav1.5, mH1, SkM2, Nav1.5c
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20271
Homologene: 22738
Stard9
Name: StAR related lipid transfer domain containing 9
Synonyms: Kif16a, E230025N21Rik, 4831403C07Rik, N-3 kinesin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668880
Homologene: 130712
Poteg
Name: POTE ankyrin domain family, member G
Synonyms: 4921537P18Rik, 4930456F22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70952
Homologene: 134158
Vmn1r218
Name: vomeronasal 1 receptor 218
Synonyms: V1ri5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171256
Homologene: 110880
Nek11
Name: NIMA (never in mitosis gene a)-related expressed kinase 11
Synonyms: 4932416N14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208583
Homologene: 57008
Zmynd15
Name: zinc finger, MYND-type containing 15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 574428
Homologene: 12995
Ablim1
Name: actin-binding LIM protein 1
Synonyms: abLIM-S, 9330196J19Rik, 2210411C18Rik, abLIM-L, abLIM-M, 4833406P10Rik, Limab1, 2610209L21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226251
HGNC: HGNC:78
Homologene: 40994
Traf3ip3
Name: TRAF3 interacting protein 3
Synonyms: 6030423D04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215243
Homologene: 11885
Cntln
Name: centlein, centrosomal protein
Synonyms: B430108F07Rik, D530005L17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 338349
Homologene: 9805
Col15a1
Name: collagen, type XV, alpha 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12819
HGNC: HGNC:2192
Homologene: 1396
Meak7
Name: MTOR associated protein, eak-7 homolog
Synonyms: 4632415K11Rik, Tldc1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74347
Homologene: 32494
Fbxw24
Name: F-box and WD-40 domain protein 24
Synonyms: Gm5162
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382106
Homologene: 110776
Zmat4
Name: zinc finger, matrin type 4
Synonyms: 9630048M01Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320158
Homologene: 81899
Gzmd
Name: granzyme D
Synonyms: Ctla-5, Ctla5, CCP5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14941
Homologene: 133275
Bpifb9b
Name: BPI fold containing family B, member 9B
Synonyms: 5430413K10Rik, OTTMUSG00000015915
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 433492
Homologene: 128535
Sirpd
Name: signal regulatory protein delta
Synonyms: Gm9733
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 751864
Homologene: 135594
Ndufa8
Name: NADH:ubiquinone oxidoreductase subunit A8
Synonyms: 0610033L03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68375
HGNC: HGNC:7692
Homologene: 40932
Lztfl1
Name: leucine zipper transcription factor-like 1
Synonyms: 5530402H04Rik, 6130400H19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 93730
HGNC: HGNC:6741
Homologene: 41368
Cox18
Name: cytochrome c oxidase assembly protein 18
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231430
Homologene: 14821
4930505A04Rik
Name: RIKEN cDNA 4930505A04 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 75087
Homologene: 18988
Acox2
Name: acyl-Coenzyme A oxidase 2, branched chain
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 93732
HGNC: HGNC:120
Homologene: 74473
Ccdc7a
Name: coiled-coil domain containing 7A
Synonyms: 4930517G15Rik, 4930540C21Rik, Ccdc7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74703
Homologene: 134760
Lats2
Name: large tumor suppressor 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50523
HGNC: HGNC:6515
Homologene: 56678
Slco5a1
Name: solute carrier organic anion transporter family, member 5A1
Synonyms: A630033C23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240726
Homologene: 57135
Shd
Name: src homology 2 domain-containing transforming protein D
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20420
VEGA: 17
Homologene: 7537
Gatb
Name: glutamyl-tRNA amidotransferase subunit B
Synonyms: Pet112l, Pet112, 9430026F02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229487
HGNC: HGNC:8849
Homologene: 3357
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 12,881,301 bp
  • C to A, chromosome 1 at 34,197,246 bp
  • C to T, chromosome 1 at 193,194,515 bp
  • T to C, chromosome 2 at 31,816,631 bp
  • A to C, chromosome 2 at 36,049,300 bp
  • A to G, chromosome 2 at 38,514,785 bp
  • G to A, chromosome 2 at 120,714,659 bp
  • A to G, chromosome 2 at 154,316,277 bp
  • A to G, chromosome 3 at 15,296,554 bp
  • A to T, chromosome 3 at 85,604,561 bp
  • A to G, chromosome 3 at 122,179,745 bp
  • G to A, chromosome 3 at 138,104,943 bp
  • G to A, chromosome 3 at 159,873,111 bp
  • T to C, chromosome 4 at 47,208,536 bp
  • T to C, chromosome 4 at 84,957,049 bp
  • G to T, chromosome 5 at 73,100,353 bp
  • A to G, chromosome 5 at 90,215,018 bp
  • G to T, chromosome 5 at 101,885,198 bp
  • G to C, chromosome 7 at 64,247,407 bp
  • C to T, chromosome 7 at 102,001,580 bp
  • T to C, chromosome 8 at 23,748,507 bp
  • C to A, chromosome 8 at 27,448,020 bp
  • A to T, chromosome 8 at 92,830,625 bp
  • T to C, chromosome 8 at 119,764,048 bp
  • T to A, chromosome 8 at 128,790,120 bp
  • A to T, chromosome 9 at 105,298,339 bp
  • G to A, chromosome 9 at 109,623,531 bp
  • G to T, chromosome 9 at 119,539,745 bp
  • A to T, chromosome 9 at 123,711,054 bp
  • C to T, chromosome 11 at 30,426,217 bp
  • T to C, chromosome 11 at 44,560,115 bp
  • G to T, chromosome 11 at 70,462,561 bp
  • A to T, chromosome 11 at 97,978,696 bp
  • A to T, chromosome 12 at 100,373,544 bp
  • T to C, chromosome 13 at 23,137,365 bp
  • A to T, chromosome 14 at 8,256,081 bp
  • T to C, chromosome 14 at 56,129,701 bp
  • G to A, chromosome 14 at 57,703,038 bp
  • A to T, chromosome 14 at 105,142,838 bp
  • C to A, chromosome 16 at 16,358,775 bp
  • G to A, chromosome 17 at 55,976,315 bp
  • A to G, chromosome 18 at 37,967,770 bp
  • T to C, chromosome 19 at 57,182,286 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8536 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067890-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.