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Strain Name:
C57BL/6J-MtgxR7707Btlr/Mmmh
Stock Number:
067893-MU
Citation ID:
RRID:MMRRC_067893-MU
Other Names:
R7707 (G1)
Major Collection:

Strain Information

Sbf2
Name: SET binding factor 2
Synonyms: SBF2, 4833411B01Rik, mMTMH1, B430219L04Rik, Mtmr13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319934
HGNC: HGNC:2135
Homologene: 41810
Uso1
Name: USO1 vesicle docking factor
Synonyms: transcytosis associated protein p115, TAP, Vdp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56041
Homologene: 2754
Tnpo1
Name: transportin 1
Synonyms: D13Ertd688e, Kpnb2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238799
HGNC: HGNC:6401
Homologene: 5358
Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: DSD-1-PG, phosphacan, PTPzeta, PTPbeta, Rptpbeta, Ptpz, Ptprz, RPTPz
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Chrm4
Name: cholinergic receptor, muscarinic 4
Synonyms: Chrm-4, muscarinic acetylcholine receptor 4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12672
HGNC: HGNC:1953
Homologene: 20192
Thbs3
Name: thrombospondin 3
Synonyms: Thbs-3, TSP3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 21827
Homologene: 5159
Wwp1
Name: WW domain containing E3 ubiquitin protein ligase 1
Synonyms: SDRP1, Tiul1, AIP5, 8030445B08Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 107568
Homologene: 21385
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 79,614,247 bp
  • T to C, chromosome 1 at 163,392,440 bp
  • T to C, chromosome 1 at 183,404,429 bp
  • G to T, chromosome 2 at 76,902,062 bp
  • A to T, chromosome 2 at 84,773,699 bp
  • A to G, chromosome 2 at 88,864,809 bp
  • A to G, chromosome 2 at 91,927,354 bp
  • A to G, chromosome 2 at 109,997,591 bp
  • G to A, chromosome 2 at 157,464,658 bp
  • A to T, chromosome 2 at 158,261,173 bp
  • T to C, chromosome 3 at 30,624,892 bp
  • A to G, chromosome 3 at 85,676,253 bp
  • A to T, chromosome 3 at 89,224,900 bp
  • A to G, chromosome 3 at 101,459,922 bp
  • T to C, chromosome 4 at 19,627,645 bp
  • T to A, chromosome 4 at 34,598,691 bp
  • A to T, chromosome 4 at 84,884,616 bp
  • A to T, chromosome 4 at 119,444,866 bp
  • G to A, chromosome 4 at 119,733,959 bp
  • C to T, chromosome 4 at 141,805,467 bp
  • A to G, chromosome 5 at 57,720,330 bp
  • G to T, chromosome 5 at 65,610,133 bp
  • A to T, chromosome 5 at 72,162,738 bp
  • A to G, chromosome 5 at 87,081,508 bp
  • A to G, chromosome 5 at 92,201,936 bp
  • T to A, chromosome 5 at 113,137,986 bp
  • A to T, chromosome 5 at 123,253,887 bp
  • A to G, chromosome 6 at 5,430,968 bp
  • A to G, chromosome 6 at 23,002,296 bp
  • G to A, chromosome 6 at 41,178,613 bp
  • A to T, chromosome 6 at 48,461,527 bp
  • A to G, chromosome 6 at 122,323,780 bp
  • A to T, chromosome 6 at 138,079,747 bp
  • C to A, chromosome 7 at 24,626,597 bp
  • G to A, chromosome 7 at 24,916,881 bp
  • A to T, chromosome 7 at 30,443,098 bp
  • T to C, chromosome 7 at 30,539,791 bp
  • C to T, chromosome 7 at 44,344,301 bp
  • C to T, chromosome 7 at 81,476,782 bp
  • T to C, chromosome 7 at 98,451,669 bp
  • T to C, chromosome 7 at 110,330,713 bp
  • C to T, chromosome 8 at 121,117,902 bp
  • A to T, chromosome 8 at 129,219,179 bp
  • A to T, chromosome 9 at 37,413,122 bp
  • G to T, chromosome 9 at 44,073,460 bp
  • A to T, chromosome 9 at 120,952,865 bp
  • A to T, chromosome 10 at 23,921,237 bp
  • C to A, chromosome 10 at 75,511,286 bp
  • T to A, chromosome 10 at 79,975,901 bp
  • T to A, chromosome 10 at 89,414,358 bp
  • T to A, chromosome 10 at 94,188,165 bp
  • A to T, chromosome 10 at 120,146,584 bp
  • T to C, chromosome 10 at 121,083,959 bp
  • A to G, chromosome 11 at 32,522,851 bp
  • C to T, chromosome 11 at 58,965,284 bp
  • A to G, chromosome 11 at 66,118,958 bp
  • G to T, chromosome 11 at 100,383,052 bp
  • C to T, chromosome 11 at 118,410,898 bp
  • C to A, chromosome 12 at 55,777,292 bp
  • A to G, chromosome 12 at 65,226,207 bp
  • A to C, chromosome 12 at 117,715,344 bp
  • C to A, chromosome 13 at 46,429,129 bp
  • T to C, chromosome 13 at 98,890,787 bp
  • A to G, chromosome 14 at 32,102,008 bp
  • G to A, chromosome 14 at 43,604,875 bp
  • A to C, chromosome 14 at 55,516,314 bp
  • CAGCTGGAGGAGC to CAGC, chromosome 15 at 78,436,913 bp
  • T to A, chromosome 15 at 97,713,102 bp
  • T to A, chromosome 16 at 59,074,271 bp
  • A to T, chromosome 17 at 24,510,709 bp
  • C to A, chromosome 17 at 25,795,410 bp
  • A to T, chromosome 18 at 37,011,792 bp
  • A to G, chromosome 18 at 52,483,654 bp
  • C to A, chromosome 19 at 6,857,469 bp
  • T to A, chromosome 19 at 38,403,123 bp
  • T to C, chromosome 19 at 42,738,147 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7707 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067893-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.