Strain Name:
C57BL/6J-MtgxR8132Btlr/Mmmh
Stock Number:
067895-MU
Citation ID:
RRID:MMRRC_067895-MU
Other Names:
R8132 (G1)
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, DRP, Dmdl
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Snap25
Name: synaptosomal-associated protein 25
Synonyms: sp, Bdr, GENA 70, SNAP-25
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20614
Homologene: 13311
Hgf
Name: hepatocyte growth factor
Synonyms: scatter factor, NK1, SF/HGF, NK2, C230052L06Rik, HGF/SF
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15234
HGNC: HGNC:4893
Homologene: 503
Nphs1
Name: nephrosis 1, nephrin
Synonyms: nephrin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54631
HGNC: HGNC:7908
Homologene: 20974
Swap70
Name: SWA-70 protein
Synonyms: 70kDa
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20947
Homologene: 7557
Ncapg2
Name: non-SMC condensin II complex, subunit G2
Synonyms: Luzp5, Mtb, 5830426I05Rik, mCAP-G2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76044
VEGA: 12
Homologene: 9820
Rsf1
Name: remodeling and spacing factor 1
Synonyms: Hbxap, p325, XAP8, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Mrps35
Name: mitochondrial ribosomal protein S35
Synonyms: MRPS28, MRP-S28, MDSO23
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232536
Homologene: 11048
Cops7b
Name: COP9 signalosome subunit 7B
Synonyms: D1Wsu66e, COP9 complex S7b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26895
Homologene: 8068
Sos1
Name: SOS Ras/Rac guanine nucleotide exchange factor 1
Synonyms: 4430401P03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20662
VEGA: 17
Homologene: 4117
Arhgef1
Name: Rho guanine nucleotide exchange factor 1
Synonyms: Lbcl2, Lsc
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16801
HGNC: HGNC:681
Homologene: 3454
Syngap1
Name: synaptic Ras GTPase activating protein 1 homolog (rat)
Synonyms: Syngap
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240057
Homologene: 84739
Lrrc55
Name: leucine rich repeat containing 55
Synonyms: LOC241528, A330097E02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241528
VEGA: 2
Homologene: 19385
Ms4a4d
Name: membrane-spanning 4-domains, subfamily A, member 4D
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66607
Homologene: 113790
Trim25
Name: tripartite motif-containing 25
Synonyms: Zfp147, estrogen-responsive finger protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217069
Homologene: 48325
Ttc7b
Name: tetratricopeptide repeat domain 7B
Synonyms: Ttc7l1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104718
VEGA: 12
Homologene: 14675
Dennd1a
Name: DENN domain containing 1A
Synonyms: 6030446I19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227801
Homologene: 17141
Gemin4
Name: gem nuclear organelle associated protein 4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 276919
Homologene: 69193
Nek3
Name: NIMA (never in mitosis gene a)-related expressed kinase 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23954
HGNC: HGNC:7746
Homologene: 1869
Zbtb41
Name: zinc finger and BTB domain containing 41
Synonyms: 9830132G07Rik, 8430415N23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226470
Homologene: 27795
Or6k14
Name: olfactory receptor family 6 subfamily K member 14
Synonyms: MOR105-7, MOR105-8, GA_x6K02T2P20D-21063569-21062619, Olfr427, Olfr426, MOR105-9, GA_x6K02T2P20D-21075927-21074980, MOR105-13_p
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 259162
Homologene: 133035
Naip1
Name: NLR family, apoptosis inhibitory protein 1
Synonyms: Birc1a, D13Lsd1, Naip
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17940
VEGA: 13
HGNC: HGNC:7634
Homologene: 113589
Tmem147
Name: transmembrane protein 147
Synonyms: 5033425B17Rik, 2010004E11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69804
Homologene: 12330
Or10q1b
Name: olfactory receptor family 10 subfamily Q member 1B
Synonyms: MOR266-8, GA_x6K02T2RE5P-4037809-4038768, Olfr1491
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258342
Spag16
Name: sperm associated antigen 16
Synonyms: 4921511D23Rik, 4930585K05Rik, 4930524F24Rik, Pf20, Wdr29
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66722
Homologene: 11572
Speg
Name: SPEG complex locus
Synonyms: D1Bwg1450e, BPEG, Apeg1, SPEG, SPEGalpha, SPEGbeta
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11790
Homologene: 55619
CK137956
Name: cDNA sequence CK137956
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 635169
Homologene: 57187
Calr3
Name: calreticulin 3
Synonyms: Crt2, calsperin, 6330586I20Rik, 1700031L01Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73316
Homologene: 57091
Grk3
Name: G protein-coupled receptor kinase 3
Synonyms: Adrbk-2, beta ARK2, Adrbk2, 4833444A01Rik, Bark-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320129
HGNC: HGNC:290
Homologene: 21072
Hip1r
Name: huntingtin interacting protein 1 related
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 29816
Homologene: 78348
Clca3b
Name: chloride channel accessory 3B
Synonyms: Clca4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229927
HGNC: HGNC:2017
Homologene: 135610
Fdps
Name: farnesyl diphosphate synthetase
Synonyms: Fdpsl1, 6030492I17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 110196
HGNC: HGNC:3631
Homologene: 1519
Or5ac22
Name: olfactory receptor family 5 subfamily AC member 22
Synonyms: Olfr204, MOR182-3, GA_x54KRFPKG5P-55529713-55528796
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258994
Homologene: 79425
Abcb10
Name: ATP-binding cassette, sub-family B member 10
Synonyms: ABC-me
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56199
HGNC: HGNC:41
Homologene: 6474
Nudt15
Name: nudix hydrolase 15
Synonyms: MTH2, nudix (nucleoside diphosphate linked moiety X)-type motif 15, A730068G11Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 214254
VEGA: 14
Homologene: 10109
Hyal6
Name: hyaluronoglucosaminidase 6
Synonyms: 4932701A20Rik, Hyal-ps1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74409
HGNC: HGNC:5324
Homologene: 78028
Zeb2
Name: zinc finger E-box binding homeobox 2
Synonyms: 9130203F04Rik, SIP1, Zfhx1b, Zfx1b, D130016B08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 24136
Homologene: 8868
Tmem156
Name: transmembrane protein 156
Synonyms: LOC243025
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243025
Homologene: 49811
Chrng
Name: cholinergic receptor, nicotinic, gamma polypeptide
Synonyms: Acrg, Achr-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11449
HGNC: HGNC:1967
Homologene: 3810
Jph1
Name: junctophilin 1
Synonyms: mitsugumin72, JP-1, ENSMUSG00000054314
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 57339
Homologene: 10761
Or10c1
Name: olfactory receptor family 10 subfamily C member 1
Synonyms: Olfr95, GA_x6K02T2PSCP-1651760-1650822, MOR263-6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258506
HGNC: HGNC:8165
Homologene: 71990
Rpa3
Name: replication protein A3
Synonyms: C330026P08Rik, 14kDa
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68240
Homologene: 68285
Abhd16b
Name: abhydrolase domain containing 16B
Synonyms: BC050777
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241850
Homologene: 15422
Or8a1b
Name: olfactory receptor family 8 subfamily A member 1B
Synonyms: Olfr160, M72, GA_x6K02T2PVTD-31389446-31388517, MOR171-3, MOR171-3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80706
HGNC: HGNC:8469
Homologene: 12726
Pcdha5
Name: protocadherin alpha 5
Synonyms: Crnr6, Cnr6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12941
HGNC: HGNC:8671
Homologene: 49565
Tdpoz6
Name: TD and POZ domain containing 6
Synonyms: Gm37596, Gm9107
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 668325
Igkv5-39
Name: immunoglobulin kappa variable 5-39
Synonyms: LOC384415
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 620017
Igip
Name: IgA inducing protein
Synonyms: 6330403M23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 109169
Homologene: 128307
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 17,016,155 bp
  • A to G, chromosome 1 at 70,381,302 bp
  • A to G, chromosome 1 at 75,422,995 bp
  • G to T, chromosome 1 at 86,587,194 bp
  • A to G, chromosome 1 at 87,205,996 bp
  • T to C, chromosome 1 at 139,423,217 bp
  • T to A, chromosome 1 at 174,100,171 bp
  • T to A, chromosome 2 at 37,858,060 bp
  • T to A, chromosome 2 at 44,989,130 bp
  • T to C, chromosome 2 at 85,191,915 bp
  • A to T, chromosome 2 at 136,769,828 bp
  • G to A, chromosome 2 at 181,493,967 bp
  • G to A, chromosome 3 at 89,099,386 bp
  • G to A, chromosome 3 at 93,692,145 bp
  • A to T, chromosome 3 at 144,847,174 bp
  • T to C, chromosome 4 at 88,557,683 bp
  • T to A, chromosome 4 at 127,951,282 bp
  • C to T, chromosome 5 at 16,602,331 bp
  • T to A, chromosome 5 at 65,075,755 bp
  • A to G, chromosome 5 at 112,961,489 bp
  • C to T, chromosome 5 at 123,997,227 bp
  • A to C, chromosome 6 at 8,256,790 bp
  • A to T, chromosome 6 at 24,740,828 bp
  • A to G, chromosome 6 at 69,900,605 bp
  • T to A, chromosome 6 at 147,048,163 bp
  • C to T, chromosome 7 at 24,907,662 bp
  • C to T, chromosome 7 at 24,919,749 bp
  • A to G, chromosome 7 at 30,482,053 bp
  • T to C, chromosome 7 at 30,728,447 bp
  • CG to CGACGGCGGGG, chromosome 7 at 97,579,908 bp
  • A to G, chromosome 7 at 110,255,877 bp
  • A to T, chromosome 8 at 22,157,020 bp
  • C to T, chromosome 8 at 72,427,179 bp
  • C to T, chromosome 8 at 123,965,018 bp
  • C to T, chromosome 9 at 37,712,073 bp
  • T to A, chromosome 10 at 12,682,410 bp
  • T to C, chromosome 11 at 76,212,913 bp
  • C to A, chromosome 11 at 89,016,606 bp
  • T to C, chromosome 12 at 100,446,872 bp
  • T to A, chromosome 12 at 116,444,347 bp
  • T to G, chromosome 13 at 100,437,375 bp
  • G to A, chromosome 14 at 73,521,659 bp
  • G to T, chromosome 15 at 76,190,573 bp
  • T to C, chromosome 16 at 59,314,544 bp
  • G to A, chromosome 17 at 26,958,180 bp
  • T to A, chromosome 17 at 37,211,316 bp
  • T to G, chromosome 17 at 80,408,602 bp
  • A to G, chromosome 18 at 36,301,213 bp
  • T to C, chromosome 18 at 36,960,641 bp
  • C to A, chromosome 19 at 11,557,946 bp
  • G to A, chromosome 19 at 13,705,220 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8132 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067895-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.