Strain Name:
C57BL/6J-MtgxR8382Btlr/Mmmh
Stock Number:
067896-MU
Citation ID:
RRID:MMRRC_067896-MU
Other Names:
R8382 (G1)
Major Collection:

Strain Information

Jade1
Name: jade family PHD finger 1
Synonyms: D530048A03Rik, Phf17
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269424
Homologene: 18162
Plxnd1
Name: plexin D1
Synonyms: b2b1863Clo, 6230425C21Rik, b2b553Clo
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67784
HGNC: HGNC:9107
Homologene: 22866
Depdc5
Name: DEP domain containing 5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 277854
Homologene: 34718
Top3b
Name: topoisomerase (DNA) III beta
Synonyms: Topo III beta
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 21976
Homologene: 2923
Zfr
Name: zinc finger RNA binding protein
Synonyms: C920030H05Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22763
Homologene: 8009
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, p325, C030033M12Rik, Hbxap, XAP8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Rnf17
Name: ring finger protein 17
Synonyms: MMIP-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 30054
VEGA: 14
Homologene: 23727
Uba6
Name: ubiquitin-like modifier activating enzyme 6
Synonyms: Ube1l2, 5730469D23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231380
Homologene: 10080
Taf1c
Name: TATA-box binding protein associated factor, RNA polymerase I, C
Synonyms: mTAFI95
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21341
Homologene: 21163
Lig4
Name: ligase IV, DNA, ATP-dependent
Synonyms: 5830471N16Rik, tiny, DNA ligase IV
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319583
HGNC: HGNC:6601
Homologene: 1736
Prim1
Name: DNA primase, p49 subunit
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19075
HGNC: HGNC:9369
Homologene: 730
Slc7a5
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
Synonyms: Gm42049, TA1, LAT1, D0H16S474E
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20539
Homologene: 55759
Anapc4
Name: anaphase promoting complex subunit 4
Synonyms: D5Ertd249e, 2610306D21Rik, APC4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52206
Homologene: 40873
Frmd4b
Name: FERM domain containing 4B
Synonyms: GRSP1, 6030440G05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232288
Homologene: 14916
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Pico, Acz
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Cpsf1
Name: cleavage and polyadenylation specific factor 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 94230
VEGA: 15
HGNC: HGNC:2324
Homologene: 40865
Gm19410
Name: predicted gene, 19410
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100502846
Homologene: 132117
Cblif
Name: cobalamin binding intrinsic factor
Synonyms: Gif
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14603
HGNC: HGNC:4268
Homologene: 3773
Atg9a
Name: autophagy related 9A
Synonyms: Apg9l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 245860
Homologene: 34495
A2ml1
Name: alpha-2-macroglobulin like 1
Synonyms: Ovos2, BC048546
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232400
Homologene: 45969
Sp140l2
Name: Sp140 nuclear body protein like 2
Synonyms: C130026I21Rik, OTTMUSG00000029174
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 620078
Homologene: 131208
Cacna1i
Name: calcium channel, voltage-dependent, alpha 1I subunit
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239556
HGNC: HGNC:1396
Homologene: 69331
Or10d5
Name: olfactory receptor family 10 subfamily D member 5
Synonyms: GA_x6K02T2PVTD-33651220-33650288, MOR224-2, Olfr975
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258825
VEGA: 9
Homologene: 27275
Meiob
Name: meiosis specific with OB domains
Synonyms: 4930528F23Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75178
VEGA: 17
Homologene: 102013
Fcgbp
Name: Fc fragment of IgG binding protein
Synonyms: A430096B05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 215384
Homologene: 68369
Zfyve16
Name: zinc finger, FYVE domain containing 16
Synonyms: B130024H06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218441
Homologene: 8826
Or4a27
Name: olfactory receptor family 4 subfamily A member 27
Synonyms: Olfr1197, MOR225-10P, GA_x6K02T2Q125-50202854-50201910, MOR225-14
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 433449
Homologene: 123770
Vmn2r17
Name: vomeronasal 2, receptor 17
Synonyms: EG384221
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384221
Homologene: 104825
Or8b44
Name: olfactory receptor family 8 subfamily B member 44
Synonyms: Olfr907, MOR165-5, GA_x6K02T2PVTD-32204729-32205661
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258801
VEGA: 9
Homologene: 27268
Spata31e3
Name: spermatogenesis associated 31 subfamily E member 3
Synonyms: LOC380882, Gm906
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 380882
VEGA: 13
Homologene: 134512
Ear6
Name: eosinophil-associated, ribonuclease A family, member 6
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 93719
Homologene: 40596
Tekt5
Name: tektin 5
Synonyms: 3300001K11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70426
Homologene: 71928
Nalf1
Name: NALCN channel auxiliary factor 1
Synonyms: Fam155a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270028
Homologene: 83472
Med24
Name: mediator complex subunit 24
Synonyms: D11Ertd307e, 100kDa, Trap100, Pparb2, R75526, Gse2, Thrap4, DRIP100
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23989
Homologene: 40795
Ccdc87
Name: coiled-coil domain containing 87
Synonyms: 4931419P11Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 399599
VEGA: 19
Homologene: 49531
Kncn
Name: kinocilin
Synonyms: L5, Kino
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 654462
Homologene: 88613
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 75,185,698 bp
  • G to A, chromosome 1 at 85,246,950 bp
  • A to T, chromosome 2 at 88,729,513 bp
  • A to G, chromosome 3 at 41,564,934 bp
  • A to G, chromosome 4 at 115,886,750 bp
  • T to A, chromosome 5 at 14,677,066 bp
  • C to T, chromosome 5 at 32,927,898 bp
  • T to A, chromosome 5 at 52,858,935 bp
  • A to G, chromosome 5 at 86,131,337 bp
  • G to T, chromosome 5 at 109,428,521 bp
  • G to A, chromosome 6 at 97,305,248 bp
  • A to T, chromosome 6 at 115,972,472 bp
  • T to C, chromosome 6 at 128,560,682 bp
  • C to T, chromosome 7 at 28,117,337 bp
  • CGGCGGCGG to CGGCGGCGGGGGCGGCGG, chromosome 7 at 97,579,917 bp
  • T to C, chromosome 8 at 9,207,972 bp
  • C to T, chromosome 8 at 9,972,346 bp
  • T to A, chromosome 8 at 35,809,148 bp
  • G to T, chromosome 8 at 119,603,050 bp
  • A to T, chromosome 8 at 121,885,952 bp
  • A to T, chromosome 9 at 38,499,292 bp
  • A to G, chromosome 9 at 39,950,159 bp
  • T to C, chromosome 10 at 74,643,395 bp
  • A to T, chromosome 10 at 128,020,269 bp
  • G to A, chromosome 11 at 98,717,711 bp
  • T to C, chromosome 13 at 50,247,438 bp
  • A to T, chromosome 13 at 92,513,820 bp
  • T to C, chromosome 14 at 51,854,113 bp
  • TG to T, chromosome 14 at 56,424,542 bp
  • C to T, chromosome 15 at 12,152,968 bp
  • A to G, chromosome 15 at 76,600,951 bp
  • G to A, chromosome 15 at 80,376,816 bp
  • T to C, chromosome 16 at 10,395,064 bp
  • T to C, chromosome 16 at 16,888,003 bp
  • A to G, chromosome 17 at 24,827,939 bp
  • A to G, chromosome 19 at 4,839,990 bp
  • A to T, chromosome 19 at 11,749,726 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8382 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067896-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.