Strain Name:
C57BL/6J-MtgxR8423Btlr/Mmmh
Stock Number:
067899-MU
Citation ID:
RRID:MMRRC_067899-MU
Other Names:
R8423 (G1)
Major Collection:

Strain Information

Tnrc6b
Name: trinucleotide repeat containing 6b
Synonyms: A730065C02Rik, D230019K20Rik, 2700090M07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 213988
VEGA: 15
Homologene: 66194
Knl1
Name: kinetochore scaffold 1
Synonyms: 5730505K17Rik, Casc5, 2310043D08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76464
Homologene: 44890
Miga1
Name: mitoguardin 1
Synonyms: C030011O14Rik, Mita1, Fam73a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 215708
Homologene: 18369
Mynn
Name: myoneurin
Synonyms: 2810011C24Rik, SBBIZ1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80732
Homologene: 10253
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Bub1
Name: BUB1, mitotic checkpoint serine/threonine kinase
Synonyms: Bub1a, D2Xrf87
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12235
HGNC: HGNC:1148
Homologene: 37910
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: 2810449H11Rik, D130015N03Rik, tbl
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Clec16a
Name: C-type lectin domain family 16, member A
Synonyms: 4932416N17Rik, curt
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74374
Homologene: 71019
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: Garnl1, Tulip1, 4930400K19Rik, 2310003F20Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Trim66
Name: tripartite motif-containing 66
Synonyms: Tif1d, D7H11orf29
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330627
Homologene: 28044
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7, LOC381341, Dnahc7a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Galnt9
Name: polypeptide N-acetylgalactosaminyltransferase 9
Synonyms: GalNAc-T9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231605
HGNC: HGNC:4131
Homologene: 72793
Tfap2a
Name: transcription factor AP-2, alpha
Synonyms: AP-2 alpha, Tcfap2a, Ap2tf, Ap2, AP2alpha, Ap-2 (a)
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21418
VEGA: 13
Homologene: 2421
Fam135a
Name: family with sequence similarity 135, member A
Synonyms: 4921533L14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68187
Homologene: 32665
Dclk3
Name: doublecortin-like kinase 3
Synonyms: Click-I, -II related, Dcamkl3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245038
Homologene: 70580
Clvs2
Name: clavesin 2
Synonyms: Rlbp1l2, A330019N05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215890
Homologene: 27894
Enpep
Name: glutamyl aminopeptidase
Synonyms: Ly51, aminopeptidase-A, 6030431M22Rik, APA, Bp-1/6C3, Ly-51
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13809
HGNC: HGNC:3355
Homologene: 68216
Hoxc11
Name: homeobox C11
Synonyms: Hox-3.7
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 109663
HGNC: HGNC:5123
Homologene: 130362
Chd3
Name: chromodomain helicase DNA binding protein 3
Synonyms: Prp9-1, Chd7, 2600010P09Rik, Mi-2 alpha, Prp7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216848
HGNC: HGNC:1918
Homologene: 62693
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: 9430031G15Rik, LTBP-1, b2b1000Clo, Ltbp1L
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Slc6a18
Name: solute carrier family 6 (neurotransmitter transporter), member 18
Synonyms: Xtrp2, XT2, D630001K16Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 22598
VEGA: 13
Homologene: 40785
Carmil3
Name: capping protein regulator and myosin 1 linker 3
Synonyms: Lrrc16b
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268747
VEGA: 14
Homologene: 74564
Pik3r3
Name: phosphoinositide-3-kinase regulatory subunit 3
Synonyms: p55pik, p55
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18710
HGNC: HGNC:8981
Homologene: 2690
Clnk
Name: cytokine-dependent hematopoietic cell linker
Synonyms: MIST
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27278
Homologene: 8450
Ttc28
Name: tetratricopeptide repeat domain 28
Synonyms: 2310015L07Rik, TPRBK
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 209683
Homologene: 41023
Gbp4
Name: guanylate binding protein 4
Synonyms: Mpa-2, Mpa2, Mag-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17472
Homologene: 128731
Ampd1
Name: adenosine monophosphate deaminase 1
Synonyms: Ampd-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229665
HGNC: HGNC:468
Homologene: 20
Ccno
Name: cyclin O
Synonyms: Ccnu, Ung2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218630
VEGA: 13
Homologene: 50171
Col20a1
Name: collagen, type XX, alpha 1
Synonyms: 1700051I12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 73368
Homologene: 75138
Adam6b
Name: a disintegrin and metallopeptidase domain 6B
Synonyms: 4930523C11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238405
Homologene: 128362
Tgm1
Name: transglutaminase 1, K polypeptide
Synonyms: TG K, TGase 1, K polypeptide, 2310004J08Rik, protein-glutamine-gamma-glutamyltransferase, TGase1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21816
VEGA: 14
Homologene: 306
Fbxl12
Name: F-box and leucine-rich repeat protein 12
Synonyms: 3110048D16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 30843
Homologene: 32198
Plscr4
Name: phospholipid scramblase 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235527
Homologene: 23217
Carf
Name: calcium response factor
Synonyms: Als2cr8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241066
Homologene: 11689
Cnr2
Name: cannabinoid receptor 2
Synonyms: CB2-R, CB2, cannabinoid receptor 2 (spleen)
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12802
HGNC: HGNC:2160
Homologene: 1389
Or4a75
Name: olfactory receptor family 4 subfamily A member 75
Synonyms: Olfr1248, MOR231-10, GA_x6K02T2Q125-51059648-51058725
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258787
Homologene: 133613
Vmn1r6
Name: vomeronasal 1 receptor 6
Synonyms: V1rc20
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171193
Homologene: 128340
Fbxo40
Name: F-box protein 40
Synonyms: 9830003A13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207215
Homologene: 9459
Or3a1b
Name: olfactory receptor family 3 subfamily A member 1B
Synonyms: MOR255-6, GA_x6K02T2P1NL-4278037-4278984, Olfr401
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258701
HGNC: HGNC:8282
Homologene: 73922
Lrrc8b
Name: leucine rich repeat containing 8 family, member B
Synonyms: R75581, 2210408K08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 433926
Homologene: 9103
Gm340
Name: predicted gene 340
Synonyms: LOC381224
Type: Gene
Species: Mouse
Chromosome: 19
Zfp61
Name: zinc finger protein 61
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22719
Homologene: 74923
Plat
Name: plasminogen activator, tissue
Synonyms: tPA, D8Ertd2e, t-PA
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18791
HGNC: HGNC:9051
Homologene: 717
Heatr4
Name: HEAT repeat containing 4
Synonyms: Gm17673
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 101055670
Homologene: 45728
Or13c7d
Name: olfactory receptor family 13 subfamily C member 7D
Synonyms: Olfr159, mOR37e, MOR262-5, GA_x6K02T2N78B-16165641-16166600, Olfr37e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 29849
Homologene: 128097
Vmn1r238
Name: vomeronasal 1 receptor, 238
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 100312476
Homologene: 128342
Lipt2
Name: lipoyl(octanoyl) transferase 2 (putative)
Synonyms: 2610209A20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67164
Homologene: 41659
Gm17175
Name: predicted gene 17175
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 102641463
C1rb
Name: complement component 1, r subcomponent B
Synonyms: Gm8551, mC1rB
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 667277
HGNC: HGNC:1246
Homologene: 1313
Dusp28
Name: dual specificity phosphatase 28
Synonyms: 0710001B24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67446
Homologene: 45491
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 24,021,917 bp
  • C to A, chromosome 1 at 53,472,904 bp
  • T to A, chromosome 1 at 60,150,593 bp
  • T to C, chromosome 1 at 92,907,184 bp
  • A to T, chromosome 2 at 89,617,987 bp
  • T to G, chromosome 2 at 119,070,032 bp
  • G to A, chromosome 2 at 127,807,830 bp
  • A to G, chromosome 2 at 180,998,705 bp
  • A to G, chromosome 3 at 30,603,784 bp
  • T to C, chromosome 3 at 103,080,989 bp
  • T to G, chromosome 3 at 129,309,125 bp
  • A to T, chromosome 3 at 152,322,408 bp
  • T to C, chromosome 4 at 43,770,598 bp
  • C to T, chromosome 4 at 116,222,375 bp
  • C to T, chromosome 4 at 135,917,516 bp
  • A to G, chromosome 5 at 38,794,910 bp
  • T to A, chromosome 5 at 105,119,934 bp
  • G to A, chromosome 5 at 105,480,756 bp
  • A to G, chromosome 5 at 110,596,245 bp
  • G to A, chromosome 5 at 111,233,341 bp
  • G to A, chromosome 6 at 57,002,510 bp
  • T to A, chromosome 6 at 124,574,658 bp
  • A to G, chromosome 7 at 24,292,034 bp
  • T to C, chromosome 7 at 100,160,243 bp
  • T to A, chromosome 7 at 109,475,392 bp
  • G to T, chromosome 8 at 22,772,232 bp
  • C to A, chromosome 9 at 20,638,864 bp
  • T to C, chromosome 9 at 66,508,160 bp
  • C to T, chromosome 9 at 92,490,790 bp
  • C to T, chromosome 9 at 111,468,719 bp
  • T to C, chromosome 10 at 33,622,859 bp
  • A to T, chromosome 11 at 69,354,426 bp
  • T to C, chromosome 11 at 74,121,666 bp
  • A to G, chromosome 12 at 55,659,062 bp
  • A to G, chromosome 12 at 83,980,330 bp
  • A to G, chromosome 12 at 113,490,910 bp
  • A to T, chromosome 13 at 40,719,230 bp
  • T to A, chromosome 13 at 73,665,574 bp
  • A to G, chromosome 13 at 112,988,144 bp
  • T to A, chromosome 14 at 51,571,613 bp
  • A to G, chromosome 14 at 55,499,065 bp
  • A to T, chromosome 14 at 55,705,643 bp
  • G to A, chromosome 15 at 80,929,418 bp
  • G to A, chromosome 15 at 102,954,742 bp
  • A to G, chromosome 16 at 10,576,663 bp
  • A to T, chromosome 16 at 36,970,585 bp
  • T to C, chromosome 17 at 75,292,857 bp
  • G to T, chromosome 18 at 3,123,365 bp
  • T to C, chromosome 18 at 49,865,116 bp
  • T to C, chromosome 19 at 41,585,449 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8423 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067899-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.