Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR8447Btlr/Mmmh
Stock Number:
067902-MU
Citation ID:
RRID:MMRRC_067902-MU
Other Names:
R8447 (G1)
Major Collection:

Strain Information

Gli1
Name: GLI-Kruppel family member GLI1
Synonyms: Zfp-5, Zfp5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14632
VEGA: 10
HGNC: HGNC:4317
Homologene: 3859
Med1
Name: mediator complex subunit 1
Synonyms: TRAP 220, TRAP220, CRSP210, DRIP205, Pparbp, l11Jus15, PBP
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19014
HGNC: HGNC:9234
Homologene: 21002
Ggta1
Name: glycoprotein galactosyltransferase alpha 1, 3
Synonyms: GALT, alpha Gal, Gal, glycoprotein alpha galactosyl transferase 1, alpha3GalT, Ggta-1, Ggta
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14594
HGNC: HGNC:4253
Homologene: 7730
Lcmt1
Name: leucine carboxyl methyltransferase 1
Synonyms: Lcmt, LCMT-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 30949
Homologene: 41123
Kdm3a
Name: lysine (K)-specific demethylase 3A
Synonyms: 1700105C21Rik, Tsga, C230043E16Rik, Jmjd1, Jmjd1a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 104263
Homologene: 10196
Tm9sf2
Name: transmembrane 9 superfamily member 2
Synonyms: P76, 1500001N15Rik, D14Ertd64e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68059
Homologene: 21004
Eml4
Name: echinoderm microtubule associated protein like 4
Synonyms: 4930443C24Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78798
VEGA: 17
HGNC: HGNC:1316
Homologene: 56841
Akap12
Name: A kinase anchor protein 12
Synonyms: SSeCKS, Tsga12, Srcs5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 83397
VEGA: 10
HGNC: HGNC:370
Homologene: 3740
F2rl3
Name: F2R like thrombin or trypsin receptor 3
Synonyms: PAR4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14065
HGNC: HGNC:3540
Homologene: 36148
Tmem245
Name: transmembrane protein 245
Synonyms: A630051L19Rik, D730040F13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242474
HGNC: HGNC:1363
Homologene: 41841
Clec16a
Name: C-type lectin domain family 16, member A
Synonyms: 4932416N17Rik, curt
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74374
Homologene: 71019
Tmem135
Name: transmembrane protein 135
Synonyms: 2810439K08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72759
Homologene: 11295
Zp3
Name: zona pellucida glycoprotein 3
Synonyms: Zp-3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22788
Homologene: 5178
Lepr
Name: leptin receptor
Synonyms: Obr, leptin receptor gene-related protein, OB-RGRP, LEPROT, obl, obese-like, Modb1, Leprb
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16847
HGNC: HGNC:6554
Homologene: 1731
Grin2c
Name: glutamate receptor, ionotropic, NMDA2C (epsilon 3)
Synonyms: NMDAR2C, NR2C, GluRepsilon3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14813
HGNC: HGNC:4587
Homologene: 647
Tcf20
Name: transcription factor 20
Synonyms: SPBP, stromelysin 1 PDGF responsive element binding protein, 2810438H08Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21411
VEGA: 15
Homologene: 4131
Pah
Name: phenylalanine hydroxylase
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18478
HGNC: HGNC:8582
Homologene: 234
Ripor2
Name: RHO family interacting cell polarization regulator 2
Synonyms: 1700108N18Rik, E430013J17Rik, 6330500D04Rik, Fam65b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 193385
Homologene: 9284
Kank4
Name: KN motif and ankyrin repeat domains 4
Synonyms: Ankrd38
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242553
Homologene: 18244
Pwp2
Name: PWP2 periodic tryptophan protein homolog (yeast)
Synonyms: Pwp2, 6530411D08Rik, Pwp2h
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 110816
VEGA: 10
HGNC: HGNC:9711
Homologene: 3702
Cars1
Name: cysteinyl-tRNA synthetase 1
Synonyms: CA3, Cars
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27267
HGNC: HGNC:1493
Homologene: 1328
Diablo
Name: diablo, IAP-binding mitochondrial protein
Synonyms: 0610041G12Rik, Smac, 1700006L01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66593
Homologene: 10532
Dynll2
Name: dynein light chain LC8-type 2
Synonyms: 1700064A15Rik, 6720463E02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68097
Homologene: 115597
Sh2d3c
Name: SH2 domain containing 3C
Synonyms: Shep1, SH2-containing Eph receptor-binding protein 1, Cas/HEF1-associated signal transducer, Chat, Nsp3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27387
Homologene: 69145
Fance
Name: Fanconi anemia, complementation group E
Synonyms: 2810451D06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72775
HGNC: HGNC:3586
Homologene: 11066
Cfap46
Name: cilia and flagella associated protein 46
Synonyms: 9330101J02Rik, Ttc40
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 212124
Abcb4
Name: ATP-binding cassette, sub-family B member 4
Synonyms: mdr-2, Mdr2, Pgy-2, Pgy2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18670
HGNC: HGNC:45
Homologene: 136368
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329628
Homologene: 14377
Or4k37
Name: olfactory receptor family 4 subfamily K member 37
Synonyms: GA_x6K02T2Q125-72379864-72380781, MOR248-18, MOR248-14P, Olfr1281
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257979
Homologene: 73992
Lipe
Name: lipase, hormone sensitive
Synonyms: HSL, 4933403G17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16890
HGNC: HGNC:6621
Homologene: 3912
Tmem94
Name: transmembrane protein 94
Synonyms: 2310067B10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71947
Homologene: 8831
Adam10
Name: a disintegrin and metallopeptidase domain 10
Synonyms: kuz, kuzbanian, 1700031C13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11487
HGNC: HGNC:188
Homologene: 865
Spata20
Name: spermatogenesis associated 20
Synonyms: Tisp78
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217116
Homologene: 11264
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: C130004B06Rik, LOC384050, 1110020C03Rik, Wdr65
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68625
Homologene: 51350
Or9s14
Name: olfactory receptor family 9 subfamily S member 14
Synonyms: GA_x6K02T2R7CC-81146179-81145211, MOR208-2, Olfr1410
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258484
Homologene: 74205
Abcc3
Name: ATP-binding cassette, sub-family C member 3
Synonyms: 1700019L09Rik, MRP3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76408
HGNC: HGNC:54
Homologene: 68364
Mpv17l
Name: Mpv17 transgene, kidney disease mutant-like
Synonyms: M-LP
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 93734
Homologene: 13547
Ldhb
Name: lactate dehydrogenase B
Synonyms: lactate dehydrogenase-B, Ldh-2, H-Ldh
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16832
HGNC: HGNC:6541
Homologene: 55647
Kndc1
Name: kinase non-catalytic C-lobe domain (KIND) containing 1
Synonyms: VKIND, very-kind, 2410012C07Rik, B830014K08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76484
Homologene: 45138
Obox1
Name: oocyte specific homeobox 1
Synonyms: 7420700M11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71468
Homologene: 44937
Coro2b
Name: coronin, actin binding protein, 2B
Synonyms: E130012P22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235431
HGNC: HGNC:2256
Homologene: 21228
Or11h6
Name: olfactory receptor family 11 subfamily H member 6
Synonyms: GA_x6K02T2PMLR-6361495-6362481, MOR106-11, Olfr745
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258296
Homologene: 27116
Rpe
Name: ribulose-5-phosphate-3-epimerase
Synonyms: 5730518J08Rik, 2810429B02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66646
Homologene: 12005
Or6c76
Name: olfactory receptor family 6 subfamily C member 76
Synonyms: GA_x6K02T2PULF-11454600-11455541, MOR108-4, Olfr809
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258321
Homologene: 138308
Slc17a2
Name: solute carrier family 17 (sodium phosphate), member 2
Synonyms: NPT3, C730032N17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218103
Homologene: 4260
Or5t16
Name: olfactory receptor family 5 subfamily T member 16
Synonyms: GA_x6K02T2Q125-48475870-48474938, MOR179-3, Olfr1101
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258584
Homologene: 74087
Prl7a2
Name: prolactin family 7, subfamily a, member 2
Synonyms: PLP-F, Prlpf
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19114
Homologene: 49263
Akr1e1
Name: aldo-keto reductase family 1, member E1
Synonyms: 1810061I10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56043
Homologene: 74313
Or4f4b
Name: olfactory receptor family 4 subfamily F member 4B
Synonyms: GA_x6K02T2Q125-72534883-72535821, MOR245-6, Olfr1289
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258399
Pate1
Name: prostate and testis expressed 1
Synonyms: Gm17252
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 100312987
Homologene: 89136
Castor1
Name: cytosolic arginine sensor for mTORC1 subunit 1
Synonyms: 2410008K03Rik, Gatsl3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71962
Homologene: 81920
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 66,701,029 bp
  • C to A, chromosome 1 at 92,607,772 bp
  • A to G, chromosome 2 at 32,752,659 bp
  • C to T, chromosome 2 at 35,402,561 bp
  • T to A, chromosome 2 at 86,988,541 bp
  • T to A, chromosome 2 at 111,328,962 bp
  • T to A, chromosome 2 at 111,483,756 bp
  • T to C, chromosome 3 at 38,979,675 bp
  • T to C, chromosome 4 at 56,906,261 bp
  • T to A, chromosome 4 at 98,778,492 bp
  • T to C, chromosome 4 at 101,814,491 bp
  • C to T, chromosome 4 at 118,614,931 bp
  • A to C, chromosome 5 at 8,907,278 bp
  • C to A, chromosome 5 at 14,681,409 bp
  • T to C, chromosome 5 at 123,517,766 bp
  • G to A, chromosome 5 at 135,984,390 bp
  • A to G, chromosome 6 at 71,611,897 bp
  • A to G, chromosome 6 at 73,138,774 bp
  • A to T, chromosome 6 at 142,498,630 bp
  • A to T, chromosome 7 at 15,555,616 bp
  • G to T, chromosome 7 at 25,380,592 bp
  • T to C, chromosome 7 at 89,154,032 bp
  • T to A, chromosome 7 at 123,421,602 bp
  • C to A, chromosome 7 at 139,680,986 bp
  • T to C, chromosome 7 at 139,901,205 bp
  • T to C, chromosome 7 at 143,570,029 bp
  • T to C, chromosome 8 at 72,763,335 bp
  • A to T, chromosome 9 at 35,686,335 bp
  • C to T, chromosome 9 at 62,426,560 bp
  • T to A, chromosome 9 at 70,748,118 bp
  • A to G, chromosome 10 at 4,356,289 bp
  • T to A, chromosome 10 at 78,172,039 bp
  • T to C, chromosome 10 at 87,581,965 bp
  • T to C, chromosome 10 at 127,330,237 bp
  • T to G, chromosome 10 at 129,776,502 bp
  • T to C, chromosome 11 at 4,220,165 bp
  • G to T, chromosome 11 at 87,983,893 bp
  • A to T, chromosome 11 at 94,364,060 bp
  • C to A, chromosome 11 at 94,482,254 bp
  • C to A, chromosome 11 at 98,169,414 bp
  • A to G, chromosome 11 at 115,257,389 bp
  • G to T, chromosome 11 at 115,797,197 bp
  • G to A, chromosome 11 at 115,797,870 bp
  • C to A, chromosome 13 at 4,598,794 bp
  • T to C, chromosome 13 at 23,822,326 bp
  • T to A, chromosome 13 at 24,723,788 bp
  • A to T, chromosome 13 at 27,665,958 bp
  • T to C, chromosome 14 at 50,642,551 bp
  • C to A, chromosome 14 at 122,139,768 bp
  • G to A, chromosome 15 at 82,853,236 bp
  • C to A, chromosome 16 at 10,741,623 bp
  • T to A, chromosome 16 at 13,941,000 bp
  • T to A, chromosome 17 at 28,326,181 bp
  • A to T, chromosome 17 at 83,448,227 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8447 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067902-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.