Strain Name:
C57BL/6J-MtgxR8470Btlr/Mmmh
Stock Number:
067914-MU
Citation ID:
RRID:MMRRC_067914-MU
Other Names:
R8470 (G1)
Major Collection:

Strain Information

Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: spectrin G, Spnb-2, non-erythrocytic, brain spectrin, Spnb2, elf1, elf3, 9930031C03Rik, beta fodrin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Rasgrp2
Name: RAS, guanyl releasing protein 2
Synonyms: Caldaggef1, CalDAG-GEFI
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19395
HGNC: HGNC:9879
Homologene: 4250
Map1b
Name: microtubule-associated protein 1B
Synonyms: Mtap-5, Mtap5, LC1, Mtap1b, MAP5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17755
VEGA: 13
HGNC: HGNC:6836
Homologene: 38111
Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms: GCN2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27103
Homologene: 40891
Nup107
Name: nucleoporin 107
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103468
VEGA: 10
Homologene: 5555
Myo9a
Name: myosin IXa
Synonyms: 4732465J09Rik, C130068I12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270163
HGNC: HGNC:7608
Homologene: 21371
Cecr2
Name: CECR2, histone acetyl-lysine reader
Synonyms: 2610101O16Rik, cat eye syndrome chromosome region, candidate 2, 2810409N01Rik, Gtl4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330409
HGNC: HGNC:1840
Homologene: 64662
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Prrg4
Name: proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
Synonyms: TMG4, 9930111I18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228413
Homologene: 11451
Fancm
Name: Fanconi anemia, complementation group M
Synonyms: D12Ertd364e, C730036B14Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104806
VEGA: 12
Homologene: 35378
Anpep
Name: alanyl aminopeptidase, membrane
Synonyms: Cd13, aminopeptidase N, Apn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16790
HGNC: HGNC:500
Homologene: 68163
Epha3
Name: Eph receptor A3
Synonyms: Tyro4, Hek, Hek4, Mek4, End3, Cek4
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13837
VEGA: 16
HGNC: HGNC:3387
Homologene: 21083
Trpm3
Name: transient receptor potential cation channel, subfamily M, member 3
Synonyms: B930001P07Rik, 6330504P12Rik, LTRPC3, melastatin 2, MLSN2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226025
VEGA: 19
Homologene: 62287
Ccdc175
Name: coiled-coil domain containing 175
Synonyms: 4930403N07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73936
VEGA: 12
Homologene: 79144
Il1r2
Name: interleukin 1 receptor, type II
Synonyms: CD121b, Il1r-2, IL-1 receptor beta chain
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16178
HGNC: HGNC:5994
Homologene: 7783
Adamts16
Name: ADAM metallopeptidase with thrombospondin type 1 motif 16
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 271127
Homologene: 15146
Rtp4
Name: receptor transporter protein 4
Synonyms: 5830458K16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67775
Homologene: 56944
Cerkl
Name: ceramide kinase-like
Synonyms: Rp26
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228094
Homologene: 52396
Or10h5
Name: olfactory receptor family 10 subfamily H member 5
Synonyms: Gm4461, Olfr1564
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100043474
Homologene: 133726
Topaz1
Name: testis and ovary specific PAZ domain containing 1
Synonyms: Gm9524
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 671232
VEGA: 9
Homologene: 19835
Ush1c
Name: USH1 protein network component harmonin
Synonyms: Usher syndrome 1C, harmonin, 2010016F01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72088
Homologene: 77476
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Abraxas2
Name: BRISC complex subunit
Synonyms: KIAA0157, Fam175b, C430003P19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 109359
Homologene: 12970
Zfp518a
Name: zinc finger protein 518A
Synonyms: 6330417C12Rik, 2810401C22Rik, Zfp518
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72672
VEGA: 19
Homologene: 19378
B130006D01Rik
Name: RIKEN cDNA B130006D01 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320616
VEGA: 11
Rxfp2
Name: relaxin/insulin-like family peptide receptor 2
Synonyms: Gpr106, LGR8, Great
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 140498
Homologene: 15402
Gm3486
Name: predicted gene 3486
Type: Gene
Species: Mouse
Chromosome: 14
Stap1
Name: signal transducing adaptor family member 1
Synonyms: STAP-1, Brdg1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56792
Homologene: 8103
Pknox2
Name: Pbx/knotted 1 homeobox 2
Synonyms: Prep2, D230005H23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208076
Homologene: 32527
Or7g35
Name: olfactory receptor family 7 subfamily G member 35
Synonyms: Olfr855, MOR148-1, GA_x6K02T2PVTD-13330461-13331399
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258517
HGNC: HGNC:8466
Homologene: 74176
Atxn7l2
Name: ataxin 7-like 2
Synonyms: 2610528J18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72522
Homologene: 17728
Prr5l
Name: proline rich 5 like
Synonyms: 2600010E01Rik, 4833411O04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72446
Homologene: 11753
Ssbp1
Name: single-stranded DNA binding protein 1
Synonyms: 2810480P10Rik, G630031O20Rik, mtDBP
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381760
Homologene: 74462
Or4p20
Name: olfactory receptor family 4 subfamily P member 20
Synonyms: MOR225-9P, GA_x6K02T2Q125-49911636-49910701, Olfr1181
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258060
Homologene: 86666
Irgq
Name: immunity-related GTPase family, Q
Synonyms: FKSG27
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210146
Homologene: 17696
Pcdha11
Name: protocadherin alpha 11
Synonyms: A830022B16Rik, Cnr7, Crnr7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12942
HGNC: HGNC:8665
Homologene: 75095
Btf3l4b
Name: basic transcription factor 3 like 4B
Synonyms: Gm20075
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100504125
VEGA: 13
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 40,123,256 bp
  • C to A, chromosome 2 at 79,342,407 bp
  • A to T, chromosome 2 at 88,423,884 bp
  • T to C, chromosome 2 at 101,717,085 bp
  • A to G, chromosome 2 at 104,849,156 bp
  • A to G, chromosome 2 at 118,462,726 bp
  • G to A, chromosome 3 at 108,206,969 bp
  • A to G, chromosome 5 at 86,094,743 bp
  • T to G, chromosome 5 at 150,070,369 bp
  • A to G, chromosome 6 at 40,478,007 bp
  • A to G, chromosome 6 at 85,641,375 bp
  • A to T, chromosome 6 at 120,756,933 bp
  • A to T, chromosome 7 at 24,534,290 bp
  • A to G, chromosome 7 at 46,209,250 bp
  • A to G, chromosome 7 at 79,839,521 bp
  • A to T, chromosome 7 at 132,874,956 bp
  • T to G, chromosome 9 at 19,584,969 bp
  • C to T, chromosome 9 at 36,923,690 bp
  • T to G, chromosome 9 at 59,832,290 bp
  • T to C, chromosome 9 at 122,774,108 bp
  • A to C, chromosome 10 at 82,290,480 bp
  • A to T, chromosome 10 at 117,770,469 bp
  • C to A, chromosome 11 at 30,120,758 bp
  • C to T, chromosome 11 at 95,726,349 bp
  • T to C, chromosome 12 at 65,125,157 bp
  • T to C, chromosome 12 at 72,155,618 bp
  • A to G, chromosome 13 at 70,836,377 bp
  • C to A, chromosome 13 at 96,080,924 bp
  • T to A, chromosome 13 at 99,516,442 bp
  • T to C, chromosome 14 at 41,484,581 bp
  • A to T, chromosome 16 at 23,610,077 bp
  • T to C, chromosome 16 at 63,844,147 bp
  • A to G, chromosome 17 at 33,215,894 bp
  • A to G, chromosome 18 at 37,012,884 bp
  • T to A, chromosome 19 at 6,403,565 bp
  • T to C, chromosome 19 at 22,910,137 bp
  • G to A, chromosome 19 at 40,915,718 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8470 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067914-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.