Strain Name:
C57BL/6J-MtgxR8534Btlr/Mmmh
Stock Number:
068503-MU
Citation ID:
RRID:MMRRC_068503-MU
Other Names:
R8534 (G1)
Major Collection:

Strain Information

Slc12a6
Name: solute carrier family 12, member 6
Synonyms: KCC3, gaxp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107723
Homologene: 21069
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Pcf11
Name: PCF11 cleavage and polyadenylation factor subunit
Synonyms: 5730417B17Rik, 2500001H09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74737
Homologene: 32282
Npy5r
Name: neuropeptide Y receptor Y5
Synonyms: Y5R
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18168
HGNC: HGNC:7958
Homologene: 21241
Pias2
Name: protein inhibitor of activated STAT 2
Synonyms: Dib, 6330408K17Rik, ARIP3, PIASxbeta, PIASxalpha, PIASxb, Miz1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17344
VEGA: 18
Homologene: 20979
Vps54
Name: VPS54 GARP complex subunit
Synonyms: Vps54l, 5330404P15Rik, mSLP8, wr
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245944
Homologene: 5605
Ggnbp2
Name: gametogenetin binding protein 2
Synonyms: DIF-3, Zfp403, D330017P12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217039
Homologene: 11750
Zfat
Name: zinc finger and AT hook domain containing
Synonyms: LOC380993, Zfp406, Zfat1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 380993
Homologene: 16829
Phc1
Name: polyhomeotic 1
Synonyms: Rae-28, Mph1, rae28, Edr1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13619
HGNC: HGNC:3182
Homologene: 107079
Pms2
Name: PMS1 homolog2, mismatch repair system component
Synonyms: mismatch repair, DNA mismatch repair
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18861
Homologene: 133560
Insig1
Name: insulin induced gene 1
Synonyms: Insig-1, 1810013C12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231070
HGNC: HGNC:6083
Homologene: 4047
Ccdc187
Name: coiled-coil domain containing 187
Synonyms: 4932418E24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329366
Homologene: 77630
Lingo1
Name: leucine rich repeat and Ig domain containing 1
Synonyms: UNQ201, LERN1, 4930471K13Rik, LINGO-1, Lrrn6a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235402
Homologene: 41891
Elavl1
Name: ELAV like RNA binding protein 1
Synonyms: Hua, 2410055N02Rik, W91709, HuR, ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 15568
HGNC: HGNC:3312
Homologene: 20367
Kmt5a
Name: lysine methyltransferase 5A
Synonyms: 2410195B05Rik, PR-SET7, Setd8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67956
Homologene: 41372
Rrbp1
Name: ribosome binding protein 1
Synonyms: mRRp0, ES/130, p180, mRRp1.8, mRRp2, mRRp5.4, mRRp10, mRRp16.8, mRRp15b, mRRp15a, mRRp41, mRRp47, 5730465C04Rik, 1700087N07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 81910
Homologene: 68138
Slc4a4
Name: solute carrier family 4 (anion exchanger), member 4
Synonyms: NBC, NBC1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54403
Homologene: 55776
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: MDHC7, E030034C22Rik, B230373P09Rik, Dnahc1, G1-415-19, ferf1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Ruvbl2
Name: RuvB-like AAA ATPase 2
Synonyms: p47, mp47
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20174
Homologene: 4856
Trpm6
Name: transient receptor potential cation channel, subfamily M, member 6
Synonyms: CHAK2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225997
VEGA: 19
Homologene: 9767
Tnr
Name: tenascin R
Synonyms: janusin, restrictin, TN-R, J1-tenascin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21960
Homologene: 124416
Slc1a1
Name: solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Synonyms: MEAAC1, EAAC1, EAAT3, D130048G10Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20510
Homologene: 20881
Ahrr
Name: aryl-hydrocarbon receptor repressor
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 11624
HGNC: HGNC:346
Homologene: 49215
G6pc2
Name: glucose-6-phosphatase, catalytic, 2
Synonyms: IGRP, islet specific glucose-6-phosphatase, G6pc-rs
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14378
Homologene: 41423
Wdr17
Name: WD repeat domain 17
Synonyms: 3010002I12Rik, B230207L18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244484
Homologene: 12460
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: VLGR1, Mass1, Mgr1, Gpr98
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Rab44
Name: RAB44, member RAS oncogene family
Synonyms: 9830134C10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 442827
Homologene: 53300
Pik3r2
Name: phosphoinositide-3-kinase regulatory subunit 2
Synonyms: p85beta
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18709
HGNC: HGNC:8980
Homologene: 3687
Per2
Name: period circadian clock 2
Synonyms: mPer2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18627
HGNC: HGNC:8846
Homologene: 7885
Abcb11
Name: ATP-binding cassette, sub-family B member 11
Synonyms: PFIC2, ABC16, PGY4, Lith1, sister of P-glycoprotein, Bsep
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27413
HGNC: HGNC:42
Homologene: 74509
Spink14
Name: serine peptidase inhibitor, Kazal type 14
Synonyms: Gm5505
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 433178
Homologene: 37400
Myh4
Name: myosin, heavy polypeptide 4, skeletal muscle
Synonyms: MyHC-IIb, MHC2B, Myhsf, MM, MYH-2B, Minmus, Minimsc
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17884
HGNC: HGNC:7574
Homologene: 123880
Elmod3
Name: ELMO/CED-12 domain containing 3
Synonyms: ELMOD3, RBM29, C330008I15Rik, Rbed1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232089
Homologene: 12978
Cyp2c54
Name: cytochrome P450, family 2, subfamily c, polypeptide 54
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 404195
VEGA: 19
Homologene: 137231
Adgrb1
Name: adhesion G protein-coupled receptor B1
Synonyms: B830018M07Rik, Bai1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 107831
HGNC: HGNC:943
Homologene: 1287
Cbfa2t3
Name: CBFA2/RUNX1 translocation partner 3
Synonyms: MTGR2, ETO-2, A630044F12Rik, Eto2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12398
HGNC: HGNC:1537
Homologene: 74543
Tsnaxip1
Name: translin-associated factor X (Tsnax) interacting protein 1
Synonyms: TXI1, 1700016K08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72236
Homologene: 10194
Spmap2l
Name: sperm microtubule associated protein 2 like
Synonyms: 1700023E05Rik, Thegl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71868
Homologene: 128474
Or7g33
Name: olfactory receptor family 7 subfamily G member 33
Synonyms: GA_x6K02T2PVTD-13277703-13276786, MOR154-1, Olfr853
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258908
HGNC: HGNC:8466
Homologene: 133623
Itih4
Name: inter alpha-trypsin inhibitor, heavy chain 4
Synonyms: Itih-4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16427
HGNC: HGNC:6169
Homologene: 1670
Pip
Name: prolactin induced protein
Synonyms: GCDFP-15, gross cystic disease fluid protein 15, mSMGP
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18716
HGNC: HGNC:8993
Homologene: 1990
Kndc1
Name: kinase non-catalytic C-lobe domain (KIND) containing 1
Synonyms: VKIND, very-kind, 2410012C07Rik, B830014K08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76484
Homologene: 45138
Nlrx1
Name: NLR family member X1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270151
VEGA: 9
Homologene: 11623
Ceacam5
Name: CEA cell adhesion molecule 5
Synonyms: 1600029H12Rik, Psg30
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73250
HGNC: HGNC:1819
Homologene: 115938
6820408C15Rik
Name: RIKEN cDNA 6820408C15 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228778
Homologene: 51916
4921504E06Rik
Name: RIKEN cDNA 4921504E06 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70909
Homologene: 87049
Or5b102
Name: olfactory receptor family 5 subfamily B member 102
Synonyms: GA_x6K02T2RE5P-3390804-3391727, MOR202-14, Olfr1454
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258687
HGNC: HGNC:8324
Homologene: 120159
Agmo
Name: alkylglycerol monooxygenase
Synonyms: A530016O06Rik, Tmem195
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319660
Homologene: 45620
Zfp2
Name: zinc finger protein 2
Synonyms: mkr-2, Zfp-2, Fnp-2, 9930007F06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22678
Homologene: 121779
Slc35b3
Name: solute carrier family 35, member B3
Synonyms: 4921526O06Rik, PAPST2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 108652
VEGA: 13
Homologene: 9313
Acbd7
Name: acyl-Coenzyme A binding domain containing 7
Synonyms: 9230116B18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78245
Homologene: 82242
Pabpn1l
Name: poly(A)binding protein nuclear 1-like
Synonyms: LOC382035, ePABP2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382035
Homologene: 19736
Tmem59
Name: transmembrane protein 59
Synonyms: thymic dendritic cell-derived factor 1, MTDCF1, 3110046P06Rik, 1110001M20Rik, D4Ertd20e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56374
HGNC: HGNC:1239
Homologene: 3583
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240427
Homologene: 9192
Slc50a1
Name: solute carrier family 50 (sugar transporter), member 1
Synonyms: Rga, Rag1ap1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19729
Homologene: 40647
B020011L13Rik
Name: RIKEN cDNA B020011L13 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 547097
Homologene: 140625
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 34,190,307 bp
  • G to A, chromosome 1 at 91,423,937 bp
  • C to A, chromosome 1 at 117,801,304 bp
  • G to A, chromosome 1 at 159,919,015 bp
  • A to T, chromosome 2 at 3,340,713 bp
  • A to C, chromosome 2 at 19,540,342 bp
  • A to G, chromosome 2 at 26,275,565 bp
  • T to A, chromosome 2 at 69,220,125 bp
  • G to T, chromosome 2 at 69,323,846 bp
  • G to A, chromosome 2 at 111,228,035 bp
  • T to A, chromosome 2 at 112,343,967 bp
  • A to G, chromosome 2 at 143,988,175 bp
  • A to G, chromosome 2 at 152,441,262 bp
  • G to A, chromosome 3 at 89,270,403 bp
  • T to C, chromosome 4 at 107,185,885 bp
  • C to T, chromosome 5 at 28,075,118 bp
  • T to A, chromosome 5 at 77,059,478 bp
  • A to T, chromosome 5 at 89,135,722 bp
  • C to A, chromosome 5 at 124,460,572 bp
  • T to C, chromosome 5 at 143,923,627 bp
  • T to C, chromosome 6 at 41,851,487 bp
  • A to G, chromosome 6 at 72,566,684 bp
  • G to A, chromosome 6 at 122,338,580 bp
  • A to T, chromosome 7 at 17,750,746 bp
  • A to T, chromosome 7 at 45,429,694 bp
  • A to G, chromosome 7 at 92,653,224 bp
  • C to A, chromosome 7 at 139,923,753 bp
  • A to T, chromosome 8 at 4,289,864 bp
  • T to G, chromosome 8 at 54,648,230 bp
  • C to A, chromosome 8 at 66,682,036 bp
  • A to T, chromosome 8 at 70,774,668 bp
  • A to G, chromosome 8 at 105,838,738 bp
  • T to C, chromosome 8 at 122,622,619 bp
  • T to C, chromosome 8 at 122,638,914 bp
  • C to T, chromosome 9 at 19,537,309 bp
  • A to G, chromosome 9 at 44,262,773 bp
  • T to A, chromosome 9 at 56,621,069 bp
  • A to G, chromosome 11 at 21,277,706 bp
  • C to T, chromosome 11 at 50,900,800 bp
  • A to T, chromosome 11 at 67,243,509 bp
  • C to T, chromosome 11 at 84,837,989 bp
  • A to G, chromosome 12 at 37,252,539 bp
  • T to A, chromosome 13 at 38,944,590 bp
  • A to G, chromosome 13 at 74,220,680 bp
  • A to G, chromosome 13 at 81,386,768 bp
  • A to T, chromosome 14 at 30,901,022 bp
  • G to T, chromosome 14 at 31,301,848 bp
  • G to T, chromosome 15 at 68,165,847 bp
  • G to T, chromosome 15 at 73,839,824 bp
  • A to T, chromosome 15 at 74,543,508 bp
  • A to G, chromosome 17 at 29,144,573 bp
  • G to A, chromosome 18 at 44,031,012 bp
  • A to G, chromosome 18 at 77,097,387 bp
  • T to C, chromosome 18 at 78,783,327 bp
  • T to A, chromosome 19 at 13,064,068 bp
  • A to T, chromosome 19 at 18,892,095 bp
  • C to T, chromosome 19 at 28,905,346 bp
  • A to C, chromosome 19 at 40,047,586 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8534 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068503-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.